keyword
https://read.qxmd.com/read/37961525/cross-sectional-associations-between-prenatal-maternal-per-and-poly-fluoroalkyl-substances-and-bioactive-lipids-in-three-environmental-influences-on-child-health-outcomes-echo-cohorts
#21
Himal Suthar, Tomás Manea, Dominic Pak, Megan Woodbury, Stephanie M Eick, Amber Cathey, Deborah J Watkins, Rita S Strakovsky, Brad A Ryva, Subramaniam Pennathur, Lixia Zeng, David Weller, June-Soo Park, Sabrina Smith, Erin DeMicco, Amy Padula, Rebecca C Fry, Bhramar Mukherjee, Andrea Aguiar, Sarah Dee Geiger, Shukhan Ng, Gredia Huerta-Montanez, Carmen Vélez-Vega, Zaira Rosario, Jose F Cordero, Emily Zimmerman, Tracey J Woodruff, Rachel Morello-Frosch, Susan L Schantz, John D Meeker, Akram Alshawabkeh, Max T Aung
BACKGROUND: Per- and poly-fluoroalkyl substances (PFAS) exposure can occur through ingestion of contaminated food and water, and inhalation of indoor air contaminated with these chemicals from consumer and industrial products. Prenatal PFAS exposures may confer risk for pregnancy-related outcomes such as hypertensive and metabolic disorders, preterm birth, and impaired fetal development through intermediate metabolic and inflammation pathways. OBJECTIVE: Estimate associations between maternal pregnancy PFAS exposure (individually and as a mixture) and bioactive lipids...
November 7, 2023: medRxiv
https://read.qxmd.com/read/37948331/deep-phenotyping-of-the-lipidomic-response-in-covid-19-and-non-covid-19-sepsis
#22
JOURNAL ARTICLE
Hu Meng, Arjun Sengupta, Emanuela Ricciotti, Antonijo Mrčela, Divij Mathew, Liudmila L Mazaleuskaya, Soumita Ghosh, Thomas G Brooks, Alexandra P Turner, Alessa Soares Schanoski, Nicholas F Lahens, Ai Wen Tan, Ashley Woolfork, Greg Grant, Katalin Susztak, Andrew G Letizia, Stuart C Sealfon, E John Wherry, Krzysztof Laudanski, Aalim M Weljie, Nuala J Meyer, Garret A FitzGerald
BACKGROUND: Lipids may influence cellular penetrance by viral pathogens and the immune response that they evoke. We deeply phenotyped the lipidomic response to SARs-CoV-2 and compared that with infection with other pathogens in patients admitted with acute respiratory distress syndrome to an intensive care unit (ICU). METHODS: Mass spectrometry was used to characterise lipids and relate them to proteins, peripheral cell immunotypes and disease severity. RESULTS: Circulating phospholipases (sPLA2, cPLA2 (PLA2G4A) and PLA2G2D) were elevated on admission in all ICU groups...
November 2023: Clinical and Translational Medicine
https://read.qxmd.com/read/37942331/enhancement-of-prostaglandin-d-2-d-prostanoid-1-signaling-reduces-intestinal-permeability-by-stimulating-mucus-secretion
#23
JOURNAL ARTICLE
Akane Hayashi, Naoaki Sakamoto, Koji Kobayashi, Takahisa Murata
INTRODUCTION: The intestinal barrier plays a crucial role in distinguishing foods from toxins. Prostaglandin D2 (PGD2 ) is one of the lipid-derived autacoids synthesized from cell membrane-derived arachidonic acid. We previously reported that pharmacological stimulation of PGD2 receptor, D prostanoid 1 (DP1) attenuated the symptoms of azoxymethane/dextran sodium sulfate-induced colitis and ovalbumin-induced food allergy in mouse models. These observations suggested that DP1 stimulation protects the intestinal barrier...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37909412/effect-of-stretching-on-inflammation-in-a-subcutaneous-carrageenan-mouse-model-analyzed-at-single-cell-resolution
#24
JOURNAL ARTICLE
Lisbeth Berrueta, Dennis Muñoz-Vergara, Daniel Martin, Rebecca Thompson, Brian E Sansbury, Matthew Spite, Gary J Badger, Helene M Langevin
Understanding the factors that influence the biological response to inflammation is crucial, due to its involvement in physiological and pathological processes, including tissue repair/healing, cancer, infections, and autoimmune diseases. We have previously demonstrated that in vivo stretching can reduce inflammation and increase local pro-resolving lipid mediators in rats, suggesting a direct mechanical effect on inflammation resolution. Here we aimed to explore further the effects of stretching at the cellular/molecular level in a mouse subcutaneous carrageenan-inflammation model...
