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Metastatic ewing's sarcoma

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https://read.qxmd.com/read/30724024/bone-marrow-biopsy-in-the-initial-staging-of-ewing-sarcoma-experience-from-a-single-institution
#1
Marilena Cesari, Alberto Righi, Marco Colangeli, Marco Gambarotti, Paolo Spinnato, Andrea Ferraro, Alessandra Longhi, Massimo Eraldo Abate, Emanuela Palmerini, Anna Paioli, Cristina Ferrari, Davide Maria Donati, Piero Picci, Stefano Ferrari
BACKGROUND: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. PROCEDURE: A monoinstitutional retrospective analysis reviewed clinical charts, imaging, and histology of patients with diagnosis of ES treated at the Rizzoli Institute between 1998 and 2017. RESULTS: The cohort included 504 cases of ES of bone; 137 (27%) had metastases at diagnosis, while the remaining 367 had localized disease...
February 5, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30680447/osteoma-like-melorheostosis-a-rare-type-of-skeletal-dysplasia-depicted-on-fdg-pet-ct
#2
Alain S Abi-Ghanem, Karl Asmar, Fouad Boulos, Samar Muwakkit
Melorheostosis, also known as Leri's disease, is a rare benign form of mesodermal mixed sclerosing bone dysplasia. We report the unusual case of a 14-year-old boy with melorheostosis in the lower extremity that went undiagnosed due to concurrent Ewing sarcoma in the opposite limb, confounding the findings for metastatic disease. The diagnosis was made on FDG PET/CT when the patient presented for post Ewing sarcoma treatment follow-up. The different types of melorheostosis as well as the challenge of diagnosing this rare entity are discussed in this report...
January 25, 2019: Skeletal Radiology
https://read.qxmd.com/read/30651917/isolated-delayed-metastasis-to-the-talus-from-ewing-s-sarcoma
#3
Layla Nasr, Lena Naffaa, Alaeddine El Alayli, Miguel R Abboud, Nabil J Khoury
Bone metastasis to the hands and feet, known as acrometastasis, is a very rare finding and tends to be associated with extensive metastasis. We herein report the case of a 14-year-old girl known to have a history of successfully treated Ewing's sarcoma arising from the ribs, who presented with a pathologically proven isolated metastatic lesion to the talus 7 years after achieving clinical and radiologic remission. We describe the imaging findings on MRI, CT scan and PET-CT. To our knowledge, talar metastasis from Ewing's sarcoma has been previously reported only twice in the English literature...
August 2018: Journal of Radiology Case Reports
https://read.qxmd.com/read/30597012/enhancing-the-safety-of-ovarian-cortex-autotransplantation-cancer-cells-are-purged-completely-from-human-ovarian-tissue-fragments-by-pharmacological-inhibition-of-yap-taz-oncoproteins
#4
Callista L Mulder, Lotte L Eijkenboom, Catharina C M Beerendonk, Didi D M Braat, Ronald Peek
STUDY QUESTION: Is it possible to eliminate metastasized cancer cells from ovarian cortex fragments prior to autotransplantation without compromising the ovarian tissue or follicles? SUMMARY ANSWER: Ex vivo pharmacological inhibition of YAP/TAZ by Verteporfin enabled us to efficiently eradicate experimentally induced small tumours, derived from leukaemia and rhabdomyosarcoma, from human ovarian tissue fragments. WHAT IS KNOWN ALREADY: Autotransplantation of ovarian tissue fragments that contain metastasized tumour cells may reintroduce the malignancy to the recipient...
December 28, 2018: Human Reproduction
https://read.qxmd.com/read/30588089/the-efficacy-and-safety-of-apatinib-in-ewing-s-sarcoma-a-retrospective-analysis-in-one-institution
#5
Yitian Wang, Li Min, Yong Zhou, Yi Luo, Hong Duan, Chongqi Tu
Background: Ewing's sarcoma (ES) is a highly aggressive and metastatic neoplasm occurring mainly in children and young adults. The standard treatment of localized ES requires a combination of surgery, chemotherapy, and radiotherapy. Although the 5-year survival rate for local ES has improved, the survival rate and prognosis are still very poor for metastatic or recurrent ES patients. The aim of this study was to investigate the efficacy and safety of apatinib, a specific vascular endothelial growth factor receptor 2 inhibitor, in ES patients...
