Akiko Sankoda, Hitomi Suzuki, Misa Imaizumi, Ai Yoshihara, Sakiko Kobayashi, Miyuki Katai, Katsuhiko Hamada, Yoh Hidaka, Aya Yoshihara, Hannah Nakamura, Sumihisa Kubota, Maiko Kakita-Kobayashi, Akira Iwase, Takashi Sugiyama, Erika Ota, Naoko Arata
BACKGROUND: Subclinical hypothyroidism, elevated thyroid-stimulating hormone (TSH) and normal free thyroxine (FT4) levels, is associated with multiple adverse pregnancy outcomes. Despite the uncertainty regarding the effectiveness of levothyroxine treatment on pregnancy outcomes in subclinical hypothyroidism, levothyroxine is widely administered with a threshold TSH level of 2.5 mU/L. The aim of this study is to investigate the efficacy of periconceptional levothyroxine treatment for subclinical hypothyroidism, including TSH levels >2...
February 18, 2024: Thyroid: Official Journal of the American Thyroid Association