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https://read.qxmd.com/read/30758440/critical-illness-polyneuromyopathy-in-septic-patients-is-it-possible-to-diagnose-it-in-a-bedside-clinical-examination
#1
Débora Schmidt, Ana Cláudia Coelho, Fernando Nataniel Vieira, Vitor Félix Torres, Augusto Savi, Silvia Regina Rios Vieira
OBJECTIVE: To determine the sensitivity and specificity of peripheral and respiratory muscle strength tests in diagnosing critical illness polyneuromyopathy (CIPNM), compared with an electrophysiological examination. METHODS: Fifty septic patients who required mechanical ventilation for at least five days, and without a previous history of muscle weakness, were included. Peripheral muscle strength was assessed using the Medical Research Council (MRC) score, handgrip strength by dynamometry, and respiratory muscle strength with maximum respiratory pressures...
January 2019: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/30745060/left-bundle-branch-block-after-transcatheter-aortic-valve-implantation-with-edwards-sapien-3-valve-influence-of-the-valve-depth-implantation
#2
Leire Unzué, Eulogio García, Belén Díaz-Antón, Francisco José Rodríguez-Rodrigo, Miguel Rodríguez Del Río, Rodrigo Teijeiro, Juan Medina, Francisco Javier Parra
OBJECTIVES: The aim of this study is to determine the relation between the valve depth implantation and the new-onset left bundle branch block (LBBB) in patients treated with transcatheter aortic valve implantation (TAVI) using Edwards Sapien 3 (S3) prosthesis. BACKGROUND: LBBB is the most common conduction disturbance after TAVI. The S3 has been associated with a higher incidence of LBBB. A deep valve implant could be related to new-onset LBBB with S3. METHODS: Seventy-six consecutive patients treated with transfemoral TAVI with S3 were included...
January 9, 2019: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/30739377/chronic-hepatitis-b-the-interplay-between-intrahepatic-lymphocyte-population-and-viral-antigens-in-relation-to-liver-damage
#3
Cecilia Graciela Giadans, Daniela Alejandra Ríos, Beatriz Ameigeiras, Adriana Mónica Pietrantonio, Néstor Lucio Lucatelli, Leila Haddad, Eduardo Mullen, Fabiana Heinrich, Elena De Matteo, Diego Flichman, Pamela Valva, María Victoria Preciado
In Chronic Hepatitis B (CHB) infection, virus and immune response interplay is thought to be responsible for pathogenesis. Yet, the impact of each immune cell population and viral protein expression in liver damage is still unknown. Our aim was to study the interplay between intrahepatic immune response and viral activity in relation to CHB liver damage. Immunostaining was performed in 29 liver biopsies from untreated CHB patients to characterize liver infiltrate [Th (CD4+), CTL (CD8+), Treg (FoxP3+), Th17 (IL-17A+) and Th1 (Tbet+)] and viral antigen expression (HBsAg and HBcAg)...
February 9, 2019: Journal of Viral Hepatitis
https://read.qxmd.com/read/30698657/calculation-of-accurate-interatomic-contact-surface-areas-for-the-quantitative-analysis-of-non-bonded-molecular-interactions
#4
Judemir Ribeiro, Carlos Ríos-Vera, Francisco Melo, Andreas Schüller
Summary: Intra- and intermolecular contact surfaces are routinely calculated for a large array of applications in bioinformatics but are typically approximated from differential solvent accessible surface area calculations and not calculated directly. These approximations do not properly take the effects of neighboring atoms into account and tend to deviate considerably from the true contact surface. We implemented an extension of the original Shrake-Rupley algorithm to accurately estimate interatomic contact surface areas of molecular structures and complexes...
January 29, 2019: Bioinformatics
https://read.qxmd.com/read/30698402/effectiveness-of-health-education-in-patients-with-fibromyalgia-a-systematic-review
#5
María C García-Ríos, Santiago Navarro-Ledesma, Rosa M Tapia-Haro, Sonia Toledano-Moreno, Antonio Casas-Barragán, María Correa-Rodríguez, María E Aguilar-Ferrándiz
INTRODUCTION: Fibromyalgia (FM) is a chronic illness characterised by the presence of generalised musculoskeletal pain among other symptoms, which reduce the quality of life of the patient. Clinical interventions such as patient education on central pain management could lead to promising results. The aim of this study is to evaluate the effectiveness of education techniques on the main symptoms such as pain, quality of life, anxiety, functionality or catastrophisation in the treatment of FM...