2018: Cancer Management and Research
https://read.qxmd.com/read/30578902/kdm3a-is-associated-with-tumor-metastasis-and-modulates-colorectal-cancer-cell-migration-and-invasion
#6
Jiaming Liu, Tiansong Liang, Weiguo Zhangsun
Lysine demethylase 3A (KDM3A) is been suggested to accelerate tumor cell migration and invasion in breast cancer, cervical cancer, Ewing sarcoma and neuroblastoma. The role of KDM3A in colorectal cancer progression and metastasis remains unknown. The aim of this study is to explore the clinical significance and biological function of KDM3A in colorectal cancer. In our results, we found KDM3A expression was significantly increased in colorectal cancer metastatic lesions compared with primary lesions, but had no statistical difference between colorectal cancer tissues and normal colorectal tissues...
December 19, 2018: International Journal of Biological Macromolecules
https://read.qxmd.com/read/30570842/is-there-a-role-of-high-dose-chemotherapy-and-autologous-stem-cell-transplantation-in-the-treatment-of-ewing-s-sarcoma-and-osteosarcomas
#7
Nuri Karadurmus, Ugur Sahin, Bilgin Bahadir Basgoz, Taner Demirer
Although osteosarcomas are rare tumors, they are the most common primary bone tumors in children and adolescents younger than 20 years with a remarkable male predominance. Ewing's sarcoma (ES) is the second most common primary bone tumor in children and adolescents. The preferred actual treatment modality for osteosarcoma patients is neoadjuvant chemotherapy followed by complete surgical excision and adjuvant chemotherapy including agents such as doxorubicin, cisplatin, ifosfamide, and high-dose methotrexate which are widely used and accepted as being efficacious treatment strategies in osteosarcoma patients...
September 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://read.qxmd.com/read/30570510/improved-outcome-in-local-ewing-sarcoma-with-an-intensified-pilot-treatment-protocol-scmcie-94
#8
Shifra Ash, Isaac Yaniv, Helen Toledano, Jerry Stein, Yehuda Kollender, Eyal Fenig, Osnat Konen, Zvi Bar-Sever, Josephine Issakov, Smadar Avigad, Ian J Cohen
This study evaluated the effect of an intensified pilot protocol, SCMCIE 94, on the outcome of Ewing sarcoma (EWS). The cohort included 121 patients with local or metastatic EWS treated at a tertiary pediatric medical center with the SCMCIE 94 (protocol 3, 1994 to 2011) or an earlier protocol (protocol 2, 1988 to 1994; protocol 1, 1985 to 1988). All protocols included 4 to 6 courses of chemotherapy, radiation, and surgery. Clinical data were collected retrospectively by chart review. Survival rates for protocol 3 were as follows: all patients-5-year event-free survival (EFS): 52...
December 18, 2018: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/30567503/atypical-localization-of-intraosseous-angioleiomyoma-in-the-rib-of-a-pediatric-patient-a-case-report
#9
Goran Djuričić, Zorica Milošević, Tijana Radović, Nataša Milčanović, Predrag Djukić, Marko Radulovic, Jelena Sopta
BACKGROUND: This is the first reported case of a primary intraosseous angioleiomyoma and the second case of a primary leiomyoma of the rib, irrespective of age. Angioleiomyomas mostly occur in patients of advanced age, in any part of the body, particularly the lower extremities and present as painful, slow-growing nodules in the dermis, subcutaneous fat or deep fascia. Other localizations, especially bone, are considered extremely rare, as well as their occurrence in paediatric patients...
December 19, 2018: BMC Medical Imaging
https://read.qxmd.com/read/30553605/colonic-ewing-sarcoma-pnet-associated-with-liver-metastases-a-systematic-review-and-case-report
#10
Pietro Parcesepe, Guido Giordano, Caterina Zanella, Jacopo Giuliani, Filippo Greco, Andrea Bonetti, Massimo Pancione, Erminia Manfrin, Enrico Molinari, Tiziana Pia Latiano, Mario Rosario D'Andrea, Matteo Fassan, Nunzio Olivieri, Andrea Remo
Ewing Sarcoma is a highly lethal undifferentiated tumor of bone. ES is a small round cell tumor with etiological and characteristic chromosomal translocations between TET/FET (TLS/FUS, EWSR1, and TAF15) and ETS (E26 transformation-specific) family genes. Generally, therapeutic approach for metastatic Ewing Sarcoma includes both local (surgery and radiotherapy) and systemic (chemotherapy) disease control with an overall cure rate of 20%. For extra-osseous tumors, the most common primary sites of disease are trunk, extremities, head and neck, retroperitoneum...
