keyword
https://read.qxmd.com/read/35115489/an-instructive-role-for-interleukin-7-receptor-%C3%AE-in-the-development-of-human-b-cell-precursor-leukemia
#1
JOURNAL ARTICLE
Ifat Geron, Angela Maria Savino, Hila Fishman, Noa Tal, John Brown, Virginia A Turati, Chela James, Jolanda Sarno, Michal Hameiri-Grossman, Yu Nee Lee, Avigail Rein, Hillary Maniriho, Yehudit Birger, Anna Zemlyansky, Inna Muler, Kara L Davis, Victoria Marcu-Malina, Nicole Mattson, Oren Parnas, Rabea Wagener, Ute Fischer, João T Barata, Catriona H M Jamieson, Markus Müschen, Chun-Wei Chen, Arndt Borkhardt, Ilan Richard Kirsch, Arnon Nagler, Tariq Enver, Shai Izraeli
Kinase signaling fuels growth of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Yet its role in leukemia initiation is unclear and has not been shown in primary human hematopoietic cells. We previously described activating mutations in interleukin-7 receptor alpha (IL7RA) in poor-prognosis "ph-like" BCP-ALL. Here we show that expression of activated mutant IL7RA in human CD34+ hematopoietic stem and progenitor cells induces a preleukemic state in transplanted immunodeficient NOD/LtSz-scid IL2Rγnull mice, characterized by persistence of self-renewing Pro-B cells with non-productive V(D)J gene rearrangements...
February 3, 2022: Nature Communications
https://read.qxmd.com/read/34165562/erratum-to-comprehensive-gene-expression-analysis-detects-global-reduction-of-proteasome-subunits-in-schizophrenia
#2
Libi Hertzberg, Nicola Maggio, Inna Muler, Assif Yitzhaky, Michael Majer, Vahram Haroutunian, Or Zuk, Pavel Katsel, Eytan Domany, Mark Weiser
No abstract text is available yet for this article.
June 24, 2021: Schizophrenia Bulletin
https://read.qxmd.com/read/33141894/comprehensive-gene-expression-analysis-detects-global-reduction-of-proteasome-subunits-in-schizophrenia
#3
JOURNAL ARTICLE
Libi Hertzberg, Nicola Maggio, Inna Muler, Assif Yitzhaky, Michael Majer, Vahram Haroutunian, Or Zuk, Pavel Katsel, Eytan Domany, Mark Weiser
BACKGROUND: The main challenge in the study of schizophrenia is its high heterogeneity. While it is generally accepted that there exist several biological mechanisms that may define distinct schizophrenia subtypes, they have not been identified yet. We performed comprehensive gene expression analysis to search for molecular signals that differentiate schizophrenia patients from healthy controls and examined whether an identified signal was concentrated in a subgroup of the patients. METHODS: Transcriptome sequencing of 14 superior temporal gyrus (STG) samples of subjects with schizophrenia and 15 matched controls from the Stanley Medical Research Institute (SMRI) was performed...
April 29, 2021: Schizophrenia Bulletin
https://read.qxmd.com/read/32376074/gene-expression-meta-analysis-reveals-the-down-regulation-of-three-gaba-receptor-subunits-in-the-superior-temporal-gyrus-of-patients-with-schizophrenia
#4
JOURNAL ARTICLE
Assaf Frajman, Nicola Maggio, Inna Muler, Vahram Haroutunian, Pavel Katsel, Assif Yitzhaky, Mark Weiser, Libi Hertzberg
One of the main theories accounting for the underlying pathophysiology of schizophrenia posits alterations in GABAergic neurotransmission. While previous gene expression studies of postmortem brain samples typically report the down-regulation of GABA related genes in schizophrenia, the results are often inconsistent and not uniform across studies. We performed a systematic gene expression analysis of 22 GABA related genes in postmortem superior temporal gyrus (STG) samples of 19 elderly subjects with schizophrenia (mean age: 77) and 14 matched controls from the Icahn school of Medicine at Mount Sinai (MSSM) cohort...
May 3, 2020: Schizophrenia Research
https://read.qxmd.com/read/32321078/effects-of-ici-182-780-an-er%C3%AE-and-er%C3%AE-antagonist-and-g-1-a-gper-agonist-on-autophagy-in-breast-cancer-cells
#5
JOURNAL ARTICLE
Mari Luminosa Muler, Fernanda Antunes, Gabriel Cicolin Guarache, Rafaela Brito Oliveira, Rodrigo Portes Ureshino, Claudia Bincoletto, Gustavo José da Silva Pereira, Soraya Soubhi Smaili
OBJECTIVE: To investigate if ICI 182,780 (fulvestrant), a selective estrogen receptor alpha/beta (ERα/ERβ) antagonist, and G-1, a selective G-protein-coupled receptor (GPER) agonist, can potentially induce autophagy in breast cancer cell lines MCF-7 and SKBr3, and how G-1 affects cell viability. METHODS: Cell viability in MCF-7 and SKBr3 cells was assessed by the MTT assay. To investigate the autophagy flux, MCF-7 cells were transfected with GFP-LC3, a marker of autophagosomes, and analyzed by real-time fluorescence microscopy...