January 28, 2019: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/30683515/can-we-predict-recurrence-in-who-g1-g2-pancreatic-neuroendocrine-neoplasms-results-from-a-multi-institutional-spanish-study
#6
F Ausania, P Senra Del Rio, M A Gomez-Bravo, E Martin-Perez, J A Pérez-Daga, D Dorcaratto, T González-Nicolás, S Sanchez-Cabus, A Tardio-Baiges
INTRODUCTION: Pancreatic neuroendocrine neoplasms (PNEN) are rare tumours and well differentiated PNEN are associated with relatively indolent physiological behaviour. For this reason, only few studies have investigated those factors associated with recurrence in this group of patients. The aim of this study is to analyse whether it is possible to predict tumour recurrence in World Health Organization (WHO) 2017 G1-G2 PNEN patients. METHODS: This is a retrospective multi-institutional study...
January 19, 2019: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30677626/variability-in-intensive-care-unit-length-of-stay-after-liver-transplant-determinants-and-potential-opportunities-for-improvement
#7
Alejandro Pita, Brian Nguyen, Daisy Rios, Nicolas Maalouf, Mary Lo, Yuri Genyk, Linda Sher, J Perren Cobb
PURPOSE: Recovery after liver transplant (LT) requires extensive resources, including prolonged intensive care unit stays. The objective of this study was to use an assessment tool to determine if LT recipients remain in ICU beyond designated indications. METHODS: Records from 100 consecutive LTs performed in a single institution were retrospectively reviewed. An admission, discharge, and triage screening (ADT) tool was utilized to assess the indications for each ICU day...
January 9, 2019: Journal of Critical Care
https://read.qxmd.com/read/30668186/is-cervical-length-evaluated-by-transvaginal-ultrasonography-helpful-in-detecting-true-preterm-labor
#8
Maria Carolina Maia, Roseli Nomura, Fernanda Mendonça, Livia Rios, Antonio Moron
OBJECTIVE: To investigate whether sonographic cervical markers can identify women in true preterm labor and predict delivery within 7 d and before 34 or 37 gestational weeks. METHODS: This was a prospective observational study of women with singleton pregnancies and intact membranes given a diagnosis of preterm labor between 25 and 34 weeks and 6 d of gestation and who underwent transvaginal evaluation of the following characteristics: cervical length (CL), CL zeta score, absence of endocervical glandular echo, presence of cervical funneling, and presence of amniotic fluid sludge...
January 22, 2019: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/30665612/prediction-of-hypocalcemia-after-total-thyroidectomy-using-indocyanine-green-angiography-of-parathyroid-glands-a-simple-quantitative-scoring-system
#9
Silvia Gálvez-Pastor, Nuria M Torregrosa, Antonio Ríos, Beatriz Febrero, Rafael González-Costea, María A García-López, María D Balsalobre, Patrícia Pastor-Pérez, Pablo Moreno, José L Vázquez-Rojas, José M Rodríguez
BACKGROUND: Hypocalcemia is one of the most common complications after total thyroidectomy. Recently, indocyanine green (ICG) angiography of the parathyroid glands (PGs) has been suggested as a reliable tool for predicting postoperative hypocalcemia. The aim of our study was to evaluate the performance of a simple quantitative score based on ICG angiography of the PGs (4-ICG score) for predicting postoperative hypocalcemia. METHODS: Thirty nine consecutive patients who underwent total thyroidectomy for multinodular goiter were included...
January 4, 2019: American Journal of Surgery
https://read.qxmd.com/read/30658415/synthesis-in-silico-and-in-vitro-evaluation-of-long-chain-alkyl-amides-from-2-amino-4-quinolone-derivatives-as-biofilm-inhibitors
#10
Mariana Paola Espinosa-Valdés, Sara Borbolla-Alvarez, Ana Elena Delgado-Espinosa, Juan Francisco Sánchez-Tejeda, Anabelle Cerón-Nava, Osvaldo Javier Quintana-Romero, Armando Ariza-Castolo, Diego Fernando García-Del Río, Marco A Loza-Mejía
Infection from multidrug resistant bacteria has become a growing health concern worldwide, increasing the need for developing new antibacterial agents. Among the strategies that have been studied, biofilm inhibitors have acquired relevance as a potential source of drugs that could act as a complement for current and new antibacterial therapies. Based on the structure of 2-alkyl-3-hydroxy-4-quinolone and N -acylhomoserine lactone, molecules that act as mediators of quorum sensing and biofilm formation in Pseudomonas aeruginosa, we designed, prepared, and evaluated the biofilm inhibition properties of long chain amide derivatives of 2-amino-4-quinolone in Staphylococcus aureus and P...
