keyword
https://read.qxmd.com/read/38534999/a-comparison-of-68-ga-psma-pet-ct-based-split-renal-function-with-99m-tc-mag3-renography-in-patients-with-metastatic-castration-resistant-prostate-carcinoma-treated-with-177-lu-psma
#1
JOURNAL ARTICLE
Lerato Gabela, Thokozani Mkhize, Bawinile Hadebe, Lerwine Harry, Thembelihle Nxasana, Nontobeko Ndlovu, Venesen Pillay, Sphelele Masikane, Maryam Patel, Nozipho Elizabeth Nyakale, Mariza Vorster
BACKGROUND: Physiological PSMA expression in the cells of the proximal renal tubules and consecutive radiopharmaceutical binding and retention could potentially lead to radioligand-therapy-induced nephrotoxicity. Thus, patients with metastatic castration-resistant prostate cancer undergo 99m Tc-Mercaptoacetyltriglycine (MAG3) renal scintigraphy to assess kidney function and to exclude renal obstruction as part of their workup for PSMA-targeted radioligand therapy (RLT). 99m Tc-MAG-3 renal scintigraphy often requires an additional visit to the nuclear medicine department and patients spend 30-90 min in the department, which is inconvenient and takes up camera time...
March 8, 2024: Diagnostics
https://read.qxmd.com/read/38531689/systematic-review-of-targeted-axillary-dissection-in-node-positive-breast-cancer-treated-with-neoadjuvant-systemic-therapy-variation-in-type-of-marker-and-timing-of-placement
#2
JOURNAL ARTICLE
Sabine R de Wild, Linetta B Koppert, Thiemo J A van Nijnatten, Loes F S Kooreman, Marie-Jeanne T F D Vrancken Peeters, Marjolein L Smidt, Janine M Simons
BACKGROUND: In node-positive (cN+) breast cancer treated with neoadjuvant systemic therapy, combining sentinel lymph node biopsy and targeted lymph node excision, that is targeted axillary dissection, increases accuracy. Targeted axillary dissection procedures differ in terms of the targeted lymph node excision technique. This systematic review aimed to provide an overview of targeted axillary dissection procedures regarding definitive marker type and timing of placement: before neoadjuvant systemic therapy (1-step procedure) or after neoadjuvant systemic therapy adjacent to a clip placed before the neoadjuvant therapy (2-step procedure)...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38523604/longitudinal-trajectories-of-cognitive-decline-and-cerebral-blood-flow-abnormalities-in-octogenarian-men-with-normal-global-cognition
#3
JOURNAL ARTICLE
Arkadiusz Siennicki-Lantz, Lena André-Petersson, Sölve Elmståhl
AIMS: Cognitive and perfusion changes have been previously observed in older men with Mini Mental State Examination scores>24 points. We aimed to investigate time change in cognitive domains in a cohort of non-demented men between age 68 and 82, and how they are expressed in regional defects estimated by Cerebral Blood Flow (rCBF). METHODS: 103 men at age 81 with MMSE scores >24 (mean 28.4 ± 1.7), no dementia or stroke, were examined with the same cognitive test battery at age 68 and age 81: Synonyms (SRB-1), Block design (SRB-3), Paired Associates, Digit Symbol Substitution and Benton Visual Retention test...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38520623/detection-of-cardiac-amyloidosis-on-routine-bone-scintigraphy-an-important-gatekeeper-role-for-the-nuclear-medicine-physician
#4
JOURNAL ARTICLE
Mohit Nebhwani, Karina Chaibekava, Anouk Achten, Marish I F J Oerlemans, Michelle Michels, Peter van der Meer, Hans L A Nienhuis, Jerremy Weerts, Vanessa van Empel, Hans-Peter Brunner-La Rocca, Sandra Sanders-van Wijk, Jochem van der Pol, Christian Knackstedt
Cardiac amyloidosis (CA)-mostly transthyretin-related (ATTR-CA)-has recently gained interest in cardiology. Bone scintigraphy (BS) is one of the main screening tools for ATTR-CA but also used for various other reasons. The objective was to evaluate whether all CA cases are detected and what happens during follow-up. All routine BS performed at the Maastricht University Medical Center (May 2012-August 2020) were screened for the presence of CA. Scans performed for suspected CA were excluded. A Perugini stage ≥1 was classified as positive necessitating further examination...
