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Poor ovarian respond

Mariana Carlos Alves, Andreia Leitão Marques, Helena Barros Leite, Ana Paula Sousa, Teresa Almeida-Santos
INTRODUCTION: Medically assisted reproduction in natural cycle has been investigated, especially in women with poor response to conventional ovarian stimulation, with endometrial receptivity improvement, lower cost and possibility of successive cycles. The disadvantages are: lower profitability per treatment cycle and higher cancellation rate. The aim of this study was to determine the rate of clinical pregnancy in infertile women subjected to medically assisted reproduction in natural cycle...
February 1, 2019: Acta Médica Portuguesa
Haroon Latif Khan, Shahzad Bhatti, Samina Suhail, Rohina Gul, Aisha Awais, Humaira Hamayun, Farah Enver, Sana Abbas, Zahira Hassan, Rameen Nisar, Saba Sardar, Warda Asif
BACKGROUND: Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their healthy lives. The poor ovarian response is a substantial limiting factor amplified with higher maternal age and associated with a considerably lower likelihood of pregnancy. METHODS: A present analytical prospective cross-sectional study was conducted to explore whether infertile women below the age of 40 years have low ovarian reserve than fertile women of same age, assessed by Antral follicle count (AFC) and anti-Müllerian hormone (AMH), at tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital...
February 11, 2019: Reproductive Biology and Endocrinology: RB&E
Marzie Farimani, Safoura Heshmati, Jalal Poorolajal, Maryam Bahmanzadeh
The prevalence of poor response to gonadotropin stimulation is approximately 9-24% in women undergoing in vitro fertilization. Interestingly, due to containing a variety of growth factors, platelet-rich plasma (PRP) can play an important role in tissue regeneration and healing. Thus, in this research, we aimed to investigate the intra-ovarian injection of PRP in women with poor ovarian response. To this goal, 23 poor responders constituted the study population, from among whom 19 women were enrolled. These patients underwent ovarian stimulation according to the Shanghai protocol...
February 5, 2019: Molecular Biology Reports
Mahmoud Salama, Teresa K Woodruff
Several fertility restoration options are not feasible for some cancer patients, poor responders, and patients with premature ovarian failure who have diminished ovarian reserve. In order to preserve and restore fertility in such patients, new strategies should be offered including artificial human ovary technology. In this mini-review, we explore from bench to bedside the current developments and future possibilities of artificial human ovary technology to restore fertility. This article is protected by copyright...
February 3, 2019: Acta Obstetricia et Gynecologica Scandinavica
J K Bosdou, C A Venetis, B C Tarlatzis, G F Grimbizis, E M Kolibianakis
STUDY QUESTION: Does the outcome of the comparison of live birth rates between the first frozen embryo transfer (ET) (in a freeze-only cycles strategy, i.e. frozen ET group) and a fresh embryo transfer (fresh ET group) differ considering the type of ovarian response? SUMMARY ANSWER: Α significantly higher probability of live birth is present in high, but not normal, responders, after the first frozen ET in a freeze-only cycle strategy as compared to a fresh ET...
January 28, 2019: Human Reproduction
Aditi Bhatt, Snita Sinukumar, Sanket Mehta, Dileep Damodaran, Shabber Zaveri, Praveen Kammar, Suniti Mishra, Loma Parikh, Rohit Ranade, Prasanth Penumadu, Firoz Rajan
OBJECTIVES: The goals were to study • The pattern of pathological response to neoadjuvant chemotherapy (NACT) and its clinical implications • The impact of chemotherapy response grade (CRG) on survival METHODS: A retrospective analysis of patients undergoing interval cytoreductive surgery (CRS) between January 2013 to December 2017 was performed. The surgical and pathological reports were analyzed and surgical and pathological PCI compared. The pathological response to chemotherapy was assessed using the score developed by Bohm...
January 9, 2019: European Journal of Surgical Oncology
Wei Wang, Hong Liu, Jing Li, Daimin Wei, Jiangtao Zhang, Jianfeng Wang, Jinlong Ma, Yuhua Shi, Zi-Jiang Chen
BACKGROUND: Women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) with poor ovarian respond (POR) always have very low clinical pregnancy rates. In previous data, dehydroepiandrosterone (DHEA) was suggested as a promising treatment and maybe has a good pregnancy outcome. But there is no sufficient evidence from randomized clinical trials evaluating the effect of DHEA preconceptional treatment on live birth in POR. METHODS: This trial is a multicenter active-placebo double-blind clinical trial (1:1 treatment ratio of active versus placebo)...
