keyword
https://read.qxmd.com/read/38534761/genetic-signatures-for-distinguishing-chemo-sensitive-from-chemo-resistant-responders-in-prostate-cancer-patients
#1
JOURNAL ARTICLE
Lemohang Gumenku, Mamello Sekhoacha, Beynon Abrahams, Samson Mashele, Aubrey Shoko, Ochuko L Erukainure
Prostate cancer remains a significant public health concern in sub-Saharan Africa, particularly impacting South Africa with high mortality rates. Despite many years of extensive research and significant financial expenditure, there has yet to be a definitive solution to prostate cancer. It is not just individuals who vary in their response to treatment, but even different nodules within the same tumor exhibit unique transcriptome patterns. These distinctions extend beyond mere differences in gene expression levels to encompass the control and networking of individual genes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38523295/squamous-cell-carcinoma-malignant-transformation-in-mature-cystic-teratoma-of-the-ovary-a-case-report-and-review-of-the-literature
#2
REVIEW
Amir Masoud Jafari-Nozad, Najmeh Jahani, Narges Nazeri
BACKGROUND: Mature cystic teratoma of the ovary is classified among the benign ovarian germ cell neoplasms, and its malignant transformation occurs very rarely (in about 2%). As a result of nonspecific signs and symptoms, preoperative diagnosis of theses malignancies is a challenge to clinicians, resulting in delayed diagnosis (in advanced stages) and poor outcomes. CASE PRESENTATION: We report the case of a 43-year-old Iranian woman with progressive distension of the abdomen and hypogastric pain, who was diagnosed with squamous cell carcinoma transformation in a mature cystic teratoma of the ovary confirmed by histopathology examination...
March 25, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38494342/association-between-body-mass-index-and-in-vitro-fertilization-intra-cytoplasmic-sperm-injection-outcomes-an-analysis-of-15-124-normal-ovarian-responders-in-china
#3
JOURNAL ARTICLE
Danlei Zheng, Yuanyuan Wang, Lixue Chen, Lin Zeng, Rong Li
BACKGROUND: High body mass index (BMI) results in decreased fecundity, and women with high BMI have reduced rates of clinical pregnancy and live birth in in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI). Meanwhile, ovarian responses show great heterogeneity in patients with a high BMI. This study aimed to analyze the effects of a high BMI on IVF/ICSI outcomes in the Chinese female with normal ovarian response. METHODS: We performed a retrospective cohort study comprising 15,124 patients from the medical record system of the Reproductive Center of Peking University Third Hospital, with 3530 (23...
March 18, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38436182/age-and-dual-trigger-were-found-to-be-significant-predictors-of-live-birth-in-poseidon-group-3-and-4-women-treated-with-the-gnrh-antagonist-protocol-a-retrospective-cohort-study
#4
JOURNAL ARTICLE
B Varlı, Y E Sukur, B Ozmen, M Sönmezer, C Atabekoğlu, R Aytaç, B Berker
OBJECTIVE: Despite recent advancements in assisted reproductive technology (ART), the effective management of patients with poor ovarian response (POR) remains a formidable challenge. While various treatment strategies and predictors of live births have been documented to provide guidance to fertility specialists in managing poor responders, research efforts have predominantly encompassed all POSEIDON groups. In this study, our objective was to analyze the factors correlated with live births (LB) within a subset of the POSEIDON groups, with a particular focus on POSEIDON groups 3 and 4...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38433576/abrogation-of-klf5-sensitizes-brca1-proficient-pancreatic-cancer-to-parp-inhibition
#5
JOURNAL ARTICLE
Zheng Zhang, Yuxin Liu, Yaolin Xu, Zijin Xu, Jinbin Jia, Yun Jin, Wenquan Wang, Liang Liu
Poly ADP-ribose polymerase (PARP) inhibitor monotherapies are selectively effective in patients with pancreatic, breast, prostate, and ovarian cancers with BRCA1 mutations. Cancer patients with more frequent wild-type BRCA show poor responses to PARP inhibitors. Moreover, patients who are initially sensitive to these inhibitors eventually respond poorly to drugs. In the present study, we discover that abrogation of Kruppel-like factor 5 (KLF5) significantly inhibits homologous recombination, which is the main mechanism for DNA double-stranded repair...
