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https://read.qxmd.com/read/30710646/population-genomic-analysis-and-de-novo-assembly-reveal-the-origin-of-weedy-rice-as-an-evolutionary-game
#1
Jian Sun, Dianrong Ma, Liang Tang, Minghui Zhao, Guangchen Zhang, Wenjia Wang, Jiayu Song, Xiang Li, Zimeng Liu, Wenxing Zhang, Quan Xu, Yuncheng Zhou, Jianzhong Wu, Toshio Yamamoto, Fei Dai, Song Li, Gang Zhou, Hongkun Zheng, Zhengjin Xu, Wenfu Chen
Crop weediness, especially that of weedy rice (Oryza sativa f. spontanea), remains mysterious. Weedy rice possesses robust ecological adaptability; however, how this strain originated and gradually formed proprietary genetic features remains unclear. Here, we demonstrate that weedy rice at Asian high latitudes (WRAH) is phylogenetically well-defined and presents unselected genomic spectra in many weedy-cultivated divergence islands. We also explored some novel QTLs for weedy-specific traits and proposed that a genome block in the end of chromosome 1 contributes to rice weediness...
January 30, 2019: Molecular Plant
https://read.qxmd.com/read/30703702/bioreduction-of-hexavalent-chromium-using-a-novel-strain-crb-7-immobilized-on-multiple-materials
#2
Minghui Wu, Yunzhen Li, Junjie Li, Ying Wang, Heng Xu, Yun Zhao
In this study, a novel Cr(VI) tolerant strain CRB-7 identified as Bacillus sp., was isolated and characterized for its high Cr(VI) reduction. The strain CRB-7 grew well and effectively reduced Cr(VI) under various conditions including pH (7-9), temperature (30-40 °C) and Cr(VI) concentrations (50-250 mg L-1 ). It almost completely reduced 120 mg L-1 Cr(VI) within 48 h under optimized condition of pH 7 and 37 °C. Further characterization by SEM-EDS and FTIR analyses indicated Cr(VI) removal mechanism of CRB-7 was predominately via bioreduction with little amount of bioadsorption...
January 22, 2019: Journal of Hazardous Materials
https://read.qxmd.com/read/30697111/genetic-enhancement-of-lodging-resistance-in-rice-due-to-the-key-cell-wall-polymer-lignin-which-affects-stem-characteristics
#3
Sitong Liu, Yuwei Huang, Hai Xu, Minghui Zhao, Quan Xu, Fengcheng Li
Lodging in crops seriously restricts plant growth and grain production. The genetic modification of cell walls to enhance plant mechanical strength has been suggested as a promising approach toward improving lodging resistance. However, because of the complexity of the plant cell wall, the exact effects of its polymers on plant lodging resistance remain elusive. To address this issue, we performed large-scale analyses of a total of 56 rice ( Oryza sativa L.) varieties that displayed distinct cell wall component and lodging index...
December 2018: Breeding Science
https://read.qxmd.com/read/30696919/study-of-the-whole-genome-methylome-and-transcriptome-of-cordyceps-militaris
#4
Yujiao Chen, Yuqian Wu, Li Liu, Jianhua Feng, Tiancheng Zhang, Sheng Qin, Xingyu Zhao, Chaoxia Wang, Dongmei Li, Wei Han, Minghui Shao, Ping Zhao, Jianfeng Xue, Xiaomin Liu, Hongjie Li, Enwei Zhao, Wen Zhao, Xijie Guo, Yongfeng Jin, Yaming Cao, Liwang Cui, Zeqi Zhou, Qingyou Xia, Zihe Rao, Yaozhou Zhang
The complete genome of Cordyceps militaris was sequenced using single-molecule real-time (SMRT) sequencing technology at a coverage over 300×. The genome size was 32.57 Mb, and 14 contigs ranging from 0.35 to 4.58 Mb with an N50 of 2.86 Mb were assembled, including 4 contigs with telomeric sequences on both ends and an additional 8 contigs with telomeric sequences on either the 5' or 3' end. A methylome database of the genome was constructed using SMRT and m4C and m6A methylated nucleotides, and many unknown modification types were identified...
