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Metastatic osteosarcoma

Lynn R Griffin, Douglas H Thamm, Ariel Brody, Laura E Selmic
BACKGROUND: Factors indicative of a negative prognosis for appendicular osteosarcoma (OSA) in dogs are visible metastatic disease, location, and size of lesion. In human medicine maximum standard uptake value (SUVmax ), as measured on a fluorine18 flourodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT), is prognostic for survival for several tumor types. OBJECTIVE: Determine if SUVmax is associated with progression-free interval (PFI) and determination of survival in dogs with appendicular OSA...
February 15, 2019: Journal of Veterinary Internal Medicine
Zhi Li, Xiaomin Ding, Haihui Wu, Chao Liu
Osteosarcoma is the most common bone tumor and characterizes a high metastatic potential. In osteosarcoma, angiogenesis is reported to be closely associated with tumor metastasis. Understanding the underlying mechanisms and accordingly developing therapeutic strategies are urgently desired. Antimalarial agent, artemisinin, has been reported to inhibit tumor angiogenesis. However, we still knew little about the effects of artemisinin on angiogenesis and its potential molecular mechanisms in human osteosarcoma...
February 11, 2019: Journal of Cellular Biochemistry
Jisheng Sui, Guoqiang Shao, Lulu Zhang, Pengjun Zhang, Ting Bu, Qingqiang Yao, Liming Wang
Objective: To investigate the value of integrin α v β 3 targeted microPET/CT imaging with 68 Ga-NODAGA-RGD 2 as radiotracer for the detection of osteosarcoma and theranostics of osteosarcoma lung metastasis. Methods: The 68 Ga-NODAGA-RGD 2 and 177 Lu-NODAGA-RGD 2 were prepared via one-step method and their stability and integrin α v β 3 binding specificity were investigated in vitro . Forty-one nude mice were injected with human MG63 osteosarcoma to established the animal model bearing subcutaneous osteosarcoma ( n =21), osteosarcoma in tibia ( n =5), and osteosarcoma pulmonary metastatic ( n =15)...
February 1, 2019: Chinese Journal of Reparative and Reconstructive Surgery
Yeon Jin Cho, Woo Sun Kim, Young Hun Choi, Ji Young Ha, SeungHyun Lee, Sang Joon Park, Jung-Eun Cheon, Hyoung Jin Kang, Hee Young Shin, In-One Kim
OBJECTIVE: To retrospectively evaluate the value of computerized 3D texture analysis for differentiating pulmonary metastases from non-metastatic lesions in pediatric patients with osteosarcoma. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board. The study comprised 42 pathologically confirmed pulmonary nodules in 16 children with osteosarcoma who had undergone preoperative computed tomography between January 2009 and December 2014...
2019: PloS One
Vivek Subbiah, Peter Meade Anderson, Kalevi Kairemo, Kenneth R Hess, Winston W Huh, Vinod Ravi, Najat C Daw, Neeta Somaiah, Joseph A Ludwig, Robert S Benjamin, Sant P Chawla, David S Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie S Kleinerman, Homer A Macapinlac, Eric M Rohren
PURPOSE: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223 RaCl2 ) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers. EXPERIMENTAL DESIGN: A 3+3 phase I, dose-escalation trial of 223 RaCl2 (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years...
February 7, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Robert M Hoffman, Shuya Yano, Kentaro Igarashi
Cancer cells are methionine (MET) dependent compared to normal cells as they have an elevated requirement for MET in order to proliferate. MET restriction selectively traps cancer cells in the S/G2 phase of the cell cycle. The cell cycle phase can be visualized by color coding with the fluorescence ubiquitination-based cell cycle indicator (FUCCI). Recombinant methioninase (rMETase) is an enzyme that effectively degrades MET. rMETase induces S/G2 -phase blockage of cancer cells which is identified by the cancer cells' green fluorescence with FUCCI imaging...
2019: Methods in Molecular Biology
Kenta Watanabe, Yoshihiro Yui, Satoru Sasagawa, Kayo Suzuki, Masahiko Kanamori, Taketoshi Yasuda, Tomoatsu Kimura
Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC50 , eribulin induced cell cycle arrest and apoptosis in a metastatic osteosarcoma cell line, LM8...
