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Samina Ismail, Ali S Siddiqui, Azhar Rehman
Background and Aims: Despite advances in postoperative pain management, patients continue to experience moderate to severe pain. This study was designed to assess the strategy, effectiveness, and safety of postoperative pain management in patients undergoing major gynecological surgery. Material and Methods: This observational study included postoperative patients having major gynecological surgery from February 2016 to July 2016. Data collected on a predesigned data collection sheet included patient's demographics, postoperative analgesia modality, patient satisfaction, acute pain service assessment of numeric rating scale (NRS), number of breakthrough pains, number of rescue boluses, time required for the pain relief after rescue analgesia, and any complication for 48 h...
October 2018: Journal of Anaesthesiology, Clinical Pharmacology
Y Deng, Y Li, Y Yao, D D Feng, M Xu
OBJECTIVE: To compare the effects of ultrasound-guided interscalene brachial plexus block and C5-6 nerve root block for analgesia after shoulder arthroscopy. METHODS: In the study, 40 patients of ASA I-II were selected for elective general anesthesia to repair the shoulder ligament rupture in Peking University Third Hospital, who were randomly divided into two groups, respectively for the intermuscular brachial plexus block group (group I) and C5-6 nerve root block group (group C), n=20...
February 18, 2019: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Hannes Karwat, Marc-André Sparke, Frank Rasche, Jacobo Arango, Jonathan Nuñez, Idupulapati Rao, Danilo Moreta, Georg Cadisch
The tropical forage grass Brachiaria humidicola (Bh) controls soil microbial nitrification via biological nitrification inhibition (BNI). The aim of our study was to verify if nitrate reductase activity (NRA) in Bh roots or leaves reflects in vivo performance of BNI in soils. NRA was measured in roots and leaves of contrasting accessions and apomictic hybrids of Bh grown under controlled greenhouse and natural field conditions. Nitrate (NO3 - ) contents were measured in soil solution and in Bh stem sap to validate NRA data...
February 8, 2019: Plant Physiology and Biochemistry: PPB
D J H A Henssen, R L Witkam, J C M L Dao, D J Comes, A M Van Cappellen van Walsum, T Kozicz, Robert van Dongen, K Vissers, R H M A Bartels, G de Jong, E Kurt
Implantable Motor Cortex Stimulation (iMCS) has been performed for over 25 years to treat various intractable pain syndromes. Its effectiveness shows to be highly variable and although various studies revealed predictive variables, none of these were found repeatedly. This study uses neural network analysis (NNA) to identify predictive factors of iMCS treatment of intractable pain. A systematic review provided a database of patient data on an individual level of patients who underwent iMCS to treat refractory pain between 1991 and 2017...
February 13, 2019: Journal of Pain: Official Journal of the American Pain Society
M L Ridderikhof, E De Kruif, M F Stevens, H M Baumann, P B Lirk, J C Goslings, M W Hollmann
INTRODUCTION: In the Emergency Department, regional anesthesia is increasingly used in elderly patients with hip fractures. An example is a Fascia Iliaca Compartment Block (FICB). Traditionally, this block is administered below the inguinal ligament. There is no Emergency Department data regarding effectivity of an alternative, more cranial approach above the inguinal ligament. The objective was to determine analgesic effects of an ultrasound-guided supra-inguinal FICB in hip fracture patients in the Emergency Department...
February 11, 2019: American Journal of Emergency Medicine
Kassiani Theodoraki, Panagiota Papacharalampous, Athanasia Tsaroucha, Antonios Vezakis, Eriphilli Argyra
BACKGROUND: This prospective double-blind randomized study aimed at evaluating the short- and long-term postoperative analgesic efficacy of the ultrasound-guided tranversus abdominis plane (TAP) block in inguinal hernia repair under general anesthesia. METHODS: Sixty patients undergoing inguinal hernia repair were allocated to TAP block with either ropivacaine 0.75% 20 mL or placebo 20 mL. Postoperatively, they had access to a patient-controlled analgesia (PCA) device administering 1 mg doses of morphine as rescue analgesia...
February 12, 2019: International Journal of Surgery
Brigitte Wirth, Fabienne Riner, Cynthia Peterson, Barry Kim Humphreys, Mazda Farshad, Susanne Becker, Petra Schweinhardt
Background: A close collaboration between surgeons and non-surgical spine experts is crucial for optimal care of low back pain (LBP) patients. The affiliation of a chiropractic teaching clinic to a university hospital with a large spine division in Zurich, Switzerland, enables such collaboration. The aim of this study was to describe the trajectories and outcomes of patients with chronic LBP referred from the spine surgery division to the chiropractic teaching clinic. Methods: The patients filled in an 11-point numeric rating scale (NRS) for pain intensity and the Bournemouth Questionnaire (BQ) (bio-psycho-social measure) at baseline and after 1 week, 1, 3, 6 and 12 months...
