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hemangioma infantil

Andrew S Desrosiers, Jamil M Ibrahim, Stephanie K Jacks
A chart review was performed of all patients diagnosed with infantile hemangioma in the pediatric dermatology clinic to determine whether distance traveled by the patient affected adherence to follow-up and treatment plans. An increase in distance was associated with an increase in likelihood of nonadherence to treatment or follow-up plans. Compared to patients who lived within 10 miles of a pediatric dermatologist, families who lived farther away were less likely to adhere to treatment plans. Families who traveled over 20 miles to clinic were 7...
February 14, 2019: Pediatric Dermatology
Asami Osada, Eriko Araki, Yukio Yamashita, Tomohiro Ishii
Infantile hepatic hemangioma (IHH) can be accompanied by consumptive hypothyroidism. We report the case of a 4-mo-old boy who showed massive hepatomegaly, peripheral coldness, lethargy, and failure to thrive. An enhanced computed tomography scans demonstrated multiple hemangiomas in both lobes of the liver, and a thyroid function tests showed severe hypothyroidism: TSH 561.5 µIU/mL, free triiodothyronine (fT3 ) 1.0 pg/mL, and free thyroxine (fT4 ) < 0.7 ng/dL. IHH gradually regressed following propranolol treatment and fT4 increased to a low normal level (1...
2019: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
Amy Ruffle, Malcolm Cameron, Nicolaas Jonas, Samantha Levine, Caroline Mills, C Elizabeth Hook, Matthew J Murray
Alveolar soft part sarcoma (ASPS) is an exceptionally rare non-rhabdomyosarcomatous soft tissue sarcoma (NRSTS), characterized by the translocation t(X;17) p(11.2;q25). This translocation results in the chimeric ASPSCR1-TFE3 transcription factor which drives tumorigenesis. Complete surgical resection is crucial in allowing a successful outcome in these cases. Here, we describe an 11-month-old female infant who presented with a well-circumscribed lesion of the tongue, with the clinical and radiologic appearances of an infantile hemangioma...
February 11, 2019: Pediatric and Developmental Pathology
Changhua Wu, Lei Guo, Liang Wang, Jing Li, Changfeng Wang, Dan Song
Propranolol is the mainstay of treatment for infantile hemangiomas (IHs) benefited from its low complication in the present study. However, it has an uncertainty treating period with cumbersome methods which may be related to clinical features. This study sought to considered possible influences of short-term efficacy to medication.Retrospective analysis of 82 patients with IHs treated by propranolol was performed. The patients were grouped according to effect (excellent, good and fair/poor). ANOVA or t test was used to assess the relationships between effect and clinical features of IHs...
February 2019: Medicine (Baltimore)
Fan Wang, Honghong Li, Yin Lou, Juan Xie, Dongsheng Cao, Xueying Huang
Infantile hemangiomas (IH) are the most common infantile neoplasms and are characterized by initial proliferation during infancy and subsequent spontaneous regression within the next 5‑10 years, frequently leaving fibrous fat residues. However, the specific mechanisms underlying the differentiation of hemangioma stem cells (HemSCs) into adipocytes are not clear. The purpose of the present study was to investigate the effect of insulin‑like growth factor I (IGF‑1) on HemSCs from patients with IH and to determine the signaling mechanisms involved...
January 24, 2019: Molecular Medicine Reports
R Suárez Ramírez, A de Lucio Delgado, M González Cruz, C N Hernández León, N Hernández Siverio
Mediastinal infantile hemangioma has not been reported so far (as far as we are aware), using accurate diagnostic methods. MRI scans are essential for a correct characterization and assessment of the extension. Moreover, Endothelial cell glucose transporter 1 (GLUT1) isoform protein represents an extremely important diagnostic tool to differentiate Infantile Hemangioma from other vascular neoplasms. With regards to management, surgery appears to be the treatment of choice, although it is important to highlight that it is a rare disease and more studies are needed to establish a proper diagnostic and therapeutic protocol...
January 21, 2019: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Chao Liu, Zeliang Zhao, Zhidong Ji, Yanyan Jiang, Jiawei Zheng
Infantile hemangioma is the most common soft tissue tumors in childhood. In clinic, propranolol is widely used for infantile hemangioma therapy. However, some of the infantile hemangioma patients display resistance to propranolol treatment. Previous studies show that miR-187-3p is inhibited in hepatocellular carcinoma and lung cancer, while the role of miR-187-3p in infantile hemangioma remains unclear. In the present study, we explore the biological role of miR-187-3p in infantile hemangioma. The mRNA and protein levels of related genes were detected by real-time PCR and Western blotting...