January 4, 2019: Oncotarget
Victoria M Wu, Eric Huynh, Sean Tang, Vuk Uskoković
Despite the advances in molecularly targeted therapies, delivery across the blood-brain barrier (BBB) and the targeting of brain tumors remains a challenge. To tackle it, we made a variation on the previously proposed concept of the earthicle and fabricated an aqueous, surfactant-free ferrofluid containing superparamagnetic iron oxide nanoparticles (SPIONs) coated with silicate mesolayers and carbon shells, having 13 nm in size on average. Nanoparticles were synthesized hydrothermally and characterized using a range of spectroscopic, diffractometric, hydrodynamic and electron microscopy techniques...
January 31, 2019: Acta Biomaterialia
Shinji Miwa, Toshiharu Shirai, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kentaro Igarashi, Hiroyuki Tsuchiya
Osteosarcoma is the most common primary malignancy of bone. Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory. To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed. Since the 1880s, various immunotherapies have been utilized in patients with osteosarcoma and some patients have shown response to the treatment. Based on recent studies about the role of the immune system in malignancies, immunotherapies including immune modulators such as interleukin-2 and muramyl tripeptide, dendritic cells, immune checkpoint inhibitors, and engineered T cells have been utilized in patients with malignancies...
2019: Journal of Oncology
Dominik Deniffel, Andreas Sauter, Julia Dangelmaier, Alexander Fingerle, Ernst J Rummeny, Daniela Pfeiffer
INTRODUCTION: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies. MATERIALS AND METHODS: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies...
February 2019: European Journal of Radiology
Kai Shi, Sheng-Lin Wang, Bin Shen, Feng-Qiang Yu, Dan-Feng Weng, Jian-Hua Lin
BACKGROUND: Osteosarcoma is a malignant bone tumor with a high potential for lung metastasis, and the prognosis for patients with metastatic disease is very poor. The interaction between fibronectin (FN) and integrin αvβ3 in soft-tissue sarcoma promotes cell migration, invasion, and lung metastasis. This study aimed to investigate the prognostic significance of FN and αvβ3 in osteosarcoma. METHODS: Immunohistochemistry and western blotting were used to detect the expression of FN and αvβ3 in 60 osteosarcoma specimens and in 30 osteochondroma specimens...
January 28, 2019: World Journal of Surgical Oncology
Sita S Withers, Daniel York, Jin W Choi, Kevin D Woolard, Renee Laufer-Amorim, Ellen E Sparger, Jenna H Burton, Stephen J McSorley, Arta M Monjazeb, William J Murphy, Robert J Canter, Robert B Rebhun
Our lack of understanding of the immune microenvironment in canine osteosarcoma (cOSA) has limited the identification of potential immunotherapeutic targets. In particular, our ability to utilize readily available tissue from a dog's primary tumor to predict the type and extent of immune response in their pulmonary metastatic lesions is unknown. We therefore collected 21 matched pairs of primary tumors and pulmonary metastatic lesions from dogs with OSA and performed immunohistochemistry to quantify T lymphocyte (CD3), FOXP3+ cell, B lymphocyte (Pax-5), and CD204+ macrophage infiltration...
January 25, 2019: Veterinary and Comparative Oncology
Z-Z Li, Y-L Wang, Y-H Yu, Y-L Xing, X-F Ji
OBJECTIVE: Osteosarcoma is recognized as the most common primary malignant bone tumor, the 5-year disease-free survival rate in patients with metastatic or recurrent disease is below than 30%. Drug resistance and toxic side effects limit the therapeutic efficacy of osteosarcoma. Therefore, it is urgent to develop new drugs for osteosarcoma treatment. Muscarinic 3 (M3) acetylcholine receptor (AChR) has been demonstrated in nonneurocrest-derived malignancies such as colon, prostate, lung, and ovarian carcinomas...
