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JOURNAL ARTICLE
Blake Martin, Peter E DeWitt, Seth Russell, L Nelson Sanchez-Pinto, Melissa A Haendel, Richard Moffitt, Tellen D Bennett
No abstract text is available yet for this article.
April 15, 2022: JAMA Pediatrics
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JOURNAL ARTICLE
Christopher A French, Michael L Cheng, Glenn J Hanna, Steven G DuBois, Nicole G Chau, Christine L Hann, Simone Storck, Ravi Salgia, Matteo Trucco, Jennifer Tseng, Anastasios Stathis, Richard Piekarz, Ulrich M Lauer, Christophe Massard, Kelly Bennett, Shodeinde Coker, Ulrike Tontsch-Grunt, Martin L Sos, Sida Liao, Catherine J Wu, Kornelia Polyak, Sarina A Piha-Paul, Geoffrey I Shapiro
NUT carcinoma is a rare, aggressive cancer defined by rearrangements of the NUTM1 gene. No routinely effective treatments of NUT carcinoma exist, despite harboring a targetable oncoprotein, most commonly BRD4-NUT. The vast majority of cases are fatal. Poor awareness of the disease is a major obstacle to progress in the treatment of NUT carcinoma. While the incidence likely exceeds that of Ewing sarcoma, and BRD4-NUT heralded the bromodomain and extra-terminal domain (BET) inhibitor class of selective epigenetic modulators, NUT carcinoma is incorrectly perceived as "impossibly rare," and therefore receives comparatively little private or governmental funding or prioritization by pharma...
June 13, 2022: Clinical Cancer Research
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JOURNAL ARTICLE
Vincenzo Tufaro, Patrick W Serruys, Lorenz Räber, Martin R Bennett, Ryo Torii, Sophie Z Gu, Yoshinobu Onuma, Anthony Mathur, Andreas Baumbach, Christos Bourantas
Intravascular imaging has been often used over the recent years to examine the efficacy of emerging therapies targeting plaque evolution. Serial intravascular ultrasound, optical coherence tomography, or near infrared spectroscopy-intravascular ultrasound studies have allowed us to evaluate the effects of different therapies on plaque burden and morphology, providing unique mechanistic insights about the mode of action of these treatments. Plaque burden reduction, a decrease in necrotic core component or macrophages accumulation - that have been associated with inflammation - and an increase in fibrous cap thickness over fibroatheromas have been used as surrogate endpoints to assess the value of several drugs in inhibiting plaque evolution and improving clinical outcomes...
April 8, 2022: Cardiovascular Research
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JOURNAL ARTICLE
Bep Uink, Rebecca Bennett, Jonathan Bullen, Ashleigh Lin, Gregory Martin, Jenna Woods, Yin Paradies
Previous studies on the impacts of racism on adolescent development have largely overlooked Indigenous youth. We conducted a scoping review of the empirical literature on racism against Indigenous adolescents to determine the nature and scope of this research and to establish associations with developmental outcomes. Our literature search resulted in 32 studies with samples from the United States, Canada, Australia and New Zealand. Studies were limited to self-reported experiences of racism and thus primarily focused on perceived discrimination...
April 3, 2022: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
#205
JOURNAL ARTICLE
Karen Colwill, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, Jenny H Wang, Adrian Pasculescu, Mariam Maltseva, Lynda Rocheleau, Martin Pelchat, Mahya Fazel-Zarandi, Mariam Iskilova, Miriam Barrios-Rodiles, Linda Bennett, Kevin Yau, François Cholette, Christine Mesa, Angel X Li, Aimee Paterson, Michelle A Hladunewich, Pamela J Goodwin, Jeffrey L Wrana, Steven J Drews, Samira Mubareka, Allison J McGeer, John Kim, Marc-André Langlois, Anne-Claude Gingras, Yves Durocher
Objectives: Antibody testing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been instrumental in detecting previous exposures and analyzing vaccine-elicited immune responses. Here, we describe a scalable solution to detect and quantify SARS-CoV-2 antibodies, discriminate between natural infection- and vaccination-induced responses, and assess antibody-mediated inhibition of the spike-angiotensin converting enzyme 2 (ACE2) interaction. Methods: We developed methods and reagents to detect SARS-CoV-2 antibodies by enzyme-linked immunosorbent assay (ELISA)...