November 29, 2018: Pathology, Research and Practice
https://read.qxmd.com/read/30540865/-survival-of-pediatric-patients-with-ewing-sarcoma-treated-at-semmelweis-university
#11
Zsófia Geiszl, János Kiss, Miklós Szendrõi, Júlia Vízkeleti, Gabriella Arató, Zoltán Sápi, Gergely Kriván, Anna Mohás, Imre Rényi, Miklós Garami, Péter Hauser
The survival of children treated with Ewing sarcoma at Semmelweis University were investigated. Pediatric patients with Ewing sarcoma treated at Semmelweis University from 2001 through 2013 were analyzed in terms of overall survival and clinical factors (age, primary localization and extent of the tumor, time interval from primary complaints to diagnosis). For statistical analysis Kaplan-Meier estimated survival and log rank test were applied. Mean age and follow-up time of the 78 patients were 11.16 and 6...
December 12, 2018: Magyar Onkologia
https://read.qxmd.com/read/30538569/comparison-of-clinical-features-and-outcomes-in-patients-with-extraskeletal-vs-skeletal-ewing-sarcoma-an-seer-database-analysis-of-3-178-cases
#12
Sujing Jiang, Guannan Wang, Jieyu Chen, Ying Dong
Background: The clinicopathological characteristics, outcomes and prognostic factors of primary extraskeletal Ewing sarcoma (EES) remained insufficiently explored. We aimed to examine these aspects and compared the same with skeletal Ewing sarcoma (SES). Patients and methods: We identified Ewing sarcoma, peripheral primitive neuroectodermal tumors or Askin tumor patients who were registered in the Surveillance, Epidemiology, and End Results database from 1973 to 2014...
2018: Cancer Management and Research
https://read.qxmd.com/read/30477937/efficacy-and-safety-of-regorafenib-in-adult-patients-with-metastatic-osteosarcoma-a-non-comparative-randomised-double-blind-placebo-controlled-phase-2-study
#13
Florence Duffaud, Olivier Mir, Pascaline Boudou-Rouquette, Sophie Piperno-Neumann, Nicolas Penel, Emanuelle Bompas, Corinne Delcambre, Elsa Kalbacher, Antoine Italiano, Olivier Collard, Christine Chevreau, Esma Saada, Nicolas Isambert, Jessy Delaye, Camille Schiffler, Corinne Bouvier, Vincent Vidal, Sylvie Chabaud, Jean-Yves Blay
BACKGROUND: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. In this Article, we report the results of the osteosarcoma cohort. METHODS: In this non-comparative, double-blind, placebo-controlled, phase 2 trial, patients aged 10 years or older with histologically confirmed osteosarcoma whose disease had progressed after treatment with one to two previous lines of chemotherapy for metastatic disease and an Eastern Cooperative Oncology Group performance status of 0 or 1 were enrolled...
November 23, 2018: Lancet Oncology
https://read.qxmd.com/read/30470587/mir-708-5p-is-inversely-associated-with-ews-fli1-ewing-sarcoma-but-does-not-represent-a-prognostic-predictor
#14
Gabriela Molinari Roberto, Gabriela Maciel Vieira, Lara Elis Alberici Delsin, Marcela de Oliveira Silva, Rodrigo Guedes Hakime, Edgard Eduard Engel, Carlos Alberto Scrideli, Luiz Gonzaga Tone, María Sol Brassesco
BACKGROUND: Overall survival of Ewing sarcoma (EWS) remains poor and less than 30% of patients with metastatic or recurrent disease survive despite current treatments. Thus, there is a constant search for new biomarkers for diagnosis, prognosis and prediction of therapy. Numerous studies have reported the abnormal expression of miR-708-5p in tumors of different origins. However, its role in EWS remains unclear. PROCEDURE: qRT-PCR was performed in nineteen consecutive EWS samples and twelve non-tumor bone samples from age-matched controls...
November 13, 2018: Cancer Genetics
https://read.qxmd.com/read/30449071/ewing-s-sarcoma-of-the-head-and-neck-margins-are-not-just-for-surgeons
#15
Jebrane Bouaoud, Stephane Temam, Nathalie Cozic, Louise Galmiche-Rolland, Kahina Belhous, Frederic Kolb, Francois Bidault, Stephanie Bolle, Sarah Dumont, Valerie Laurence, Dominique Plantaz, Marie-Dominique Tabone, Perrine Marec-Berard, Quentin Quassemyar, Vincent Couloigner, Arnaud Picard, Anne Gomez-Brouchet, Marie-Cécile Le Deley, Céline Mahier-Ait Oukhatar, Natacha Kadlub, Nathalie Gaspar
BACKGROUND, METHODS: To describe the characteristics, treatments (systemic/local), and outcome (oncological/functional) of French patients with head and neck Ewing's sarcomas (HNES) registered in the Euro-Ewing 99 (EE99) database. Specific patient-level data were reviewed retrospective. RESULTS: Forty-seven HNES patients in the EE99 database had a median age of 11 years, 89% had bone tumors (skull 55%, mandible 21%, maxilla 11%), 89% had small tumors (<200 mL), and they were rarely metastatic (9%)...
