Jennifer C Coleman, Luke Tattersall, Val Yianni, Laura Knight, Hongqiang Yu, Sadie R Hallett, Philip Johnson, Ana J Caetano, Charlie Cosstick, Anne J Ridley, Alison Gartland, Maria R Conte, Agamemnon E Grigoriadis
RNA-binding proteins (RBPs) are emerging as important regulators of cancer pathogenesis. We reveal that the RBPs LARP4A and LARP4B are differentially overexpressed in osteosarcoma and osteosarcoma lung metastases, as well as in prostate cancer. Depletion of LARP4A and LARP4B reduced tumor growth and metastatic spread in xenografts, as well as inhibiting cell proliferation, motility, and migration. Transcriptomic profiling and high-content multiparametric analyses unveiled a central role for LARP4B, but not LARP4A, in regulating cell cycle progression in osteosarcoma and prostate cancer cells, potentially through modulating key cell cycle proteins such as Cyclins B1 and E2, Aurora B, and E2F1...
April 19, 2024: IScience