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liver metastasis colorectal cancer

Fumihiro Terasaki, Yusuke Yamamoto, Katsuhisa Ohgi, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Ryo Ashida, Katsuhiko Uesaka
BACKGROUND: A right-sided ligamentum teres (RSLT) is a rare congenital anomaly in which the fetal umbilical vein is connected to the right paramedian trunk. RSLT creates difficulty in liver resection with respect to decision-making regarding the resection line, deviation of the vasculobiliary architecture. We report a case in which laparoscopic left lateral sectionectomy (LLLS) was performed to treat colorectal liver metastasis (CRLM) in a patient with RSLT. CASE PRESENTATION: A 63-year-old man with a past history of rectal cancer presented to our institution due to liver metastasis in the left lateral section from rectal cancer...
March 15, 2019: Surgical Case Reports
Xiaofeng Chen, Tianzhu Qiu, Yingwei Zhu, Jing Sun, Ping Li, Biao Wang, Peinan Lin, Xiaomin Cai, Xiao Han, Fengjiao Zhao, Yongqian Shu, Lianpeng Chang, Hua Jiang, Yanhong Gu
LESSONS LEARNED: Patients with metastatic colorectal cancer with good performance status or no liver metastasis could benefit from apatinib.Circulating tumor DNA abundance may be a predictor in serial monitoring of tumor load. BACKGROUND: Apatinib, an oral vascular endothelial growth factor (VEGF) receptor-2 inhibitor, has been approved as third-line treatment for metastatic gastric cancer in China. The aim of this study was to evaluate the efficacy and safety of apatinib, in the treatment of patients with refractory metastatic colorectal cancer after failure of two or more lines of chemotherapy...
March 15, 2019: Oncologist
Mario Faenza, Giuseppe Del Torto, Pasquale Di Costanzo, Gorizio Pieretti, Rossella Lamberti, Renato Franco, Giuseppe A Ferraro, Giovanni F Nicoletti
INTRODUCTION: Metastases represent one of the most outstanding characteristics of malignant neoplasms and are relatively rare in the skin, in spite of the great extension of the cutaneous organs. Development of cutaneous metastases from colon cancer is a rare event, usually occurring in widely disseminated disease and commonly leading to a poor prognosis. As to location, cutaneous metastases often favor areas close to the primary malignancy, such as lung cancer and skin metastases on the trunk...
March 7, 2019: International Journal of Surgery Case Reports
Wen-Juan Tang, Zhuang Nie, Wen-Liang Fan, Lan Cheng, Zi-Qiao Lei, Ming Yang
The objective of this study was to evaluate the diagnostic value of 128-slice spiral CT combined with virtual colonoscopy in diagnosis of colorectal cancer. We retrospectively analyzed 45 patients of colorectal diseases who underwent definition AS+128-slice spiral CT combined with virtual colonoscopy after bowel preparation and gas injection to evaluate the clinical diagnostic value of this technology. All the patients received electronic colonoscopy and were confirmed by pathology. In total, colorectal cancer was confirmed in 42 cases and inflammation in 3 cases...
February 2019: Current Medical Science
Tao Zhang, Lu Liu, Wei Lai, Yujie Zeng, Heyang Xu, Qiusheng Lan, Pengwei Su, Zhonghua Chu
Protein phosphatase of regenerating liver‑3 (PRL‑3) is considered to be metastasis‑associated phosphatase and is associated with a poor prognosis. Additionally, tumor‑associated macrophages (TAMs) participate in cancer progression. A previous study demonstrated that PRL‑3 promotes invasion and metastasis by inducing TAM infiltration. However, the underlying mechanism has not been elucidated. In the present study, western blot analysis, polymerase chain reaction, immunohistochemistry, ELISA, mouse model experiments and functional experiments were performed to confirm that the interaction between TAMs and colorectal cancer (CRC) cells induced epithelial‑mesenchymal transition (EMT)‑associated features in CRC cells by activating mitogen‑activated protein kinase (MAPK) pathways in TAMs and upregulating the expression of interleukin (IL)‑6 and IL‑8...
March 7, 2019: Oncology Reports
D Xu, B C Xing
The incidence of colorectal cancer liver metastasis (CRLM) has gradually increased in recent years. Surgical resection is the main method to achieve long-term survival for patients with CRLM. However, only 20% of these patients have the chance to undergo surgical resection. If the unresectable metastases can be converted to resectable ones by effective conversion therapy, the 5-year survival rate of patients received liver resection can exceed to 30%, which is significantly better than palliative treatment...
