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rate spontaneous pregnancy 45 years

Joel G Ray, Alison L Park, Susie Dzakpasu, Natalie Dayan, Paromita Deb-Rinker, Wei Luo, K S Joseph
Importance: Severe maternal morbidity is defined by potentially life-threatening conditions. The association between the number of severe maternal morbidity (SMM) indicators and maternal death is not known. Objective: To quantify the association between the number of SMM indicators and maternal mortality. Design, Setting, and Participants: This population-based cohort study used provincial databases for data on all live birth and stillbirth hospital deliveries among women in Ontario, Canada, from April 1, 2002, to February 18, 2017...
November 2, 2018: JAMA network open
Ai-Lan Nguyen, Eva Kubala Havrdova, Dana Horakova, Guillermo Izquierdo, Tomas Kalincik, Anneke van der Walt, Murat Terzi, Raed Alroughani, Pierre Duquette, Marc Girard, Alexandre Prat, Cavit Boz, Patrizia Sola, Diana Ferraro, Alessandra Lugaresi, Jeannette Lechner-Scott, Michael Barnett, Francois Grand'Maison, Pierre Grammond, Cristina Ramo-Tello, Recai Turkoglu, Pamela McCombe, Eugenio Pucci, Maria Trojano, Franco Granella, Daniele Spitaleri, Vincent Van Pesch, Aysun Soysal, Celia Oreja-Guevara, Freek Verheul, Steve Vucic, Suzanne Hodgkinson, Mark Slee, Radek Ampapa, Julie Prevost, Jose Luis Sanchez Menoyo, Olga Skibina, Claudio Solaro, Javier Olascoaga, Cameron Shaw, Klaus Gregaard Madsen, Kerisha Naidoo, Robert Hyde, Helmut Butzkueven, Vilija Jokubaitis
BACKGROUND: Exposure to disease-modifying therapy (DMT) during early pregnancy in women with relapsing-remitting MS (RRMS) may be increasing. OBJECTIVE: To retrospectively determine incidence of pregnancy, DMT exposure and pregnancy outcomes in women with RRMS. METHODS: We identified all women with RRMS aged 15-45 years in the MSBase Registry between 2005-2016. Annualised pregnancy incidence rates were calculated using Poisson regression models...
January 3, 2019: Multiple Sclerosis and related Disorders
Raanan Meyer, Raoul Orvieto, Ariel Israel, Aya Mohr-Sasson, Yael Timerman, Tal Gorodesky, Shlomo Toussia-Cohen, Israel Hendler, Michal J Simchen, Ronit Machtinger
BACKGROUND: Pregnancies in the fifth and sixth decades of life have been increasing, but current data are limited regarding the outcomes of twin compared with singleton pregnancies in this age group and to twin pregnancies at younger age. OBJECTIVE: To compare obstetrical and neonatal outcomes of IVF conceived pregnancies, in twin gestations of women who were ≥45 years old at delivery to singletons at similar age and twin gestations at the age of <35 years, and to assess if the complications are mainly influenced by the very advanced maternal age or by the multifetal pregnancy...
December 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Artur Fedorowski
Postural Orthostatic Tachycardia Syndrome (POTS) is a variant of cardiovascular autonomic disorder characterised by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects younger individuals 15-45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0.2 and 1.0% in developed countries. The onset of POTS is typically precipitated by immunological stressors such as viral infection, vaccination, trauma, pregnancy, surgery or psychosocial stress. The most common complaints are dizziness, weakness, rapid heartbeat and palpitation on standing...
October 29, 2018: Journal of Internal Medicine
Mihai Dimitriu, Cringu Antoniu Ionescu, Alexandra Matei, Roxana Viezuina, George Rosu, Corina Ilinca, Mihai Banacu, Liana Ples
RATIONALE: The extent of pregnancy in adolescents and young adults, especially in low and middle-income countries, is a source of increasing concern given its social and economic impact. AIMS AND OBJECTIVE: We hypothesized that there would be correlations between female patients becoming pregnant at a young age and practices such as harmful alcohol misuse, cigarette smoking, and drug use, the use of toxic substances, low educational attainment, and an essential absence of health care seeking about the outcome of adolescent pregnancies...
October 17, 2018: Journal of Evaluation in Clinical Practice
Saeed Baradwan, Abdullah Alyousef, Abdulrhman Turkistani
Background: Iron deficiency anemia (IDA) during pregnancy is a common and preventable disorder. It remains a contributing factor to maternal morbidity and mortality and is associated with high perinatal mortality rates. Objective: To determine the prevalence of IDA and its associated clinical features among pregnant women. Methods: This analytical prospective cohort study included 1,579 pregnant women who attended an antenatal clinic, Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia, between January 2018 and April 2018...