2020: Einstein
https://read.qxmd.com/read/31651970/cognitive-development-of-infants-exposed-to-the-zika-virus-in-puerto-rico
#6
JOURNAL ARTICLE
Viviane Valdes, Carmen D Zorrilla, Laurel Gabard-Durnam, Natalia Muler-Mendez, Zarin Ibnat Rahman, Diego Rivera, Charles A Nelson
Importance: Existing research has established a causal link between Zika virus (ZIKV) infection and severe birth defects or consequent health impairments; however, more subtle cognitive impairments have not been explored. Objective: To determine whether infants of mothers with at least 1 positive ZIKV test show differences in cognitive scores at ages 3 to 6 months and ages 9 to 12 months. Design, Setting, and Participants: This cross-sectional study recruited infants enrolled in existing ZIKV study cohorts associated with the Maternal-Infant Studies Center and the Puerto Rico Clinical and Translational Research Consortium at the University of Puerto Rico and from the broader San Juan metropolitan area...
October 2, 2019: JAMA Network Open
https://read.qxmd.com/read/30146314/argonaute-mirna-complexes-silence-target-mrnas-in-the-nucleus-of-mammalian-stem-cells
#7
JOURNAL ARTICLE
Aishe A Sarshad, Aster H Juan, Ana Iris Correa Muler, Dimitrios G Anastasakis, Xiantao Wang, Pavol Genzor, Xuesong Feng, Pei-Fang Tsai, Hong-Wei Sun, Astrid D Haase, Vittorio Sartorelli, Markus Hafner
In mammals, gene silencing by the RNA-induced silencing complex (RISC) is a well-understood cytoplasmic posttranscriptional gene regulatory mechanism. Here, we show that embryonic stem cells (ESCs) contain high levels of nuclear AGO proteins and that in ESCs nuclear AGO protein activity allows for the onset of differentiation. In the nucleus, AGO proteins interact with core RISC components, including the TNRC6 proteins and the CCR4-NOT deadenylase complex. In contrast to cytoplasmic miRNA-mediated gene silencing that mainly operates on cis-acting elements in mRNA 3' untranslated (UTR) sequences, in the nucleus AGO binding in the coding sequence and potentially introns also contributed to post-transcriptional gene silencing...
September 20, 2018: Molecular Cell
https://read.qxmd.com/read/29752527/can-hydraulically-redistributed-water-assist-surrounding-seedlings-during-summer-drought
#8
JOURNAL ARTICLE
A L Muler, E J B van Etten, W D Stock, K Howard, R H Froend
Plant interaction studies provide a good understanding of the roles of key species, which can assist restoration of natural ecosystems. Among the interactions, facilitation and competition are known to affect ecosystem structure and function. We investigated whether a deep-rooted species could positively affect surrounding seedlings through hydraulic redistribution during dry months. We conducted two experiments in which seedlings from two species were growing together or isolated from source plants (field experiment) and where plants were isolated from source plants that were connected to or separated from a water table (glasshouse experiment)...
July 2018: Oecologia
https://read.qxmd.com/read/27861335/response-of-fibroblast-growth-factor-23-to-volume-interventions-in-arterial-hypertension-and-diabetic-nephropathy
#9
RANDOMIZED CONTROLLED TRIAL
Jelmer K Humalda, Sarah Seiler-Muler, Arjan J Kwakernaak, Marc G Vervloet, Gerjan Navis, Danilo Fliser, Gunnar H Heine, Martin H de Borst
Fibroblast growth factor 23 (FGF-23) rises progressively in chronic kidney disease and is associated with adverse cardiovascular outcomes. FGF-23 putatively induces volume retention by upregulating the sodium-chloride cotransporter (NCC). We studied whether, conversely, interventions in volume status affect FGF-23 concentrations.We performed a post hoc analysis of 1) a prospective saline infusion study with 12 patients with arterial hypertension who received 2 L of isotonic saline over 4 hours, and 2) a randomized controlled trial with 45 diabetic nephropathy (DN) patients on background angiotensin-converting enzyme -inhibition (ACEi), who underwent 4 6-week treatment periods with add-on hydrochlorothiazide (HCT) or placebo, combined with regular sodium (RS) or low sodium (LS) diet in a cross-over design...
