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Sebaceous Glands

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https://read.qxmd.com/read/30886049/mutant-lef1-controls-gata6-in-sebaceous-gland-development-and-cancer
#1
Bénédicte Oulès, Emanuel Rognoni, Esther Hoste, Georgina Goss, Ryan Fiehler, Ken Natsuga, Sven Quist, Remco Mentink, Giacomo Donati, Fiona M Watt
Mutations in Lef1 occur in human and mouse sebaceous gland (SG) tumors, but their contribution to carcinogenesis remains unclear. Since Gata6 controls lineage identity in SG, we investigated the link between these two transcription factors. Here, we show that Gata6 is a β-catenin-independent transcriptional target of mutant Lef1. During epidermal development, Gata6 is expressed in a subset of Sox9-positive Lef1-negative hair follicle progenitors that give rise to the upper SG Overexpression of Gata6 by in utero lentiviral injection is sufficient to induce ectopic sebaceous gland elements...
March 18, 2019: EMBO Journal
https://read.qxmd.com/read/30864673/induction-of-cardiomyocyte%C3%A2-like-cells-from-hair-follicle-cells-in-mice
#2
Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Hair follicles (HFs) are a well‑characterized niche for adult stem cells (SCs), and include epithelial and melanocytic SCs. HF cells are an accessible source of multipotent adult SCs for the generation of the interfollicular epidermis, HF structures and sebaceous glands in addition to the reconstitution of novel HFs in vivo. In the present study, it was demonstrated that HF cells are able to be induced to differentiate into cardiomyocyte‑like cells in vitro under specific conditions. It was determined that HF cells cultured on OP9 feeder cells in KnockOut‑Dulbecco's modified Eagle's medium/B27 in the presence of vascular endothelial growth factors differentiated into cardiomyocyte‑like cells that express markers specific to cardiac lineage, but do not express non‑cardiac lineage markers including neural stem/progenitor cell, HF bulge cells or undifferentiated spermatogonia markers...
March 13, 2019: International Journal of Molecular Medicine
https://read.qxmd.com/read/30821089/establishment-and-characterization-of-a-radiation-induced-dermatitis-rat-model
#3
Xiaowu Sheng, Yue Zhou, Hui Wang, Yongyi Shen, Qianjin Liao, Zhen Rao, Feiyan Deng, Luyuan Xie, Chaoling Yao, Huangxing Mao, Zhiyan Liu, Mingjing Peng, Ying Long, Yong Zeng, Lei Xue, Nina Gao, Yu Kong, Xiao Zhou
Radiation-induced dermatitis is a common and serious side effect after radiotherapy. Current clinical treatments cannot efficiently or fully prevent the occurrence of post-irradiation dermatitis, which remains a significant clinical problem. Resolving this challenge requires gaining a better understanding of the precise pathophysiology, which in turn requires establishment of a suitable animal model that mimics the clinical condition, and can also be used to investigate the mechanism and explore effective treatment options...
February 28, 2019: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30792099/androgens-modulate-keratinocyte-differentiation-indirectly-through-enhancing-growth-factor-production-from-dermal-fibroblasts
#4
Chanat Kumtornrut, Takeshi Yamauchi, Saaya Koike, Setsuya Aiba, Kenshi Yamasaki
BACKGROUND: The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated. OBJECTIVE: We hypothesized that the androgens affect the dermal fibroblasts, another androgen receptor-positive cells in the skin, resulting in abnormal keratinization through keratinocyte-fibroblast interaction...
January 26, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/30789543/steatocystoma-simplex-of-the-caruncle-case-report-and-immunohistologic-study
#5
Norman C Charles, Frederick A Jakobiec, Lina Ma, Irina Belinsky
A yellow cystic lesion of the caruncle in a 23-year-old woman proved to be a solitary steatocystoma, a rare occurrence in that location. While the histopathologic diagnosis was evident from clusters of sebaceous cells within the cyst wall, a panel of immunohistochemical stains further distinguished the lesion from a keratinous cyst. The most useful stains for differentiating the two conditions were carcinoembryonic antigen, epithelial membrane antigen, cytokeratins 17 and 19, and calretinin. Only three previous cases of caruncular steatocystoma simplex have been reported, none of which included immunohistochemical studies...
