keyword
https://read.qxmd.com/read/38524071/the-relationship-of-grade-stage-and-tobacco-usage-in-head-and-neck-squamous-cell-carcinoma-with-p53-pik3ca-and-microrna-profiles
#1
JOURNAL ARTICLE
Kamini Kiran, Nilotpal Chowdhury, Ashok Singh, Manu Malhotra, Sanjeev Kishore
BACKGROUND:  Head and neck squamous cell carcinoma (HNSCC) has multiple epigenetic modifications including post-transcriptional regulation by microRNAs (miRNAs) as well as alterations in molecular pathways due to mutations. Examining these miRNAs and location-specific molecular alterations is essential to understanding the intricacies of HNSCC and directing focused diagnoses and treatments. AIM:  To investigate tobacco-related changes in the expression of miRNAs and proteins with clinicopathological parameters of HNSCC and disease-modifying personal habits like tobacco and alcohol use...
February 2024: Curēus
https://read.qxmd.com/read/38139300/mirna-expression-profiles-in-ovarian-endometriosis-and-two-types-of-ovarian-cancer-endometriosis-associated-ovarian-cancer-and-high-grade-ovarian-cancer
#2
JOURNAL ARTICLE
Maria Szubert, Anna Nowak-Glück, Daria Domańska-Senderowska, Bożena Szymańska, Piotr Sowa, Aleksander Rycerz, Jacek R Wilczyński
Endometriosis-associated ovarian cancer (EOC) consisting of endometrioid cancer and clear-cell ovarian cancer could be promoted by many factors. miRNAs, which are small, non-coding molecules of RNA, are among them. The aim of this study was to detect miRNAs connected with the malignant transformation of endometriosis. FFPE (formalin-fixed, paraffin-embedded) samples of 135 patients operated on for endometriosis and different types of ovarian cancer (EOC and HGSOC-high-grade serous ovarian cancer) were studied...
December 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37588448/a-promotion-role-of-mir31-in-the-process-of-vocal-fold-wound-healing
#3
JOURNAL ARTICLE
Haizhou Wang, Wen Xu
The role of MIR31 in the wound healing process, specifically in vocal fold wound healing (VFWH), remains uncertain despite its potential to facilitate the process. In this study, we first constructed a literature-based pathway to examine both the positive and negative effects of MIR31 on wound healing. We then conducted animal experiments on 20 rats to investigate MIR31 expression at different time points (1, 4, and 8 weeks) after vocal fold injury. Co-expression analysis and pathway analysis were performed to explore the potential function of MIR31 in VFWH...
2023: PPAR Research
https://read.qxmd.com/read/37389967/microrna-pools-synthesized-using-tandem-solid-phase-oligonucleotide-synthesis
#4
JOURNAL ARTICLE
Sofie Slott, Kira Astakhova
Herein, we describe a new approach to make pools of microRNA targeting breast cancer cells. The microRNA pools were synthesized at once on the same solid support using the "Tandem Oligonucleotide Synthesis" strategy. We make up to four consecutive microRNAs (miR129-1-5p, miR31, miR206, and miR27b-3p) using 2'/3'OAc nucleotide phosphoramidites, with the total length of the pool reaching 88 nucleotides. The developed phosphoramidites, when combined, give a cleavable moiety that separates the microRNAs and is cleaved using standard post-RNA synthesis cleavage conditions...
June 30, 2023: Journal of Organic Chemistry
https://read.qxmd.com/read/36855912/metabolic-rewiring-in-keratinocytes-by-mir-31-5p-identifies-therapeutic-intervention-for-psoriasis
#5
JOURNAL ARTICLE
Mao-Jie Wang, Huan-Jie Huang, Yong-Yue Xu, Harmjan Vos, Can Gulersonmez, Edwin Stigter, Johan Gerritsen, Marc Pages Gallego, Robert van Es, Li Li, Hao Deng, Lin Han, Run-Yue Huang, Chuan-Jian Lu, Boudewijn Mt Burgering
Besides genetic alterations, the cellular environment also determines disease onset and progression. When different cell types contribute to disease outcome, this imposes environmental challenges as different cell types likely differ in their extracellular dependencies. Hsa-microRNA-31-5p (miR-31) is highly expressed in keratinocytes of psoriatic skin, and we show that expression in keratinocytes is induced by limited glucose availability and enables increased survival under limiting glucose conditions by increasing glutamine metabolism...