2019: Chiropractic & Manual Therapies
Dominique Musselman, Neeta Shenvi, Amita Manatunga, Andrew H Miller, Edward Lin, Nana Gletsu-Miller
BACKGROUND: Neurobehavioral symptoms and cognitive dysfunction related to mood disorders are present in individuals with severe obesity. We sought to determine acute improvements in these symptoms and relationships with adiposity, inflammation, and insulin sensitivity after roux-en-y gastric bypass (RYGB) surgery. METHODS: The self-report Zung Depression Rating (ZDRS) and Neurotoxicity Rating (NRS) scales were administered before, and at 6-months after RYGB surgery in severely obese women (body mass index > 35 kg/m2 ; N = 19)...
February 11, 2019: Physiology & Behavior
Jacques T YaDeau, David M Dines, Spencer S Liu, Michael A Gordon, Enrique A Goytizolo, Yi Lin, Aaron A Schweitzer, Kara G Fields, Lawrence V Gulotta
BACKGROUND: The pain experience for total shoulder arthroplasty (TSA) patients in the first 2 weeks after surgery has not been well described. Many approaches to pain management have been used, with none emerging as clearly superior; it is important that any approach minimizes postoperative opioid use. QUESTIONS/PURPOSES: (1) With a long-acting nerve block and comprehensive multimodal analgesia, what are the pain levels after TSA from day of surgery until postoperative day (POD) 14? (2) How many opioids do TSA patients take from the day of surgery until POD 14? (3) What are the PainOUT responses at POD 1 and POD 14, focusing on side effects from opioids usage? METHODS: From January 27, 2017 to December 6, 2017, 154 TSA patients were identified as potentially eligible for this prospective, institutional review board-approved observational study...
March 2019: Clinical Orthopaedics and related Research
Enrico D'Aniello, Fabio Arturo Iannotti, Lauren G Falkenberg, Andrea Martella, Alessandra Gentile, Fabrizia De Maio, Maria Letizia Ciavatta, Margherita Gavagnin, Joshua S Waxman, Vincenzo Di Marzo, Pietro Amodeo, Rosa Maria Vitale
The nuclear receptors (NRs) RARα, RXRα, PPARα, and PPARγ represent promising pharmacological targets for the treatment of neurodegenerative diseases. In the search for molecules able to simultaneously target all the above-mentioned NRs, we screened an in-house developed molecular database using a ligand-based approach, identifying (-)-Muqubilin (Muq), a cyclic peroxide norterpene from a marine sponge, as a potential hit. The ability of this compound to stably and effectively bind these NRs was assessed by molecular docking and molecular dynamics simulations...
February 12, 2019: Marine Drugs
Piotr Kamieniak, Joanna Bielewicz, Cezary Grochowski, Jakub Litak, Agnieszka Bojarska-Junak, Beata Daniluk, Tomasz Trojanowski
Objectives: We investigated the influence of spinal cord stimulation (SCS) on IFN- γ , IL-1 β , IL-6, TNF- α , IL-10, and TGF- β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN- γ and other cytokines in neuropathic pain (NP) development. Materials and Methods: Clinical and biochemical assessment was conducted in four groups of patients: group 0 consisted of 24 FBSS patients qualified to SCS therapy, group 1 included 17 patients who were one month after implantation, group 2 featured 12 patients who were 3 months after the implantation, and group C (the control group) with no NP...
2019: Disease Markers
Min Jung Geum, Ji Hyune Ahn, Jae Song Kim, Soo Hyun Kim, Eun Sun Son, Youn Jung Hu, Hye Jin Choi, Sandy Jeong Rhie
PURPOSE: The purpose of the study was to evaluate the impact on pain management by multidisciplinary palliative care team (mPCT) and the team pharmacist. METHODS: Patients who were admitted to palliative care unit (PCU) for at least 7 days between April 2014 and December 2015 were included. The mPCT consisted of a physician, a pharmacist, nurses, and non-clinical support staff. The team was on charge of pain management of patients who were admitted to PCU. Pain intensity was assessed at 3 time points in each patient; 1 week before PCU admission (day -7), on the day of admission (day 0), and 1 week after admission (day 7) using 0 to 10 numerical rating scale (NRS)...
February 12, 2019: American Journal of Hospice & Palliative Care
Yao Wang, Karin Coyne, Howard Sofen, Nancy Santanello, Brooke Currie, Zuoshun Zhang, Kristine Nograles
BACKGROUND: Pruritus is a prevalent and bothersome symptom of scalp psoriasis. Validated scales assessing scalp itch are needed to assess treatment efficacy. OBJECTIVE: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast. METHODS: The Scalp Itch NRS, Modified Whole Body Itch NRS, Global Assessment of Psoriasis Severity-Scalp (GAPS-S), and Global Impression of Change-Scalp Itch (GIC-SI) were assessed among patients with moderate to severe scalp psoriasis...
