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Sreenivasa Reddy Konudula, Peethamber L, Madhusudhanan Ponnusamy, Dhanapathi H, Nandini Pandit
A 5-month-old boy with ultrasonography showing bilateral hydronephrosis, referred for renal scan. On Tc-L,L,ethylenedicysteine (Tc-LLEC) renal scan, tracer blush in flow images in the region of urinary bladder was seen and tumor mass was suspected. Contrast-enhanced CT showed a soft tissue mass in sacrococcygeal region. Histopathological examination of biopsy tissue revealed malignant round cell tumor and immunohistochemistry consistent with neuroblastoma. I-MIBG scan revealed uptake in the pelvic mass with no distant metastasis...
February 8, 2019: Clinical Nuclear Medicine
Vivek Subbiah, Peter Meade Anderson, Kalevi Kairemo, Kenneth R Hess, Winston W Huh, Vinod Ravi, Najat C Daw, Neeta Somaiah, Joseph A Ludwig, Robert S Benjamin, Sant P Chawla, David S Hong, Funda Meric-Bernstam, Gregory Ravizzini, Eugenie S Kleinerman, Homer A Macapinlac, Eric M Rohren
PURPOSE: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (223 RaCl2 ) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers. EXPERIMENTAL DESIGN: A 3+3 phase I, dose-escalation trial of 223 RaCl2 (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years...
February 7, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
V Lago, P Bello, B Montero, L Matute, P Padilla-Iserte, S Lopez, M Agudelo, S Domingo
INTRODUCTION: There is limited evidence favoring the use of the sentinel lymph node technique in ovarian cancer, and no standardized approach has been studied. The objective of the present pilot study is to determine the feasibility of the sentinel lymph node technique by applying a clinical algorithm. METHODS: Patients with confirmed ovarian cancer were included. 99mTc and indocyanine green were injected into the ovarian and infundubulo-pelvic ligament stump. A gamma probe and near-infrared fluorescence imaging were used for sentinel lymph node detection...
February 2019: International Journal of Gynecological Cancer
Sailaja Aka, J Sai Moulika, Vs Krishna Mohan, R Ramya Priya, Ranadheer Manthri, T C Kalawat
99m Tc-EC (Technetium-99m-ethylenedicysteine) is a renal tubular imaging agent introduced as an alternative to 99m Tc-MAG3 (Technetium-99m-mercaptoacetyltriglycine) (1). This radiopharmaceutical can be easily labeled at room temperature and has high radiochemical purity and long stability for at least 8 h. Within 1 h 70% of 99m Tc-EC is excreted in the urine (2). 99m Tc-EC provides the same Scintigraphic information as 99m Tc-MAG3. The Hepato biliary excretion of 99m Tc-EC is very low and usually does not affect image interpretation on routine imaging, the possibility of visualization of the gall bladder should be kept in mind while reporting the 99mTc-EC renogram (1)...
January 2019: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Anuja Anand, Pankaj Dougall
Presenting known treated case of hepatocellular carcinoma, complaining of non specific backache. 99mTc methylene diphosphonate bone scan showed photopenic area in sternal body, which could be easily thought of osteolytic metastasis from hepatocellular carcinoma; however CT scan revealed it to be sternal foramina- a normal variant of sternum. The possibility of a sternal foramen should be mentioned to the clinician because infiltration, biopsy or acupuncture of this area may lead to fatal cardiac complications...
January 2019: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Mohsen Qutbi, Reyhana Ahmadi
Rim sign is assumed as an ominous sign of gangrenous cholecystitis and mandates an urgent surgery. The main mechanism by which this phenomenon arises is increased regional blood flow as a result of an inflammatory process. Therefore, it is expected that this finding be visualized in varieties of scans with various radiopharmaceuticals, including myocardial perfusion scan with Tc-MIBI as an extracardiac finding. Herein, we present a case of acute cholecystitis with a rim sign on preoperative myocardial perfusion SPECT using Tc-MIBI, which posed the possibility of gangrene and perforation and thus the need for urgent surgical intervention...
January 25, 2019: Clinical Nuclear Medicine
Jung W Choi, Mikalai Budzevich, Shaowei Wang, Kenneth Gage, Veronica Estrella, Robert J Gillies
99m-Technetium-labeled (99mTc) erythrocyte imaging with planar scintigraphy is widely used for evaluating both patients with occult gastrointestinal bleeding and patients at risk for chemotherapy-induced cardiotoxicity. While a number of alternative radionuclide-based blood pool imaging agents have been proposed, none have yet to achieve widespread clinical use. Here, we present both in vitro and small animal in vivo imaging evidence that the high physiological expression of the glucose transporter GLUT1 on human erythrocytes allows uptake of the widely available radiotracer 2-deoxy-2-(18F)fluoro-D-glucose (FDG), at a rate and magnitude sufficient for clinical blood pool positron emission tomographic (PET) imaging...