November 17, 2018: Cancer Medicine
https://read.qxmd.com/read/30412903/risk-factors-for-detectable-metastatic-disease-at-presentation-in-ewing-sarcoma-an-analysis-of-the-seer-registry
#16
Dipak B Ramkumar, Niveditta Ramkumar, Benjamin J Miller, Eric R Henderson
BACKGROUND: Ewing family of tumors (EFT) represents the second-most common primary bone malignancy in children and adolescents. Approximately 25% of patients have radiographically detectable metastatic disease at presentation and experience poorer five-year survival, yet risk factors for metastatic disease at presentation are poorly characterized. We sought to study patient characteristics associated with metastatic disease upon presentation for patients with EFT. METHODS: We identified EFT cases in the Surveillance, Epidemiology, and End Results Program (SEER) registry from 2004 to 2012...
December 2018: Cancer Epidemiology
https://read.qxmd.com/read/30365478/spinal-ewing-sarcoma-metastatic-to-bilateral-orbits
#17
Lawrence Chan, Marez Megalla, Jenna M Kim, Renelle Pointdujour-Lim
A 39-year-old woman with primary spinal Ewing sarcoma and known lung metastases presented with painless bilateral decreased visual acuity over a 1-month period. Examination revealed bilateral disc edema. MRI of the brain/orbits showed metastatic lesions to the dura and bilateral orbits. Venous sinus thrombosis extending to the jugular vein was also noted. To the authors' knowledge, this is the first case of bilateral orbital metastasis and papilledema secondary to Ewing sarcoma and related hypercoagulability...
October 24, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30339522/clinical-and-radiographic-presentation-of-pelvic-sarcoma-in-children
#18
Muayad Kadhim, Nariman Abol Oyoun, Richard B Womer, John P Dormans
INTRODUCTION: Pelvic sarcomas may present with vague symptoms. The aim of this study was to examine the characteristics and clinical presentations of different types of pelvic sarcoma in children. METHODS: This is a retrospective cohort study of patients up to 21 years of age with the diagnosis of pelvic sarcoma between January 2000 and June 2013. Data on demographics, tumor type and location, and clinical presentation were collected from the medical records. RESULTS: A total of 59 patients [37 males (62...
2018: SICOT-J
https://read.qxmd.com/read/30275176/spinal-ewing-sarcoma-debuting-with-cord-compression-have-we-discovered-the-thread-of-ariadne
#19
REVIEW
Stergios Boussios, Catherine Hayward, Deirdre Cooke, Nikolaos Zakynthinakis-Kyriakou, Alexandros K Tsiouris, Aikaterini A Chatziantoniou, Foivos S Kanellos, Afroditi Karathanasi
Ewing's sarcoma (ES) of the spine with cord or radicular compression as an initial sign is infrequent. It is unclear, in alleviating a neurological deficit, whether decompressive laminectomy is preferred over chemotherapy. Herein, a literature review of the treatment approaches to the primary or metastatic ES of the spine has been performed. Collected data included clinical features of the patients, treatment, and outcome. There are reported 69 cases with initial presentation of cord or radicular compression of spinal cord, arising from primary or metastatic ES, treated either with initial chemotherapy and/or radiotherapy (RT) (33...
October 2018: Anticancer Research
https://read.qxmd.com/read/30173130/oesophageal-narrowing-during-combination-chemotherapy-in-ewing-s-sarcoma-is-vincristine-a-culprit
#20
Kunal Das, Santosh Singh, BrahmaPrakash Kalra, Nitika Agrawal
Vincristine is a widely used chemotherapeutic agent in paediatric oncology. A 7-year-old boy was diagnosed with non-metastatic Ewing's sarcoma of the pelvis. He was started on chemotherapy with vincristine-cyclophosphamide-adriamycin alternate with ifosfamide-etoposide. He developed recurrent vomiting after three cycles of chemotherapy. Evaluation showed oesophageal stricture involving the middle and lower third part. Biopsy was non-conclusive. His symptoms improved with dilatation. A chemotherapy-induced neuropathic dysmotility was suspected, and his chemotherapy was continued with serial dilatation...
September 1, 2018: BMJ Case Reports
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