keyword
https://read.qxmd.com/read/38518506/breakthrough-covid-19-in-people-with-multiple-sclerosis-on-disease-modifying-treatments-is-it-still-a-severe-disease
#21
JOURNAL ARTICLE
Paolo Immovilli, Irene Schiavetti, Alessandro Franceschini, Paola De Mitri, Lorenza Gelati, Eugenia Rota, Donata Guidetti
INTRODUCTION: Disease modifying treatments (DMTs) for multiple sclerosis (MS) are effective in preventing both relapses and disability progression. Highly effective treatments (HETs) are more effective than platform therapy in preventing confirmed disability progression (CDP), when used early. Infections may complicate HETs administration, and their prevention through vaccination is crucial in order to assure the safety of people with MS (pwMS). The aim of the present study is to describe the effect of MS DMTs on COVID-19 vaccination and the risk of breakthrough infection in a cohort of pwMS...
March 8, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38517523/phenotype-variability-and-natural-history-of-x-linked-myopathy-with-excessive-autophagy
#22
JOURNAL ARTICLE
Gorka Fernández-Eulate, Girolamo Alfieri, Marco Spinazzi, Isabelle Ackermann-Bonan, Fanny Duval, Guilhem Solé, Florence Caillon, Sandra Mercier, Yann Pereon, Armelle Magot, Antoine Pegat, Emmanuelle Salort-Campana, Brigitte Chabrol, Svetlana Gorokhova, Martin Krahn, Valerie Biancalana, Teresinha Evangelista, Anthony Behin, Corinne Metay, Tanya Stojkovic
OBJECTIVE: X-linked myopathy with excessive autophagy (XMEA) linked to the VMA21 gene leads to autophagy failure with progressive vacuolation and atrophy of skeletal muscles. Current knowledge of this rare disease is limited. Our objective was to define the clinical, radiological, and natural history of XMEA. METHODS: We conducted a retrospective study collecting clinical, genetic, muscle imaging, and biopsy data of XMEA patients followed in France and reviewed the literature for additional cases...
March 22, 2024: Journal of Neurology
https://read.qxmd.com/read/38517521/persons-with-multiple-sclerosis-older-than-55%C3%A2-years-an-analysis-from-the-german-ms-registry
#23
JOURNAL ARTICLE
Yasemin Goereci, David Ellenberger, Paulus Rommer, Veronika Dunkl, Heidrun Golla, Uwe Zettl, Alexander Stahmann, Clemens Warnke
BACKGROUND: Persons with MS (PwMS) ≥ 55 years are underrepresented in therapy studies leading to a lack of evidence. OBJECTIVE AND METHODS: To study the subgroup of PwMS ≥ 55 years in the German MS registry in comparison with PwMS < 55 years. Endpoints of interest were the grade of disability, leading symptoms, clinical and magnetic resonance imaging activity, and use of disease modifying therapy...
March 22, 2024: Journal of Neurology
https://read.qxmd.com/read/38516994/exercise-to-mitigate-cerebrovascular-aging-a-geroscience-perspective
#24
JOURNAL ARTICLE
Amani M Norling, Lewis A Lipsitz
Aging is characterized by a progressive loss of cellular functions that increase the risk of developing chronic diseases, vascular dysfunction, and neurodegenerative conditions. The field of geroscience has identified cellular and molecular hallmarks of aging that may serve as targets for future interventions to reduce the risk of age-related disease and disability. These hallmarks include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication...
March 22, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38516735/evaluating-emerging-drugs-in-phase-ii-iii-for-the-treatment-of-amyotrophic-lateral-sclerosis
#25
REVIEW
Xiaoyan Li, Richard Bedlack
INTRODUCTION: Amyotrophic Lateral Sclerosis is a rapidly progressive motor neuron disorder causing severe disability and premature death. Owing to the advances in uncovering ALS pathophysiology, efficient clinical trial design and research advocacy program, several disease-modifying drugs have been approved for treating ALS. Despite this progress, ALS remains a rapidly disabling and life shortening condition. There is a critical need for more effective therapies. AREAS COVERED: Here, we reviewed the emerging ALS therapeutics undergoing phase II & III clinical trials...