November 1, 2023: Journal of Cellular Physiology
https://read.qxmd.com/read/37898426/prostaglandin-15d-pgj-2-inhibits-proliferation-of-lung-adenocarcinoma-cells-by-inducing-ros-production-and-activation-of-apoptosis-via-sirtuin-1
#25
JOURNAL ARTICLE
Julia Slanovc, Mateja Mikulčić, Nicole Jahn, Nassim Ghaffari Tabrizi Wizsy, Wolfgang Sattler, Ernst Malle, Andelko Hrzenjak
Lung adenocarcinoma (LUADC) belongs to the most prevalent and lethal cancer types. As 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2 ) displays anti-oxidative, -inflammatory, and -cancer properties, we investigated whether this cyclopentenone PG, a stable degradation end-product of cyclooxygenase-generated PGD2 , exerts beneficial effects in three LUADC cell lines (A549, H1299, H23). We here report that 15d-PGJ2 had substantial cytotoxic effects in all three LUADC cell lines by promoting early apoptosis and inhibiting the cell cycle, proliferation, and migration...
October 26, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37895951/one-step-automatic-radiosynthesis-and-evaluation-of-18-f-tm-30089-as-gpr44-radiotracer
#26
JOURNAL ARTICLE
Jiangling Peng, Wei Tang, Jeffrey Rawson, Lynn Miao, Nelson Gonzalez, Runkai Yin, Jiaqi Chen, Melinda Ji, Zhixuan Li, Anna Gao, Andy Z Wu, John E Shively, Fouad Kandeel, Junfeng Li
Recently, a G-protein coupled receptor 44 (GPR44) was discovered to play a significant role in the process of inflammation-related diseases, including cancer and diabetes. However, the precise role of GPR44 has yet to be fully elucidated. Currently, there is a strong and urgent need for the development of GPR44 radiotracers as a non-invasive methodology to explore the exact mechanism of GPR44 on inflammation-related diseases and monitor the progress of therapy. TM-30089 is a potent GPR44 antagonist that exhibits a high specificity and selectivity for GPR44...
October 17, 2023: Pharmaceuticals
https://read.qxmd.com/read/37891648/rosmarinic-acid-treatment-protects-against-lethal-h1n1-virus-mediated-inflammation-and-lung-injury-by-promoting-activation-of-the-h-pgds-pgd-2-ho-1-signal-axis
#27
JOURNAL ARTICLE
Beixian Zhou, Linxin Wang, Sushan Yang, Yueyun Liang, Yuehan Zhang, Xiping Pan, Jing Li
BACKGROUND: Rosmarinic acid (RosA) is a natural phenolic compound that possesses a wide-range of pharmacological properties. However, the effects of RosA on influenza A virus-mediated acute lung injury remain unknown. In this study, we aimed to explore whether RosA could protect against H1N1 virus-mediated lung injury and elucidate the underlying mechanisms. METHODS: Mice were intragastrically administered with RosA for 2 days before intranasal inoculation of the H1N1 virus (5LD50 ) for the establishment of an acute lung injury model...
October 27, 2023: Chinese Medicine
https://read.qxmd.com/read/37779524/macroarray-expression-analysis-of-cytokines-and-prostaglandin-metabolism-related-genes-in-chronic-rhinosinusitis
#28
JOURNAL ARTICLE
Aiko Oka, Kengo Kanai, Takaya Higaki, Seiichiro Makihara, Yohei Noda, Shin Kariya, Mizuo Ando, Wataru Nishimura, Mitsuhiro Okano
BACKGROUND: Chronic rhinosinusitis (CRS) can be divided into endotypes by functional or pathophysiologic findings. OBJECTIVE: The aim of this study was to analyze the expression of cytokines, prostaglandin (PG) synthases, and their receptors related to the pathogenesis of CRS, especially those contributing to nasal polyp (NP) formation. METHODS: NPs and uncinate tissue (UT) samples were collected from 90 patients who underwent endoscopic sinus surgery...