March 4, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38368517/investigating-ovulation-induction-outcomes-in-patients-with-decreased-ovarian-reserve-treated-with-double-stimulation-during-the-follicular-and-luteal-phases-compared-to-the-conventional-antagonist-cycle-a-randomized-clinical-trial
#6
JOURNAL ARTICLE
Fatemeh Ghahghayi, Abolfazl Payandeh, Aida Najafian, Marzieh Ghasemi, Ayob Jabari Jabari
BACKGROUND: It is difficult to obtain healthy oocytes in poor ovarian responders with conventional treatment methods. Thus, the need to investigate new methods is essential. This study aims to investigate ovulation induction outcomes in patients with decreased ovarian reserve (DOR) in two groups treated with double stimulation (DuoStim) during the follicular and luteal phases in comparison with the antagonist cycle. MATERIALS AND METHODS: This was a randomised clinical trial that enrolled the patients with reduced ovarian reserve...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38368516/comparison-in-vitro-fertilization-outcomes-between-doustim-and-minimal-stimulation-protocols-in-poor-ovarian-responders-a-randomized-clinical-trial
#7
JOURNAL ARTICLE
Nasrin Saharkhiz, Saghar Salehpoor, Sedigheh Hosseini, Leila Nazari, Samaneh Sheibani, Tahereh Doohandeh
BACKGROUND: Various protocols have been approved to improve the response rate leading to successful fertilization in poor ovarian responders (PORs). The application of double ovarian stimulation (DuoStim) in the follicular and luteal phases of the same ovarian cycle has been shown as an intriguing option to achieve more oocyte retrievals in the shortest time. The aim of the current study is to compare the outcomes of different protocols, minimal stimulation (MS) and Duostim. MATERIALS AND METHODS: This randomized clinical trial was performed on 42 in vitro fertilization (IVF) candidates with POR diagnosis...
February 2, 2024: International Journal of Fertility & Sterility
https://read.qxmd.com/read/38358433/significance-of-serum-amh-and-antral-follicle-count-discrepancy-for-the-prediction-of-ovarian-stimulation-response-in-poseidon-criteria-patients
#8
JOURNAL ARTICLE
Alyssa Hochberg, Michael H Dahan, Hakan Yarali, Lan N Vuong, Sandro C Esteves
PURPOSE: To determine the risk of not being a poor responder in ovarian stimulation (OS) for in vitro fertilization (IVF) when ovarian reserve markers are discordant-one falling within Poseidon's criteria normal range (e.g., anti-Müllerian hormone (AMH) ≥ 1.2 ng/mL or antral follicle count (AFC) ≥ 5), and the other in the poor ovarian reserve range. METHODS: A tri-center retrospective cohort study (2015-2017) involving women with discordant AMH and AFC values undergoing their first IVF/ICSI cycle using conventional OS (cOS, ≥ 150 IU/day of follicle-stimulating hormone)...
February 15, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38355537/cai-s-prescription-inhibits-granulosa-cell-apoptosis-through-arhgap4-on-poor-ovarian-responders
#9
JOURNAL ARTICLE
Zheng Wang, Denghao Liu, Yonghong Nie, Qinhua Zhang
PURPOSE: Poor ovarian response (POR) is a big challenge for in vitro fertilization. The traditional Chinese medicine, Cai's Prescription of Tonifying Kidney and Strengthening Vitals (Cai's Prescription) has yielded satisfactory results for POR treatment clinically, but systematic scientific research of Cai's Prescription is not well reported. This study aimed to investigate the clinical effect of Cai's Prescription on poor ovarian responders and its biological mechanism. METHODS: Serum was collected from poor ovarian responders, and IL-1β, INFγ, FSH, E2 and AMH levels were analyzed by ELISA...
February 14, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38301510/reduced-embryo-yield-obtained-from-superstimulated-ewes-with-low-circulating-amh-concentration-is-improved-by-lengthening-the-fsh-treatment
#10
JOURNAL ARTICLE
C Brochado, B J Duran, J D Kieffer, A Pinczak, A Menchaca, A Garcia-Guerra
The aim of the present study was to evaluate: 1) the association between AMH, AFC, superovulatory response and embryo yield in sheep; and 2) the effect of FSH treatment length during superstimulation of the first follicular wave on ovarian response and embryo yield, particularly in ewes with low and high AMH. The experiment was performed on 63 Polled Dorset ewes that received an ovarian superstimulatory treatment during the first follicular wave (Day 0 protocol). Ewes were administered a total dose of 240 mg of FSH distributed in six (6-dose regimen, n = 30) or eight (8-dose regimen, n = 33) decreasing doses administered 12 h apart...