2018: Journal of Blood Medicine
Jennifer Sanderson Slutsker, Robin R Hennessy, Julia A Schillinger
Congenital syphilis occurs when syphilis is transmitted from a pregnant woman to her fetus; congenital syphilis can be prevented through screening and treatment during pregnancy. Transmission to the fetus can occur at any stage of maternal infection, but is more likely during primary and secondary syphilis, with rates of transmission up to 100% at these stages (1). Untreated syphilis during pregnancy can cause spontaneous abortion, stillbirth, and early infant death. During 2013-2017, national rates of congenital syphilis increased from 9...
October 5, 2018: MMWR. Morbidity and Mortality Weekly Report
Winnie Huiyan Sim, Hamon Ng, Penelope Sheehan
PURPOSE: To provide center-based outcome data on obstetric and neonatal complications arising from expectantly managed pregnancies affected by preterm prelabor rupture of membranes (PPROM) before viability. MATERIALS AND METHODS: We collected data on 130 consecutive pregnancies complicated by spontaneous rupture of membranes before 24 week's gestation, occurring over a 7-year period. These were women who delivered >24 h after membrane rupture, and had no signs of chorioamnionitis or advanced labor at admission...
August 13, 2018: Journal of Maternal-fetal & Neonatal Medicine
U Valerie, S De Brucker, M De Brucker, V Vloeberghs, P Drakopoulos, S Santos-Ribeiro, H Tournaye
STUDY QUESTION: Should we opt for surgical vasovasostomy or IVF/ICSI after a vasectomy? SUMMARY ANSWER: Both options reveal acceptable pregnancy rates though the time to pregnancy was significantly lower in the immediate IVF/ICSI group. WHAT IS KNOWN ALREADY: About 7.4% of men regret their vasectomy and express a renewed child wish. The choice between surgical vasectomy reversal or ICSI remains difficult for patients and their fertility specialist...
July 1, 2018: Human Reproduction
Noni Richards, David Reith, Michael Stitely, Alesha Smith
BACKGROUND: Antiepileptic drugs (AEDs) are used by pregnant women to manage conditions such as epilepsy and bipolar disorder even though they pose a risk to the developing foetus. This study aimed to determine the overall use of AEDs by women during their childbearing years and women who are pregnant and the association between AED use and rates of pregnancy termination and spontaneous abortion. METHODS: Retrospective population based cohort study using administrative databases in New Zealand between 2008 and 2014...
April 6, 2018: BMC Pregnancy and Childbirth
F W Wang, S M Fu, Y C Jin, X H Gong, H D Cheng, K J Wu
Objective: To investigate the principles of diagnosis and treatment of breast cancer during pregnancy. Methods: Clinical data of patients with breast cancer during pregnancy admitted to Obstetrics and Gynecology Hospital of Fudan University between January 2012 to July 2017 were analyzed retrospectively. A total of 17 patients were diagnosed with breast cancer in pregnancy, the median age was 32 years (range from 25 to 45 years old), pathological staging revealed 2 patient with stage 0, 1 with stage Ⅱa, 7 with stage Ⅱb, 1 with stage Ⅲa, 2 with stage Ⅲc, 4 with stage Ⅳ...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Vitaly A Kushnir, Maxie Safdie, Sarah K Darmon, David F Albertini, David H Barad, Norbert Gleicher
INTRODUCTION: Infertile women with severely diminished ovarian reserve who have low birth chances with in vitro fertilization (IVF) are often denied treatment with autologous oocytes. This study was designed to determine age-specific treatment efficacy and clinical characteristics of infertile women with severely diminished ovarian reserve who had live birth following IVF with autologous oocytes. METHODS: This retrospective cohort study investigated 291 infertile women who underwent 482 IVF cycles with autologous oocytes during 2004 to 2016 at our academically affiliated private fertility center...
June 2018: Reproductive Sciences
Pierre-Yves Robillard, Malik Boukerrou, Francesco Bonsante, Thomas C Hulsey, Gustaaf Dekker, Jean-Bernard Gouyon, Silvia Iacobelli
PURPOSE: To investigate the association between maternal age and spontaneous breech presentation. MATERIAL AND METHODS: Fifteen-year observational study over (2001-2015). All consecutive singleton births delivered at the Centre Hospitalier Universitaire Sud Reunion's maternity. The only single exclusion criterion was uterine malformations (N = 123) women. RESULTS: Of the 60,963 singleton births, there was a linear association (χ2 for linear trend, p< 0...
February 2018: Journal of Maternal-fetal & Neonatal Medicine
Emiko Kanazawa, Akira Nakashima, Koji Yonemoto, Misako Otsuka, Naomi Yoshioka, Takeshi Kuramoto, Hiroshi Mitao, Hiroto Imaishi, Kan Komai, Kimio Ushijima
AIM: This retrospective cohort study evaluated the effectiveness of injury to the endometrium prior to the frozen-thawed embryo transfer (FET) cycle in patients with repeated implantation failure (RIF) in our clinic. METHODS: Included in this study were 173 patients, aged ≤ 41 years, who failed to become pregnant after repeating fair and/or good embryo transfer more than twice between February 2012 and February 2015. The patients were divided into three groups: Group A (n = 38) underwent soft curettage to the endometrium twice, prior to the FET cycle; Group B (n = 45) underwent hysteroscopy prior to the FET cycle, with no significant factors, such as endometrial polyp; and Group C (n = 90) was the no-treatment group...