March 22, 2024: Expert Opinion on Emerging Drugs
https://read.qxmd.com/read/38516223/exploring-the-healthcare-access-challenges-faced-by-visually-impaired-young-women-in-nepal-navigating-sexual-harassment-and-stigma-within-healthcare-settings
#26
JOURNAL ARTICLE
Amit Timilsina, Pabitra Neupane, Janaki Pandey, Aastha Subedi, Subash Thapa
INTRODUCTION: Despite global progress in gender equality, still not every woman has access to safe and the highest quality health care. Visually impaired young adult women represent one of the most vulnerable groups with a poorer ability to access necessary healthcare services. This study aims to explore and comprehend the experiences of visually impaired young adult women in accessing healthcare services in Nepal. METHODS: A descriptive phenomenological study was conducted among 16 visually impaired women aged 20 to 35 years who had utilized healthcare services within the past 12 months...
June 2024: Dialogues Health
https://read.qxmd.com/read/38514374/impact-of-foot-functionality-in-patients-with-systemic-sclerosis-cross-sectional-study
#27
JOURNAL ARTICLE
Esther Chicharro-Luna, Miguel Ángel Gracia-Vesga, Laura Ramos-Petersen, Gabriel Gijón-Nogueron
BACKGROUND: Progressive systemic sclerosis or systemic scleroderma (SS) is a chronic and rare autoimmune disease that mainly affects the skin and various internal organs. Raynaud's phenomenon and digital ulcers are some of the symptoms that affect the foot, causing a decrease in the quality of life of patients. The objective of this study is to determine the functionality of the feet in patients with SS and determine the impact on their daily lives. METHODS: A sample of 165 patients (154 women, 11 men) diagnosed with SS with a mean age of 46...
March 7, 2024: Journal of Tissue Viability
https://read.qxmd.com/read/38514338/-chinese-expert-consensus-on-multidisciplinary-decision-making-model-for-mobility-limitation-in-older-adults-2024-edition
#28
JOURNAL ARTICLE
(no author information available yet)
Mobility limitation is an age-related geriatric syndrome that is affected by multiple factors such as aging, multimorbidity, nutritional status, chronic pain, psychological and social factors, which increases the risk of adverse events such as pressure ulcers, venous thrombosis, constipation, frailty, disability, falls and death in older adults. Early identification of mobility limitation and individualized comprehensive management are of great significance to maintain the functional status and quality of life of older adults...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38514197/worsening-of-health-disparities-across-covid-19-pandemic-stages-in-korea
#29
JOURNAL ARTICLE
Hyejin Lee, Hyunwoo Nam, Jae-Ryun Lee, Hyemin Jung, Jin Yong Lee
OBJECTIVES: With the end of the coronavirus disease 2019 (COVID-19) pandemic, the health outcomes of this disease in Korea must be examined. We aimed to investigate health outcomes and disparities linked to socioeconomic status during the COVID-19 pandemic in Korea and to identify risk factors for hospitalization and mortality. METHODS: This nationwide retrospective study incorporated an analysis of individuals with and without COVID-19 in Korea between January 1, 2020, and December 31, 2022...
March 13, 2024: Epidemiology and Health
https://read.qxmd.com/read/38513597/a-new-frontier-in-precision-medicine-exploring-the-role-of-extracellular-vesicles-in-chronic-obstructive-pulmonary-disease
#30
REVIEW
Zixuan Gou, Hongrun Yang, Ruijia Wang, Shihan Wang, Qirui Chen, Ziyu Liu, Ying Zhang
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease characterized by progressive respiratory difficulties. It has a high incidence and disability rate worldwide. However, currently there is still a lack of highly effective treatment methods for COPD, only symptom relief is possible. Therefore, there is an urgent need to explore new treatment options. Almost all cells can secrete extracellular vesicles (EVs), which participate in many physiological activities by transporting cargoes and are associated with the pathogenesis of various diseases...
