Elisa Molinelli, Gabriele Ceccarelli, Sonia Fantone, Eleonora Di Mercurio, Daisy Gambini, Andrea Maurizi, Jessica Perugini, Giovanni Tossetta, Valerio Brisigotti, Edoardo De Simoni, Claudia Sapigni, Giulio Rizzetto, Anna Campanati, Oriana Simonetti, Daniela Marzioni, Annamaria Offidani
In the last decades, the concept of adipose organ has emerged, giving adipose tissue an active endocrine and immunologic function through the secretion of multiple cytokines and chemokines that seem to be implicated in the development and progression of several cancer, including cutaneous melanoma. In this pilot experimental study, we analyzed the expression in the peritumor subcutaneous adipose tissue of the most significant adipokines involved in the processes of carcinogenesis and metastasis in a population of melanoma patients and in two control groups composed of melanocytic nevi and epidermoid cysts, respectively...
June 19, 2023: Pigment Cell & Melanoma Research