March 23, 2024: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/38517361/geraniol-attenuates-oxidative-stress-and-neuroinflammation-mediated-cognitive-impairment-in-d-galactose-induced-mouse-aging-model
#5
JOURNAL ARTICLE
Peramaiyan Rajendran, Fatma J Al-Saeedi, Rebai Ben Ammar, Basem M Abdallah, Enas M Ali, Najla Khaled Al Abdulsalam, Sujatha Tejavat, Duaa Althumairy, Vishnu Priya Veeraraghavan, Sarah Abdulaziz Alamer, Gamal M Bekhet, Emad A Ahmed
D-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents' models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. Herein, we examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. The study was conducted using six groups of mice (6 mice per group)...
March 20, 2024: Aging
https://read.qxmd.com/read/38511767/temporal-evolution-of-postsurgical-bone-repair-in-a-rabbit-model-a-99mtc-tc-mdp-scintigraphic-study
#6
JOURNAL ARTICLE
A Yoneda, K J C C de Lacerda, L Alexandre-Santos, E N Itikawa, P Louzada-Junior, L Wichert-Ana
Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits. For this purpose, we conducted a longitudinal, prospective, case-control study in which scintigraphic variables were measured in both the right forearm (case-operated) and the left forearm (control - non-operated)...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38510824/clinical-values-of-whole-body-blood-pool-scans-and-spect-for-evaluation-of-congenital-vascular-malformation
#7
JOURNAL ARTICLE
Junik Son, Chae Moon Hong, Jaetae Lee, Ho Yun Chung, Byeong-Cheol Ahn
PURPOSE: This study examines the diagnostic potential of whole-body blood pool scintigraphy (WBBPS) using technetium-99 m-labeled red blood cells to detect congenital vascular malformations (CVMs). It aims to compare its efficacy with traditional imaging techniques such as magnetic resonance imaging (MRI) and ultrasonography (USG), emphasizing its potential advantages in terms of characterization of lesions and capacity for whole-body assessment. METHODS: The efficacy of WBBPS and single-photon emission computed tomography (SPECT)/computed tomography (CT) imaging in diagnosing CVMs, comparing them with USG and MRI results, was evaluated in this retrospective study...
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38510821/the-biodistribution-and-utility-of-99m-tc-ethylenedicysteine-deoxyglucose-99m-tc-glucosamine-in-the-identification-of-active-disease-in-patients-with-rheumatoid-arthritis-a-single-center-prospective-study
#8
JOURNAL ARTICLE
Osayande Evbuomwan, Barend Jansen Van Rensburg, Gerrit Engelbrecht, Cathryn H S Driver, Mathys Labuschagne, Joseph Sempa, Je'nine Horn-Lodewyk
PURPOSE: Our objectives were to investigate the utility of 99m Tc-ethylenedicysteine-deoxyglucose (ECDG) in identifying active disease in the joints of patients with rheumatoid arthritis (RA), as well as to evaluate the biodistribution of this radiopharmaceutical. METHODS: A prospective study was conducted at the Department of Nuclear Medicine of the University of the Free State/Universitas Academic Hospital in Bloemfontein, South Africa. Twenty-two participants from the rheumatology department diagnosed with RA according to the ACR/EULAR classification criteria were enrolled...
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38500743/unexpected-99m-tc-pertechnetate-avidity-of-lymph-node-metastases-predicts-better-response-to-radioiodine-therapy-in-differentiated-thyroid-cancer-patients-with-lymph-node-metastases
#9
JOURNAL ARTICLE
Jie Liu, Xin Li, Linfa Li, Yuhua Yin, Hu Cai, Heqing Yi
OBJECTIVE: To investigate the value of 99m Tc-pertechnetate scan in postoperative differentiated thyroid cancer (DTC) patients with lymph node (LN) metastases (LNM) uptake 99m Tc-pertechnetate, especially the predictive value to their response to radioiodine-131 (131 I) therapy. METHODS: This retrospective study collected 752 patients with DTC and LNM treated at Zhejiang Cancer Hospital between May 2012 and December 2017. Depending on the ability of LNM uptake 99m Tc-pertechnetate, the patients were grouped as the 99m Tc-pertechnetate-avid (n=88) vs...
2024: American Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38498732/tumor-induced-parkinsonism-due-to-a-large-meningioma-diagnosed-by-99mtc-trodat-1-spect-ct
#10
JOURNAL ARTICLE
Abdolmajid Alipour, Tahereh Ghaedian, Babak Yazdani, Abbas Rakhsha, Vahid Reza Ostovan
A 67-year-old woman complained of rest and postural tremors in her left upper extremity, associated with bradykinesia and gait disorder since 2 years ago, with no significant response to antiparkinsonism drugs. Dopamine transporter SPECT/CT revealed a remarkable area of 99mTc-TRODAT-1 uptake in a huge tumoral lesion in the right frontotemporal region, compressing and dislocating the right striatum with evidence of significant midline shift. The patient underwent surgical resection with a diagnosis of meningioma on preoperative MRI and postoperative histology report, experiencing a marked recovery in symptoms after 1 month...