January 15, 2019: Trials
Francesc Fàbregues, Roser Solernou, Janisse Ferreri, Marta Guimerá, Sara Peralta, Gemma Casals, Joana Peñarrubia, Montserrat Creus, Dolors Manau
OBJECTIVE: Transdermal testosterone has been used in different doses and in different stimulation protocols in poor responders. The aim of the present study is to compare the luteal estradiol/GnRH antagonists protocol versus long GnRH agonists in poor responder patients according to the Bologna criteria, in which transdermal testosterone has been used prior to the stimulation with gonadotropins. METHODS: In this retrospective analysis, a total of 141 poor responder patients according to the Bologna criteria were recruited...
January 7, 2019: JBRA Assisted Reproduction
Mahnaz Ashrafi, Arezoo Arabipoor, Azar Yahyaei, Zahra Zolfaghari, Firouzah Ghaffari
BACKGROUND: Recently, a novel approach with delaying the start of controlled ovarian stimulation along with gonadotropin-releasing hormone (GnRH) antagonist pretreatment for 7 days after estrogen priming for further suppression of endogenous follicle stimulating hormone (FSH) during the early follicular phase, resulting in more FSH-responsive follicles and thus improving synchronous follicular development was introduced. Two clinical trials have examined this strategy and reported controversial results...
December 28, 2018: Reproductive Biology and Endocrinology: RB&E
Laurice Bou Nemer, Haolin Shi, Bruce Richard Carr, Ruth Ann Word, Orhan Bukulmez
Premature follicular rupture during in vitro fertilization (IVF) is a well-known culprit for cycle cancellation. We sought to evaluate whether a single oral dose of ibuprofen will have an effect on the follicular fluid (FF) levels of inflammatory markers involved in ovulation. This is a prospective within-subjects study following nine patients undergoing IVF. Every patient underwent a first cycle of minimal stimulation IVF followed by a second cycle using the same stimulation protocol, except one oral dose of ibuprofen 800 mg was administered 15-18 h post-trigger injection...
December 20, 2018: Systems Biology in Reproductive Medicine
Asifa Majeed, P S Divyashree, Kamini A Rao
Context: Poor response is reported in 9%-24% of stimulated cycles. Color Doppler indices of follicular blood flow are correlated with oocyte recovery, fertilization rate, developmental potential of oocyte, and pregnancy rate in in vitro fertilization (IVF) treatment. Aim: The aim of this study is to find out the correlation between perifollicular vascularity with clinical outcomes in poor ovarian responders during IVF cycles. Settings and Design: A total of 49 poor ovarian responder women undergoing conventional IVF-embryo transfer procedure at a tertiary care hospital between September 2014 and 2015 were included in the study...
July 2018: Journal of Human Reproductive Sciences
T Madani, M Hemat, A Arabipoor, S H Khodabakhshi, Z Zolfaghari
PURPOSE: To evaluate the effect of double stimulations during the follicular and luteal phases in women with poor ovarian response (POR) in in-vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles. BASIC PROCEDURES: This prospective clinical study was performed in Royan Institute from October 2014 to January 2016. 121 patients were diagnosed as POR on the basis of Bologna criteria were included. Double stimulations were performed during the follicular and luteal phases by Letrozole, Clomid, hMG and GnRH-agonist...
December 12, 2018: Journal of gynecology obstetrics and human reproduction
Kayhan Yakin, Ozgur Oktem, Basak Balaban, Bulent Urman
PURPOSE: The ESHRE Working Group on Poor Ovarian Response defined a set of variables to define poor responders, named as the Bologna Criteria, but several concerns have been raised regarding their applicability and prognostic significance. In order to evaluate the clinical relevance of the criteria, we retrospectively analyzed the ovarian response and live birth rates in women who had consecutive IVF attempts, according to their fulfillment of the criteria. METHODS: The study group comprised 1153 and 288 women who had two and three consecutive ovarian stimulation (OS) cycles between May 2010 and January 2017, respectively...
November 27, 2018: Archives of Gynecology and Obstetrics
Jeanne M Quinn, Molly M Greenwade, Marguerite L Palisoul, Gregory Opara, Katina Massad, Lei Guo, Peinan Zhao, Hollie Beck-Noia, Ian S Hagemann, Andrea R Hagemann, Carolyn K McCourt, Premal H Thaker, Matthew A Powell, David G Mutch, Katherine C Fuh
Ovarian cancer (OvCa), one of the deadliest malignancies in female cancer patients, is characterized by recurrence and poor response to cytotoxic chemotherapies. Fewer than 30% of patients with resistant disease will respond to additional chemotherapy treatments. This study aims to determine whether and how inhibition of the receptor tyrosine kinase AXL can restore sensitivity to front-line platinum and taxane therapy in OvCa. AXL staining was quantified in a patient tissue microarray and correlated with chemoresponse of patients...