February 14, 2019: Ophthalmic Plastic and Reconstructive Surgery
https://read.qxmd.com/read/30775086/biophysical-basis-of-skin-cancer-margin-assessment-using-raman-spectroscopy
#6
Xu Feng, Matthew C Fox, Jason S Reichenberg, Fabiana C P S Lopes, Katherine R Sebastian, Mia K Markey, James W Tunnell
Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear...
January 1, 2019: Biomedical Optics Express
https://read.qxmd.com/read/30774262/histological-changes-of-immediate-skin-expansion-of-the-distal-limb-of-rats
#7
Ahmed Khalaf Ali, Adamu Abdul Abubakar, Ubedullah Kaka, Zamri Radzi, Nurul Hayah Khairuddin, Md Sabri Mohd Yusoff, Mohamad Yusof Loqman
Aim: Tissue expansion is an applicable technique to reconstruct many surgical defects. The aim of this research was to evaluate the histological changes caused by immediate skin tissue expansion in rats as an animal model. Materials and Methods: Immediate skin tissue expansion in 18 adult female rats was performed using three different sizes (small, medium, and big) of polymethylmethacrylate tissue expanders at the dorsal surface of the metatarsal area of the right limb...
December 2018: Veterinary World
https://read.qxmd.com/read/30763861/lymphoepithelial-cyst-of-the-pancreas-a-case-report-and-summary-of-imaging-features-of-pancreatic-cysts
#8
Yosuke Namba, Akihiko Oshita, Takashi Nishisaka, Maiko Namba, Tamito Sasaki, Yasuhiro Matsugu, Toshiyuki Itamoto
INTRODUCTION: A lymphoepithelial cyst (LEC) of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. PRESENTATION OF CASE: We report a case of a 49-year-old man who presented with weight loss and diarrhea. The serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were slightly elevated to 6.7 ng/mL (reference value <5.0 ng/mL) and 45 U/mL (reference value <37 U/mL), respectively...
January 30, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30762198/the-skin-rejuvenation-associated-treatment-fraxel-laser-microbotox-and-low-g-prime-hyaluronic-acid-preliminary-results
#9
Dario Bertossi, Giorgio Giampaoli, Alessandra Lucchese, Maurizio Manuelli, Massimo Albanese, Riccardo Nocini, Pier Francesco Nocini
Minimally invasive facial rejuvenation procedures reached an all-time high in the 2016. This reveals a growing interest in a smoother, younger, and tighter look accessible using the esthetic medicine tools like botulinum toxin and dermal filler injections, laser, and microdermabrasion. Forty-five patients from 35 to 52 years old (medium age 43.8), 38 women and 7 men underwent 5 sessions of Fraxel laser, 1 session of very low G prime HA, and Microbotox injection treatments from January 2016 and January 2017, were included in this study...
February 14, 2019: Lasers in Medical Science
https://read.qxmd.com/read/30745961/efficacy-of-surgical-excision-for-nevus-sebaceous-vietnamese-experience
#10
Thuong Nguyen Van, Hien Le Thanh, Tan Nguyen Manh, Phuong Pham Thi Minh, Kiem Pham Cao, Sơn Nguyen Hong, Nghi Dinh Huu, Van Tran Cam, My Le Huyen, Khang Tran Hau, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Nevus Sebaceous (NS) is hamartoma predominantly composed of sebaceous glands and is classified as a type of epidermal nevus. In most case, clinical manifestation of NS is typical, so histopathology examination is important only in atypical lesions for its risk of malignancy. Clinical symptoms are plaques or papules (100%), appearing in the head area (100%) with smooth surface (65.8%), usually with hair loss (60.7%). The histopathology is mostly characterized by the image of sebaceous gland hyperplasia (100%), no hair follicles (60...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
https://read.qxmd.com/read/30745635/a-study-of-the-histopathological-features-of-alopecias-on-transverse-sections-of-scalp-biopsies
#11
Mankul Goyal, Sujay Khandpur, M Ramam, Vinod Kumar Sharma, Manoj Kumar Singh
Background: Transverse sections of scalp biopsies are performed for the assessment of alopecias and are considered advantageous over vertical sections. Aim: The aim was to study the histopathological features of alopecias on transverse sections of scalp biopsies. Methods: It was a descriptive study. Clinically confirmed cases of noncicatricial and cicatricial alopecias were subjected to 4 mm scalp biopsies, which were sectioned transversely and analyzed...
