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Jonathan Vigne, Stéphane Emery, Nicolas Lemarie, Bénédicte Chavent, François Hallouard, Dominique Le Guludec, François Rouzet, Marc Fraysse, Rémy De Mil
Fractionated elution consists in collecting the fractions of an eluate with the highest radioactive concentration. It may be useful to meet the requirements of a subset of clinical radiopharmacy procedures. This study aims to describe and evaluate straightforward procedures allowing to readily perform fractionated elution on dry and wet columns Mo/Tc generators by using calibrated vials. The main objectives of this study consisted in determining the relationship between eluate volume and elution yield using different vials calibration and assessing repeatability of the procedure...
September 2018: Nuclear Medicine Communications
Magdalena Gumiela
Intensive efforts were undertaken during the last few decades for the separation of cyclotron-produced 99m Tc from 99 Mo and new papers have been published on this topic since the last review [1]. In the future the cyclotron-based methods can replace reactor-based technology in producing this medical radioisotope and the nuclear reaction 100 Mo(p,2n)99m Tc appears to be the most worthwhile approach. New ways of producing of 99m Tc require efficient separation methods. Several strategies for separation of 99m Tc from 99 Mo have been already developed...
March 2018: Nuclear Medicine and Biology
Meysam Eyvazlou, Ali Dadashpour Ahangar, Azin Rahimi, Mohammad Reza Davarpanah, Seyed Soheil Sayyahi, Mehdi Mohebali
INTRODUCTION: Reducing human error is an important factor for enhancing safety protocols in various industries. Hence, analysis of the likelihood of human error in nuclear industries such as radiopharmaceutical production facilities has become more essential. METHODS: This cross-sectional descriptive study was conducted to quantify the probability of human errors in a99 Mo/99m Tc generator production facility in Iran. First, through expert interviews, the production process of the99 Mo/99m Tc generator was analyzed using hierarchical task analysis (HTA)...
February 13, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
Amanda J Youker, Sergey D Chemerisov, Peter Tkac, Michael Kalensky, Thad A Heltemes, David A Rotsch, George F Vandegrift, John F Krebs, Vakho Makarashvili, Dominique C Stepinski
99 Mo, the parent of the widely used medical isotope 99m Tc, is currently produced by irradiation of enriched uranium in nuclear reactors. The supply of this isotope is encumbered by the aging of these reactors and concerns about international transportation and nuclear proliferation. Methods: We report results for the production of 99 Mo from the accelerator-driven subcritical fission of an aqueous solution containing low enriched uranium. The predominately fast neutrons generated by impinging high-energy electrons onto a tantalum convertor are moderated to thermal energies to increase fission processes...
March 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Sally W Schwarz
No abstract text is available yet for this article.
September 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Christian Schütze, Bernd O Knoop, Iris Vehrenkamp, Frank Rudolf, Lilli Geworski
UNLABELLED: Dose calibrators are one of the most important and most frequently used instruments for the determination of activities in nuclear medicine. For guaranteeing a constant quality of the dose calibrators' measurements, constancy checks including the examination of the system linearity have to be performed regularly, usually measured using 99mTc. The 99mTc eluate extracted from a 99Mo/99mTc generator is contaminated with molybdenum. Not accounting for the molybdenum impurity might lead to an exceed of the tolerance limit of 5% deviation to the reference value for this constancy check...
August 5, 2016: Nuklearmedizin. Nuclear Medicine
Naser Ali
The Ministry of Health (MOH) in the state of Kuwait currently depends on importing the radioisotope molybdenum (Mo) in its isotopic form (Mo) to fulfill its demands. The present study was conducted on all nuclear medicine departments in the state of Kuwait. Daily, weekly, and monthly data were analyzed to statistically determine the current and future demands for the isotope Tc. This analysis was performed by collecting and analyzing data on MOH consumption of Tc for different diagnostic applications. The overall results indicate a partial decrease of 1...