January 29, 2019: Scientific Reports
https://read.qxmd.com/read/30689632/effects-of-hiit-and-mict-on-cardiovascular-risk-factors-in-adults-with-overweight-and-or-obesity-a-meta-analysis
#5
LiQiang Su, JinMei Fu, ShunLi Sun, GuangGao Zhao, Wei Cheng, ChuanChuan Dou, MingHui Quan
OBJECTIVE: The purpose of this study was to evaluate the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiovascular disease (CVD) risk factors in adults with overweight and obesity. METHODS: Twenty-two articles were included by searching six databases, the total number of subjects was 620 in these articles. Outcomes were synthesised using a random-effects meta-analysis of the Standardized mean difference (SMD) in CVD risk factors...
2019: PloS One
https://read.qxmd.com/read/30685033/enzyme-free-colorimetric-detection-of-microrna-21-using-metal-chelator-as-label-for-signal-generation-and-amplification
#6
Jiafang Piao, Qian Zhao, Dianming Zhou, Weipan Peng, Weichen Gao, Minghui Chen, Guiming Shu, Xiaoqun Gong, Jin Chang
MicroRNAs (miRNAs) were reported to be potential tumor markers for early diagnosis of cancer. Due to its short sequence, low expression level and high susceptibility to degradation, the stable and sensitive detection method of miRNAs is arduous to establish. In this work, we designed a metal chelator (ethylenediamine tetraacetic acid disodium salt, EDTA•2Na) labeled oligonucleotides as the plasmonic signal supraregulator probe to control the generation of gold nanoparticles (AuNPs). Based on another complementary oligonucleotides of target miRNA labeling SiO2 microparticles (SiO2 MPs) as the detecting platform, EDTA•2Na labeled oligonucleotide probes were immobilized on the SiO2 platform through the sandwich structure in the presence of target miRNA...
April 4, 2019: Analytica Chimica Acta
https://read.qxmd.com/read/30662567/an-innovative-unlocked-mechanism-by-a-double-key-avenue-for-one-pot-detection-of-microrna-21-and-microrna-141
#7
Weipan Peng, Qian Zhao, Minghui Chen, Jiafang Piao, Weichen Gao, Xiaoqun Gong, Jin Chang
The accurate and quantitative detection of microRNAs (miRNAs) as next-generation, reliable biomarkers will provide vital information for cancer research and treatment. However, their unique, intrinsic features pose quite a challenge for miRNA profiling, especially for multiplexed detection. Thus, there is a strong and an ever-growing need to develop an accurate, simple, sensitive and specific miRNA sensing method. Methods: In this study, a simple and novel sensor is presented that uses a flow cytometry (FCM) method based on the double key "unlocked mechanism" and a fluorescence enrichment signal amplification strategy...
2019: Theranostics
https://read.qxmd.com/read/30634597/genome-wide-characterization-and-identification-of-trihelix-transcription-factor-and-expression-profiling-in-response-to-abiotic-stresses-in-rice-oryza-sativa-l
#8
Jiaming Li, Minghui Zhang, Jian Sun, Xinrui Mao, Jing Wang, Jingguo Wang, Hualong Liu, Hongliang Zheng, Zhen Zhen, Hongwei Zhao, Detang Zou
Trihelix transcription factors play a role in plant growth, development and various stress responses. Here, we identified 41 trihelix family genes in the rice genome. These OsMSL s (Myb/SANT-LIKE) were located on twelve chromosomes. Synteny analysis indicated only six duplicated gene pairs in the rice trihelix family. Phylogenetic analysis of these OsMSL s and the trihelix genes from other species divided them into five clusters. OsMSL s from different groups significantly diverged in terms of gene structure and conserved functional domains...
