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Aishe A Sarshad, Aster H Juan, Ana Iris Correa Muler, Dimitrios G Anastasakis, Xiantao Wang, Pavol Genzor, Xuesong Feng, Pei-Fang Tsai, Hong-Wei Sun, Astrid D Haase, Vittorio Sartorelli, Markus Hafner
In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that embryonic stem cells (ESCs) contain high levels of nuclear AGO proteins and that in ESCs nuclear AGO protein activity allows for the onset of differentiation. In the nucleus, AGO proteins interact with core RISC components, including the TNRC6 proteins and the CCR4-NOT deadenylase complex. In contrast to cytoplasmic miRNA-mediated gene silencing that mainly operates on cis-acting elements in mRNA 3' untranslated (UTR) sequences, in the nucleus AGO binding in the coding sequence and potentially introns also contributed to post-transcriptional gene silencing...
September 20, 2018: Molecular Cell
A L Muler, E J B van Etten, W D Stock, K Howard, R H Froend
Plant interaction studies provide a good understanding of the roles of key species, which can assist restoration of natural ecosystems. Among the interactions, facilitation and competition are known to affect ecosystem structure and function. We investigated whether a deep-rooted species could positively affect surrounding seedlings through hydraulic redistribution during dry months. We conducted two experiments in which seedlings from two species were growing together or isolated from source plants (field experiment) and where plants were isolated from source plants that were connected to or separated from a water table (glasshouse experiment)...
July 2018: Oecologia
Jelmer K Humalda, Sarah Seiler-Muler, Arjan J Kwakernaak, Marc G Vervloet, Gerjan Navis, Danilo Fliser, Gunnar H Heine, Martin H de Borst
Fibroblast growth factor 23 (FGF-23) rises progressively in chronic kidney disease and is associated with adverse cardiovascular outcomes. FGF-23 putatively induces volume retention by upregulating the sodium-chloride cotransporter (NCC). We studied whether, conversely, interventions in volume status affect FGF-23 concentrations.We performed a post hoc analysis of 1) a prospective saline infusion study with 12 patients with arterial hypertension who received 2 L of isotonic saline over 4 hours, and 2) a randomized controlled trial with 45 diabetic nephropathy (DN) patients on background angiotensin-converting enzyme -inhibition (ACEi), who underwent 4 6-week treatment periods with add-on hydrochlorothiazide (HCT) or placebo, combined with regular sodium (RS) or low sodium (LS) diet in a cross-over design...
November 2016: Medicine (Baltimore)
J V Sokurenko, P V Zelenikhin, V V Ulyanova, A I Kolpakov, D Muler, O N Ilinskaya
Binase--Bacillus pumilus RNase--endonuclease cleaves the phosphodiester bond between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotides with the formation of corresponding intermediate 2',3'-cGMP. Subsequent hydrolysis of 2',3'-cGMP into 3'-phosphate is highly specific and occurs slowly So the question arises about the existing time of that positional isomer during RNA catalytic cleavage by binase and about 2',3'-cGMP role in antitumor activity of the enzyme: In present work by means of enzyme-linked immunosorbent assay we established that during catalytic cleavage of RNA by binase 2',3'-cGMP is preserved in reaction mixture for an hour, at the same time phosphodiesterases activation doesn't lead to the total elimination of 2',3'-cGMP...
January 2015: Bioorganicheskaia Khimiia
Jonathan Rodríguez, James Montoya-Lerma, Zoraida Calle
Recent studies have shown an insecticidal effect of Tithonia diversifolia (Hemsl.) Gray (Asterales: Asteraceae) foliage on workers of Atta cephalotes L. and inhibitory effects of this plant on the growth of the symbiotic fungus Leucoagaricus gongylophorus (A. Müler) Singer. To evaluate the potential of T. diversifolia as a biological control treatment of this important pest, we assessed the effect of green manure (mulch) of this plant on natural nests of A. cephalotes, in Cali, Colombia. Three treatments were randomly assigned to 30 nests: 1) green mulch of T...
2015: Journal of Insect Science
Miroslav Stevanović
Twelve new species of the genus Cephennium Müler & Kunze, 1822 are described: C. (s. str.) irenae sp. n. (from Serbia, Bosnia and Herzegovina, and Montenegro); C. (s. str.) sladjanae sp. n. and C. (s. str.) fallax sp. n. (both from Serbia and Bulgaria); C. (s. str.) viti sp. n. (from Serbia, Macedonia, Greece and Bulgaria); C. (s. str.) fairchildi sp. n., C. (s. str.) ivanjicense sp. n., C. (s. str.) serbicum sp. n. and C. (s. str.) remisianum sp. n. (all from Serbia); C. (s. str.) assingi sp. n. and C. (s...