April 2016: Health Physics
Neuza T O Fukumori, Erica M M Endo, Carlos F Felgueiras, Margareth M N Matsuda, João A Osso Junior
In this work, molybdenum-99 loaded columns were challenged with Bacillus subtilis vegetative cells and Bacillus pumilus spores inside and outside the alumina column, and microbial recovery and radiation effect were assessed. Alumina was a barrier for the passage of microorganisms regardless the species, whilst spores were more retained than vegetative cells with a lower microbial recovery, without significant differences between 9.25 and 74 GBq generators. Bacillus pumilus biological indicator showed lower recoveries, suggesting a radiation inactivating effect on microorganisms...
January 2016: Applied Radiation and Isotopes
Diana Páez, Pilar Orellana, Claudia Gutiérrez, Raúl Ramirez, Fernando Mut, Leonel Torres
The practice of nuclear medicine (NM) in the Latin American and Caribbean region has experienced important growth in the last decade. However, there is great heterogeneity among countries regarding the availability of technology and human resources. According to data collected through June 2014 by the International Atomic Energy Agency (IAEA), the total number of γ cameras in the region is 1,231, with an average of 2.16 per million inhabitants. Over 90% of the equipment is SPECT cameras; 7.6% of which have hybrid technology...
October 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Maroor R A Pillai, Ashutosh Dash, Furn F Russ Knapp
This paper discusses the benefits of obtaining (99m)Tc from non-fission reactor-produced low-specific-activity (99)Mo. This scenario is based on establishing a diversified chain of facilities for the distribution of (99m)Tc separated from reactor-produced (99)Mo by (n,γ) activation of natural or enriched Mo. Such facilities have expected lower investments than required for the proposed chain of cyclotrons for the production of (99m)Tc. Facilities can receive and process reactor-irradiated Mo targets then used for extraction of (99m)Tc over a period of 2 wk, with 3 extractions on the same day...
January 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
A D Roberts, C G R Geddes, N Matlis, K Nakamura, J P O'Neil, B H Shaw, S Steinke, J van Tilborg, W P Leemans
(99)Mo photonuclear yield was measured using high-energy electrons from Laser Plasma Accelerators and natural molybdenum. Spectroscopically resolved electron beams allow comparisons to Monte Carlo calculations using known (100)Mo(γ,n)(99)Mo cross sections. Yields are consistent with published low-energy data, and higher energy data are well predicted from the calculations. The measured yield is (15±2)×10(-5) atoms/electron (0.92±0.11 GBq/μA) for 25 mm targets at 33.7 MeV, rising to (1391±20)×10(-5) atoms/electron (87±2 GBq/μA) for 54 mm/ 1...
February 2015: Applied Radiation and Isotopes
Vijay Sharma, Jothilingam Sivapackiam, Scott E Harpstrite, Julie L Prior, Hannah Gu, Nigam P Rath, David Piwnica-Worms
Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged...
2014: PloS One
J Adam, J Kadeřávek, F Kužel, J Vašina, Z Rehák
Nuclear medicine is an important field of nuclear medicine, especially thanks to its role in in vivo imaging of important processes in human organism. An overwhelming majority of nuclear medicine examinations comprises of planar scintigraphy and single photon emission computed tomography, for decades relying on the labeling by metastable technetium nuclide (99mTc), used with a great diversity of ligands for various applications. Nuclear medicine departments utilize commercially available molybdenum technetium generators, being able to elute the nuclide at any time and prepare the radiopharmaceutical...