November 26, 2018: Molecular Cancer Therapeutics
Yu Xiao, Yong Wang, Min Wang, Kai Liu
BACKGROUND: To investigate the impact of follicular flushing on the number of oocytes retrieved and embryo quality and to determine the optimal number of flushings for poor ovarian responders (PORs) undergoing in vitro fertilization (IVF). METHODS: This retrospective study included 291 IVF cycles in 224 patients who were PORs and had no more than three dominant follicles on retrieval day. During oocyte retrieval, follicular fluid was aspirated and examined for an oocyte...
November 16, 2018: BMC Women's Health
Afsoon Zarei, Mohammad Ebrahim Parsanezhad, Maryam Azizi Kutenaei, Bahia Namavar Jahromi, Parastoo Soheil Esfahani, Pardis Bakhshaei
Objectives: We sought to determine the effects of the delayed start protocol with gonadotropin-releasing hormone (GnRH) antagonists in poor responders undergoing in vitro fertilization (IVF). Methods: This randomized clinical trial was conducted during a 15-month period from April 2014 to July 2015 in clinics in Shiraz, Iran. A total of 42 poor responders with primary infertility were randomly assigned to the controlled ovarian stimulation group utilizing the delayed start protocol (n = 21) or the traditional group (n = 21) using GnRH antagonist, Cetrotide...
November 2018: Oman Medical Journal
Ahmed M Maged, Radwa M Fahmy, Hamsa Rashwan, Maryam Mahmood, Sarah M Hassan, Hala Nabil, Ayman Hany, Rehab Lotfy, Yossra S Lasheen, Sherif Dahab, Mohamed Darwish
OBJECTIVE: To assess the effects of body mass index (BMI) on the outcome of IVF cycles among poor responders. METHODS: A prospective cohort study in Egypt enrolled 185 poor responders who underwent intracytoplasmic sperm injection via an antagonist protocol between 2012 and 2017. Participants were classified into three groups by BMI (calculated as weight in kilograms divided by the square of height in meters): 18.5-24.9 (normal, n=48); 25-29.9 (overweight, n=54); 30 or higher (obese, n=83)...
February 2019: International Journal of Gynaecology and Obstetrics
Maruška Čuš, Veljko Vlaisavljević, Katja Repnik, Uroš Potočnik, Borut Kovačič
PURPOSE: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in selected genes, responsible for hormonal regulation of folliculogenesis, are associated with response to controlled ovarian hyperstimulation (COH) and clinical characteristics of women enrolled in in vitro fertilization (IVF) programs. METHODS: In a cross-sectional study, 60 (IVF) patients underwent COH by using gonadotropin-releasing hormone (GnRH) antagonist and recombinant follicle-stimulating hormone (rFSH) protocol...
November 8, 2018: Journal of Assisted Reproduction and Genetics
Yoshiyuki Kobayashi, Tsutomu Tabata, Mayu Omori, Eiji Kondo, Toru Hirata, Kenta Yoshida, Masayuki Sekine, Atsuo Itakura, Takayuki Enomoto, Tomoaki Ikeda
BACKGROUND: In recent years, the incidence of malignant disease in pregnancy has been increasing, but there are few large-scale surveys of malignant disease in pregnancy in Japan. The aim of this study was to survey malignant disease occurring during pregnancy in Japan. METHODS: Malignant disease in pregnancy was defined as diagnosis or treatment for malignant disease, except in situ carcinoma during pregnancy, or within 1-year postpartum. First, a primary survey questionnaire of the incidence of malignant disease in pregnancy and the number of deliveries over the course of 2014 was sent to 510 medical centers in Japan...
October 27, 2018: International Journal of Clinical Oncology
Léa Delbos, Elsa Parot-Schinkel, Hady El Hachem, Guillaume Legendre, Philippe Descamps, Lisa Boucret, Véronique Ferré-L'Hotellier, Pauline Jeanneteau, Cécile Dreux, Catherine Morinière, Pascale May-Panloup, Pierre-Emmanuel Bouet
BACKGROUND: To date, there is no consensus on the ideal management strategy of patients with poor ovarian response (POR) to controlled ovarian stimulation (COS) for in vitro fertilization (IVF). Currently, these patients are given the choice of: (1) canceling the cycle; (2) proceeding with COS regardless of the poor response, and performing the oocyte retrieval and transfer of embryos when available; or (3) conversion to an intrauterine insemination (IUI). When the decision to proceed with the COS cycle is taken, it is not clear whether IVF or conversion to IUI is the best choice...
October 17, 2018: Trials
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