keyword
https://read.qxmd.com/read/38493591/immune-cells-at-the-feto-maternal-interface-comprehensive-characterization-and-insights-into-term-labor
#21
JOURNAL ARTICLE
Angela Mosebarger, Manuel S Vidal, Giovana Fernanda Cosi Bento, Ryan C V Lintao, Mary Elise L Severino, Ananth Kumar Kammala, Ramkumar Menon
Immune cells at the feto-maternal interface play an important role in pregnancy; starting at implantation, maintenance of pregnancy, and parturition. The role of decidual immune cells in induction of labor still needs to be understood. Published reports on this topic show heterogeneity in methods of cell isolation, assay, analysis and cellular characterization making it difficult to collate available information in order to understand the contribution of immune cells at term leading to parturition. In the present study, available literature was reviewed to study the differences in immune cells between the decidua basalis and decidua parietalis, as well as between immune cells in term and preterm labor...
March 16, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38492272/experiences-of-implementing-and-working-with-obstetric-emergency-triage-a-qualitative-study-among-swedish-midwifes-auxiliary-nurses-and-obstetricians
#22
JOURNAL ARTICLE
Linnéa Lindroos, Verena Sengpiel, Helen Elden
INTRODUCTION: Obstetric emergency triage is a relatively new form of emergency triage and is not yet implemented in Sweden. Adaptations enables safe assessment of the childbearing woman, fetus and labor status. Failure to identify severely ill childbearing women and women post childbirth has repeatedly led to adverse outcomes. Introducing obstetric emergency triage constitutes a profound alteration in management that may challenge preconceived notions on how to provide best care. This study aimed at exploring and describing obstetric staff's experiences of working with obstetric emergency triage...
March 11, 2024: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://read.qxmd.com/read/38485520/efficacy-and-safety-of-oral-and-vaginal-administration-of-misoprostol-for-induction-of-labor-in-high-risk-obese-pregnant-women-with-hypertension-or-diabetes-mellitus
#23
JOURNAL ARTICLE
Shi Tian, Li Wang, Yi-Wei Han, Yan-Nan Liu, Feng-Qiu Li, Xiao-Hua Jin
OBJECTIVE: This study aims to compare the safety and efficacy of misoprostol administered orally and vaginally in obese pregnant women at term with either gestational hypertension or diabetes. METHODS: A total of 264 pregnant women were enrolled and categorized into two groups based on their primary condition: hypertension (134 cases) or diabetes mellitus (130 cases) and were further divided into subgroups for misoprostol administration: orally (Oral group) or vaginally (Vaginal group)...
December 2024: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/38485434/indole-3-acetic-acid-promotes-growth-in-bloom-forming-microcystis-via-an-antioxidant-response
#24
JOURNAL ARTICLE
Hunter R Baylous, Matthew F Gladfelter, Malia I Gardner, Madalynn Foley, Alan E Wilson, Morgan M Steffen
Interactions between bacteria and phytoplankton in the phycosphere facilitate and constrain biogeochemical cycling in aquatic ecosystems. Indole-3-acetic acid (IAA) is a bacterially produced chemical signal that promotes growth of phytoplankton and plants. Here, we explored the impact of IAA on bloom-forming cyanobacteria and their associated bacteria. Exposure to IAA and its precursor, tryptophan, resulted in a strong growth response in a bloom of the freshwater cyanobacterium, Microcystis. Metatranscriptome analysis revealed the induction of an antioxidant response in Microcystis upon exposure to IAA, potentially allowing populations to increase photosynthetic rate and overcome internally generated reactive oxygen...