2022: Clinical & Translational Immunology
#206
REVIEW
Mandy O J Grootaert, Martin R Bennett
Sirtuins are NAD+ -dependent deacetylase and deacylase enzymes that control important cellular processes, including DNA damage repair, cellular metabolism, mitochondrial function and inflammation. Consequently, mammalian sirtuins are regarded as crucial regulators of cellular function and organism healthspan. Sirtuin activity and NAD+ levels decrease with age in many tissues, and reduced sirtuin expression is associated with several cardiovascular diseases. By contrast, increased sirtuin expression and activity slows disease progression and improves cardiovascular function in preclinical models and delays various features of cellular ageing...
October 2022: Nature Reviews. Cardiology
#207
REVIEW
Jason Beringer, Caitlin E Moore, Jamie Cleverly, David I Campbell, Helen Cleugh, Martin G De Kauwe, Miko U F Kirschbaum, Anne Griebel, Sam Grover, Alfredo Huete, Lindsay B Hutley, Johannes Laubach, Tom Van Niel, Stefan K Arndt, Alison C Bennett, Lucas A Cernusak, Derek Eamus, Cacilia M Ewenz, Jordan P Goodrich, Mingkai Jiang, Nina Hinko-Najera, Peter Isaac, Sanaa Hobeichi, Jürgen Knauer, Georgia R Koerber, Michael Liddell, Xuanlong Ma, Craig Macfarlane, Ian D McHugh, Belinda E Medlyn, Wayne S Meyer, Alexander J Norton, Jyoteshna Owens, Andy Pitman, Elise Pendall, Suzanne M Prober, Ram L Ray, Natalia Restrepo-Coupe, Sami W Rifai, David Rowlings, Louis Schipper, Richard P Silberstein, Lina Teckentrup, Sally E Thompson, Anna M Ukkola, Aaron Wall, Ying-Ping Wang, Tim J Wardlaw, William Woodgate
In 2020, the Australian and New Zealand flux research and monitoring network, OzFlux, celebrated its 20th anniversary by reflecting on the lessons learned through two decades of ecosystem studies on global change biology. OzFlux is a network not only for ecosystem researchers, but also for those 'next users' of the knowledge, information and data that such networks provide. Here, we focus on eight lessons across topics of climate change and variability, disturbance and resilience, drought and heat stress and synergies with remote sensing and modelling...
March 22, 2022: Global Change Biology
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REVIEW
Aryan Haratian, Arif Musa, Ryan Field, Saif Farhan, Collin Bennett, Christopher Cooke, Rakesh D Patel, Ilyas S Aleem, Martin C Eichler, Karan Rajalingam, Carlin Lee, Samuel Bederman
Background: This study aimed to evaluate the role of intravenous lidocaine as a supplemental pain control modality in patients undergoing spine surgery. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) involving the use of supplemental intravenous lidocaine in spine surgery. We developed a comprehensive search strategy to adequately screen for randomized controlled trials involving intravenous lidocaine in spine surgery. Continuous outcomes included postoperative opiate consumption and postoperative pain scores...
September 2021: N Am Spine Soc J
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JOURNAL ARTICLE
Funda Meric-Bernstam, Nizar M Tannir, Othon Iliopoulos, Richard J Lee, Melinda L Telli, Alice C Fan, Angela DeMichele, Naomi B Haas, Manish R Patel, James J Harding, Martin H Voss, Taofeek K Owonikoko, Bradley Carthon, Ramaprasad Srinivasan, Johanna C Bendell, Yonchu Jenkins, Sam H Whiting, Keith Orford, Mark K Bennett, Todd M Bauer
PURPOSE: Dual inhibition of glucose and glutamine metabolism results in synergistic anticancer effects in solid tumor models. Telaglenastat, an investigational, small-molecule, glutaminase inhibitor, exhibits modest single-agent activity in renal cell carcinoma (RCC) patients. This phase Ib trial evaluated telaglenastat plus cabozantinib or everolimus, agents known to impair glucose metabolism in patients with metastatic RCC (mRCC). PATIENTS AND METHODS: mRCC patients received escalating doses of telaglenastat [400-800 mg per os (p...
April 14, 2022: Clinical Cancer Research
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MULTICENTER STUDY
Blake Martin, Peter E DeWitt, Seth Russell, Adit Anand, Katie R Bradwell, Carolyn Bremer, Davera Gabriel, Andrew T Girvin, Janos G Hajagos, Julie A McMurry, Andrew J Neumann, Emily R Pfaff, Anita Walden, Jacob T Wooldridge, Yun Jae Yoo, Joel Saltz, Ken R Gersing, Christopher G Chute, Melissa A Haendel, Richard Moffitt, Tellen D Bennett
IMPORTANCE: Understanding of SARS-CoV-2 infection in US children has been limited by the lack of large, multicenter studies with granular data. OBJECTIVE: To examine the characteristics, changes over time, outcomes, and severity risk factors of children with SARS-CoV-2 within the National COVID Cohort Collaborative (N3C). DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of encounters with end dates before September 24, 2021, was conducted at 56 N3C facilities throughout the US...