February 2, 2019: Cell Structure and Function
M Dakoutrou, A Alexopoulos, M Miligkos, E Georgiadou, C Kanaka-Gantenbein, T Kakourou
Infantile hemangiomas (IHs) are common benign vascular tumors of infancy1 . Although most of them tend to resolve spontaneously, it is estimated that approximately 10% require intervention due to complications or disfigurements2-4 . The discovery of the inhibitory effects of propranolol, a non selective b blocker, during the prolipherative phase of IHs was an important development in the treatment of IHs, though its mechanism of action is not yet clear4 . This article is protected by copyright. All rights reserved...
February 1, 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Shuang Chen, Kaiwen Zhuang, Kaiyi Sun, Qin Yang, Xin Ran, Xiaoxi Xu, Chan Mu, Bin Zheng, Yanrong Lu, Jun Zeng, Yalin Dai, Pradhan Sushmita, Yuping Ran
Infantile hemangioma (IH) is the most common benign vascular tumor of infancy. We have previously reported that itraconazole, a common anti-fungal agent, can clinically improve or cure IH; however, the underlying molecular mechanisms are still unclear. Here, we show that itraconazole treatment significantly inhibits the proliferation and promotes apoptosis of the endothelial cells of mouse hemangioma (EOMA) cell line and infantile primary hemangioma endothelial cell (HemEC). Itraconazole also remarkably reduced angiogenesis of HemEC in vitro...
January 25, 2019: Journal of Investigative Dermatology
Mu-Chieh Tsai, Hsi-Che Liu, Chun-Yan Yeung
RATIONALE: Hepatic hemangioma is rarely discovered during the infantile period. Although most of the cases are asymptomatic, some of them may suffer life-threatening situations. In this regard, early detection is mandatory for preventing the ominous consequences that might be culminated from the disease. PATIENT CONCERNS: A 2-month-14-day-old female infant was found incidentally to have multiple hepatic lesions during a newborn ultrasound screen. She was born smoothly at term after a non-eventful pregnancy course...
January 2019: Medicine (Baltimore)
Yssra S Soliman, Amor Khachemoune
Infantile hemangioma (IH) is the most common vascular tumor of infancy, affecting up to 10% of all infants. Our understanding of IH and its management has greatly evolved. The etiology of IH is unclear but hypoxia is thought to play a key role. Furthermore, GLUT1, IGF2, and HIF-1-? are thought to be important mediators. Current management options include active observation, medical treatment, and surgical intervention. The goals of treatment are preventing cosmetic disfiguration, psychosocial distress, and life-threatening complications...
September 15, 2018: Dermatology Online Journal
Lidia Babiak-Choroszczak, Kaja Giżewska-Kacprzak, Grażyna Dawid, Elżbieta Gawrych, Maciej Bagłaj
BACKGROUND: Propranolol is an effective method of treatment for infantile hemangiomas (IH). A recent concern is a shift of the therapy into outpatient settings. OBJECTIVES: The aim of the study was to evaluate the safety of initiating and maintaining propranolol therapy for IH. MATERIAL AND METHODS: The study involved 55 consecutive children with IH being treated with propranolol. The patients were assessed in the hospital at the initiation of the therapy and later in outpatient settings during and after the therapy...
January 15, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mădălina Bota, Eva Fischer-Fodor, Ovidiu-Vasile Bochiș, Mihai Cenariu, Gheorghe Popa, Cristina Lucia Blag, Alexandru Tătaru
Infantile hemangioma is one of the most common benign tumors affecting children, with ~10-15% requiring medical treatment. These tumors consist of endothelial cells and stromal components, including fibroblasts, pericytes and mast cells. Effects of propranolol treatment in combination with bevacizumab or vincristine on cell growth were compared in the current study using human umbilical vein endothelial cells (HUVECs) and BJ human normal fibroblasts (BJs) to determine potential synergic effects in vitro . Inhibition of cell growth was investigated using MTT assays and cytotoxicity of the drugs in various combinations was expressed as half inhibitory concentration (IC50 )...