March 2024: Harmful Algae
https://read.qxmd.com/read/38482325/effect-of-vaginal-douching-with-normal-saline-before-insertion-of-dinoprostone-vaginal-insert-for-labor-induction
#25
JOURNAL ARTICLE
Manju Lata Verma, Manjari Pandey, Uma Singh, Rekha Sachan, Pushp Lata Sankhwar
OBJECTIVE: Vaginal pH has been suggested to be one of the causative factors, responsible for variation in prostaglandin efficacy for induction of labour. The purpose of this study was to analyse the effect of vaginal douching with normal saline before insertion of dinoprostone vaginal insert for induction of labour. METHODS: This randomised controlled study was done in the Department of Obstetrics and Gynaecology for a period of 1 year. Using a computer-generated random number table, subjects were allocated in two groups...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38477629/respiratory-morbidity-among-offspring-misclassified-as-growth-restricted
#26
JOURNAL ARTICLE
Omri Zamstein, Tamar Wainstock, Eyal Sheiner
OBJECTIVE: An ultrasound-based diagnosis implies that some fetuses suspected to be growth-restricted (FGR) are discovered at birth to be appropriately grown (appropriate for gestational age [AGA] birth weight, between the 10th and 90th percentile). These fetuses may thus be exposed to unnecessary medical interventions, including early labor induction. In this study, we have evaluated the long-term respiratory health of offspring misclassified as FGR. STUDY DESIGN: A population-based cohort analysis was conducted, including deliveries of AGA singletons between 1991 and 2021 at a tertiary referral hospital...
March 13, 2024: Pediatric Pulmonology
https://read.qxmd.com/read/38477600/time-matters-cervical-ripening-balloon-for-6-versus-12%C3%A2-h-retrospective-comparison-between-two-protocols
#27
JOURNAL ARTICLE
Inna Bleicher, Michal Korobochka, Shlomi Sagi, Rami Sammour
OBJECTIVE: Recently, two randomized controlled trials compared removal of cervical ripening balloon (CRB) after 6 versus 12 h. Their results showed similar Bishop score changes in both groups and a shorter time to delivery in the 6-h group. Neither of the studies was powered to show difference in mode of delivery. The aim of this study was to compare mode of delivery when the CRB was removed after 6 versus 12 h. METHODS: A historical control study comparing induction of labor with a CRB between two time periods, one in which the CRB was removed after 12 h (12-h group), and the other in which it was removed after 6 h (6-h group)...
March 13, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38477187/timing-of-induction-of-labor-in-suspected-macrosomia-retrospective-cohort-study-systematic-review-and-meta-analysis
#28
REVIEW
D A Badr, A Carlin, C Kadji, X Kang, M M Cannie, J C Jani
OBJECTIVE: Large-for-gestational-age (LGA) is associated with several adverse maternal and neonatal outcomes. Although many studies have found that early induction of labor (eIOL) in LGA reduces the incidence of shoulder dystocia (SD), no current guidelines recommend this particular strategy, due to concerns about increased rates of cesarean delivery (CD) and neonatal complications. The purpose of this study was to assess whether the timing of IOL in LGA fetuses affects maternal and neonatal outcomes in a single center; and to combine these results with the evidence reported in the literature...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38475003/pctc-net-a-crack-segmentation-network-with-parallel-dual-encoder-network-fusing-pre-conv-based-transformers-and-convolutional-neural-networks
#29
JOURNAL ARTICLE
Ji-Hwan Moon, Gyuho Choi, Yu-Hwan Kim, Won-Yeol Kim
Cracks are common defects that occur on the surfaces of objects and structures. Crack detection is a critical maintenance task that traditionally requires manual labor. Large-scale manual inspections are expensive. Research has been conducted to replace expensive human labor with cheaper computing resources. Recently, crack segmentation based on convolutional neural networks (CNNs) and transformers has been actively investigated for local and global information. However, the transformer is data-intensive owing to its weak inductive bias...
February 24, 2024: Sensors
https://read.qxmd.com/read/38472584/sex-specific-element-accumulation-in-honey-bees-apis-mellifera
#30
JOURNAL ARTICLE
Nenad M Zarić, Robert Brodschneider, Walter Goessler
Honey bees are social insects that show division of labor and sexual dimorphism. Female honey bees differentiate in two different castes, queens or worker bees, while males are called drones. Worker bees have different tasks in the hive including collection of food, its processing, caring for brood, protecting the hive, or producing wax. The drones' only role is to mate with a virgin queen. Many studies have dealt with differences in physiology, behavior, and morphology of workers and drones. This is the first study that demonstrates differences in element accumulation and composition between workers and drones honey bees...