March 20, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38513425/substantial-and-comparable-suppression-of-disease-activity-following-early-initiation-of-cladribine-tablets-ocrelizumab-or-alemtuzumab-as-first-pharmacologic-treatment-for-relapsing-multiple-sclerosis-a-real-world-study
#31
JOURNAL ARTICLE
Raed Alroughani, Jasem Al-Hashel, Samar Farouk Ahmed
BACKGROUND: We describe the efficacy and safety of recent high efficacy disease DMTs in DMT-naive patients with highly active RMS. METHODS: This was a retrospective, cross sectional study from the Kuwait national MS registry. Patients with RMS who received alemtuzumab, cladribine tablets or ocrelizumab as their first DMT for RMS, with ≥2 year of follow up were included. The primary endpoint was the change in relapse rate from treatment initiation to 1 year; changes in disability (Expanded Disability Status Scale [EDSS]), radiologic activity, the proportion with no evidence of disease activity-3 (NEDA-3), and the frequency of adverse events were secondary endpoints...
March 19, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38513414/fibrodysplasia-ossificans-progressiva-a-rare-disease-due-to-unawareness-case-report-and-literature-review
#32
Yabello Hirbo Guyolla, Fasil Tesfaye Abebe, Abduselam Jemal Ahmed
INTRODUCTION AND IMPORTANCE: Fibrodysplasia Ossificans Progressiva is an ultra-rare genetic disorder of progressive soft tissue ossification. Due to unawareness and poor clinical suspicion, the rate of misdiagnosis, delay in diagnosis, and unnecessary diagnostic procedures leading to permanent injury and lifelong disability is common. Here we report this rare genetic disorder in a six years old child who was initially misdiagnosed as multiple exostoses and operated on. CASE PRESENTATION: A 6 year old child presented with swellings over the posterior neck and back for four years...
March 19, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38512713/cognitive-approaches-in-the-rehabilitation-of-upper-limbs-function-in-children-with-cerebral-palsy-a-systematic-review-and-meta-analysis
#33
JOURNAL ARTICLE
Andrea Demeco, Anna Molinaro, Martina Ambroggi, Antonio Frizziero, Elisa Fazzi, Cosimo Costantino, Giovanni Buccino
INTRODUCTION: Cerebral palsy (CP) is the predominant cause of children disability. It is characterized by motor, sensory, and postural deficits due to a non-progressive injury to the developing central nervous system. In recent years, new rehabilitation techniques targeting the central representations of motor patterns have been introduced: the most used are action observation therapy (AOT), motor imagery (MI), and mirror therapy (MT). Aim of this study is to assess the effectiveness of these cognitive strategies on the recovery of upper limb motor functions in children with CP...
March 21, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38512694/impact-of-baseline-neuropathy-severity-on-vutrisiran-treatment-response-in-the-phase-3-helios-a-study
#34
JOURNAL ARTICLE
Marco Luigetti, Dianna Quan, John L Berk, Isabel Conceição, Yohei Misumi, Chi-Chao Chao, Shaun Bender, Emre Aldinc, John Vest, David Adams
INTRODUCTION: Hereditary transthyretin (ATTRv, v for variant) amyloidosis is a rare, progressive, fatal disease with multisystem manifestations, caused by pathogenic variants in the transthyretin (TTR) gene. Vutrisiran, an RNA interference therapeutic that results in rapid TTR knockdown, improved neuropathy and quality of life (QOL) versus external placebo in patients with ATTRv amyloidosis with polyneuropathy in the phase 3 HELIOS-A study (NCT03759379). This post hoc analysis evaluates the impact of baseline neuropathy severity on response to vutrisiran treatment...
March 21, 2024: Neurology and Therapy
https://read.qxmd.com/read/38512378/temporal-trends-in-prevalence-and-disability-of-chronic-kidney-disease-caused-by-specific-etiologies-an-analysis-of-the-global-burden-of-disease-study-2019
#35
JOURNAL ARTICLE
Xin Qing, Junyi Jiang, Chunlei Yuan, Kunke Xie, Ke Wang
BACKGROUND: The prevalence of disability in CKD is high. In this context the aim of the present study was to assess the  temporal trends of prevalence and disability progression for chronic kidney disease (CKD) caused by specific etiologies. METHODS: Using data from the Global Burden of Diseases Study (GBD) 2019, we examined the age-standardized rates of CKD prevalence and disability-adjusted life-years for different etiologies, including Type 1/2 diabetes mellitus (T1DM/T2DM), glomerulonephritis, and hypertension...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38512346/results-of-inaugural-international-down-syndrome-societal-services-and-supports-survey
#36
JOURNAL ARTICLE
Daniel J Kats, Karen Donelan, Souvik Banerjee, Gert de Graaf, Ellen Skladzien, Brian Takashi Hooper, Rose Mordi, Tetiana Mykhailenko, Frank Buckley, Stephanie L Santoro, Vasiliki Patsiogiannis, Kavita Krell, Kelsey Haugen, Brian G Skotko
PURPOSE: We previously designed the Down Syndrome Societal Services and Supports Survey (DS-4S) to measure country-specific supports for people with Down syndrome (DS) across multiple life domains (healthcare, education, policy, independence, and community inclusion). We now report and analyze the results. METHODS: We partnered with international DS consortia, who distributed the DS-4S to 154 cumulative members representing over 100 countries. Organizations were included if they had a holistic focus on the lives of people with DS and if at least 50% of their members either have DS or are family members of people with DS...