March 18, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38496158/high-diagnostic-accuracy-of-thyroid-stimulating-hormone-tsh-receptor-antibodies-in-distinguishing-graves-disease-and-subacute-thyrotoxicosis-in-the-indian-population
#11
JOURNAL ARTICLE
Lakshmi T Naga Nitin, Shilpa Lakkundi, Sagar Reddy S L, Dhananjaya M Shanthaiah, Sumanas G Datta, Umalakhmi Annavarapu, Vijaya Sarathi
BACKGROUND AND OBJECTIVE: Thyrotoxicosis is a common clinical condition encountered in endocrine practice. Graves' disease and subacute thyroiditis are the two common causes of thyrotoxicosis and often have overlapping clinical and biochemical features. 99mTc thyroid scintigraphy is the most commonly used confirmatory test to differentiate the two conditions but is not available in the majority of the second-tier cities of India. However, obtaining thyroid stimulating hormone (TSH) receptor antibodies (TSHrAb), another accurate test to differentiate the two conditions, in second-tier cities by outsourcing to labs in major cities is a feasible option nowadays...
February 2024: Curēus
https://read.qxmd.com/read/38487344/comparison-of-diagnostic-efficacy-between-99m-tc-methylene-diphosphate-spect-ct-and-mri-for-bone-and-joint-infections-a-multicenter-retrospective-analysis
#12
MULTICENTER STUDY
Hao Gao, Guoquan Li, Congxiao Fu, Jun Ren, Fei Kang, Wen Luo, Qian Yin, Cheng Zhou, Bo Li, Shuaikun Lu, Hu Wang, Yong Zhang, Yunfei Zhang
OBJECTIVE: There is currently no non-invasive examination that can fully determine the diagnosis of osteomyelitis. SPECT/CT tomographic fusion imaging can provide both local metabolic activity and anatomical information to determine the condition and location. This study evaluates the diagnostic efficacy of 99m Tc-MDP SPECT/CT in bone infections, compared to MRI. METHODS: In this multicenter retrospective study, 363 patients with suspected bone and joint infections or osteomyelitis were included...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38459598/detection-of-her2-expression-using-99m-tc-nm-02-nanobody-in-patients-with-breast-cancer-a-non-randomized-non-blinded-clinical-trial
#13
JOURNAL ARTICLE
Lingzhou Zhao, Yan Xing, Changcun Liu, Shaofei Ma, Wenhua Huang, Zhen Cheng, Jinhua Zhao
BACKGROUND: 99m Tc radiolabeled nanobody NM-02 (99m Tc-NM-02) is a novel single photon emission computed tomography (SPECT) probe with a high affinity and specificity for human epidermal growth factor receptor 2 (HER2). In this study, a clinical imaging trial was conducted to investigate the relationship between 99m Tc-NM-02 uptake and HER2 expression in patients with breast cancer. METHODS: Thirty patients with pathologically confirmed breast cancer were recruited and imaged with both 99m Tc-NM-02 SPECT/computed tomography (CT) and 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET)/CT...
March 8, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38454067/maximal-detrusor-pressure-can-be-predicted-using-technetium-99m-mertcaptoacetyltriglycine-renal-scintigraphy-in-the-early-stages-of-spinal-cord-injury
#14
JOURNAL ARTICLE
Su Ji Lee, Ji Cheol Shin
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To investigate the potential of technetium-99m-mercaptoacetyltriglycine (99mTc-MAG-3) renal scintigraphy for predicting maximal detrusor pressure in the early stages of spinal cord injury (SCI). SETTING: Tertiary rehabilitation facility. METHODS: Medical records of individuals with SCI admitted between January 2020 and April 2023 who underwent both 99mTc-MAG-3 renal scintigraphy and urodynamic study within 90 days of SCI onset were retrospectively reviewed...
March 7, 2024: Spinal Cord
https://read.qxmd.com/read/38437863/correction-99mtc-mdp-bone-scan-and-18f-fdg-pet-ct-imaging-of-primary-hepatic-osteosarcoma
#15
JOURNAL ARTICLE
Yao Liu, Wen Tang, Zhongke Huang
No abstract text is available yet for this article.