March 13, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38468190/the-effects-of-intravenous-hydration-regimens-in-nulliparous-women-undergoing-induction-of-labor-a-systematic-review-and-meta-analysis
#31
REVIEW
Lauren Kearney, Susannah Brady, Nicole Marsh, Miranda Davies-Tuck, Rachael Nugent, Victoria Eley
INTRODUCTION: Labor is both a physiological and physical activity that requires energy expenditure by the woman. Despite this, women are often fasted in labor, with hydration requirements addressed predominantly by intravenous therapy. Little is known about how best to manage this in nulliparous women undergoing induction of labor, who can be prone to lengthy labors. Therefore, we undertook a systematic review and meta-analysis to determine the effects of intravenous hydration regimens on nulliparous women undergoing induction of labor...
March 11, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38465162/a-case-report-of-spontaneous-vaginal-delivery-under-general-anesthesia-in-a-patient-with-a-large-cerebral-aneurysm
#32
Gregory W Kirschen, Lucy Brown, Joy Davis, Dan Kim, David J Berman, Timour Al-Khindi, Justin Caplan, Shannon M Osborne
Cerebral aneurysms are rarely encountered in pregnancy. Their antepartum and intrapartum management remain clinically challenging, primarily due to concern regarding potential rupture. We present a case of a patient in preterm labor at risk for imminent delivery with a 10mm cerebral aneurysm. She was recommended for cesarean section (CS), yet delivered via spontaneous vaginal delivery in the operating room after induction of general anesthesia for the intended CS. Her aneurysm and neurologic function remained intact postpartum...
February 2024: Curēus
https://read.qxmd.com/read/38464102/deep-learning-model-using-continuous-skin-temperature-data-predicts-labor-onset
#33
Chinmai Basavaraj, Azure D Grant, Shravan G Aras, Elise N Erickson
BACKGROUND: Changes in body temperature anticipate labor onset in numerous mammals, yet this concept has not been explored in humans. METHODS: We evaluated patterns in continuous skin temperature data in 91 pregnant women using a wearable smart ring. Additionally, we collected daily steroid hormone samples leading up to labor in a subset of 28 pregnancies and analyzed relationships among hormones and body temperature trajectory. Finally, we developed a novel autoencoder long-short-term-memory (AE-LSTM) deep learning model to provide a daily estimation of days until labor onset...
February 27, 2024: medRxiv
https://read.qxmd.com/read/38462259/soft-tissue-dystocia-due-to-paradoxical-contraction-of-the-levator-ani-as-a-cause-of-prolonged-second-stage-concept-diagnosis-and-potential-treatment
#34
REVIEW
Aly Youssef, Elena Brunelli, Marta Fiorentini, Gianluigi Pilu, Federico Spelzini
Smaller pelvic floor dimensions seem to have been an evolutionary need to provide adequate support for the pelvic organs and the fetal head. Pelvic floor dimension and shape contributed to the complexity of human birth. Maternal pushing associated with pelvic floor muscle relaxation is key to vaginal birth. Using transperineal ultrasound, pelvic floor dimensions can be objectively measured in both static and dynamic conditions, such as pelvic floor muscle contraction and pushing. Several studies have evaluated the role of the pelvic floor in labor outcomes...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462257/trial-of-labor-after-cesarean-vaginal-birth-after-cesarean-and-the-risk-of-uterine-rupture-an-expert-review
#35
REVIEW
Uma Deshmukh, Annalies E Denoble, Moeun Son
The decision to pursue a trial of labor after cesarean delivery is complex and depends on patient preference, the likelihood of successful vaginal birth after cesarean delivery, assessment of the risks vs benefits of trial of labor after cesarean delivery, and available resources to support safe trial of labor after cesarean delivery at the planned birthing center. The most feared complication of trial of labor after cesarean delivery is uterine rupture, which can have catastrophic consequences, including substantial maternal and perinatal morbidity and mortality...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462256/tafoxiparin-a-novel-drug-candidate-for-cervical-ripening-and-labor-augmentation-results-from-2-randomized-placebo-controlled-studies
#36
REVIEW