2019: PloS One
Mihaela Stanciu, Loredana Camelia Boicean, Florina Ligia Popa
RATIONALE: Primary hyperparathyroidism, usually as a result of a hyperfunctioning parathyroid gland, represents more than 90% cases of patients evaluated for hypercalcemia. Combined techniques of preoperative scintigraphy and SPECT/CT serve as a successful minimally-invasive parathyroidectomy. This recent imaging method provides four-dimensional functional images with advanced contrast resolution which greatly facilitates preoperative localization of parathyroid adenomas. PATIENT CONCERNS: We presented the case of a male Caucasian patient, aged 67 years, who was investigated for hypercalcemia...
January 2019: Medicine (Baltimore)
Enrico Gabriele Piersanti, Luigi Sgattone, Luciano Di Stefano, Giacomo Migliorati
Radionuclides are increasingly used in hospitals for diagnostic and therapeutic purposes, such as functional research, diagnostic imaging, and in the performance of radioiodine therapy. Their use produces radioactive waste, and risks environmental contamination. The present study involves 486 samples of radioactive waste produced in hospitals in Abruzzo, Italy, during 2000 - 2015. Measurements were carried out with the gamma spectrometry technique: Germanium detector (PTG) with 8000 acquisition channels, power range 59 - 1836 keV, resolution 1 keV, overall efficiency 30%, measurement time 60000 Seconds...
December 31, 2018: Veterinaria Italiana
Ximin Shi, Hongli Jing, Fang Li, Yupei Zhao, Zhenghua Wang, Li Huo
PURPOSE: Tumor-induced osteomalacia (TIO) is rare paraneoplastic disorder generally caused by small benign neoplasm. Somatostatin receptor imaging has emerged as imaging of the choice in the localization of the causative tumors in new patients with clinical diagnosis of TIO. An accurate localization of the causative tumor using somatostatin receptor imaging followed by successful surgical removal offers cure of the disease. In small percentage of the patients, however, there can be recurrent disease after the surgery...
January 18, 2019: Clinical Nuclear Medicine
Ryotaro Tokorodani, Tatsuaki Sumiyoshi, Takehiro Okabayashi, Yasuhiro Hata, Yoshihiro Noda, Sojiro Morita, Hiromitsu Daisaki, Yukinori Okada, Eisuke Yasuda
PURPOSE: To determine the utility of mean standardized uptake value (SUVmean ) of whole liver measured by 99m Tc-GSA SPECT/CT fusion imaging, for evaluation of liver fibrosis. MATERIALS AND METHODS: Eighty-six patients who underwent hepatectomy were enrolled, and were classified into the non-fibrosis or fibrosis group based on the pathological findings in the resected liver specimen. Univariate and multivariate analyses were performed between the two groups on four blood biochemical indices (albumin, total bilirubin, platelet count, and prothrombin time activity) and two 99m Tc-GSA scintigraphy-derived liver function indices (LHL15 and SUVmean ) to evaluate the independent predictive value for severe fibrosis...
January 17, 2019: Japanese Journal of Radiology
Roel S Driessen, Ibrahim Danad, Wijnand J Stuijfzand, Pieter G Raijmakers, Stefan P Schumacher, Pepijn A van Diemen, Jonathon A Leipsic, Juhani Knuuti, S Richard Underwood, Peter M van de Ven, Albert C van Rossum, Charles A Taylor, Paul Knaapen
BACKGROUND: Fractional flow reserve (FFR) computation from coronary computed tomography angiography (CTA) datasets (FFRCT ) has emerged as a promising noninvasive test to assess hemodynamic severity of coronary artery disease (CAD), but has not yet been compared with traditional functional imaging. OBJECTIVES: The purpose of this study was to evaluate the diagnostic performance of FFRCT and compare it with coronary CTA, single-photon emission computed tomography (SPECT), and positron emission tomography (PET) for ischemia diagnosis...
January 22, 2019: Journal of the American College of Cardiology
Fernanda Gobbi de Bitencourt, Guilherme Oliveira Petersen, Cássia Virginia Garcia
Radiopharmaceuticals are radioactive compounds that can be used for diagnostic and therapeutic purposes. Technetium (99mTc) Sestamibi is the most commercialized radiopharmaceutical in the world. It includes a coordination complex consisting of the radioisotope 99m Technetium bound to six copper tetramibi tetrafluorborate ligands, which is mainly used to image the myocardium via scintigraphy. As radiopharmaceuticals are regarded as drugs, they are subject to the same regulations; therefore, the objective of this study is to develop a quantification method for the active pharmaceutical ingredient before their complexation with the radioisotope by employing high-performance liquid chromatography (HPLC) methodology...
