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Subclinic hypothyroidism

Bruce E Johnson
No abstract text is available yet for this article.
February 19, 2019: Annals of Internal Medicine
Owain Leng, Salman Razvi
Background: Both overt hypothyroidism as well as minor elevations of serum thyrotropin (TSH) levels associated with thyroid hormones within their respective reference ranges (termed subclinical hypothyroidism) are relatively common in older individuals. There is growing evidence that treatment of subclinical hypothyroidism may not be beneficial, particularly in an older person. These findings are relevant at a time when treatment with thyroid hormones is increasing and more than 10-15% of people aged over 80 years are prescribed levothyroxine replacement therapy...
2019: Thyroid Research
V Mandese, E Bigi, P Bruzzi, G Palazzi, B Predieri, L Lucaccioni, M Cellini, L Iughetti
BACKGROUND: Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crises may be involved. Aims of this study were to evaluate the growth pattern, endocrine complications, and metabolic alterations and to detect the relationship between these conditions and the SCD severity in affected children and adolescents...
February 11, 2019: BMC Pediatrics
Sidra Azim, Christian Nasr
Subclinical hypothyroidism is defined by an elevated serum thyroid-stimulating hormone (TSH) level along with a normal free thyroxine (T4 ) level. Whether it should be treated remains controversial. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities.
February 2019: Cleveland Clinic Journal of Medicine
Gabriela Brenta, Alejandro Sosa Caballero, Maria Tereza Nunes
OBJECTIVE: Latin American Thyroid Society (LATS) Hypothyroidism Clinical Practice Guidelines recommend case finding of hypothyroid patients in multiple and different situations that agree with other Society guidelines. However, the detection of hypothyroidism in type 2 diabetes mellitus (T2DM) or metabolic syndrome (MetS) patients is not mentioned in particular. In the recent years, several basic and epidemiologic studies have appeared showing that a lower thyroid function and MetS/T2DM are associated...
January 2019: Endocrine Practice
Mitsuru Masaki, Kumi Koide, Akiko Goda, Ayako Miyazaki, Tohru Masuyama, Masahiro Koshiba
Acute exercise has been reported to increase thyroid hormone levels and decrease arterial stiffness in healthy young subjects. However, the effect of acute aerobic exercise on circulating thyroid hormone levels and arterial stiffness in patients with subclinical hypothyroidism remains unclear. The aim of this study was to investigate the effects of acute aerobic exercise on arterial stiffness and thyroid hormone levels, and any relationship between these endpoints, in patients with subclinical hypothyroidism...
February 6, 2019: Heart and Vessels
Claudia Irene Maushart, Rahel Loeliger, Gani Gashi, Mirjam Christ-Crain, Matthias Johannes Betz
Objective Hypothyroidism is a frequent endocrine disorder with common symptoms of increased cold sensitivity and unintended weight gain, indicating changes in energy expenditure (EE) and response to cold exposure. Thyroid hormones (TH) play an important role for proper function of brown adipose tissue (BAT) and cold induced thermogenesis (CIT) in rodents, but the role of hypothyroidism on CIT in humans is uncertain. Methods This was a prospective observational study. We recruited 42 patients presenting with subclinical or overt hypothyroidism in whom TH replacement was planned...
February 6, 2019: Thyroid: Official Journal of the American Thyroid Association
Kate Wiles
No abstract text is available yet for this article.
February 2019: Drug and Therapeutics Bulletin
Lorenzo Iughetti, Giulia Vivi, Antonio Balsamo, Andrea Corrias, Antonino Crinò, Maurizio Delvecchio, Luigi Gargantini, Nella Augusta Greggio, Graziano Grugni, Uros Hladnik, Alba Pilotta, Letizia Ragusa, Alessandro Salvatoni, Malgorzata Wasniewska, Giovanna Weber, Barbara Predieri
Background Prader-Willi syndrome (PWS) is a genetic disorder due to loss of expression of paternally transcribed genes of the imprinted region of chromosome 15q11-13. PWS is characterized by peculiar signs and symptoms and many endocrine abnormalities have been described (growth hormone deficiency, hypogonadotropic hypogonadism). The abnormalities of thyroid function are discussed in literature and published data are discordant. The aim of our study was to report the thyroid function in patients with PWS to identify the prevalence of thyroid dysfunction...
