Andi Flory, Carlos A Ruiz-Perez, Ana G Clavere-Graciette, Jill M Rafalko, Allison L O'Kell, Brian K Flesner, Lisa M McLennan, Susan C Hicks, Prachi Nakashe, Ashley Phelps-Dunn, Lauren R DiMarzio, Chelsea D Warren, Todd A Cohen, Jason Chibuk, Ilya Chorny, Daniel S Grosu, Dana W Y Tsui, John A Tynan, Kristina M Kruglyak
OBJECTIVE: To validate the performance of a novel, integrated test for canine cancer screening that combines cell-free DNA quantification with next-generation sequencing (NGS) analysis. SAMPLE: Retrospective data from a total of 1,947 cancer-diagnosed and presumably cancer-free dogs were used to validate test performance for the detection of 7 predefined cancer types (lymphoma, hemangiosarcoma, osteosarcoma, leukemia, histiocytic sarcoma, primary lung tumors, and urothelial carcinoma), using independent training and testing sets...
February 7, 2024: Journal of the American Veterinary Medical Association