January 25, 2024: Theriogenology
https://read.qxmd.com/read/38289204/progesterone-levels-on-hcg-day-and-oocyte-maturation-in-a-mexican-ivf-program
#11
JOURNAL ARTICLE
Alfredo Cortés-Vazquez, Denisse Veliz-Figueroa, Karla Vargas-Estrada, Jesús-Daniel Moreno-García, Alfredo Cortés-Algara
OBJECTIVE: Does progesterone levels on hCG day influence maturation rates and number of mature oocytes during ovarian stimulation for IVF/ICSI cycles?. METHODS: A retrospective, observational, analytic, cross-sectional and cohort study was performed at the Reproductive Endocrinology Department of the Centro Médico Nacional 20 de Noviembre in Mexico City between 2015 to 2020. All female patients underwent an ovarian stimulation cycle for IVF/ICSI, either with a mild or conventional stimulation protocol...
January 30, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38280716/core-fucosylation-regulates-the-ovarian-response-via-fsh-receptor-during-follicular-development
#12
JOURNAL ARTICLE
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li
INTRODUCTION: Ovarian low response to follicle-stimulating hormone (FSH) causes infertility featuring hypergonadotropic hypogonadism, ovarian failure, and/or defective ovarian response. OBJECTIVES: N-glycosylation is essential for FSH receptor (FSHR). Core fucosylation catalyzed by fucosyltransferase 8 (FUT8) is the most common N-glycosylation. Core fucosylation level changes between individuals and plays important roles in multiple physiological and pathological conditions...
January 25, 2024: Journal of Advanced Research
https://read.qxmd.com/read/38215359/poor-concordance-between-cancer-antigen-125-and-recist-assessment-for-progression-in-patients-with-platinum-sensitive-relapsed-ovarian-cancer-on-maintenance-therapy-with-a-poly-adp-ribose-polymerase-inhibitor
#13
JOURNAL ARTICLE
Angelina Tjokrowidjaja, M L Friedlander, Jonathan A Ledermann, Robert L Coleman, Mansoor R Mirza, Ursula A Matulonis, Eric Pujade-Lauraine, Sarah J Lord, Clare L Scott, Sandra Goble, Whitney York, Chee K Lee
PURPOSE: Cancer antigen-125 (CA-125) is recommended by treatment guidelines and widely used to diagnose ovarian cancer recurrence. The value of CA-125 as a surrogate for disease progression (PD) and its concordance with radiologic progression are unclear, particularly for women with platinum-sensitive relapsed ovarian cancer (PSROC) who have responded to chemotherapy and treated with maintenance poly(ADP-ribose) polymerase inhibitor (PARPi). METHODS: In this pooled analysis of four randomized trials of maintenance PARPi or placebo (Study 19, SOLO2, ARIEL3, and NOVA), we extracted data on CA-125 PD as defined by Gynecologic Cancer InterGroup criteria and RECIST v1...
January 12, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38214306/the-efficacy-of-platelet-rich-plasma-on-women-with-poor-ovarian-response-a-systematic-review-and-meta-analysis
#14
JOURNAL ARTICLE
Lingling Wu, Fenfang Su, Peixin Luo, Qingqing Dong, Mengni Ma, Guangyong Ye
BACKGROUND: Platelet-rich plasma (PRP) is a therapeutic approach that is gaining attention for its potential in the treatment of poor ovarian response. This meta-analysis aimed to systematically review and analyze clinical studies to evaluate the impact of PRP on poor responders undergoing ovarian stimulation for IVF. METHODS: A comprehensive search was conducted in electronic databases, including PubMed, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant studies published in English...
December 2024: Platelets
https://read.qxmd.com/read/38212837/personalizing-the-first-dose-of-fsh-for-ivf-icsi-patients-through-machine-learning-a-non-inferiority-study-protocol-for-a-multi-center-randomized-controlled-trial
#15
JOURNAL ARTICLE
Nuria Correa, Jesus Cerquides, Josep Lluis Arcos, Rita Vassena, Mina Popovic
BACKGROUND: Adequately selecting the initial follicle-stimulating hormone (FSH) dose during controlled ovarian stimulation (COS) is key for success in assisted reproduction. The objective of COS is to obtain an optimal number of oocytes to increase the chances of achieving a pregnancy, while avoiding complications for the patient. Current clinical protocols do achieve good results for the majority of patients, but further refinements in individualized FSH dosing may reduce the risk of poor ovarian response while also limiting the risk of ovarian hyperstimulation syndrome (OHSS) risk...