January 2019: Indian Journal of Dermatology
https://read.qxmd.com/read/30739729/partial-thickness-wound-does-mechanism-of-injury-influence-healing
#12
Shagufta Jabeen, Ethan C S Clough, Alison M Thomlinson, Sarah L Chadwick, Mark W J Ferguson, Mamta Shah
Wound healing is a complex multistep process which is temporally and spatially controlled. In partial thickness wounds, regeneration is possible from the stem cells in the edges of the wound and from the remnants of the epidermal appendages (such as hair follicles and sebaceous glands). This study examines whether the mechanism of injury influences healing of wounds of similar depth. Burn and excisional wounds were created on the back of Hampshire pigs and harvested at 7, 14, 28, 44, 57 and 70days after injury and processed for histology and immunohistochemistry...
February 7, 2019: Burns: Journal of the International Society for Burn Injuries
https://read.qxmd.com/read/30737272/short-chain-fatty-acids-from-cutibacterium-acnes-activate-both-a-canonical-and-epigenetic-inflammatory-response-in-human-sebocytes
#13
James A Sanford, Alan M O'Neill, Christos C Zouboulis, Richard L Gallo
The regulation of cutaneous inflammatory processes is essential for the human skin to maintain homeostasis in the presence of the dense communities of resident microbes that normally populate this organ. Forming the hair follicle-associated sebaceous gland, sebocytes are specialized lipid-producing cells that can release inflammatory mediators. Cytokine and chemokine expression by pilosebaceous epithelial cells (i.e., sebocytes and follicular keratinocytes) has been proposed to contribute to the common human skin disease acne vulgaris...
February 8, 2019: Journal of Immunology: Official Journal of the American Association of Immunologists
https://read.qxmd.com/read/30732579/damage-to-sebaceous-gland-and-the-efficacy-of-moisturizer-after-whole-breast-radiotherapy-a-randomized-controlled-trial
#14
Mami Ogita, Kenji Sekiguchi, Keiko Akahane, Ryoko Ito, Chiori Haga, Satoru Arai, Yasushi Ishida, Jiro Kawamori
BACKGROUND: We conducted a randomized trial to evaluate the efficacy of heparinoid moisturization for radiation dermatitis. We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficacy of heparinoid moisturizer. METHODS: Patients receiving adjuvant breast RT were randomly assigned into three groups; prophylaxis, post-WBRT and control groups. Patients used moisturizer on the irradiated breast from the beginning of RT in the prophylaxis group, 2 weeks post-RT in the post-WBRT group, and no moisturizer in the control group...
February 7, 2019: BMC Cancer
https://read.qxmd.com/read/30725294/case-report-of-a-proposed-novel-endoscopic-whitehead-pimple-sign-of-ectopic-esophageal-sebaceous-glands-based-on-their-mimicking-the-dermatologic-and-histopathologic-characteristics-of-cutaneous-whitehead-pimples-closed-comedones
#15
https://read.qxmd.com/read/30719727/could-isotretinoin-flare-hidradentis-suppurativa-a-case-series
#16
C G Gallagher, S K Kirthi, C C Cotter, J R Revuz, A M T Tobin
We report eight cases of patients with severe acne who were treated with Isotretinoin and developed painful nodules in their axillae and groin consistent with Hidradenitis Suppurativa (HS). The pathogenesis of HS is still not completely understood; recent research from a study in 2011 of biopsies from HS lesions showed a reduction or absence of sebaceous glands compared to normal skin in HS patients and the author suggested this contributes to the pathogenesis of the disease. Interestingly the main effect of Isotretinoin is to decrease the size and action of sebaceous glands; so hypothetically, as Isotretinoin acts by reducing the sebaceous glands further it could potentially aggravate the condition...