August 2023: J Allergy Clin Immunol Glob
https://read.qxmd.com/read/37772683/differential-roles-of-cyclooxygenase-enzymes-in-the-regulation-of-murine-juvenile-undifferentiated-spermatogonia
#29
JOURNAL ARTICLE
Amy Tran-Guzman, Amina Khan, Martine Culty
BACKGROUND: Acetaminophen and ibuprofen are widely administered to babies due to their presumed safety as over-the-counter drugs. However, no reports exist on the effects of cyclooxygenase inhibitors on undifferentiated spermatogonia and spermatogonial stem cells. Infancy represents a critical period for spermatogonial stem cell formation and disrupting spermatogonial stem cells or their precursors may be associated with infertility and testicular cancer formation. OBJECTIVES: The goal of this study was to examine the molecular and functional impact of cyclooxygenase inhibition and silencing on early steps of undifferentiated spermatogonia (u spg) and spermatogonial stem cell development, to assess the potential reproductive risk of pharmaceutical cyclooxygenase inhibitors...
September 29, 2023: Andrology
https://read.qxmd.com/read/37730258/-effect-of-moxibustion-of-acupoints-for-both-lung-and-intestine-disorders-on-lung-inflammation-and-intestinal-short-chain-fatty-acids-in-asthmatic-model-rats
#30
JOURNAL ARTICLE
Yi-Tian Lai, Jing-Ying Zhou, Ling Ren, Mi Liu, Guo-Shan Zhang
OBJECTIVE: To explore the mechanism of moxibustion in the treatment of asthmatic inflammation from the point of short-chain fatty acids (SCFAs) in rats with asthma. METHODS: A total of 48 SD rats (half male and half female) were randomly divided into 4 groups: normal, model, lung treatment and joint-treatment of lung and intestine (joint-treatment), with 12 rats in each group. The asthma model was made by subcutaneous (bilateral back and inguinal regions) and intraperitoneal injection of mixture solution of ovalbumin and aluminium hydroxide gel (on day 1 and 8) and followed by inhalation of atomized 1% ovalbumin (20 min from day 15, once daily for one week)...
September 25, 2023: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/37705535/aspirin-eugenol-ester-ameliorates-lps-induced-inflammatory-responses-in-raw264-7-cells-and-mice
#31
JOURNAL ARTICLE
Xu Liu, Qi Tao, Youming Shen, Xiwang Liu, Yajun Yang, Ning Ma, Jianyong Li
Introduction: Inflammation is a defensive response of the body and the pathological basis of many diseases. However, excessive inflammation and chronic inflammation impair the homeostasis of the organism. Arachidonic acid (AA) has a close relationship with inflammation and is the main mediator of the pro-inflammatory response. Based on the prodrug principle, the new pharmaceutical compound aspirin eugenol ester (AEE) was designed and synthesized. However, the effects of AEE on key enzymes, metabolites and inflammatory signaling pathways in the AA metabolic network have not been reported...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37687175/gas-chromatography-mass-spectrometry-based-cerebrospinal-fluid-metabolomics-to-reveal-the-protection-of-coptisine-against-transient-focal-cerebral-ischemia-reperfusion-injury-via-anti-inflammation-and-antioxidant
#32
JOURNAL ARTICLE
Junjie Zhang, Ao Qi, Lulu Liu, Chun Cai, Hui Xu
Coptisine (Cop) exerts a neuroprotective effect on central nervous system disease, particularly ischemic stroke. However, its protective mechanism is still unclear. This study aimed to investigate the protective effect of Cop on cerebral ischemia-reperfusion (IR) rats with a middle cerebral artery occlusion model by integrating a gas chromatography-mass spectrometry (GC-MS)-based metabolomics approach with biochemical assessment. Our results showed that Cop could improve neurobehavioral function and decrease the ischemia size in IR rats...