February 12, 2019: Journal of Dermatological Treatment
Ezgi Demirozogul, Atakan Yilmaz, Mert Ozen, Ibrahim Turkcuer, Murat Seyit, Cuneyt Arikan
INTRODUCTION: Although acute musculoskeletal pain has a wide range of causes from tendinitis, muscle spasm, to bone and joint injuries, it is a frequent occurrence in emergency services. Paracetamol and non-steroidal anti-inflammatory analgesics (NSAID) are common used in the treatment of musculoskeletal pain. This study sets out to compare the effectiveness of intravenous dexketoprofen and paracetamol in musculoskeletal pain relief. METHODS: This prospective, randomized, double blind, controlled study was carried out in a university emergency room...
February 4, 2019: American Journal of Emergency Medicine
Pernille Steen Pettersen, Tuhina Neogi, Karin Magnusson, Hilde Berner Hammer, Till Uhlig, Tore K Kvien, Ida K Haugen
OBJECTIVES: Pain sensitization, an important osteoarthritis (OA) pain mechanism, has not been substantially investigated in persons with hand OA. It is unknown how peripheral and central sensitization is related to self-reported hand pain. METHODS: Persons with verified hand OA in the Nor-Hand study underwent quantitative sensory testing of pressure pain Thresholds (PPT) locally (painful and non-painful finger joint) and remotely (wrist, trapezius and tibialis anterior muscle), and temporal summation (TS), a manifestation of central sensitization...
February 11, 2019: Arthritis & Rheumatology
Haojie Guo, Minjun Li, Tianle Wang, Hai Wu, Huan Zhou, Chunyan Xu, Feng Yu, Xipeng Liu, Jianhua He
A novel DNA polymerase found in the deep-sea vent phage NrS-1, was confirmed to have both DNA polymerase and primase activities. In this polymerase, the N-terminal residues 1-300 (referred to as N300) are the core region required for polymerizing DNA and catalyzing de novo DNA synthesis. Here, the crystal structure of N300 was solved at a resolution of 1.80 Å. The overall structure consists of a prim/pol domain and a helix bundle domain, which are separated by a 14-residue-long flexible tether (residues 177-190)...
February 7, 2019: Biochemical and Biophysical Research Communications
Janelle D Vaughns, Elaine F Williams, Eleanor R Mackey, Jane C Muret, John van den Anker, Evan P Nadler, Zenaide M Quezado
AIM: To examine the impact of preexisting psychiatric/psychological diagnoses on perioperative analgesic requirements in adolescents with morbid obesity undergoing bariatric surgery. METHODS: A retrospective cohort study of adolescents with morbid obesity undergoing bariatric surgery. Primary and secondary outcomes included perioperative analgesic intake and pain scores (Numerical Rating Scale (0-10) NRS) throughout the hospital stay. RESULTS: From our Bariatric Surgery Research Registry, we identified 17 adolescents with psychiatric/psychological diagnoses prior to undergoing bariatric surgery...
February 9, 2019: Obesity Surgery
Kristian D Friesgaard, Hans Kirkegaard, Claus-Henrik Rasmussen, Matthias Giebner, Erika F Christensen, Lone Nikolajsen
BACKGROUND: Prehospital acute pain is a frequent symptom that is often inadequately managed. The concerns of opioid induced side effects are well-founded. To ensure patient safety, ambulance personnel are therefore provided with treatment protocols with dosing restrictions, however, with the concomitant risk of insufficient pain treatment of the patients. The aim of this study was to investigate the impact of a liberal intravenous fentanyl treatment protocol on efficacy and safety measures...
February 7, 2019: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Weiwei Zhang, Wenwen Yu, Xiaoyuan Ding, Chenyang Yin, Jing Yan, Endong Yang, Feng Guo, Dongdong Sun, Weiyun Wang
A novel nanoparticle (Au-LTSL-GA.A) uses the thermosensitive liposome (LTSL) to encapsulate ganoderic acid A (GA.A), which successfully transforms the polarity of GA.A and has excellent water solubility. The multifunctional Au-LTSL-GA.A, a self-assembled thermal nanomaterial, was used in antibacterial and anticancer applications in combination with near-infrared (NIR) irradiation. The designed Au-LTSL-GA.A nanoparticle was used as a nano-photosensitizer to achieve synergistic photochemotherapy based on the phototherapy sensitization property of Au nanorods (NRs) and antitumour activity of GA...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Mohammad Bashirpour, Matin Forouzmehr, Seyed Ehsan Hosseininejad, Mohammadreza Kolahdouz, Mohammad Neshat
An efficient terahertz (THz) photoconductive antenna (PCA), as a major constituent for the generation or detection of THz waves, plays an essential role in bridging microwave-to-photonic gaps. Here, we propose an impressive approach comprising the use of arrayed zinc oxide nanorods (ZnO NRs) as an optical nanoantenna over an anti-reflective layer (silicon nitride) in the antenna gap to boost the photocurrent and consequently the THz signal. The numerical approach applied in investigating the optical behavior of the structure, demonstrates a significant field enhancement within the LT-GaAs layer due to the optical antenna performing simultaneously as a concentrator and an antireflector which behaves as a graded-refractive index layer...
February 5, 2019: Scientific Reports
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