February 5, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30712873/homeostatic-control-of-sebaceous-glands-by-innate-lymphoid-cells-regulates-commensal-bacteria-equilibrium
#17
Tetsuro Kobayashi, Benjamin Voisin, Do Young Kim, Elizabeth A Kennedy, Jay-Hyun Jo, Han-Yu Shih, Amanda Truong, Thomas Doebel, Keiko Sakamoto, Chang-Yi Cui, David Schlessinger, Kazuyo Moro, Susumu Nakae, Keisuke Horiuchi, Jinfang Zhu, Warren J Leonard, Heidi H Kong, Keisuke Nagao
Immune cells and epithelium form sophisticated barrier systems in symbiotic relationships with microbiota. Evidence suggests that immune cells can sense microbes through intact barriers, but regulation of microbial commensalism remain largely unexplored. Here, we uncovered spatial compartmentalization of skin-resident innate lymphoid cells (ILCs) and modulation of sebaceous glands by a subset of RORγt+ ILCs residing within hair follicles in close proximity to sebaceous glands. Their persistence in skin required IL-7 and thymic stromal lymphopoietin, and localization was dependent on the chemokine receptor CCR6...
January 25, 2019: Cell
https://read.qxmd.com/read/30702455/intraoral-cutaneous-hamartomas-clinicopathologic-and-immunohistochemical-characteristics-of-3-cases
#18
Peter E Wilkinson, Rajaram Gopalakrishnan, Prokopios P Argyris
Intraoral cutaneous hamartomas (ICHs) are uncommon mucosal lesions characterized microscopically by a combination of cutaneous structures, including various stages of follicular and sebaceous elements. Due to their rarity, the clinicopathologic and immunohistochemical attributes of ICHs have not been thoroughly delineated. Three cases of ICH were identified from our records, and formalin-fixed paraffin-embedded sections were immunohistochemically stained with antibodies against androgen receptor, estrogen receptor, and progesterone receptor, p63, factor XIIIα, and CD34...
January 22, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30693453/a-guide-to-yellow-oral-mucosal-entities-etiology-and-pathology
#19
Duane R Schafer, Sarah H Glass
When faced with an uncertain clinical pathosis in the oral cavity, identifying the color of the mucosal lesion helps to narrow down a differential diagnosis. Although less common than red and white lesions, yellow lesions encompass a small group of distinct mucosal pathologic entities. Adipose tissue, lymphoid tissue, and sebaceous glands are naturally occurring yellow constituents of the oral cavity and become apparent with associated developmental or neoplastic lesions. Reactive and inflammatory lesions can create a yellow hue due to purulence, necrosis, and calcification...
January 31, 2019: Head and Neck Pathology
https://read.qxmd.com/read/30688020/clinical-efficacy-of-0-5-topical-mangosteen-extract-in-nanoparticle-loaded-gel-in-treatment-of-mild-to-moderate-acne-vulgaris-a-12-week-split-face-double-blinded-randomized-controlled-trial
#20
Suparuj Lueangarun, Karuna Sriviriyakul, Therdpong Tempark, Chittima Managit, Pongtip Sithisarn
BACKGROUND: Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. OBJECTIVES: To evaluate the efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel (containing alpha-mangostin) compared with 1% clindamycin gel for treatment of mild-to-moderate acne vulgaris. METHODS: Patients aged 18-40 years were enrolled in this double-blinded, split-face, randomized, control study...
January 27, 2019: Journal of Cosmetic Dermatology
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