November 2016: Medicine (Baltimore)
https://read.qxmd.com/read/26050470/-identification-of-2-3-cgmp-as-an-intermediate-of-rna-catalytic-cleavage-by-binase-and-evaluation-of-its-biological-action
#10
JOURNAL ARTICLE
J V Sokurenko, P V Zelenikhin, V V Ulyanova, A I Kolpakov, D Muler, O N Ilinskaya
Binase--Bacillus pumilus RNase--endonuclease cleaves the phosphodiester bond between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotides with the formation of corresponding intermediate 2',3'-cGMP. Subsequent hydrolysis of 2',3'-cGMP into 3'-phosphate is highly specific and occurs slowly So the question arises about the existing time of that positional isomer during RNA catalytic cleavage by binase and about 2',3'-cGMP role in antitumor activity of the enzyme: In present work by means of enzyme-linked immunosorbent assay we established that during catalytic cleavage of RNA by binase 2',3'-cGMP is preserved in reaction mixture for an hour, at the same time phosphodiesterases activation doesn't lead to the total elimination of 2',3'-cGMP...
January 2015: Bioorganicheskaia Khimiia
https://read.qxmd.com/read/25843585/effect-of-tithonia-diversifolia-mulch-on-atta-cephalotes-hymenoptera-formicidae-nests
#11
JOURNAL ARTICLE
Jonathan Rodríguez, James Montoya-Lerma, Zoraida Calle
Recent studies have shown an insecticidal effect of Tithonia diversifolia (Hemsl.) Gray (Asterales: Asteraceae) foliage on workers of Atta cephalotes L. and inhibitory effects of this plant on the growth of the symbiotic fungus Leucoagaricus gongylophorus (A. Müler) Singer. To evaluate the potential of T. diversifolia as a biological control treatment of this important pest, we assessed the effect of green manure (mulch) of this plant on natural nests of A. cephalotes, in Cali, Colombia. Three treatments were randomly assigned to 30 nests: 1) green mulch of T...
2015: Journal of Insect Science
https://read.qxmd.com/read/25081778/study-of-the-genus-cephennium-m%C3%A3-ler-kunze-1822-coleoptera-staphylinidae-scydmaeninae-from-the-balkan-peninsula-part-ii-new-species-of-the-subgenus-cephennium-s-str
#12
JOURNAL ARTICLE
Miroslav Stevanović
Twelve new species of the genus Cephennium Müler & Kunze, 1822 are described: C. (s. str.) irenae sp. n. (from Serbia, Bosnia and Herzegovina, and Montenegro); C. (s. str.) sladjanae sp. n. and C. (s. str.) fallax sp. n. (both from Serbia and Bulgaria); C. (s. str.) viti sp. n. (from Serbia, Macedonia, Greece and Bulgaria); C. (s. str.) fairchildi sp. n., C. (s. str.) ivanjicense sp. n., C. (s. str.) serbicum sp. n. and C. (s. str.) remisianum sp. n. (all from Serbia); C. (s. str.) assingi sp. n. and C. (s...
2014: Zootaxa
https://read.qxmd.com/read/24121004/interplay-between-apoptosis-and-autophagy-a-challenging-puzzle-new-perspectives-on-antitumor-chemotherapies
#13
JOURNAL ARTICLE
C Bincoletto, A Bechara, G J S Pereira, C P Santos, F Antunes, J Peixoto da-Silva, M Muler, R D Gigli, P T Monteforte, H Hirata, A Jurkiewicz, S S Smaili
Autophagy is a mechanism of protection against various forms of human diseases, such as cancer, in which autophagy seems to have an extremely complex role. In cancer, there is evidence that autophagy may be oncogenic in some contexts, whereas in others it clearly contributes to tumor suppression. In addition, studies have demonstrated the existence of a complex relationship between autophagy and cell death, determining whether a cell will live or die in response to anticancer therapies. Nevertheless, we still need to complete the autophagy-apoptosis puzzle in the tumor context to better address appropriate chemotherapy protocols with autophagy modulators...
November 25, 2013: Chemico-biological Interactions
https://read.qxmd.com/read/23934064/does-cluster-root-activity-benefit-nutrient-uptake-and-growth-of-co-existing-species
#14
JOURNAL ARTICLE
Ana L Muler, Rafael S Oliveira, Hans Lambers, Erik J Veneklaas
Species that inhabit phosphorus- (P) and micronutrient-impoverished soils typically have adaptations to enhance the acquisition of these nutrients, for example cluster roots in Proteaceae. However, there are several species co-occurring in the same environment that do not produce similar specialised roots. This study aims to investigate whether one of these species (Scholtzia involucrata) can benefit from the mobilisation of P or micronutrients by the cluster roots of co-occurring Banksia attenuata, and also to examine the response of B...