March 1, 2023: EMBO Molecular Medicine
https://read.qxmd.com/read/36527848/exosomal-micrornas-regulate-the-heat-stress-response-in-sea-cucumber-apostichopus-japonicus
#6
JOURNAL ARTICLE
Da Huo, Fang Su, Hongsheng Yang, Lina Sun
Exosomes are small extracellular vesicles that contain nucleic acids such as microRNAs and may participate in important biological processes. We made the initial report of exosomes from sea cucumber Apostichopus japonicus, that were classically cup-shaped and had an average size of 74.65 nm, and identified specific exosome biomarkers (HSP70, TSG101, and CD9). We explored changes in the global expression of microRNAs in exosomes from the commercially important A. japonicus under normal conditions and heat-stressed conditions for 3 and 7 d...
December 15, 2022: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/36334906/delivery-of-a-peptide-microrna-blend-via-electrospun-antimicrobial-nanofibres-for-wound-repair
#7
JOURNAL ARTICLE
Adrian D Juncos Bombin, Nicholas Dunne, Helen O McCarthy
Downregulation of microRNA-31 (miR-31) and microRNA-132 (miR-132) has been associated with delayed wound healing. Therefore, it was hypothesised that intracellular delivery of miR-31 and miR-132, both as individual and blend formulations, could promote tissue repair. The use of a blend could minimise potential toxicity and achieve synergistic effects, thus maximising the therapeutic effect. miR-31 and miR-132 were condensed with a 30-mer positively charged amphipathic peptide, RALA, to form nanocomplexes with an average size <200 nm and zeta-potential ≥10 designed to facilitate cellular internalisation...
November 2, 2022: Acta Biomaterialia
https://read.qxmd.com/read/36290970/an-exosomal-mirna-biomarker-for-the-detection-of-pancreatic-ductal-adenocarcinoma
#8
JOURNAL ARTICLE
Amy Makler, Ramaswamy Narayanan, Waseem Asghar
Pancreatic ductal adenocarcinoma (PDAC) remains a difficult tumor to diagnose and treat. To date, PDAC lacks routine screening with no markers available for early detection. Exosomes are 40-150 nm-sized extracellular vesicles that contain DNA, RNA, and proteins. These exosomes are released by all cell types into circulation and thus can be harvested from patient body fluids, thereby facilitating a non-invasive method for PDAC detection. A bioinformatics analysis was conducted utilizing publicly available miRNA pancreatic cancer expression and genome databases...
October 6, 2022: Biosensors
https://read.qxmd.com/read/36057712/mir31hg-polymorphisms-are-related-to-steroid-induced-osteonecrosis-of-femoral-head-among-chinese-han-population
#9
JOURNAL ARTICLE
Yuan Wang, Yexin Wang, Da Liang, Hongtao Hu, Guangwei Li, Xiaoguang Meng, Bing Zhu, Wei Zhong
BACKGROUNDS: MIR31 host gene (MIR31HG) polymorphisms play important roles in the occurrence of osteonecrosis. However, the association of MIR31HG polymorphisms with the risk of steroid-induced osteonecrosis of the femoral head (SONFH) remains unclear. In this study, we aimed to investigate the correlation between MIR31HG polymorphisms and SONFH susceptibility in the Chinese Han population. METHODS: A total of 708 volunteers were recruited to detect the effect of seven single nucleotide polymorphisms (SNPs) in the MIR31HG gene on SONFH risk in the Chinese Han population...
September 3, 2022: BMC Musculoskeletal Disorders
https://read.qxmd.com/read/35743003/long-non-coding-rna-mir31hg-promotes-the-transforming-growth-factor-%C3%AE-induced-epithelial-mesenchymal-transition-in-pancreatic-ductal-adenocarcinoma-cells
#10
JOURNAL ARTICLE
Ching-Chung Ko, Yao-Yu Hsieh, Pei-Ming Yang
The epithelial-to-mesenchymal transition (EMT) describes a biological process in which polarized epithelial cells are converted into highly motile mesenchymal cells. It promotes cancer cell dissemination, allowing them to form distal metastases, and also involves drug resistance in metastatic cancers. Transforming growth factor β (TGFβ) is a multifunctional cytokine that plays essential roles in development and carcinogenesis. It is a major inducer of the EMT. The MIR31 host gene ( MIR31HG ) is a newly identified long non-coding (lnc)RNA that exhibits ambiguous roles in cancer...
