Luis Sanchez-Ramos, Lisa D Levine, Anthony C Sciscione, Ellen L Mozurkewich, Patrick S Ramsey, Charles David Adair, Andrew M Kaunitz, Jordan A McKinney
This review assessed the efficacy and safety of pharmacologic agents (prostaglandins, oxytocin, mifepristone, hyaluronidase, and nitric oxide donors) and mechanical methods (single- and double-balloon catheters, laminaria, membrane stripping, and amniotomy) and those generally considered under the rubric of complementary medicine (castor oil, nipple stimulation, sexual intercourse, herbal medicine, and acupuncture). A substantial body of published reports, including 2 large network meta-analyses, support the safety and efficacy of misoprostol (PGE1) when used for cervical ripening and labor induction...
March 2024: American Journal of Obstetrics and Gynecology