January 17, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/30657537/association-of-infants-exposed-to-prenatal-zika-virus-infection-with-their-clinical-neurologic-and-developmental-status-evaluated-via-the-general-movement-assessment-tool
#11
Christa Einspieler, Fabiana Utsch, Patricia Brasil, Carolina Y Panvequio Aizawa, Colleen Peyton, Renata Hydee Hasue, Fernanda Françoso Genovesi, Luana Damasceno, Maria Elisabeth Moreira, Kristina Adachi, Peter B Marschik, Karin Nielsen-Saines
Importance: There is an urgent need to assess neurodevelopment in Zika virus (ZIKV)-exposed infants. Objectives: To perform general movement assessment (GMA) at 9 to 20 weeks' postterm age and to evaluate whether the findings are associated with neurodevelopmental outcomes at age 12 months in infants prenatally exposed to acute maternal illness with rash in Brazil during the ZIKV outbreak and in age-matched controls. Design, Setting, and Participants: In this cohort study, infants prenatally exposed to acute maternal illness with rash were recruited at medical institutions in Rio de Janeiro and Belo Horizonte, Brazil, from February 1, 2016, to April 30, 2017, while infants without any exposure to maternal illness originated from the Graz University Audiovisual Research Database for the Interdisciplinary Analysis of Neurodevelopment...
January 4, 2019: JAMA network open
https://read.qxmd.com/read/30656873/virtual-reality-in-cardiopulmonary-resuscitation-training-a-randomized-trial
#12
Cristina Cerezo Espinosa, Francisca Segura Melgarejo, Rafael Melendreras Ruiz, Ángel Joaquín García-Collado, Sergio Nieto Caballero, Laura Juguera Rodríguez, Sergio Pardo Ríos, Sergio García Torrano, Elena Linares Stutz, Manuel Pardo Ríos
OBJECTIVES: To assess the efficacy of virtual reality (VR) in cardiopulmonary resuscitation (CPR) training. MATERIAL AND METHODS: Experimental, analytic, cross-sectional study of a CPR training method using VR. Participants were randomly assigned to train in a control group or a VR group. RESULTS: The mean (SD) scores on a scale of 10 after training were 9.28 (0.91) in the VR group and 7.78 (1.63) in the control group, for a mean difference of 1...
2019: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://read.qxmd.com/read/30642010/zinc-nutritional-status-in-patients-with-cystic-fibrosis
#13
Marlene Fabiola Escobedo Monge, Enrique Barrado, Carmen Alonso Vicente, María Paz Redondo Del Río, José Manuel Marugán de Miguelsanz
BACKGROUND: Zinc is an essential nutrient for all forms of life and its deficiency affects the normal growth and development of human beings. OBJECTIVE: The main aim was to investigate zinc nutritional status by serum zinc concentration (SZC) and dietary zinc intake and their association in cystic fibrosis (CF) patients. METHODS: A cross-sectional study was conducted in CF patients. Anthropometric measurements and respiratory and pancreatic tests were conducted...
January 11, 2019: Nutrients
https://read.qxmd.com/read/30625261/progression-of-the-structural-damage-in-the-sacroiliac-joints-in-patients-with-early-axial-spondyloarthritis-during-a-long-term-anti-tnf-treatment-six-year-results-of-the-esther-trial
#14
Valeria Rios Rodriguez, Kay-Geert Hermann, Anja Weiß, Joachim Listing, Hildrun Haibel, Christian Althoff, Fabian Proft, Olaf Behmer, Joachim Sieper, Denis Poddubnyy
OBJECTIVE: To evaluate radiographic progression in the sacroiliac joints (SIJ) and to identify its predictors during long-term (up to six years) treatment with tumor necrosis factor (TNF) inhibitor etanercept in patients with early axial spondyloarthritis (axSpA). METHODS: Patients with early axSpA who were treated with etanercept for up to 6 years in the ESTHER trial were selected based on the availability of X-rays of SIJ. Two blinded readers scored the X-rays according to the grading system of the modified New York criteria (range 0-4 per SIJ)...
January 9, 2019: Arthritis & Rheumatology
https://read.qxmd.com/read/30612596/measurement-of-stress-in-stable-neonates-during-ambulance-transportation-a-feasibility-study
#15
Marielle Zwissig, Laura Rio, Matthias Roth-Kleiner, Anne-Sylvie Ramelet
BACKGROUND: Stress during ambulance transportation has been described in adult healthy volunteers where indicators of stress such as heart rate, blood pressure, and cortisol increased significantly. In neonates, a few studies have described stress in ambulance with behavioural scales. However, there is no study in neonates assessing both behavioural and physiological indicators of stress simultaneously during ambulance transportation. OBJECTIVE: To assess the feasibility of a study aiming at identifying stress in clinically stable neonates during ambulance transportation in non-emergency situations...