January 10, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/30612423/vitamin-d-improves-the-outcome-of-in-vitro-fertilization-ivf-in-infertile-women-with-polycystic-ovary-syndrome-and-insulin-resistance
#9
Juan Zhao, Shan Liu, Yidan Wang, Peng Wang, Danni Qu, Minghui Liu, Wei Ma, Yuan Li
BACKGROUND: To investigate the effect of vitamin D supplementation upon the outcome of in vitro fertilization (IVF) in infertile women with polycystic ovarian syndrome (PCOS) and insulin resistance (IR). METHODS: Three hundred and five infertile patients with PCOS and insulin resistance undergoing IVF were included in this study. All participants underwent oral glucose tolerance test (OGTT). Insulin resistance was calculated by homeostasis model assessment. Vitamin D status was measured by assessing circulating levels of 25OH-VD in serum samples by radioimmunoassay...
January 4, 2019: Minerva Medica
https://read.qxmd.com/read/30601936/deepphos-prediction-of-protein-phosphorylation-sites-with-deep-learning
#10
Fenglin Luo, Minghui Wang, Yu Liu, Xing-Ming Zhao, Ao Li
Motivation: Phosphorylation is the most studied post-translational modification, which is crucial for multiple biological process. Recently, many efforts have been taken to develop computational predictors for phosphorylation site prediction, but most of them are based on feature selection and discriminative classification. Thus, it is useful to develop a novel and highly accurate predictor that can unveil intricate patterns automatically for protein phosphorylation sites. Results: In this study we present DeepPhos, a novel deep learning architecture for prediction of protein phosphorylation...
January 2, 2019: Bioinformatics
https://read.qxmd.com/read/30585268/src-3-protects-intestine-from-dss-induced-colitis-by-inhibiting-inflammation-and-promoting-goblet-cell-differentiation-through-enhancement-of-klf4-expression
#11
Wenbo Chen, Minghui Zhuo, Xuqiang Lu, Xiaochun Xia, Yang Zhao, Zhengrong Huang, Jianming Xu, Weihua Li, Chundong Yu
Goblet cell loss, which leads to the reduction of mucin secretion, is a hallmark of ulcerative colitis (UC). We previously reported that steroid receptor coactivator 3 (SRC-3), a transcriptional coactivator, contributes to host defense against Citrobacter rodentium by recruiting neutrophils, suggesting a role of SRC-3 in intestine homeostasis. However, the biological role of SRC-3 in UC remains unclear. Here, we showed that SRC-3-/- mice were more susceptible to dextran sulfate sodium (DSS)-induced colitis compared with wild-type mice after oral administration of 2% DSS dissolved in drinking water...
2018: International Journal of Biological Sciences
https://read.qxmd.com/read/30583098/an-analysis-of-the-expression-and-association-with-immune-cell-infiltration-of-the-cgas-sting-pathway-in-pan-cancer
#12
Xiang An, Yuanyuan Zhu, Tongsen Zheng, Guangyu Wang, Minghui Zhang, Jiade Li, Hongbo Ji, Shijun Li, Shucai Yang, Dandan Xu, Zhiwei Li, Tianzhen Wang, Yan He, Lei Zhang, Weiwei Yang, Ran Zhao, Dapeng Hao, Xiaobo Li
Recent evidence shows that cyclic GMP-AMP synthase (cGAS)/stimulator of interferon (IFN) genes (STING) signaling is essential for antitumor immunity by inducing the production of type I IFN and thus activating both innate and adaptive immunity based on gene knockout mouse models. However, the extensive detection of the expression of cGAS/STING signaling in human cancer and mining the roles of this signaling pathway in human cancer immunity have not been performed until now. In this study, we revealed that four key molecules (cGAS, STING, TANK binding kinase 1 [TBK1], and IFN regulatory factor 3 [IRF3]) in the cGAS/STING signaling are highly expressed in cancer tissues, and the expression levels of these genes are negatively correlated with their methylation levels in most of the detected cancer types...