2014: Zootaxa
C Bincoletto, A Bechara, G J S Pereira, C P Santos, F Antunes, J Peixoto da-Silva, M Muler, R D Gigli, P T Monteforte, H Hirata, A Jurkiewicz, S S Smaili
Autophagy is a mechanism of protection against various forms of human diseases, such as cancer, in which autophagy seems to have an extremely complex role. In cancer, there is evidence that autophagy may be oncogenic in some contexts, whereas in others it clearly contributes to tumor suppression. In addition, studies have demonstrated the existence of a complex relationship between autophagy and cell death, determining whether a cell will live or die in response to anticancer therapies. Nevertheless, we still need to complete the autophagy-apoptosis puzzle in the tumor context to better address appropriate chemotherapy protocols with autophagy modulators...
November 25, 2013: Chemico-biological Interactions
Ana L Muler, Rafael S Oliveira, Hans Lambers, Erik J Veneklaas
Species that inhabit phosphorus- (P) and micronutrient-impoverished soils typically have adaptations to enhance the acquisition of these nutrients, for example cluster roots in Proteaceae. However, there are several species co-occurring in the same environment that do not produce similar specialised roots. This study aims to investigate whether one of these species (Scholtzia involucrata) can benefit from the mobilisation of P or micronutrients by the cluster roots of co-occurring Banksia attenuata, and also to examine the response of B...
January 2014: Oecologia
Yehudit Birger, Liat Goldberg, Timothy M Chlon, Benjamin Goldenson, Inna Muler, Ginette Schiby, Jasmin Jacob-Hirsch, Gideon Rechavi, John D Crispino, Shai Izraeli
Children with Down syndrome develop a unique congenital clonal megakaryocytic proliferation disorder (transient myeloproliferative disorder [TMD]). It is caused by an expansion of fetal megakaryocyte-erythroid progenitors (MEPs) triggered by trisomy of chromosome 21 and is further enhanced by the somatic acquisition of a mutation in GATA1. These mutations result in the expression of a short-isoform GATA1s lacking the N-terminal domain. To examine the hypothesis that the Hsa21 ETS transcription factor ERG cooperates with GATA1s in this process, we generated double-transgenic mice expressing hERG and Gata1s...
August 8, 2013: Blood
B Sicardy, J L Ortiz, M Assafin, E Jehin, A Maury, E Lellouch, R Gil Hutton, F Braga-Ribas, F Colas, D Hestroffer, J Lecacheux, F Roques, P Santos-Sanz, T Widemann, N Morales, R Duffard, A Thirouin, A J Castro-Tirado, M Jelínek, P Kubánek, A Sota, R Sánchez-Ramírez, A H Andrei, J I B Camargo, D N da Silva Neto, A Ramos Gomes, R Vieira Martins, M Gillon, J Manfroid, G P Tozzi, C Harlingten, S Saravia, R Behrend, S Mottola, E García Melendo, V Peris, J Fabregat, J M Madiedo, L Cuesta, M T Eibe, A Ullán, F Organero, S Pastor, J A de Los Reyes, S Pedraz, A Castro, I de la Cueva, G Muler, I A Steele, M Cebrián, P Montañés-Rodríguez, A Oscoz, D Weaver, C Jacques, W J B Corradi, F P Santos, W Reis, A Milone, M Emilio, L Gutiérrez, R Vázquez, H Hernández-Toledo
The dwarf planet Eris is a trans-Neptunian object with an orbital eccentricity of 0.44, an inclination of 44 degrees and a surface composition very similar to that of Pluto. It resides at present at 95.7 astronomical units (1 AU is the Earth-Sun distance) from Earth, near its aphelion and more than three times farther than Pluto. Owing to this great distance, measuring its size or detecting a putative atmosphere is difficult. Here we report the observation of a multi-chord stellar occultation by Eris on 6 November 2010 UT...
October 27, 2011: Nature
Fernando A Quintana, Peter Müler, Gary L Rosner, Mark Munsell
We analyze complete sequences of successes (hits, walks, and sacrifices) for a group of players from the American and National Leagues, collected over 4 seasons. The goal is to describe how players' performances vary from season to season. In particular, we wish to assess and compare the effect of available occasion-specific covariates over seasons. The data are binary sequences for each player and each season. We model dependence in the binary sequence by an autoregressive logistic model. The model includes lagged terms up to a fixed order...