January 2019: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://read.qxmd.com/read/30612241/is-there-a-relationship-of-negative-oral-health-beliefs-with-dental-fear-and-anxiety-regarding-diverse-dental-patient-groups-a-systematic-review-and-meta-analysis
#16
Anna Paola Strieder, Thaís Marchini Oliveira, Daniela Rios, Agnes Fátima Pereira Cruvinel, Thiago Cruvinel
OBJECTIVES: This systematic review and meta-analysis aimed to critically appraise the evidence on the relationship of oral health beliefs with dental fear and anxiety in distinct patient groups. MATERIALS AND METHODS: Observational studies were retrieved by Cochrane, Embase Search, Portal BVS, Clinical Trials, Ovid, Open Gray, PubMed, Scopus, and Web of Science, and they were manually checked for the inclusion of additional articles of interest. The assessment of quality of studies was performed by the application of three different versions of the Newcastle-Ottawa Scale, for cohort, case-control, and cross-sectional studies...
January 5, 2019: Clinical Oral Investigations
https://read.qxmd.com/read/30606112/optimising-costs-in-reducing-rate-of-falls-in-older-people-with-the-improvement-of-balance-by-means-of-vestibular-rehabilitation-refovere-study-a-randomized-controlled-trial-comparing-computerised-dynamic-posturography-vs-mobile-vibrotactile-posturography-system
#17
Andrés Soto-Varela, Pilar Gayoso-Diz, Ana Faraldo-García, Marcos Rossi-Izquierdo, Isabel Vaamonde-Sánchez-Andrade, María Del-Río-Valeiras, Antonio Lirola-Delgado, Sofía Santos-Pérez
BACKGROUND: Accidental falls, especially for the elderly, are a major health issue. Balance disorders are one of their main causes. Vestibular rehabilitation (VR) has proven to be useful in improving balance of elderly patients with instability. Its major handicap is probably its cost, which has prevented its generalisation. So, we have designed a clinical trial with posturographic VR, to assess the optimum number of sessions necessary for a substantial improvement and to compare computerised dynamic posturography (CDP) (visual feedback) and mobile posturography (vibrotactile feedback)...
January 3, 2019: BMC Geriatrics
https://read.qxmd.com/read/30595804/multicenter-phase-ii-trial-of-modified-folfirinox-in-gemcitabine-refractory-pancreatic-cancer
#18
Moon Jae Chung, Huapyong Kang, Ho Gak Kim, Jong Jin Hyun, Jun Kyu Lee, Kwang Hyuck Lee, Myung Hwan Noh, Dae Hwan Kang, Sang Hyub Lee, Seungmin Bang
AIM: To evaluate the efficacy and safety of modified FOLFIRINOX as a second-line treatment for gemcitabine (GEM)-refractory unresectable pancreatic cancer (PC). METHODS: This study was a prospective, multicenter, one-arm, open-label, phase II trial. Patients with unresectable PC, who showed disease progression during GEM-based chemotherapy were enrolled. All patients were administered FOLFIRINOX with reduced irinotecan and oxaliplatin (RIO; irinotecan 120 mg/m2 and oxaliplatin 60 mg/m2 ), which was set according to the phase I study of FOLFIRINOX...
December 15, 2018: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/30587516/unraveling-treatment-response-in-multiple-sclerosis-a-clinical-and-mri-challenge
#19
REVIEW
Claudio Gasperini, Luca Prosperini, Mar Tintoré, Maria Pia Sormani, Massimo Filippi, Jordi Rio, Jacqueline Palace, Maria A Rocca, Olga Ciccarelli, Frederik Barkhof, Jaume Sastre-Garriga, Hugo Vrenken, Jette L Frederiksen, Tarek A Yousry, Christian Enzinger, Alex Rovira, Ludwig Kappos, Carlo Pozzilli, Xavier Montalban, Nicola De Stefano
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing availability of effective pharmacologic treatments have led to substantial advances in the management of multiple sclerosis (MS). The importance of early diagnosis and treatment is now well-established, but there is still no consensus on how to define and monitor response to MS treatments. In particular, the clinical relevance of the detection of minimal MRI activity is controversial and recommendations on how to define and monitor treatment response are warranted...
January 22, 2019: Neurology
https://read.qxmd.com/read/30584466/low-serum-tryptophan-levels-as-an-indicator-of-global-cognitive-performance-in-nondemented-women-over-50-years-of-age
#20
L A Ramos-Chávez, G Roldán-Roldán, B García-Juárez, D González-Esquivel, G Pérez de la Cruz, B Pineda, D Ramírez-Ortega, I García Muñoz, B Jiménez Herrera, C Ríos, S Gómez-Manzo, J Marcial-Quino, L Sánchez Chapul, P Carrillo Mora, V Pérez de la Cruz
Aging is a physiological decline process. The number of older adults is growing around the world; therefore, the incidence of cognitive impairment, dementia, and other diseases related to aging increases. The main cellular factors that converge in the aging process are mitochondrial dysfunction, antioxidant impairment, inflammation, and immune response decline, among others. In this context, these cellular changes have an influence on the kynurenine pathway (KP), the main route of tryptophan (Trp) catabolism...
2018: Oxidative Medicine and Cellular Longevity
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