January 2017: Journal of Obstetrics and Gynaecology Research
Kathrine Fodstad, Anne Cathrine Staff, Katariina Laine
INTRODUCTION AND HYPOTHESIS: Knowledge on sexual complaints and time to sexual resumption after obstetric anal sphincter injury (OASI) is scarce. The aim of the study was to investigate self-reported sexual activity and coital problems 1 year postpartum in relation to perineal trauma, in addition to delivery mode. METHODS: Among 2,846 women recruited during pregnancy, all women who delivered with OASI (n = 42, all third-degree perineal tears), in addition to 20 randomly selected controls per OASI case, a total of 882 women, were sent a self-administered questionnaire addressing time to coital resumption after delivery and potential coital difficulty 1 year postpartum...
October 2016: International Urogynecology Journal
Jean Marie Kasia, Jean Dupont Kemfang Ngowa, Yolande Salome Mimboe, Michel Toukam, Anny Ngassam, Claude Cyrile Noa, Etienne Belinga, Alexis Medou
BACKGROUND: More than 70 million couples suffer from infertility worldwide. The aim of this study was to evaluate the fertility outcomes after laparoscopic fimbrioplasty and neosalpingostomy in female infertility. METHODS: Laparoscopic distal tuboplasty was carried out for 402 cases at the Gynecological Endoscopic Surgery and Human Reproductive Teaching Hospital in Yaoundé-Cameroon in Central Africa from December 2002 to December 2007. Laparoscopic fimbrioplasty and neosalpingostomy were done using bipolar electrocoagulation and conventional endoscopic instruments...
April 2016: Journal of Reproduction & Infertility
Xavier Santamaria, Sergio Cabanillas, Irene Cervelló, Cristina Arbona, Francisco Raga, Jaime Ferro, Julio Palmero, Jose Remohí, Antonio Pellicer, Carlos Simón
STUDY QUESTION: Could cell therapy using autologous peripheral blood CD133+ bone marrow-derived stem cells (BMDSCs) offer a safe and efficient therapeutic approach for patients with refractory Asherman's syndrome (AS) and/or endometrial atrophy (EA) and a wish to conceive? SUMMARY ANSWER: In the first 3 months, autologous cell therapy, using CD133+ BMDSCs in conjunction with hormonal replacement therapy, increased the volume and duration of menses as well as the thickness and angiogenesis processes of the endometrium while decreasing intrauterine adhesion scores...
May 2016: Human Reproduction
Lorene A Temming, Jennifer K Durst, Methodius G Tuuli, Molly J Stout, Jeffrey M Dicke, George A Macones, Alison G Cahill
BACKGROUND: Transvaginal measurement of cervical length (CL) has been advocated as a screening tool to prevent preterm birth, but controversy remains regarding the overall utility of universal screening. OBJECTIVE: We aimed to evaluate the acceptability of a universal CL screening program. Additionally we evaluated risk factors associated with declining screening and subsequent delivery outcomes of women who accepted or declined screening. STUDY DESIGN: This was a retrospective cohort study of transvaginal CL screening at a single institution from July 1, 2011, through December 31, 2014...
April 2016: American Journal of Obstetrics and Gynecology
Nigel Pereira, Selma Amrane, Elie Hobeika, Jovana P Lekovich, Pak H Chung, Zev Rosenwaks
The primary objective of this study is to investigate the effect of transvaginal ultrasonogram (TVUS)-guided cyst aspiration or gonadotropin releasing hormone antagonist (GnRH-ant) administration for the management of solitary ovarian cysts detected at the start of in vitro fertilization (IVF) cycles on the outcomes of the same cycles. This is a single-center, retrospective, cohort study of patients who had TVUS-guided cyst aspiration or GnRH-ant treatment for ovarian cysts detected at the start of IVF during a 5-year period...
July 2016: Gynecological Endocrinology
Esther Granot, Etienne M Sokal
The major route of hepatitis C virus (HCV) infection in the pediatric age group is vertical, with infection occurring in up to 5% of infants born to mothers positive for HCV-RNA. The natural course of pediatric HCV infection is characterized by a high rate of spontaneous clearance, an asymptomatic clinical course, and normal or mild histologic changes. Cirrhosis is reported in 1-2% of children, and progression to severe chronic liver disease and HCC occurs 20-30 years after infection. Treatment with pegylated interferon (Peg-IFN) + ribavirin results in a sustained viral response (SVR) reaching 100% in children with HCV genotypes 2 or 3 but only 45-55% in those infected with genotypes 1 or 4...
November 2015: Israel Medical Association Journal: IMAJ
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