January 2019: Experimental and Therapeutic Medicine
Li Li, Li Wei, Zi-Gang Xu, Lin Ma
BACKGROUND: Concerns have been raised that propranolol treatment of infantile hemangioma (IH) may be associated with increased risks of adverse effects and growth impairment in preterm infants due to their immature development. OBJECTIVE: This study aimed to find out whether treatment of IH with propranolol in preterm infants is associated with higher incidences of long-term adverse effects and growth impairment in comparison with term infants. METHODS: The clinical data of 55 preterm infants and 180 term infants with IH treated with oral propranolol for 6 months were retrospectively collected and analyzed...
January 7, 2019: American Journal of Clinical Dermatology
Daniel P Krowchuk, Ilona J Frieden, Anthony J Mancini, David H Darrow, Francine Blei, Arin K Greene, Aparna Annam, Cynthia N Baker, Peter C Frommelt, Amy Hodak, Brian M Pate, Janice L Pelletier, Deborah Sandrock, Stuart T Weinberg, Mary Anne Whelan
Infantile hemangiomas (IHs) occur in as many as 5% of infants, making them the most common benign tumor of infancy. Most IHs are small, innocuous, self-resolving, and require no treatment. However, because of their size or location, a significant minority of IHs are potentially problematic. These include IHs that may cause permanent scarring and disfigurement (eg, facial IHs), hepatic or airway IHs, and IHs with the potential for functional impairment (eg, periorbital IHs), ulceration (that may cause pain or scarring), and associated underlying abnormalities (eg, intracranial and aortic arch vascular abnormalities accompanying a large facial IH)...
January 2019: Pediatrics
Dawn H Siegel
Infantile hemangiomas (IH) are the most common vascular tumor of infancy with an estimated 80,000 annual diagnoses in the United States. The genetic mechanisms underlying IH and the related multi-organ birth defect syndromes, PHACE (an acronym for Posterior fossa brain malformations, segmental facial Hemangiomas, Arterial anomalies, Cardiac defects, Eye anomalies, and sternal clefting or supraumbilical raphe) and LUMBAR (an acronym for Lower body hemangiomas, Urogenital anomalies, Myelopathy, Bone deformities, Anorectal malformations/Arterial anomalies, Renal anomalies) remain unsolved...
December 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
Yuan Liang, Yun Liu Chen, Mu Tong Zhao, Zhao Yang Wang, Li Li, Bin Zhang, Chun Ping Shen, Shan Wang, Zi Gang Xu, Lin Ma
The field of pediatric dermatology treatment has been rich in new developments. Several recent therapeutic advances in pediatric dermatology have been made. This review will focus on critical approach to the new treatments for several entities encountered in pediatric dermatology. The use of biologics and small molecules in children with atopic dermatitis and psoriasis, exciting advances in the use of propranolol and other beta-blockers for the treatment of infantile hemangiomas, the use of sirolimus for vascular anomalies will be discussed...
December 7, 2018: Dermatologic Therapy
Megan N Kelchen, Nicole K Brogden
Topical beta-blocker formulations are commonly used to treat infantile hemangiomas (IHs); however, the skin concentrations and drug permeation through the skin have not been quantified. Microneedles (MNs) may increase local skin concentrations, which could further enhance lesion clearance and improve dosing regimens. The objective of this study was to quantify skin concentrations and drug permeation of two beta-blockers, propranolol and timolol, in vitro after application to intact skin and skin pretreated with solid MNs of two lengths...
December 6, 2018: Biomedical Microdevices
Zeshan Shabbir, Ainy Javaid
Infantile hepatic hemangioma (IHH) historically called "hemangiomaendothelioma" refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Contrast enhanced CT demonstrated typical features of diffuse infantile hepatic hemangiomas.
December 2018: JPMA. the Journal of the Pakistan Medical Association
Cristina Padula, Sara Nicoli, Silvia Pescina, Patrizia Santi
BACKGROUND/AIMS: Infantile hemangioma (IH), the most common benign tumor of childhood, is currently treated with propranolol. The aim of this work was to study in vitro propranolol permeation and skin retention from an original polymeric film, composed of polyvinyl alcohol and an acrylic polymer. METHODS: Propranolol polymeric films were applied in occlusive and non-occlusive conditions, on either full thickness skin or isolated epidermis. Experiments were performed also on stripped skin, to simulate the skin permeability of damaged skin...
November 12, 2018: Colloids and Surfaces. B, Biointerfaces
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