August 30, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37669705/prostaglandin-d-2-regulates-escherichia-coli-induced-inflammatory-responses-through-tlr2-tlr4-and-nlrp3-in-macrophages
#33
JOURNAL ARTICLE
Zhiguo Gong, Wei Mao, Feng Jin, Shuangyi Zhang, Jiamin Zhao, Peipei Ren, Zhuoya Yu, Yunjie Bai, Chao Wang, Jinshan Cao, Bo Liu
Prostaglandin D2 (PGD2 ) synthesis is closely associated with the innate immune response mediated by pattern recognition receptors (PPRs). We determined PGD2 synthesis whether mediated by Toll-like receptor 2 (TLR2), TLR4 and Nod-like receptor pyrin domain-containing protein 3 (NLRP3) in Escherichia coli (E. coli)-, lipopolysaccharide (LPS)- and Braun lipoprotein (BLP)-stimulated macrophages. Our data demonstrate that TLR2, TLR4, and NLRP3 could regulate the synthesis of PGD2 through cyclo-oxygenase-2 (COX-2) and hematopoietic PGD synthase (H-PGDS) in E...
September 3, 2023: Prostaglandins & Other Lipid Mediators
https://read.qxmd.com/read/37666361/roles-of-lipocalin-type-and-hematopoietic-prostaglandin-d-synthases-in-mouse-retinal-angiogenesis
#34
JOURNAL ARTICLE
Daiki Horikami, Erika Sekihachi, Keisuke Omori, Yui Kobayashi, Koji Kobayashi, Nanae Nagata, Kaori Kurata, Akiyoshi Uemura, Takahisa Murata
Normal angiogenesis is essential for retinal development and maintenance of visual function in the eye, and its abnormality can cause retinopathy and other eye diseases. Prostaglandin D2 (PGD2 ) is an anti-angiogenic lipid mediator produced by lipocalin-type or hematopoietic PGD synthase (L-PGDS or H-PGDS). However, the exact role of these PGD synthases remains unclear. Therefore, we compared the roles of these synthases in murine retinal angiogenesis under physiological and pathological conditions. On postnatal day (P) 8, the WT murine retina was covered with an elongated vessel...
September 2, 2023: Journal of Lipid Research
https://read.qxmd.com/read/37665561/anti-allergic-and-anti-inflammatory-effects-of-bakuchiol-on-ovalbumin-induced-allergic-rhinitis-in-mice
#35
JOURNAL ARTICLE
Han Bing Yao, Hesham S Almoallim, Sulaiman Ali Alharbi, Hui Feng
Allergic rhinitis (AR) is a prevalent inflammatory disease primarily affecting the nasal mucosa and is caused by allergies. The common symptoms of AR include rhinorrhea, sneezing, itchy nose, congestion, teary eyes, and nasal rubbings. The present study assessed the beneficial properties of bakuchiol on OVA-induced AR in mice via the regulation of inflammatory responses. AR was induced by injecting (i.p.) OVA (50 µg) and aluminum hydroxide (1 mg) into mice at various time intervals. The bakuchiol treatment was done at dosages of 10 and 20 mg/kg with dexamethasone (2...
September 4, 2023: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/37596586/panax-quinquefolius-saponins-combined-with-dual-antiplatelet-therapy-enhanced-platelet-inhibition-with-alleviated-gastric-injury-via-regulating-eicosanoids-metabolism
#36
JOURNAL ARTICLE
Wenting Wang, Lei Song, Lin Yang, Changkun Li, Yan Ma, Mei Xue, Dazhuo Shi
BACKGROUND: Panax quinquefolius saponin (PQS) was shown beneficial against platelet adhesion and for gastroprotection. This study aimed to investigate the integrated efficacy of PQS with dual antiplatelet therapy (DAPT) on platelet aggregation, myocardial infarction (MI) expansion and gastric injury in a rat model of acute MI (AMI) and to explore the mechanism regarding arachidonic acid (AA)-derived eicosanoids metabolism. METHODS: Wistar rats were subjected to left coronary artery occlusion to induce AMI model followed by treatment with DAPT, PQS or the combined therapy...
