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Hylaluronic acid

Y Gall
Hyaluronan (HA) is a key component of the extra-cellular matrix and is involved in several mechanisms of the wound healing process. It is highly hygroscopic and is involved in the visco-elasticity of the skin. The properties of this molecule depend on its molecular weight. Native high molecular weight HA has structural properties whereas HA degradation products (oligomers) stimulate endothelial cell proliferation and migration. HA oligomers modulate inflammatory processes and promote neo-angiogenesis during the different steps of wound healing...
April 2010: Annales de Dermatologie et de Vénéréologie
Heejeong Lee, Il-Hwan Cho, Myeong Hee Moon
Molecular weight distribution (MWD) and structural deformation of ultrahigh molecular weight (MW) sodium hylaluronate (10(5)-10(8) g/mol) were studied under different sample dissolution temperature conditions, using on-line flow field-flow fractionation (FlFFF) and multiangle light scattering (MALS). Sodium hyaluronate (NaHA) materials from sarcoma fluid have been studied by dissolving them in water at three different temperature conditions (5 degrees C, 50 degrees C, and 90 degrees C). Frit inlet asymmetrical flow field-flow fractionation (FI-AFlFFF), with field programming, was utilized for the separation of NaHA by MW, and on-line observation of light scattering of fractionated NaHA by MALS was performed in order to determine the MWD and molecular conformation...
October 27, 2006: Journal of Chromatography. A
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