November 20, 2018: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/30543300/a-biomimetic-nanodecoy-traps-zika-virus-to-prevent-viral-infection-and-fetal-microcephaly-development
#13
Lang Rao, Wenbiao Wang, Qian-Fang Meng, Mingfu Tian, Bo Cai, Yingchong Wang, Aixin Li, Minghui Zan, Feng Xiao, Lin-Lin Bu, Geng Li, Andrew Li, Yingle Liu, Shi-Shang Guo, Xingzhong Zhao, Tza-Huei Wang, Wei Liu, Jianguo Wu
Zika virus (ZIKV) has emerged as a global health threat due to its unexpected causal link to devastating neurological disorders such as fetal microcephaly. However, to date, no approved vaccine or specific treatment is available for ZIKV infection. Here, we develop a biomimetic nanodecoy (ND) that can trap ZIKV, divert ZIKV away from its intended targets, and inhibit ZIKV infection. The ND, which is composed of a gelatin nanoparticle core camouflaged by mosquito medium host cell membranes, effectively adsorbs ZIKV and inhibits ZIKV replication in ZIKV-susceptible cells...
December 13, 2018: Nano Letters
https://read.qxmd.com/read/30537707/blue-rubber-bleb-nevus-syndrome-a-possible-cause-for-growth-retardation-and-pubertal-delay
#14
Yi Pan, Lu Zhang, Minghui Duan, Hong Yang, Duoduo Zhao, Weifeng Li
OBJECTIVE: To describe a rare case of Blue Rubber Bleb Nevus (BRBNS) with growth retardation and pubertal delay. CLINICAL PRESENTATION AND INTERVENTION: A 16-year-old boy with severe iron deficiency anemia was diagnosed with BRBNS, showing growth retardation and pubertal delay simultaneously. The patient was treated conservatively with intravenous iron therapy and his puberty advanced gradually. CONCLUSION: Given that growth retardation and pubertal delay are rare in BRBNS patients, this case reminds us to include BRBNS in the differential diagnosis of growth retardation...
December 10, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://read.qxmd.com/read/30533007/prempdi-estimates-and-interprets-the-effects-of-missense-mutations-on-protein-dna-interactions
#15
Ning Zhang, Yuting Chen, Feiyang Zhao, Qing Yang, Franco L Simonetti, Minghui Li
Protein-DNA interactions play important roles in regulations of many vital cellular processes, including transcription, translation, DNA replication and recombination. Sequence variants occurring in these DNA binding proteins that alter protein-DNA interactions may cause significant perturbations or complete abolishment of function, potentially leading to diseases. Developing a mechanistic understanding of impacts of variants on protein-DNA interactions becomes a persistent need. To address this need we introduce a new computational method PremPDI that predicts the effect of single missense mutation in the protein on the protein-DNA interaction and calculates the quantitative binding affinity change...
December 11, 2018: PLoS Computational Biology
https://read.qxmd.com/read/30524417/a-surface-protein-from-lactobacillus-plantarum-increases-the-adhesion-of-lactobacillus-strains-to-human-epithelial-cells
#16
Guangqiang Wang, Minghui Zhang, Jianxin Zhao, Yongjun Xia, Phoency F-H Lai, Lianzhong Ai
Adhesion to epithelial cells is considered important for Lactobacillus to exert probiotic effects. In this study, we found that trypsin treatment decreased the adhesion ability of Lactobacillus plantarum AR326 and AR269, which exhibit good adhesion ability, and surface proteins extracts increased the adhesion of the strains with poor adhesion ability. By SDS-polyacrylamide gel electrophoresis and mass spectrometry analysis, the main component of the surface proteins was detected and identified as a protein of approximately 37 kDa...