February 23, 2019: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Hanqing Li, Juan Su, Jiaye Jiang, Yuan Li, Zhongyuan Gan, Yan Ding, Yaqing Li, Jiaqi Liu, Shunchun Wang, Yan Ke
In this study, we purified a water-soluble polysaccharide, SBPW3, from the whole plant of Scutellaria barbata D. Don through ethanol precipitation, deproteinization, lyophilization, dialysis and separation using a DEAE cellulose column and a Superdex 200 gel filtration chromatography column. SBPW3 is a homogeneous polysaccharide with a molecular weight of 10.2 kDa and is composed of rhamnose (2.51%), arabinose (25.68%), xylose (10.94%), mannose (12.56%), glucose (20.59%) and galactose (27.72%). FT-IR spectrum analysis of the polysaccharide showed that SBPW3 contained a pyranose ring...
March 8, 2019: International Journal of Biological Macromolecules
Yiwei Huang, Mengnan Zhao, Jiacheng Yin, Tao Lu, Xiaodong Yang, Guangda Yuan, Ming Li, Yu Liu, Cheng Zhan, Qun Wang
BACKGROUND: Colorectal cancer (CRC) has a high worldwide incidence with a tendency to metastasize to the lungs. We aimed to identify clinical factors related to lung metastasis (LM) and analyze the prognosis of patients after LM. METHODS: Multivariate logistic regression analysis was used to identify risk factors for LM from CRC. Univariate and multivariate Cox proportional hazard models were performed to identify potentially important prognostic factors for patients with LM...
March 11, 2019: International Journal of Colorectal Disease
Francesco Guerra, Simone Guadagni, Benedetta Pesi, Niccolò Furbetta, Gregorio Di Franco, Matteo Palmeri, Mario Annecchiarico, Emilio Eugeni, Andrea Coratti, Alberto Patriti, Luca Morelli
BACKGROUND: Current evidence supporting robotics to perform minimally invasive liver resection is based on single center case series reporting surgical outcomes in heterogeneous groups of patients. On the contrary, relatively scarce data specifically focusing on secondary hepatic malignancies is available. The objective of this study is to assess short- and long-term outcomes following liver resection for colorectal liver metastasis on a multi-institutional series of patients. METHODS: All consecutive patients undergoing robotic surgery for colorectal liver metastasis at three different tertiary hospitals over a 10-year time frame were included in this analysis...
March 2019: Surgical Oncology
Changzheng He, Zhenyu Zou, Shaoyou Xia, Xiaowei Xing, Shidong Hu, Zilong Hu, Yuxuan Li, Songyan Li, Hongliang Zhang, Yu Yang, Yichen Liu, Xiaolei Xu, Boyan Liu, Yufeng Wang, Yingxin Xu, Xiaohui Du
BACKGROUND: Lymph node metastasis (LNM) remains a major obstacle to treat colorectal cancer (CRC). Increasing evidences have suggested that bufadienolides contain several fractions displaying antitumor activity and may be applied in lymphatic chemotherapy. However, effects of the highly efficient and lowly toxic (HELT) bufadienolides on CRC in lymphatic chemotherapy have not been reported. METHODS: Adenosine triphosphate tumor chemosensitivity assays (ATP-TCA) was performed to detect the inhibition rate (IR) of fractions of bufadienolides to cytokine-induced killer (CIK) cells and tumor cells...
March 6, 2019: International Immunopharmacology
Rui Li, Rui Zhou, Hui Wang, Weidong Li, Mingxin Pan, Xueqing Yao, Wanqi Zhan, Shibin Yang, Lijun Xu, Yanqing Ding, Liang Zhao
Metastasis is a complex process that requires the interaction between tumor cells and their microenvironment. As an important regulator of intestinal microenvironment, gut microbiota plays a significant role in the initiation and progression of colorectal cancer (CRC), but the underlying mechanisms remain elusive. In this study, a metastasis-related secretory protein cathepsin K (CTSK) was identified as a vital mediator between the imbalance of intestinal microbiota and CRC metastasis. We implanted MC38 cells into the cecal mesentry of antibiotic-treated mice with intragastrically administration of E...
March 8, 2019: Cell Death and Differentiation
Ming-Yu Zhang, Rong-Jun Zhang, Hui-Jie Jiang, Hao Jiang, Hai-Long Xu, Wen-Bin Pan, Yi-Qiao Wang, Xin Li
BACKGROUND: Positron emission tomography (PET) imaging is a non-invasive functional imaging method used to reflect tumor spatial information, and to provide biological characteristics of tumor progression. The aim of this study was to focus on the application of 18 F-fluoromisonidazole (FMISO) PET quantitative parameter of maximum standardized uptake value (SUVmax) ratio to detect the liver metastatic potential of human colorectal cancer (CRC) in mice. METHODS: Colorectal liver metastases (CRLM) xenograft models were established by injecting tumor cells (LoVo, HT29 and HCT116) into spleen of mice, tumor-bearing xenograft models were established by subcutaneously injecting tumor cells in the right left flank of mice...