February 1, 2022: JAMA Network Open
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JOURNAL ARTICLE
Nicole L Welch, Meilin Zhu, Catherine Hua, Juliane Weller, Marzieh Ezzaty Mirhashemi, Tien G Nguyen, Sreekar Mantena, Matthew R Bauer, Bennett M Shaw, Cheri M Ackerman, Sri Gowtham Thakku, Megan W Tse, Jared Kehe, Marie-Martine Uwera, Jacqueline S Eversley, Derek A Bielwaski, Graham McGrath, Joseph Braidt, Jeremy Johnson, Felecia Cerrato, Gage K Moreno, Lydia A Krasilnikova, Brittany A Petros, Gabrielle L Gionet, Ewa King, Richard C Huard, Samantha K Jalbert, Michael L Cleary, Nicholas A Fitzgerald, Stacey B Gabriel, Glen R Gallagher, Sandra C Smole, Lawrence C Madoff, Catherine M Brown, Matthew W Keller, Malania M Wilson, Marie K Kirby, John R Barnes, Daniel J Park, Katherine J Siddle, Christian T Happi, Deborah T Hung, Michael Springer, Bronwyn L MacInnis, Jacob E Lemieux, Eric Rosenberg, John A Branda, Paul C Blainey, Pardis C Sabeti, Cameron Myhrvold
The coronavirus disease 2019 (COVID-19) pandemic has demonstrated a clear need for high-throughput, multiplexed and sensitive assays for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses and their emerging variants. Here, we present a cost-effective virus and variant detection platform, called microfluidic Combinatorial Arrayed Reactions for Multiplexed Evaluation of Nucleic acids (mCARMEN), which combines CRISPR-based diagnostics and microfluidics with a streamlined workflow for clinical use...
May 2022: Nature Medicine
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JOURNAL ARTICLE
Hannah C Slater, Xavier C Ding, Sophia Knudson, Daniel J Bridges, Hawela Moonga, Neil J Saad, Martin De Smet, Adam Bennett, Sabine Dittrich, Laurence Slutsker, Gonzalo J Domingo
BACKGROUND: A new more highly sensitive rapid diagnostic test (HS-RDT) for Plasmodium falciparum malaria (Alere™/Abbott Malaria Ag P.f RDT [05FK140], now called NxTek™ Eliminate Malaria Ag Pf) was launched in 2017. The test has already been used in many research studies in a wide range of geographies and use cases. METHODS: In this study, we collate all published and available unpublished studies that use the HS-RDT and assess its performance in (i) prevalence surveys, (ii) clinical diagnosis, (iii) screening pregnant women, and (iv) active case detection...
February 4, 2022: BMC Infectious Diseases
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JOURNAL ARTICLE
Rajiv Agarwal, Henry J Domenico, Sreenivasa R Balla, Daniel W Byrne, Jennifer G Whisenant, Marcella C Woods, Barbara J Martin, Mohana B Karlekar, Marc L Bennett
CONTEXT: The optimal strategy for implementing mortality-predicting algorithms to facilitate clinical care, prognostic discussions, and palliative care interventions remains unknown. OBJECTIVES: To develop and validate a real-time predictive model for 180 day mortality using routinely available clinical and laboratory admission data and determine if palliative care exposure varies with predicted mortality risk. METHODS: Adult admissions between October 1, 2013 and October...
May 2022: Journal of Pain and Symptom Management
#214
JOURNAL ARTICLE
A Poveda, S Lheureux, N Colombo, D Cibula, K Lindemann, J Weberpals, M Bjurberg, A Oaknin, M Sikorska, A González-Martín, R Madry, M J Rubio Pérez, J Ledermann, R Davidson, C Blakeley, J Bennett, A Barnicle, E Škof
OBJECTIVE: The phase IIIb OPINION trial (NCT03402841) investigated olaparib maintenance monotherapy in patients without a deleterious or suspected deleterious germline BRCA1/BRCA2 mutation (gBRCAm) who had platinum-sensitive relapsed ovarian cancer (PSROC) and had received ≥2 previous lines of platinum-based chemotherapy. METHODS: In this single-arm, open-label, international study, patients who had responded to platinum-based chemotherapy received maintenance olaparib tablets (300 mg twice daily) until disease progression or unacceptable toxicity...