February 25, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
Sikandar Hayat Khan, Aamir Ijaz
Subclinical-hypothyroidism is identified as suboptimal thyroid hormonal production associated with mild TSH (thyroid stimulating hormone) elevation. Though several non-thyroidal illness in the later stages, medications and dietary supplements may resemble SCH (subclinical-hypothyroidism), but mild persistent subnormal thyroidal pathologies are usually termed as SCH. This review briefly describes the various cardiovascular risk associations with subclinicalhypothyroidism and attempts to provide an insight into the risk and benefit association, which a patient faces once treated for SCH...
February 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
María Fernanda Modarelli, Osvaldo J Ponzo
Subclinical hypothyroidism (SH), elevation of the level of thyrotrophin with normal thyroid hormones, along with goiter (glandular size > 25g), increased in recent decades. In order to relate the prevalence of goiter and SH with the consumption of groundwater, as a population etiological risk factor, we analyzed 879 clinical histories from a medical center in the city of Glew in the South Buenos Aires suburbs. The population was studied according to age (20 to 60 and 12 to 19 years) and type of water consumed (potable water or groundwater)...
2019: Medicina
Sima Nazarpour, Fahimeh Ramezani Tehrani, Firoozeh Sajedi, Razieh Bidhendi Yarandi, Fereidoun Azizi
BACKGROUND: Despite the known adverse effects of maternal overt hypothyroidism on the neurocognitive development of children, there is uncertainty regarding the impact of gestational thyroid dysfunction or autoimmune thyroiditis on infant/child neurological development. This study aims to evaluate the impact of levothyroxine (LT4) treatment on the psychomotor developmental status of three-year-old children born to mothers with mild thyroid impairment (subclinical hypothyroidismwith/without autoimmune thyroiditis)...
January 28, 2019: Trials
Sofia Macedo Silva, Alexandra Carvalho, Maria Lopes-Pereira, Vera Fernandes
INTRODUCTION: Subclinical hypothyroidism, defined as an increase of thyroid stimulating hormone levels with normal levels of thyroid hormones, could have a multiorgan impact. There seem to be differences in the elderly (over 65 years of age) which indicate that there should be a different approach in terms of diagnosis and the treatment. MATERIAL AND METHODS: Electronic database search and narrative bibliographical review. RESULTS: Different case studies showing the multiorgan consequences of subclinical hypothyroidism suggest that, in the elderly, there is a minor impact or even a lack of repercussion, especially in those over 80 - 85 years old...
December 28, 2018: Acta Médica Portuguesa
Daowen Zhang, Keying Cai, Guixia Wang, Shuhang Xu, Xiaodong Mao, Ang Zheng, Chao Liu, Kuanlu Fan
The aim of this study was to determine the trimester-specific reference range of thyroid function in Nanjing.A total of 805 pregnant women in the 1st, 2nd, and 3rd trimesters were recruited in the prospective, observational study during their routine antenatal clinic visit and 282 nonpregnant subjects served as controls. A questionnaire was completed by the subjects to record their personal health history, family history of thyroid disease, and consumption of estrogen or antithyroid drugs. Thyroid palpation was performed to exclude the thyroid goiter...
January 2019: Medicine (Baltimore)
Rosangela A Hoshi, Rodrigo V Andreão, Itamar S Santos, Eduardo M Dantas, José Geraldo Mill, Paulo A Lotufo, Isabela M Bensenor
Subclinical hypothyroidism (SCHypo) is associated with autonomic disturbances that can interfere in physiological responses. This study was designed to evaluate linear and nonlinear variables of heart rate variability (HRV) following postural change, comparing subjects with SCHypo to euthyroid subjects.HRV analyses were performed in 5-minute time series collected in the supine and standing positions from a subsample of 855 participants of the ELSA-Brasil study. The cardiac autonomic nervous function was evaluated by linear time and frequency domain analyses (SDNN, RMSSD, LFms, HFms, and LF/HF ratio) as well as by nonlinear symbolic dynamics (0, 1, and 2 V)...