January 2019: European Review for Medical and Pharmacological Sciences
Matthias J Arlt, Aleksandar Kuzmanov, Jess G Snedeker, Bruno Fuchs, Unai Silvan, Adam A Sabile
BACKGROUND: Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival in various carcinomas, its role in sarcoma such as osteosarcoma (OS) remains unknown. In the present study, we evaluated the prognostic value and biological relevance of Fascin-1 in OS. METHODS: The correlation between Fascin-1 expression and the outcome of OS patients was determined by immunohistochemistry analysis of Fascin-1 expression in a tissue microarray of OS tissue specimens collected during primary tumor resection...
January 17, 2019: BMC Cancer
Samuel W Brady, Xiaotu Ma, Armita Bahrami, Gryte Satas, Gang Wu, Scott Newman, Michael Rusch, Daniel K Putnam, Heather L Mulder, Donald Yergeau, Michael N Edmonson, John Easton, Ludmil B Alexandrov, Xiang Chen, Elaine R Mardis, Richard K Wilson, James R Downing, Alberto S Pappo, Benjamin J Raphael, Michael A Dyer, Jinghui Zhang
To investigate the genomic evolution of metastatic pediatric osteosarcoma, we performed whole-genome and targeted deep sequencing on 14 osteosarcoma metastases and two primary tumors from four patients (2-8 samples per patient). All four patients harbored ancestral (truncal) somatic variants resulting in TP53 inactivation and cell cycle aberrations, followed by divergence into relapse-specific lineages exhibiting a cisplatin-induced mutation signature. In three of the four patients, the cisplatin signature accounted for >40% of mutations detected in the metastatic samples...
January 16, 2019: Molecular Cancer Research: MCR
Jiang-Jiang Qin
No abstract text is available yet for this article.
January 14, 2019: EBioMedicine
S Colangeli, P Parchi, L Andreani, G Beltrami, G Scoccianti, F Sacchetti, M Ceccoli, F Totti, D A Campanacci, R Capanna
Cryotherapy, also called Cryoablation (CA), is a technique that provides a local treatment to various pathological conditions. In Musculoskeletal tumours management, Cryoablation is well accepted and validated as a treatment in palliative cures for metastatic patients. Recently, CA has been proposed also as an alternative to radiofrequency ablation in osteoid osteoma and other benign tumour treatment with promising results. Cryotherapy with argon ice-balls as local adjuvant in open surgery is a tool that can provide enlargement of surgical margins if used properly...
November 2018: Journal of Biological Regulators and Homeostatic Agents
Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda, Olivia Fromigué
BACKGROUND: Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressiveness in preclinical model and in patient tumor samples. The aim of the present study was to investigate the CYR61-induced intracellular mechanisms leading to the acquisition of an invasive phenotype by osteosarcoma cells...
January 14, 2019: BMC Cancer
Ahmed M Morsy, Marwa I Abdelgawad, Badawy M Ahmed, Khalid M Rezk, Amir M Aboelgheit, Islam K-A Ramadan, Hosam E M Kamel, Doaa M Fouad, Rania A Herdan, Shimaa H Shabaan, Hanan A Eltyb
AIM: To assess the outcome and determine predictors of survival in pediatric patients with osteosarcoma of the extremities treated with a unified chemotherapy protocol at a single institution over a 15-year period. MATERIALS AND METHODS: We performed a retrospective analysis of medical records of 48 pediatric patients with histologically verified osteosarcoma of the extremities diagnosed at South Egypt Cancer Institute and received treatment between January 2001 and December 2015...
January 8, 2019: Journal of Pediatric Hematology/oncology
Nicole J Croteau, Todd E Heaton
Metastatic disease and the complications of treating metastatic disease are the primary causes of mortality in children with solid malignancies. Nearly 25% of children with solid tumors have metastatic disease at initial diagnosis and another 20% develop metastases during or after treatment. The most common location of these metastases is the lung. The role of surgery in metastatic disease depends greatly on the histology of the primary. In general, tumors that are refractory to adjuvant therapies are most appropriate for pulmonary metastasectomy...
January 8, 2019: Children
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