March 2022: Gynecologic Oncology
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JOURNAL ARTICLE
Richard M Gunner, Rory P Wilson, Mark D Holton, Phil Hopkins, Stephen H Bell, Nikki J Marks, Nigel C Bennett, Sam Ferreira, Danny Govender, Pauli Viljoen, Angela Bruns, O Louis van Schalkwyk, Mads F Bertelsen, Carlos M Duarte, Martin C van Rooyen, Craig J Tambling, Aoife Göppert, Delmar Diesel, D Michael Scantlebury
The combined use of global positioning system (GPS) technology and motion sensors within the discipline of movement ecology has increased over recent years. This is particularly the case for instrumented wildlife, with many studies now opting to record parameters at high (infra-second) sampling frequencies. However, the detail with which GPS loggers can elucidate fine-scale movement depends on the precision and accuracy of fixes, with accuracy being affected by signal reception. We hypothesized that animal behaviour was the main factor affecting fix inaccuracy, with inherent GPS positional noise (jitter) being most apparent during GPS fixes for non-moving locations, thereby producing disproportionate error during rest periods...
January 2022: Journal of the Royal Society, Interface
#216
JOURNAL ARTICLE
Jonathan G Best, Liz Arram, Norin Ahmed, Maryam Balogun, Kate Bennett, Ekaterina Bordea, Marta G Campos, Emilia Caverly, Marisa Chau, Hannah Cohen, Hakim-Moulay Dehbi, Caroline J Doré, Stefan T Engelter, Robert Fenner, Nick Freemantle, Rachael Hunter, Martin James, Gregory Yh Lip, Macey L Murray, Bo Norrving, Nikola Sprigg, Roland Veltkamp, Iwona Zaczyk, David J Werring
RATIONALE: Atrial fibrillation causes one-fifth of ischemic strokes, with a high risk of early recurrence. Although long-term anticoagulation is highly effective for stroke prevention in atrial fibrillation, initiation after stroke is usually delayed by concerns over intracranial hemorrhage risk. Direct oral anticoagulants offer a significantly lower risk of intracranial hemorrhage than other anticoagulants, potentially allowing earlier anticoagulation and prevention of recurrence, but the safety and efficacy of this approach has not been established...
June 2022: International Journal of Stroke: Official Journal of the International Stroke Society
#217
JOURNAL ARTICLE
Charles L Bennett, Krishna Gundabolu, Larry W Kwak, Benjamin Djulbegovic, Oscar Champigneulle, Brian Josephson, Linda Martin, Steven T Rosen
No abstract text is available yet for this article.
January 2022: Lancet Haematology
#218
JOURNAL ARTICLE
Caleb P Webb, Martin Huecker, Jacob Shreffler, Bennett S McKinley, Ahsan M Khan, Isaac Shaw
OBJECTIVE: Peer support specialists (PSSs) can effectively link patients with substance use disorders (SUD) to treatment. These specialists can engage patients in treatment after emergency department (ED) visits or inpatient hospitalization, crucial points in time when these patients have contact with the health care system. We describe success of PSSs in recruiting SUD patients into treatment, with attention to racial disparities in linkage to care. METHODS: This is a retrospective, observational cohort study performed at an urban, academic medical center...
December 11, 2021: Journal of Substance Abuse Treatment
#219
JOURNAL ARTICLE
Deanna N Cannizzaro, Lydia F Naughton, Maya Z Freeman, Linda Martin, Charles L Bennett, Cecilia Bove
Background and Objectives: Fluoroquinolones (FQs) are a broad-spectrum class of antibiotics routinely prescribed for common bacterial infections despite recent recommendations to use them only for life-threatening cases. In addition to their antimicrobial properties, FQs act in the central nervous system as GABAA receptor inhibitors, which could potentially affect functionality of the vagus nerve at the forefront of gastrointestinal (GI) tract function. Alterations in neural control of digestion have been shown to be linked to Functional Gastrointestinal Disorders (FGIDs), which are usually diagnosed based on self-reported symptoms...
December 16, 2021: Medicina
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JOURNAL ARTICLE
Martin Reinhardt, Helmut Grubmüller
Free energy calculations based on atomistic Hamiltonians provide microscopic insight into the thermodynamic driving forces of biophysical or condensed matter systems. Many approaches use intermediate Hamiltonians interpolating between the two states for which the free energy difference is calculated. The Bennett acceptance ratio (BAR) and variationally derived intermediates (VI) methods are optimal estimator and intermediate states in that the mean-squared error of free energy calculations based on independent sampling is minimized...
November 2021: Physical Review. E
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