June 12, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35544594/dichotomous-role-of-mir193b-3p-in-diabetic-foot-ulcers-maintains-inhibition-of-healing-and-suppression-of-tumor-formation
#11
JOURNAL ARTICLE
Jelena Marjanovic, Horacio A Ramirez, Ivan Jozic, Rivka C Stone, Tongyu C Wikramanayake, Cheyanne R Head, Beatriz Abdo Abujamra, Nkemcho Ojeh, Robert S Kirsner, Hadar Lev-Tov, Irena Pastar, Marjana Tomic-Canic
Despite the hyperproliferative environment marked by activation of β-catenin and overexpression of c-myc , the epidermis surrounding chronic diabetic foot ulcers (DFUs) is clinically hypertrophic and nonmigratory yet does not undergo malignant transformation. We identified miR193b-3p as a master regulator that contributes to this unique cellular phenotype. We determined that induction of tumor suppressor miR193b-3p is a unique feature of DFUs that is not found in venous leg ulcers, acute wounds, or cutaneous squamous cell carcinoma (SCC)...
May 11, 2022: Science Translational Medicine
https://read.qxmd.com/read/34954131/epigenetic-regulation-is-involved-in-traffic-related-pm-2-5-aggravating-allergic-airway-inflammation-in-rats
#12
JOURNAL ARTICLE
Caihong Wang, Jing Wang, Xin Zheng, Jiaqi Zhang, Jingwei Zhang, Guoguo Qiao, Haifang Liu, Huichao Zhao, Jianying Bai, Hongmei Zhang, Zhihong Zhang
Increasing fine particulate matter (PM2.5 ) and epigenetic modifications are closely associated with the pathogenesis of asthma, but the definite mechanism remains unclear. The traffic-related PM2.5 exposure aggravated pulmonary inflammation and changed the methylation level of interferon gamma (Ifng) and interleukin (Il)4 genes, and then altered levels of affiliated cytokines of IFN-γ and IL-4 in rats with allergic airway inflammation. It also increased the level of miR146a and decreased the level of miR31...
December 23, 2021: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/33756383/the-role-of-differentially-expressed-salivary-microrna-in-oral-squamous-cell-carcinoma-a-systematic-review
#13
REVIEW
Natheer Al Rawi, Neibal Elmabrouk, Rawan Abu Kou, Sara Mkadmi, Zuha Rizvi, Zaid Hamdoon
OBJECTIVE: This study aims to systematically review the role of differentially expressed microRNA (miRNA) in saliva as potential biomarkers in oral cancer patients. DESIGN: PubMed, Scopus and EBSCO online data bases were used as well as manual searching to extract studies from January 2008 up to October 2020. RESULTS: A total of 14 studies that met the eligibility criteria were included. All selected studies were of case-control type. A total of 25 differentially expressed miRNAs were identified...
March 18, 2021: Archives of Oral Biology
https://read.qxmd.com/read/33664588/low-coverage-sequencing-of-urine-sediment-dna-for-detection-of-copy-number-aberrations-in-bladder-cancer
#14
JOURNAL ARTICLE
Yun-Xi Cai, Xu Yang, Sheng Lin, Ya-Wen Xu, Shan-Wen Zhu, Dong-Mei Fan, Min Zhao, Yuan-Bin Zhang, Xue-Xi Yang, Xin Li
Purpose: Chromosomal copy number aberrations (CNAs) are a hallmark of bladder cancer and a useful target for diagnostic explorations. Here we constructed a low-coverage whole-genome sequencing method for the detection of CNAs in urine sediment DNA from patients with bladder cancer. Patients and Methods: We conducted a prospective study using urine sediment samples from 65 patients with bladder tumors, including 54 patients with bladder cancer and 11 patients with benign bladder tumors...
2021: Cancer Management and Research
https://read.qxmd.com/read/32819595/mir31hg-exhibits-oncogenic-property-and-acts-as-a-sponge-for-mir-361-3p-in-cervical-carcinoma
#15
JOURNAL ARTICLE
Yajing Li
The long noncoding RNA (lncRNA) MIR31 Host Gene (MIR31HG) is a crucial regulator in malignant cancers. In this work, I examined the potential function and molecular mechanism of MIR31HG in cervical carcinoma progression. MIR31HG was strikingly upregulated in clinical cervical carcinoma specimens compared with that in adjacent samples. Functionally, knockdown of MIR31HG noticeably repressed cervical carcinoma cell growth and invasiveness in vitro and inhibited cervical carcinoma cell growth in vivo. Mechanistically, MIR31HG was identified as an endogenous 'sponge' through competing for miR-361-3p binding to modulate the miRNA target, epithelial membrane protein 1 (EMP1)...
September 3, 2020: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/32134327/significance-of-lncrna-mir31hg-in-predicting-the-prognosis-for-chinese-patients-with-cancer-a-meta-analysis
#16
JOURNAL ARTICLE
Yi Zhou, Yanghua Fan, Xi Zhou, Anna Mou, Yu He, Fu Wang, Yong Liu
It is important to clarify the significance of long noncoding RNA MIR31 host gene (lncRNA MIR31HG ) in predicting the prognosis for malignant tumors through meta-analysis. Electronic databases were systemically searched, from inception until 2 January 2019, to identify related articles. Meanwhile, the hazard ratios (odds ratios) and 95% CIs were computed for exploring the association between the expression of lncRNA MIR31HG and the survival (pathological variables). Eleven studies with 1041 cases were enrolled into the current meta-analysis...