February 26, 2019: Hepatobiliary & Pancreatic Diseases International: HBPD INT
KhaingZar Thin, Jian Cheng Tu, C Sudheesh
OBJECTIVES: Long non-coding RNAs (lncRNAs) consist of a cluster of RNAs having >200 nucleotides lacking protein-coding function. Recent studies indicate that lncRNAs are involved in various cellular processes and their aberrant expression may lead to tumour development and progression. They may also serve as oncogenes or tumour suppressor genes in other diseases. In this review, we emphasize current investigations involving clinical management, tumour progression and the molecular mechanism of SNHG1 in human cancer...
March 5, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Vaibhav Gupta
No abstract text is available yet for this article.
January 24, 2019: Journal of Thoracic and Cardiovascular Surgery
Jae W Lee, Meredith L Stone, Paige M Porrett, Stacy K Thomas, Chad A Komar, Joey H Li, Devora Delman, Kathleen Graham, Whitney L Gladney, Xia Hua, Taylor A Black, Austin L Chien, Krishna S Majmundar, Jeffrey C Thompson, Stephanie S Yee, Mark H O'Hara, Charu Aggarwal, Dong Xin, Abraham Shaked, Mingming Gao, Dexi Liu, Mitesh J Borad, Ramesh K Ramanathan, Erica L Carpenter, Ailing Ji, Maria C de Beer, Frederick C de Beer, Nancy R Webb, Gregory L Beatty
The liver is the most common site of metastatic disease1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a 'pro-metastatic' niche that supports the spread of tumour cells to the liver2,3 . The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth...
March 6, 2019: Nature
Yuki Yano, Kazuhiko Yoshimatsu, Hajime Yokomizo, Masano Sagawa, Hiroko Itagaki, Yoshihiko Naritaka
BACKGROUND: Previously, we aimed to predict the effect of bevacizumab in liver metastasis using the ratio of the computed tomography (CT) value for hepatic metastatic lesions in the arterial phase in contrast-enhanced (CE) CT to that on plain CT. However, there is no report on the relation between the CT contrast effect and microvessel density (MVD) in liver metastasis. PATIENTS AND METHODS: Thirty-two patients who underwent liver resection for metastasis from colorectal cancer (excluding neoadjuvant chemotherapy cases) between April 2006 and October 2011 at our Department were analyzed retrospectively...
March 2019: Anticancer Research
Eve Simoneau, Michael D'Angelica, Karim J Halazun
PURPOSE OF REVIEW: The aim of this review is to discuss existing data on liver transplantation for colorectal liver metastasis, emerging controversies, and future directions. RECENT FINDINGS: Contemporary experience with transplanting patients with liver metastasis from colon cancer is mainly derived from European centers, with a large proportion being from a single institution (SECA study), made possible in part by a relatively high donor pool. The initial results prove to be encouraging by demonstrating an overall survival advantage over unresectable patients with liver-limited disease managed with chemotherapy only...
April 2019: Current Opinion in Organ Transplantation
Felix Che-Lok Chow, Kenneth Siu-Ho Chok
Liver metastasis is the commonest form of distant metastasis in colorectal cancer. Selection criteria for surgery and liver-directed therapies have recently been extended. However, resectability remains poorly defined. Tumour biology is increasingly recognized as an important prognostic factor; hence molecular profiling has a growing role in risk stratification and management planning. Surgical resection is the only treatment modality for curative intent. The most appropriate surgical approach is yet to be established...
February 27, 2019: World Journal of Hepatology
Precious Takondwa Makondi, Po-Li Wei, Chien-Yu Huang, Yu-Jia Chang
BACKGROUND: Liver metastases are the major cause of colorectal cancer (CRC)-related deaths. However, there is no reliable clinical predictor for CRC progression to liver metastasis. In this study, we investigated possible predictors (miRNAs and biomarkers) for clinical application. METHODOLOGY: The Gene Expression Omnibus (GEO) datasets GSE49355, GSE41258 and GSE81558 for genes and GSE54088 and GSE56350 for miRNAs were used to identify common differentially expressed genes (DEGs) and miRNAs between primary CRC tissues and liver metastases...
2019: PloS One
Anne Hansen Ree, Vigdis Nygaard, Hege G Russnes, Daniel Heinrich, Vegard Nygaard, Christin Johansen, Inger R Bergheim, Eivind Hovig, Klaus Beiske, Anne Negård, Anne-Lise Borresen-Dale, Kjersti Flatmark, Gunhild M Maelandsmo
Most patients whose large bowel cancer has spread to other organs do not respond to immune therapy. We detected a rare gene mutation, termed 9p24.1 copy-number gain, in an otherwise incurable colorectal cancer that provoked an immune therapy response. We identified this gene mutation by gene-panel sequencing of DNA from a liver metastasis biopsy from a patient who had disease refractory to standard therapies. Following immune checkpoint blockade with pembrolizumab (anti-PD-1), the patient experienced conversion of the tumor phenotype from one with epithelial features to that of an inflamed microenvironment, detected by high-resolution RNA sequencing...
February 25, 2019: Cancer Immunology Research
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