2014: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
Van So Le, Zoe Phuc-Hien Do, Minh Khoi Le, Vicki Le, Natalie Nha-Truc Le
Methods of increasing the performance of radionuclide generators used in nuclear medicine radiotherapy and SPECT/PET imaging were developed and detailed for 99Mo/99mTc and 68Ge/68Ga radionuclide generators as the cases. Optimisation methods of the daughter nuclide build-up versus stand-by time and/or specific activity using mean progress functions were developed for increasing the performance of radionuclide generators. As a result of this optimisation, the separation of the daughter nuclide from its parent one should be performed at a defined optimal time to avoid the deterioration in specific activity of the daughter nuclide and wasting stand-by time of the generator, while the daughter nuclide yield is maintained to a reasonably high extent...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Federica E Buroni, Lorenzo Lodola, Marco G Persico, Carlo Aprile
The aim of the study was to validate a semiquantitative analytical method to identify the aluminium(III) [Al(III)] concentration in 99Mo/99mTc generator eluates to check the European Pharmacopoeia (Ph. Eur.) requirement (<5 μg/ml). Three different solutions measuring 20 ml - 0.2% 1,10-phenanthroline, 0.05% chrome azurol S and 20% hexamethylenetetramine - were prepared. A cellulose filter paper was subsequently immersed in them, dried overnight at room temperature and cut into rectangles. A volume of 5 μl of first eluates of various 99Mo/99mTc generators was placed onto a reagent paper and the spot colour was compared with a standard aluminium solutions scale (0-100 μg/ml)...
July 2014: Nuclear Medicine Communications
S M Qaim, S Sudár, B Scholten, A J Koning, H H Coenen
Excitation functions were calculated by the code TALYS for 10 proton-induced reactions on (100)Mo. For (100)Mo(p,d+pn)(99)Mo and (100)Mo(p,2n)(99m)Tc, calculations were also performed using the code STAPRE. Furthermore, for those two reactions and (nat)Mo(p,x)(96)Tc, evaluation of available experimental data was also carried out. The production of (99m)Tc via the (100)Mo(p,2n)-process is discussed. The ratio of atoms of long-lived (99g)Tc and (98)Tc to those of (99m)Tc is appreciably higher in cyclotron production than in generator production of (99m)Tc; this may adversely affect the preparation of (99m)Tc-chelates...
February 2014: Applied Radiation and Isotopes
Valery P Chechev, Marie-Martine Bé
Within the Decay Data Evaluation Project, as an example of a radioactive equilibrium with isomer, the (99)Mo/(99m)Tc equilibrium mixture decay characteristics are examined. The results of a new decay data evaluation are presented for (99)Mo/(99m)Tc decay to nuclear levels in (99)Tc. These evaluated data have been obtained using information published up to 2013.
May 2014: Applied Radiation and Isotopes
Germaine Mathurine, Philippa Bresser, Nadia Teixeira
BACKGROUND: South African nuclear medicine imaging departments have been fortunate in being able to receive an uninterrupted supply of molybdenum-99 (99Mo)/technetium-99m (99mTc) generators. Nuclear medicine radiographers practising in private sector services in the northern Gauteng region indicated a possible problem with the quantities of wasted and unused 99mTc radiopharmaceuticals returned to the radiopharmaceutical supply laboratory. Daily radiopharmaceutical deliveries are a combination of ordered packages and standard packages...
December 2013: Nuclear Medicine Communications
R Galea, R G Wells, C K Ross, J Lockwood, K Moore, J T Harvey, G H Isensee
Recent shortages of molybdenum-99 ((99)Mo) have led to an examination of alternate production methods that could contribute to a more robust supply. An electron accelerator and the photoneutron reaction were used to produce (99)Mo from which technetium-99m ((99m)Tc) is extracted. SPECT images of rat anatomy obtained using the accelerator-produced (99m)Tc with those obtained using (99m)Tc from a commercial generator were compared. Disks of (100)Mo were irradiated with x-rays produced by a 35 MeV electron beam to generate about 1110 MBq (30 mCi) of (99)Mo per disk...
May 7, 2013: Physics in Medicine and Biology
Ashutosh Dash, F F Russ Knapp, M R A Pillai
Several strategies for the effective separation of (99m)Tc from (99)Mo have been developed and validated. Due to the success of column chromatographic separation using acidic alumina coupled with high specific activity fission (99)Mo (F (99)Mo) for production of (99)Mo/(99m)Tc generators, however, most technologies until recently have generated little interest. The reduced availability of F (99)Mo and consequently the shortage of (99)Mo/(99m)Tc column generators in the recent past have resurrected interest in the production of (99)Mo as well as (99m)Tc by alternate routes...
February 2013: Nuclear Medicine and Biology
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