Nina Karalija, Goran Papenberg, Jarkko Johansson, Anders Wåhlin, Alireza Salami, Micael Andersson, Jan Axelsson, Dmitry Kuznetsov, Katrine Riklund, Martin Lövdén, Ulman Lindenberger, Lars Bäckman, Lars Nyberg
Dopamine decline is suggested to underlie aging-related cognitive decline, but longitudinal examinations of this link are currently missing. We analyzed 5-year longitudinal data for a sample of healthy, older adults (baseline: n = 181, age: 64-68 years; 5-year follow-up: n = 129) who underwent positron emission tomography with 11 C-raclopride to assess dopamine D2-like receptor (DRD2) availability, magnetic resonance imaging to evaluate structural brain measures, and cognitive tests. Health, lifestyle, and genetic data were also collected...
February 5, 2024: Neurobiology of Aging