2008: Bayesian Analysis
Soraya Smaili, Hanako Hirata, Rodrigo Ureshino, Priscila T Monteforte, Ana P Morales, Mari L Muler, Juliana Terashima, Karen Oseki, Tatiana R Rosenstock, Guiomar S Lopes, Claudia Bincoletto
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death. Several events are related to the increase in Ca m2+, including regulation and activation of a number of Ca2+ dependent enzymes, such as phospholipases, proteases and nucleases. Mitochondria and endoplasmic reticulum (ER) play pivotal roles in the maintenance of intracellular Ca2+ homeostasis and regulation of cell death...
September 2009: Anais da Academia Brasileira de Ciências
Gregor Hess, Barbara Müler
No abstract text is available yet for this article.
March 5, 2009: MMW Fortschritte der Medizin
C E Rupprecht, J Barrett, D Briggs, F Cliquet, A R Fooks, B Lumlertdacha, F X Meslin, T Müler, L H Nel, C Schneider, N Tordo, A I Wandeler
Rabies, an acute progressive encephalitis, is an ancient zoonosis. Its distribution encompasses all continents, except Antarctica. Agents consist of at least 11 species orgenotypes of rhabdoviruses, in the Genus Lyssavirus. Susceptible natural hosts include all mammals. Primary reservoirs reside in the Orders Carnivora and Chiroptera. A plethora of variants, maintained by a diversity of abundant hosts, presents a challenge to a strict concept of true eradication. Globally, the domestic dog remains the most significant species for viral transmission, responsible for millions of suspect human exposures and tens of thousands of fatalities...
2008: Developments in Biologicals
Jeffrey H Muler, Augusto F Paulino, Diane Roulston, Laurence H Baker
Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. The most common location of MFH are the extremities and the trunk, with the most common site for distant metastases being the lung. We describe a case with multiple synchronous sites of myxoid MFH but no lung metastases and presence of abnormalities of 19p13.
2002: Sarcoma
Maayan Amit, Noa Sela, Hadas Keren, Ze'ev Melamed, Inna Muler, Noam Shomron, Shai Izraeli, Gil Ast
BACKGROUND: Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. RESULTS: Genome-wide analysis of exonization of transposed elements revealed a higher rate of exonization within duplicated genes relative to single-copy genes. The gene for TIF-IA, an RNA polymerase I transcription initiation factor, underwent a humanoid-specific triplication, all three copies of the gene are active transcriptionally, although only one copy retains the ability to generate the TIF-IA protein...
2007: BMC Molecular Biology
Bryan J Schneider, Basil El-Rayes, Jeffery H Muler, Philip A Philip, Gregory P Kalemkerian, Kent A Griffith, Mark M Zalupski
BACKGROUND: The purposes of this study were to evaluate efficacy and toxicity of the combination of carboplatin, gemcitabine, and capecitabine in patients with carcinoma of unknown primary site (CUP). METHODS: Patients with CUP received carboplatin AUC 5 mg/mL a minute intravenously Day 1, gemcitabine 1000 mg/m(2) intravenously Days 1 and 8, and capecitabine 1600 mg/m(2) orally in divided doses, Days 1-14 of a 21-day cycle for up to 8 cycles. The primary endpoint of the study was objective response rate by intent-to-treat analysis...
August 15, 2007: Cancer
Michael A Dyer, Stacy L Donovan, Jiakun Zhang, Jonathan Gray, Angelica Ortiz, Rebeca Tenney, Jian Kong, Rando Allikmets, Melanie M Sohocki
Leber congenital amaurosis (LCA) is the most severe inherited retinopathy, with the earliest age of onset. Because this currently incurable disease is present from birth and is a relatively rare disorder, the development of animal models that closely resemble the phenotype in patients is especially important. Our previous genetic analyses of LCA patients identified mutations in the aryl-hydrocarbon interacting protein-like 1 (AIPL1) gene. Here we present development of an animal model of AIPL1-associated LCA, the Aipl1-deficient mouse...
December 20, 2004: Brain Research. Molecular Brain Research
No abstract text is available yet for this article.
April 1950: Les Annales D'oto-laryngologie
No abstract text is available yet for this article.
February 1950: Les Annales D'oto-laryngologie
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