Alessandra Tuccitto, Marcella Tazzari, Valeria Beretta, Francesca Rini, Claudia Miranda, Angela Greco, Mario Santinami, Roberto Patuzzo, Barbara Vergani, Antonello Villa, Giacomo Manenti, Loredana Cleris, Daniele Giardiello, Malcolm Alison, Licia Rivoltini, Chiara Castelli, Michela Perego
Melanoma is a highly heterogeneous tumor for which recent evidence supports a model of dynamic stemness. Melanoma cells might temporally acquire tumor-initiating properties or switch from a status of tumor-initiating cells (TICs) to a more differentiated one depending on the tumor context. However, factors driving these functional changes are still unknown. We focused on the role of cyto/chemokines in shaping TICs isolated directly from tumor specimens of two melanoma patients, namely Me14346S and Me15888S...
October 2016: Stem Cells