March 19, 2024: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://read.qxmd.com/read/38511963/the-selfstart-intervention-for-low-back-pain-patients-presenting-to-first-contact-physiotherapists-a-mixed-methods-service-evaluation
#37
JOURNAL ARTICLE
K Stevenson, T Hadley-Barrows, N Evans, L Campbell, J Southam, A Chudyk, D Ellington, B Jeeves, C Jenson, S Kleberg, H Birkinshaw, F Mair, K Dziedzic, G Peat, K P Jordan, D Yu, J Bailey, A Braybooke, C D Mallen, Jonathan C Hill
INTRODUCTION: Globally, back pain is the leading cause of years of disability. In the United Kingdom, over 20 million people live with musculoskeletal (MSK) pain, with low back pain being one of the most common causes. National strategies promote self-management and the use of digital technologies to empower populations. AIMS: To evaluate the uptake and impact of providing the SelfSTart approach (STarT Back and SelfBACK App) when delivered by a First Contact Physiotherapist (FCP) to people presenting with low back pain in primary care...
March 2024: Musculoskeletal Care
https://read.qxmd.com/read/38510563/looking-for-a-beam-of-light-to-heal-chronic-pain
#38
REVIEW
Jialing Xu, Hao Zhang, Dan Chen, Kaiyong Xu, Zifa Li, Hongyun Wu, Xiwen Geng, Xia Wei, Jibiao Wu, Wenqiang Cui, Sheng Wei
Chronic pain (CP) is a leading cause of disability and a potential factor that affects biological processes, family relationships, and self-esteem of patients. However, the need for treatment of CP is presently unmet. Current methods of pain management involve the use of drugs, but there are different degrees of concerning side effects. At present, the potential mechanisms underlying CP are not completely clear. As research progresses and novel therapeutic approaches are developed, the shortcomings of current pain treatment methods may be overcome...
2024: Journal of Pain Research
https://read.qxmd.com/read/38510450/association-of-intrinsic-capacity-with-functional-ability-sarcopenia-and-systemic-inflammation-in-pre-frail-older-adults
#39
JOURNAL ARTICLE
Reshma Aziz Merchant, Yiong Huak Chan, Denishkrshna Anbarasan, Bruno Vellas
BACKGROUND: Decline in intrinsic capacity (IC) has been shown to accelerate progression to disability. The study aims to explore association of IC composite score with functional ability, sarcopenia and systemic inflammation in pre-frail older adults. METHODS: Cross-sectional study of pre-frail older adults ≥60 years old recruited from the community and primary care centers. Composite scores of four domains of IC were measured: locomotion, vitality, cognition and psychological...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38510348/cervical-cancer-incidence-mortality-and-burden-in-china-a-time-trend-analysis-and-comparison-with-england-and-india-based-on-the-global-burden-of-disease-study-2019
#40
JOURNAL ARTICLE
Siyu Wu, Jun Jiao, Xiaoyu Yue, Yaping Wang
BACKGROUND: Cervical cancer is the fourth highest incidence of malignancy in the world and a common cause of cancer death in women. We assessed the trends of incidence and mortality and disability-adjusted life year (DALY) in China, England and India from 1990 to 2030. METHOD: Data were obtained from the Global Burden of Disease (GBD) database. We collected the number and rate of incidence, death and DALY from 1990 to 2019 and calculated the estimated annual percentage change (EAPC)...
2024: Frontiers in Public Health
keyword
keyword
162373
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.