2018: Frontiers in Microbiology
https://read.qxmd.com/read/30488367/combined-immunosuppressive-treatment-cist-in-lupus-nephritis-a-multicenter-randomized-controlled-study
#17
Yuan An, Yunshan Zhou, Liqi Bi, Bo Liu, Hong Wang, Jin Lin, Danyi Xu, Mei Wang, Jing Zhang, Yongfu Wang, Yan An, Ping Zhu, Ronghua Xie, Zhiyi Zhang, Yifang Mei, Xiangyuan Liu, Xiaoli Deng, Zhongqiang Yao, Zhuoli Zhang, Yu Wang, Weiguo Xiao, Hui Shen, Xiuyan Yang, Hanshi Xu, Feng Yu, Guochun Wang, Xin Lu, Yang Li, Yingnan Li, Xiaoxia Zuo, Yisha Li, Yi Liu, Yi Zhao, Jianping Guo, Lingyun Sun, Minghui Zhao, Zhanguo Li
OBJECTIVES: The standard strategy for treating lupus nephritis comprises glucocorticoids together with either intravenous cyclophosphamide or oral mycophenolate mofetil, but the low remission rate is still a challenge in practice. This study was aimed to seek higher remission rate of lupus nephritis using a combined strategy. METHOD: A 24-week trial was conducted in 17 rheumatology or nephrology centers in China. A total of 191 lupus nephritis patients were randomized to follow a combined immunosuppressive treatment (CIST) with intravenous cyclophosphamide, an oral immunosuppressive agent, namely mycophenolate mofetil, azathioprine or leflunomide, and hydroxychloroquine (n = 95), or receive intravenous cyclophosphamide alone (n = 96) for 24 weeks...
November 28, 2018: Clinical Rheumatology
https://read.qxmd.com/read/30486834/crosstalk-in-competing-endogenous-rna-networks-reveals-new-circular-rnas-involved-in-the-pathogenesis-of-early-hiv-infection
#18
Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang, Xiaoxu Han
BACKGROUND: The events in early HIV infection (EHI) are important determinants of disease severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not been fully understood. Circular RNAs (circRNAs) have been verified as "microRNA sponges" that regulate gene expression through competing endogenous RNA (ceRNA) networks, but circRNA expression profiles and their contribution to EHI pathogenesis are still unclear. METHODS: Two different libraries were constructed with RNA from human peripheral blood mononuclear cells from 3 HARRT-naive EHI patients and 3 healthy controls (HCs)...
November 29, 2018: Journal of Translational Medicine
https://read.qxmd.com/read/30482493/clinical-features-and-long-term-outcomes-of-diabetic-kidney-disease-a-prospective-cohort-study-from-china
#19
Bixia Gao, Shouling Wu, Jinwei Wang, Chao Yang, Shuohua Chen, Jinhong Hou, Junjuan Li, Yaozheng Yang, Kevin He, Minghui Zhao, Min Chen, Luxia Zhang
BACKGROUND: Information regarding the clinical phenotypes of diabetic kidney disease (DKD) might guide better practice for clinicians. We aim to compare the clinical features and long-term outcomes of proteinuric and non-proteinuric phenotypes of DKD, based on a prospective cohort of Chinese population. METHODS: Altogether 8811 Chinese participants with diabetes were included. Kidney function decline was defined as estimated glomerular filtration rate <60 mL/min·1...
January 2019: Journal of Diabetes and its Complications
https://read.qxmd.com/read/30479159/effects-of-cognitive-behavioral-therapy-on-people-living-with-hiv-and-depression-a-systematic-review-and-meta-analysis
#20
Ying Shi, Minghui Zhao, Si Chen, Shouqi Wang, Huanhuan Li, Jie Ying, Meiling Zhang, Yuan Li, Zhuangjie Xing, Jiao Sun
The aim of this review is to examine the efficacy of cognitive behavioral therapy (CBT) on people living with HIV (PLWH) and depression. A literature search from five electronic databases was conducted, and articles published until July 2017 were collected. The inclusion criteria included randomized controlled trials (RCTs) of CBT that were conducted among PLWH with clinically relevant depression. Comprehensive Meta-Analysis 2 was used to obtain pooled results. Seven RCTs, with a total sample size of 388 participants, met the inclusion criteria...
November 27, 2018: Psychology, Health & Medicine
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