March 4, 2024: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/38434973/comparative-analysis-of-diagnostic-efficacy-in-primary-hyperparathyroidism-a-comparison-analysis-of-11-c-choline-pet-ct-neck-ultrasonography-99m-tc-mibi-dual-phase-planar-scintigraphy-and-99m-tc-mibi-spect-ct-imaging
#16
JOURNAL ARTICLE
ZhiNing Zhang, Min Zhao, Bin Chen, YiMing Cao, Shi Gao
Objective: To compare the diagnostic efficacy of 11 C-choline PET/CT, neck ultrasonography, 99m Tc-MIBI dual-phase planar scintigraphy, and 99m Tc-MIBI SPECT/CT imaging in the diagnosis of primary hyperparathyroidism (PHPT). Methods: We conducted a retrospective analysis of 32 patients with PHPT who visited the Nuclear Medicine Department of Jilin University China-Japan Union Hospital between January 2019 and December 2022. All patients underwent 11 C-choline PET/CT, neck ultrasonography, 99m Tc-MIBI dual-phase planar scintigraphy, and 99m Tc-MIBI SPECT/CT examinations within two months before surgery...
2024: Journal of Cancer
https://read.qxmd.com/read/38425818/can-99m-tc-mdp-spect-ct-differentiate-loosening-and-infection-after-hip-and-knee-replacements
#17
JOURNAL ARTICLE
Yaxin Tian, Yanghongyan Jiang, Bei Feng, Tingting Zhao, Wenjiao Cai, Yiyuan Dong, Qian Zhao
BACKGROUND: Prosthetic loosening and infection are still common complications after joint replacement. Over the past few years, single-photon emission computed tomography-computed tomography (SPECT/CT) was widely used and showed unique value based on the combination of anatomic and metabolic information of foci. However, its performance in differentiating between prosthetic loosening and periprosthetic infection after joint replacement is still the focus of clinicians and deserves further investigation...
March 2024: Indian Journal of Orthopaedics
https://read.qxmd.com/read/38421965/pet-ct-and-spect-ct-imaging-of-90y-hepatic-radioembolization-at-therapeutic-and-diagnostic-activity-levels-anthropomorphic-phantom-study
#18
JOURNAL ARTICLE
Anna Budzyńska, Agata Kubik, Krzysztof Kacperski, Patrycja Pastusiak, Michał Kuć, Piotr Piasecki, Marcin Konior, Michał Gryziński, Mirosław Dziuk, Edward Iller
PURPOSE: Prior to 90Y radioembolization procedure, a pretherapy simulation using 99mTc-MAA is performed. Alternatively, a small dosage of 90Y microspheres could be used. We aimed to assess the accuracy of lung shunt fraction (LSF) estimation in both high activity 90Y posttreatment and pretreatment scans with isotope activity of ~100 MBq, using different imaging techniques. Additionally, we assessed the feasibility of visualising hot and cold hepatic tumours in PET/CT and Bremsstrahlung SPECT/CT images...
2024: PloS One
https://read.qxmd.com/read/38416886/molecular-breast-imaging-in-the-screening-setting
#19
JOURNAL ARTICLE
Katherine A Smith, Katie N Hunt, Gaiane M Rauch, Amy M Fowler
Early detection of breast cancer through screening mammography saves lives. However, the sensitivity of mammography for breast cancer detection is reduced in women with dense breast tissue. Imaging modalities for supplemental breast cancer screening include MRI, whole breast US, contrast-enhanced mammography, and molecular breast imaging (MBI). Molecular breast imaging with 99mTc-sestamibi is a functional imaging test to identify metabolically active areas in the breast with positioning analogous to mammography...
May 22, 2023: Journal of breast imaging
https://read.qxmd.com/read/38411131/new-multi-parameters-combination-of-technetium-99m-diethylene-triamine-pentaacetate-orbital-single-photon-emission-computed-tomography-computed-tomography-for-the-evaluation-of-graves-orbitopathy-activity
#20
JOURNAL ARTICLE
Lixin Sun, Ruchen Peng, Rongxin Sun
PURPOSE: This study investigates the new combined parameters of 99m Tc-DTPA orbital single-photon emission computed tomography/computed tomography (SPECT/CT) for the evaluation of Graves' orbitopathy (GO) activity. METHODS: A retrospective analysis was performed on 41 patients. All the patients undergone the 99mTc-DTPA orbital SPECT/CT and were categorized into active and inactive group based on the standard combined by the clinical active score (CAS), magnet resonance imaging (MRI) and/or follow-up results...
February 27, 2024: Seminars in Ophthalmology
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