Jiang Min, Shenglan Yang, Yang Cai, David R Vanderwall, Zhiping Wu, Shuping Li, Songlan Liu, Beibei Liu, Jie Wang, Yingjun Ding, Junxiong Chen, Chao Jiang, Jonathan D Wren, Anna Csiszar, Zoltan Ungvari, Céline Greco, Tomoharu Kanie, Junmin Peng, Xin A Zhang
Inflammation can impair intestinal barrier, while increased epithelial permeability can lead to inflammation. In this study, we found that the expression of Tspan8, a tetraspanin expressed specifically in epithelial cells, is downregulated in mouse model of ulcerative disease (UC) but correlated with those of cell-cell junction components, such as claudins and E-cadherin, suggesting that Tspan8 supports intestinal epithelial barrier. Tspan8 removal increases intestinal epithelial permeability and upregulates IFN-γ-Stat1 signaling...
May 19, 2023: Cellular and Molecular Life Sciences: CMLS