January 16, 2019: Biomedical Chromatography: BMC
Yihan Cao, Chen Li, Qiao Yang, Nan Wu, Ping Xu, Yueting Li, Ximin Shi, Qingqing Pan, Xia Wu, Xiaochuan Sun, Yanxue Zhao, Zhaoqi Gu, Siyi Yuan, Yuzhi Zuo, Li Li, Weihong Zhang, Weixin Hao, Jinhe Liu, Hongli Jing, Wen Zhang
Objectives: To explore the patterns of osteoarticular involvement in SAPHO syndrome. Methods: Baseline clinical characteristics and imaging data of 99mTc-MDP whole-body bone scintigraphy (WBBS) were collected from 157 out of 164 patients diagnosed with SAPHO syndrome. The twelve most frequently involved osteoarticular sites were analysed by hierarchical cluster analysis with the Ward minimum-variance method. Results: Three distinctive patterns of osteoarticular involvement were identified: the spinal type (70 patients, 44...
January 8, 2019: Rheumatology
Yangyun Wang, Ziling Sun, Zhizhong Chen, Yanxian Wu, Yuan Gu, Subin Lin, Yong Wang
Emerging nanomedical strategy is to construct a nanoagent that affords not only diagnostic and therapeutic functions, but also imaging-guided treatment. It is crucial to understand the in vivo biological processes of nanoagents for improving theranostic function and biosafety. Herein, we report a multimodal photoacoustic/SPECT imaging technique to dynamically monitor the in vivo behaviors of nanoagents. Near-infrared cypate-induced silk fibroin nanoassembly is chose as the object of nanoagents due to their promise in biocompatibility and aggregation-enhanced photothermal effect...
January 9, 2019: Analytical Chemistry
Valentina Mancini, Giulio Mastria, Viviana Frantellizzi, Patrizia Troiani, Stefania Zampatti, Stefania Carboni, Emiliano Giardina, Rosa Campopiano, Stefano Gambardella, Federica Turchi, Barbara Petolicchio, Massimiliano Toscano, Mauro Liberatore, Alessandro Viganò, Vittorio Di Piero
Genetic mutations of sporadic hemiplegic migraine (SHM) are mostly unknown. SHM pathophysiology relies on cortical spreading depression (CSD), which might be responsible for ischemic brain infarction. Cystic fibrosis (CF) is caused by a monogenic mutation of the chlorine transmembrane conductance regulator (CFTR), possibly altering brain excitability. We describe the case of a patient with CF, who had a migrainous stroke during an SHM attack. A 32-year-old Caucasian male was diagnosed with CF, with heterozygotic delta F508/unknown CFTR mutation...
January 8, 2019: Headache
Nicoletta Urbano, Manuel Scimeca, Elena Bonanno, Orazio Schillaci
No abstract text is available yet for this article.
January 8, 2019: Future Oncology
Alessia Gimelli, Francesca Menichetti, Ezio Soldati, Riccardo Liga, Nicola Scelza, Giulio Zucchelli, Andrea Di Cori, Luca Segreti, Andrea Vannozzi, Maria Grazia Bongiorni, Paolo Marzullo
AIMS: Sympathetic dys-innervation may play an important role in the development of post-ischemic ventricular arrhythmias (VA). Aim of this study was to prove that perfusion/innervation mismatch (PIM) evaluated by SPECT can identify areas of local abnormal ventricular activities (LAVA) on electroanatomic mapping (EAM). METHODS: Sixteen patients referred to post-ischemic VA catheter ablation underwent pre-procedural and 1-month post-ablation 123 I-MIBG/99m Tc-tetrofosmin rest SPECT myocardial imaging...
January 2, 2019: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Marco Dauriz, Chiara Maneschi, Claudia Castelli, Anna Tomezzoli, Arnaldo Fuini, Luca Landoni, Giuseppe Malleo, Marco Ferdeghini, Enzo Bonora, Paolo Moghetti
Context: Nesidioblastosis is a rare cause of adult hypoglycemia. Current medical therapy can mitigate disease symptoms. However, side-effects and limited efficacy may prevent long-term disease management. Case description: A 63-year-old Caucasian lady presented at our Institution on April 2017, with a history of distal spleno-pancreatectomy for well-differentiated insulinoma in 2013. Hypoglycaemic events did not resolve after surgery and residual nesidioblastosis near the pancreatic resection margins was identified...
December 28, 2018: Journal of Clinical Endocrinology and Metabolism
Christian Kuehnel, Thomas Winkens, Martin Freesmeyer
Fusion imaging with nuclear medicine and ultrasound via mobile handheld gamma cameras has been recently introduced, however a phantom for the registration accuracy of this fusion approach is still lacking. We developed a hybrid phantom, consisting of poly-methyl methacrylate and exchangeable ultrasound (US) compatible windows made of silicone or poly-vinyl chloride. A standard balloon catheter, filled with a mixture of [99mTc]TcO4 and water, was positioned at the center of the water-filled phantom. This approach enabled an objective measurement of the registration accuracy...
December 20, 2018: Applied Radiation and Isotopes
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