March 5, 2020: Biomarkers in Medicine
https://read.qxmd.com/read/32104069/associations-between-mirnas-and-two-different-cancers-breast-and-colon
#17
JOURNAL ARTICLE
Berrin Papila Kundaktepe, Volkan Sozer, Cigdem Papila, Sinem Durmus, Pinar Cigdem Kocael, Gonul Simsek, Remise Gelisgen, Kagan Zengin, Kenan Ulualp, Hafize Uzun
Objective: Screening approaches using microRNAs (miRNAs) have been gaining increased attention owing to their potential applications in the diagnosis, prognosis, and monitoring of cancer, because aberrant miRNA expression plays a role in the development and advancement of malignancies. The objectives of this study were to characterize mir21, miR31, mir143, mir145, and control RNU43, which are differentially expressed in peripheral blood mononuclear cells (PBMCs) of breast and colorectal cancer patients, compared to that in controls and to establish whether this is specific to breast and colon cancer for use as tumor markers...
2020: Cancer Management and Research
https://read.qxmd.com/read/31623173/foxc1-regulation-of-mir-31-5p-confers-oxaliplatin-resistance-by-targeting-lats2-in-colorectal-cancer
#18
JOURNAL ARTICLE
Hsi-Hsien Hsu, Wei-Wen Kuo, Hui-Nung Shih, Sue-Fei Cheng, Ching-Kuo Yang, Ming-Cheng Chen, Chuan-Chou Tu, Vijaya Padma Viswanadha, Po-Hsiang Liao, Chih-Yang Huang
Colorectal cancer (CRC) is the second leading cause of cancer-related illness worldwide and one of the most common malignancies. Therefore, colorectal cancer research and cases have gained increasing attention. Oxaliplatin (OXA) is currently used in first-line chemotherapy to treat stage III and stage IV metastatic CRC. However, patients undergoing chemotherapy often develop resistance to chemo drugs being used. Evidence has confirmed that microRNAs regulate downstream genes in cancer biology and thereby have roles related to tumor growth, proliferation, invasion, angiogenesis, and multi-drug resistance...
October 16, 2019: Cancers
https://read.qxmd.com/read/31441682/inhibition-of-mir31-and-mir92a-as-oncological-biomarkers-in-rko-colon-cancer-cells-treated-with-kaempferol-3-o-glycoside-isolated-from-black-bean
#19
JOURNAL ARTICLE
Janet Alejandra Gutierrez-Uribe, Mauricio Salinas-Santander, Delia Serna-Guerrero, Sergio Roman Othon Serna-Saldivar, Ana Maria Rivas-Estilla, Clara Patricia Rios-Ibarra
MicroRNAs (miRNAs) are small molecules of 19-23 nucleotides of RNA that act as regulators of the expression of proteins in eukaryotic cells. Currently, the participation of miRNAs in the development of different types of cancer has been observed. To evaluate the inhibitory effect of kaempferol-3- O -glycoside on the expression of oncological biomarkers, miR31 and miR92a in a colon cancer cell line (RKO) were analyzed. Cells were cultured and treated with 1 mM kaempferol-3- O -glycoside isolated from black bean...
August 23, 2019: Journal of Medicinal Food
https://read.qxmd.com/read/30934838/the-interplay-between-mirna-related-variants-and-age-related-macular-degeneration-evidence-of-association-of-mir146a-and-mir27a
#20
JOURNAL ARTICLE
Claudia Strafella, Valeria Errichiello, Valerio Caputo, Gianluca Aloe, Federico Ricci, Andrea Cusumano, Giuseppe Novelli, Emiliano Giardina, Raffaella Cascella
The complex interplay among genetic, epigenetic, and environmental variables is the basis for the multifactorial origin of age-related macular degeneration (AMD). Previous results highlighted that single nucleotide polymorphisms (SNPs) of CFH , ARMS2 , IL-8 , TIMP3 , SLC16A8 , RAD51B , VEGFA , and COL8A1 were significantly associated with the risk of AMD in the Italian population. Given these data, this study aimed to investigate the impact of SNPs in genes coding for MIR146A, MIR31, MIR23A, MIR27A, MIR20A, and MIR150 on their susceptibility to AMD...
March 29, 2019: International Journal of Molecular Sciences
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