Gunvor Ekman-Ordeberg, Margareta Hellgren-Wångdahl, Annika Jeppson, Leena Rahkonen, Marie Blomberg, Karin Pettersson, Carina Bejlum, Malin Engberg, Mette Ludvigsen, Jukka Uotila, Kati Tihtonen, Gunilla Hallberg, Maria Jonsson
BACKGROUND: Slow progression of labor is a common obstetrical problem with multiple associated complications. Tafoxiparin is a depolymerized form of heparin with a molecular structure that eliminates the anticoagulant effects of heparin. We report on 2 phase II clinical studies of tafoxiparin in primiparas. Study 1 was an exploratory, first-in-pregnant-women study and study 2 was a dose-finding study. OBJECTIVE: Study 1 was performed to explore the effects on labor time of subcutaneous administration of tafoxiparin before onset of labor...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462255/the-physiology-and-pharmacology-of-oxytocin-in-labor-and-in-the-peripartum-period
#37
REVIEW
Kerstin Uvnäs-Moberg
Oxytocin is a reproductive hormone implicated in the process of parturition and widely used during labor. Oxytocin is produced within the supraoptic nucleus and paraventricular nucleus of the hypothalamus and released from the posterior pituitary lobe into the circulation. Oxytocin is released in pulses with increasing frequency and amplitude in the first and second stages of labor, with a few pulses released in the third stage of labor. During labor, the fetus exerts pressure on the cervix of the uterus, which activates a feedforward reflex-the Ferguson reflex-which releases oxytocin...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462254/outpatient-cervical-ripening-and-labor-induction-with-low-dose-vaginal-misoprostol-reduces-the-interval-to-delivery-a-systematic-review-and-network-meta-analysis
#38
REVIEW
Gustavo Vilchez, Rachel Meislin, Lifeng Lin, Katherine Gonzalez, Jordan McKinney, Andrew Kaunitz, Joanne Stone, Luis Sanchez-Ramos
OBJECTIVE: Several systematic reviews and meta-analyses have summarized the evidence on the efficacy and safety of various outpatient cervical ripening methods. However, the method with the highest efficacy and safety profile has not been determined conclusively. We performed a systematic review and network meta-analysis of published randomized controlled trials to assess the efficacy and safety of cervical ripening methods currently employed in the outpatient setting. DATA SOURCES: With the assistance of an experienced medical librarian, we performed a systematic search of the literature using MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, and ClinicalTrials...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462253/single-balloon-catheter-with-concomitant-vaginal-misoprostol-is-the-most-effective-strategy-for-labor-induction-a-meta-review-with-network-meta-analysis
#39
REVIEW
Luis Sanchez-Ramos, Lifeng Lin, Gustavo Vilchez-Lagos, Jose Duncan, Niamh Condon, Jason Wheatley, Andrew M Kaunitz
OBJECTIVE: Several systematic reviews and meta-analyses have been conducted to summarize the evidence for the efficacy of various labor induction agents. However, the most effective agents or strategies have not been conclusively determined. We aimed to perform a meta-review and network meta-analysis of published systematic reviews to determine the efficacy and safety of currently employed pharmacologic, mechanical, and combined methods of labor induction. DATA SOURCES: With the assistance of an experienced medical librarian, we performed a systematic search of the literature using PubMed, EMBASE, and the Cochrane Central Register of Control Trials...
March 2024: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/38462252/methods-for-the-induction-of-labor-efficacy-and-safety
#40
REVIEW
Luis Sanchez-Ramos, Lisa D Levine, Anthony C Sciscione, Ellen L Mozurkewich, Patrick S Ramsey, Charles David Adair, Andrew M Kaunitz, Jordan A McKinney
This review assessed the efficacy and safety of pharmacologic agents (prostaglandins, oxytocin, mifepristone, hyaluronidase, and nitric oxide donors) and mechanical methods (single- and double-balloon catheters, laminaria, membrane stripping, and amniotomy) and those generally considered under the rubric of complementary medicine (castor oil, nipple stimulation, sexual intercourse, herbal medicine, and acupuncture). A substantial body of published reports, including 2 large network meta-analyses, support the safety and efficacy of misoprostol (PGE1) when used for cervical ripening and labor induction...
March 2024: American Journal of Obstetrics and Gynecology
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