January 11, 2024: Trials
https://read.qxmd.com/read/38201589/relapsed-ovarian-cancer-patients-with-ascites-and-or-pleural-effusion-still-benefit-from-treatment-a-real-life-study
#16
JOURNAL ARTICLE
Mariana Rebordão-Pires, Marta F Estrada, António Gomes, Filipa Silva, Carlota Baptista, Maria João Ramos, Ana Fortuna, Pedro Simões, Gabriela Sousa, Ana Marreiros, Rita Fior
(1) Background: Relapsed HGSOC with ascites and/or pleural effusion is a poor-prognostic population and poorly represented in clinical studies. We questioned if these patients are worth treating. In other words, if these patients received the most effective treatment, would it change the course of this disease? To our knowledge this is the first real-life study to evaluate this question in this low-survival population. (2) Methods: To tackle this question we performed a retrospective, multi-centric, real-life study, that reviewed relapsed HGSOC patients with ascites and/or pleural effusion...
December 28, 2023: Cancers
https://read.qxmd.com/read/38199789/does-dual-oocyte-retrieval-with-continuous-fsh-administration-increase-the-number-of-mature-oocytes-in-low-responders-an-open-label-randomized-controlled-trial
#17
JOURNAL ARTICLE
L Boudry, I Mateizel, K Wouters, E Papaleo, S Mackens, M De Vos, A Racca, T Adriaenssens, H Tournaye, C Blockeel
STUDY QUESTION: Is there an increase in the total number of metaphase II (MII) oocytes between a conventional ovarian stimulation (OS) and a double uninterrupted stimulation? SUMMARY ANSWER: There is no increase in the total number of MII oocytes when comparing one conventional OS to a continuous stimulation with double oocyte aspiration. WHAT IS KNOWN ALREADY: Based on the concept of multiple follicular waves, the combination of two stimulations in the same ovarian cycle has gained interest in patients with a low ovarian reserve...
January 10, 2024: Human Reproduction
https://read.qxmd.com/read/38174816/individualised-gonadotropin-dose-selection-using-markers-of-ovarian-reserve-for-women-undergoing-in-vitro-fertilisation-plus-intracytoplasmic-sperm-injection-ivf-icsi
#18
REVIEW
Olina Ngwenya, Sarah F Lensen, Andy Vail, Ben Willem J Mol, Frank J Broekmans, Jack Wilkinson
BACKGROUND: During a stimulated cycle of in vitro fertilisation or intracytoplasmic sperm injection (IVF/ICSI), women receive daily doses of gonadotropin follicle-stimulating hormone (FSH) to induce multifollicular development in the ovaries. A normal response to stimulation (e.g. retrieval of 5 to 15 oocytes) is considered desirable. Generally, the number of eggs retrieved is associated with the dose of FSH. Both hyper-response and poor response are associated with an increased chance of cycle cancellation...
January 4, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38169411/do-we-overlook-predictive-factors-in-poseidon-1-patients-a-retrospective-analysis-co-evaluating-antral-follicle-counts-diameters
#19
JOURNAL ARTICLE
Gürkan Uncu, Kiper Aslan, Cihan Cakir, Berrin Avci, Isil Kasapoglu, Carlo Alviggi
BACKGROUND: An unexpected impaired ovarian response pertains to an insufficient reaction to controlled ovarian hyperstimulation. This deficient reaction is identified by a reduced count of mature follicles and retrieved oocytes during an IVF cycle, potentially diminishing the likelihood of a successful pregnancy. This research seeks to examine whether the characteristics of antral follicles can serve as predictive indicators for the unexpected impaired ovarian response to controlled ovarian stimulation (COS)...
January 2, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38165675/utilization-of-cryopreserved-oocytes-in-patients-with-poor-ovarian-response-after-planned-oocyte-cryopreservation
#20
JOURNAL ARTICLE
Yuval Fouks, Denny Sakkas, Pietro E Bortoletto, Alan S Penzias, Emily A Seidler, Denis A Vaughan
IMPORTANCE: Poor ovarian response (POR) to stimulation may impact patients' desire or need to utilize cryopreserved oocytes for family building in the future. These findings, captured by Society for Assisted Reproductive Technology (SART) national data, underscore the need for tailored counseling and further research into the decision-making processes influencing oocyte utilization. OBJECTIVE: To examine the association of ovarian response to stimulation and the number of vitrified oocytes with the likelihood and timing of patients returning for oocyte utilization following planned oocyte cryopreservation (OC)...
January 2, 2024: JAMA Network Open
keyword
keyword
162407
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.