Rafael Barnabé Domingues, Marita von Rautenfeld, Caroline Mayara Kavalco, Carolina Caliari, Celso Dellagiustina, Lucas Furtado da Fonseca, Fabio Ramos Costa, Andreza da Cruz Silva Reis, Gabriel Silva Santos, Gabriel Azzini, André Pinto Lemos de Faria, Napoliane Santos, Luyddy Pires, Stephany Cares Huber, Ansar Mahmood, Ignacio Dallo, Peter Everts, José Fábio Lana
Chronic wounds, characterized by prolonged healing processes, pose a significant medical challenge with multifaceted aetiologies, including local and systemic factors. Here, it explores the complex pathogenesis of chronic wounds, emphasizing the disruption in the normal phases of wound healing, particularly the inflammatory phase, leading to an imbalance in extracellular matrix (ECM) dynamics and persistent inflammation. Senescent cell populations further contribute to impaired wound healing in chronic lesions...
April 2024: International Wound Journal