August 18, 2023: BMC complementary medicine and therapies
https://read.qxmd.com/read/37594194/spla2gib-promotes-pgd2-and-il-13-production-in-eosinophilic-chronic-rhinosinusitis-with-nasal-polyps
#37
JOURNAL ARTICLE
Yi-Fan Kang, Jin-Xin Liu, Kai Xu, Xue-Li Li, Xiang Lu
OBJECTIVE: Secreted phospholipase A2 Group IB (sPLA2GIB) regulates the release of arachidonic acid, prostaglandins, and other inflammatory lipid mediators. Although it has been well involved in extensive inflammatory diseases, its specific mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. In this study, we investigated the role of sPLA2GIB in the pathophysiology of CRSwNP. METHODS: Quantitative PCR, immunofluorescence staining, western blotting, and enzyme-linked immunosorbent assay (ELISA) were used to analyze the expression of sPLA2s, phospholipase A2 receptor (PLA2R), and prostaglandin D2 (PGD2) in nasal samples...
August 18, 2023: Laryngoscope
https://read.qxmd.com/read/37587718/identification-and-imaging-of-prostaglandin-isomers-utilizing-ms-3-product-ions-and-silver-cationization
#38
JOURNAL ARTICLE
Leonidas Mavroudakis, Ingela Lanekoff
Prostaglandins (PGs) are important lipid mediators involved in physiological processes, such as inflammation and pregnancy. The pleiotropic effects of the PG isomers and their differential expression from cell types impose the necessity for studying individual isomers locally in tissue to understand the molecular mechanisms. Currently, mass spectrometry (MS)-based analytical workflows for determining the PG isomers typically require homogenization of the sample and a separation method, which results in a loss of spatial information...
August 16, 2023: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/37543185/lower-serum-15-hete-predicts-nasal-ilc2-accumulation-during-cox-1-inhibition-in-aerd
#39
JOURNAL ARTICLE
Jana H Badrani, Kellen Cavagnero, Jacqueline J Eastman, Alex S Kim, Allyssa Strohm, Carol Yan, Adam Deconde, Bruce L Zuraw, Andrew A White, Sandra C Christiansen, Taylor A Doherty
BACKGROUND: Aspirin exacerbated respiratory disease (AERD) is associated with high levels of cysteinyl leukotrienes, prostaglandin D2 (PGD2), and low levels of prostaglandin E2 (PGE2). Further, 15-hydroxyeicosatetraenoic acid (15-HETE) levels may have predictive value in aspirin desensitization therapeutic outcomes. Accumulation of nasal group 2 innate lymphoid cells (ILC2s) has been demonstrated during COX-1 inhibition in AERD though the relationships between tissue ILC2 accumulation, reaction symptom severity, and novel lipid biomarkers is unknown...
August 3, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37543159/the-vasoconstrictor-activities-of-prostaglandin-d-2-via-the-thromboxane-prostanoid-receptor-and-e-prostanoid-receptor-3-outweigh-its-concurrent-vasodepressor-effect-mainly-through-d-prostanoid-receptor-1-ex-vivo-and-in-vivo
#40
JOURNAL ARTICLE
Tingting Guo, Bin Liu, Ruhui Zeng, Rui Lin, Jinwei Guo, Gang Yu, Yineng Xu, Xiangzhai Tan, Kaiqi Xie, Yingbi Zhou
Prostaglandin (PG) D2 , a commonly considered vasodilator through D prostanoid receptor-1 (DP1), might also evoke vasoconstriction via acting on the thromboxane (Tx)-prostanoid receptor (the original receptor of TxA2 ; TP) and/or E prostanoid receptor-3 (one of the vasoconstrictor receptors of PGE2 ; EP3). This study aimed to test the above hypothesis in the mouse renal vascular bed (main renal arteries and perfused kidneys) and/or mesenteric resistance arteries and determine how the vasoconstrictor mechanism influences the overall PGD2 effect on systemic blood pressure under in vivo conditions...
August 3, 2023: European Journal of Pharmacology
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