January 2019: Medicine (Baltimore)
Abbas Azimi, Shokoufeh Bonakdaran, Javad Heravian, Parvin Layegh, Negareh Yazdani, Maryam Alborzi
PURPOSE: To investigate the functional integrity of visual pathway in hypothyroid patients by pattern visual evoked potential (PVEP). METHODS: We enrolled 36 female patients with history of hypothyroidism (18 overt and 18 subclinical) aged 20 to 60 years and 36 healthy women of similar age (control group). All subjects had a complete ophthalmic examination. For VEP testing, subjects were exposed to checks subtending a visual angle of 15 and 60 min of arc. RESULTS: For the 15 min of arc check size, the mean P100 latency was significantly delayed (113 milliseconds (ms)) and amplitude significantly reduced (9...
January 24, 2019: Documenta Ophthalmologica. Advances in Ophthalmology
Kun Huang, Yeqing Xu, Shuangqin Yan, Tao Li, Yuanhong Xu, Peng Zhu, Fangbiao Tao
This article aims to understand the isolated effect of maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4 ) and antithyroid peroxidase antibodies (TPOAb) in early pregnancy on gestational diabetes mellitus (GDM). Based on a birth cohort, pregnant women presented to maternity hospitals for the first antenatal care from Nov 2008 to Oct 2010 were invited to participate in the study. A self-administered questionnaire was asked to complete to collect data on socio-economic variables, previous adverse pregnancy outcomes, method of conception, previous endocrinic and metabolic diseases, and pregnancy-related anxiety in 1st trimester of the index pregnancy...
January 24, 2019: Endocrine Journal
Joe-Elie Salem, M Benjamin Shoemaker, Lisa Bastarache, Christian M Shaffer, Andrew M Glazer, Brett Kroncke, Quinn S Wells, Mingjian Shi, Peter Straub, Gail P Jarvik, Eric B Larson, Digna R Velez Edwards, Todd L Edwards, Lea K Davis, Hakon Hakonarson, Chunhua Weng, David Fasel, Bjorn C Knollmann, Thomas J Wang, Joshua C Denny, Patrick T Ellinor, Dan M Roden, Jonathan D Mosley
Importance: Thyroid hormone levels are tightly regulated through feedback inhibition by thyrotropin, produced by the pituitary gland. Hyperthyroidism is overwhelmingly due to thyroid disorders and is well recognized to contribute to a wide spectrum of cardiovascular morbidity, particularly the increasingly common arrhythmia atrial fibrillation (AF). Objective: To determine the association between genetically determined thyrotropin levels and AF. Design, Setting, and Participants: This phenome-wide association study scanned 1318 phenotypes associated with a polygenic predictor of thyrotropin levels identified by a previously published genome-wide association study that included participants of European ancestry...
January 23, 2019: JAMA Cardiology
Burcu D Cakmak, Ulku A Turker, Muzaffer Temur, Emin Ustunyurt
AIM: Subclinical hypothyroidism is thought to be associated with adverse pregnancy outcomes but the data is conflicting and generally depends on antibody positivity and treatment. We evaluated the pregnancy outcomes in Turkish population with untreated, antibody negative subclinical hypothyroidism for the first time. METHODS: We searched for 30 015 patients between January 2016 and May 2017 retrospectively. Finally, a total of 930 pregnant women with untreated, antibody negative subclinical hypothyroidism and 7986 controls were included...
January 22, 2019: Journal of Obstetrics and Gynaecology Research
J Du, L Lin, Z Li, J B Sun, N Yuan, X Zhao, F Li, J Zhang, X M Zhang, L N Ji
Objective: To analyze the influence of different thyroid stimulating hormone (TSH) cut-offs to diagnose subclinical hypothyroidism (SCH) in the first trimester of gestation. Methods: A total of 896 pregnant women were enrolled in Peking University International Hospital between October 2016 and March 2018. Among them, 421 pregnant women with single fetus who were conformed to the criteria of National Academy of Clinical Biochemistry (NACB), without adverse pregnancy outcomes and obstetric complications, were selected to establish their self-sequential longitudinal reference ranges of thyroid function...
January 8, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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