January 2014: Oecologia
https://read.qxmd.com/read/23719302/perturbation-of-fetal-hematopoiesis-in-a-mouse-model-of-down-syndrome-s-transient-myeloproliferative-disorder
#15
JOURNAL ARTICLE
Yehudit Birger, Liat Goldberg, Timothy M Chlon, Benjamin Goldenson, Inna Muler, Ginette Schiby, Jasmin Jacob-Hirsch, Gideon Rechavi, John D Crispino, Shai Izraeli
Children with Down syndrome develop a unique congenital clonal megakaryocytic proliferation disorder (transient myeloproliferative disorder [TMD]). It is caused by an expansion of fetal megakaryocyte-erythroid progenitors (MEPs) triggered by trisomy of chromosome 21 and is further enhanced by the somatic acquisition of a mutation in GATA1. These mutations result in the expression of a short-isoform GATA1s lacking the N-terminal domain. To examine the hypothesis that the Hsa21 ETS transcription factor ERG cooperates with GATA1s in this process, we generated double-transgenic mice expressing hERG and Gata1s...
August 8, 2013: Blood
https://read.qxmd.com/read/22031441/a-pluto-like-radius-and-a-high-albedo-for-the-dwarf-planet-eris-from-an-occultation
#16
JOURNAL ARTICLE
B Sicardy, J L Ortiz, M Assafin, E Jehin, A Maury, E Lellouch, R Gil Hutton, F Braga-Ribas, F Colas, D Hestroffer, J Lecacheux, F Roques, P Santos-Sanz, T Widemann, N Morales, R Duffard, A Thirouin, A J Castro-Tirado, M Jelínek, P Kubánek, A Sota, R Sánchez-Ramírez, A H Andrei, J I B Camargo, D N da Silva Neto, A Ramos Gomes, R Vieira Martins, M Gillon, J Manfroid, G P Tozzi, C Harlingten, S Saravia, R Behrend, S Mottola, E García Melendo, V Peris, J Fabregat, J M Madiedo, L Cuesta, M T Eibe, A Ullán, F Organero, S Pastor, J A de Los Reyes, S Pedraz, A Castro, I de la Cueva, G Muler, I A Steele, M Cebrián, P Montañés-Rodríguez, A Oscoz, D Weaver, C Jacques, W J B Corradi, F P Santos, W Reis, A Milone, M Emilio, L Gutiérrez, R Vázquez, H Hernández-Toledo
The dwarf planet Eris is a trans-Neptunian object with an orbital eccentricity of 0.44, an inclination of 44 degrees and a surface composition very similar to that of Pluto. It resides at present at 95.7 astronomical units (1 AU is the Earth-Sun distance) from Earth, near its aphelion and more than three times farther than Pluto. Owing to this great distance, measuring its size or detecting a putative atmosphere is difficult. Here we report the observation of a multi-chord stellar occultation by Eris on 6 November 2010 UT...
October 27, 2011: Nature
https://read.qxmd.com/read/21909346/semi-parametric-bayesian-inference-for-multi-season-baseball-data
#17
JOURNAL ARTICLE
Fernando A Quintana, Peter Müler, Gary L Rosner, Mark Munsell
We analyze complete sequences of successes (hits, walks, and sacrifices) for a group of players from the American and National Leagues, collected over 4 seasons. The goal is to describe how players' performances vary from season to season. In particular, we wish to assess and compare the effect of available occasion-specific covariates over seasons. The data are binary sequences for each player and each season. We model dependence in the binary sequence by an autoregressive logistic model. The model includes lagged terms up to a fixed order...
2008: Bayesian Analysis
https://read.qxmd.com/read/19722016/calcium-and-cell-death-signaling-in-neurodegeneration-and-aging
#18
REVIEW
Soraya Smaili, Hanako Hirata, Rodrigo Ureshino, Priscila T Monteforte, Ana P Morales, Mari L Muler, Juliana Terashima, Karen Oseki, Tatiana R Rosenstock, Guiomar S Lopes, Claudia Bincoletto
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death. Several events are related to the increase in Ca m2+, including regulation and activation of a number of Ca2+ dependent enzymes, such as phospholipases, proteases and nucleases. Mitochondria and endoplasmic reticulum (ER) play pivotal roles in the maintenance of intracellular Ca2+ homeostasis and regulation of cell death...
September 2009: Anais da Academia Brasileira de Ciências
https://read.qxmd.com/read/19472668/-flexpen-light-handling-nd-high-dosage-accuracy-a-ready-pen-for-almost-all-insulins
#19
JOURNAL ARTICLE
Gregor Hess, Barbara Müler
No abstract text is available yet for this article.
March 5, 2009: MMW Fortschritte der Medizin
https://read.qxmd.com/read/18634470/can-rabies-be-eradicated
#20
REVIEW
C E Rupprecht, J Barrett, D Briggs, F Cliquet, A R Fooks, B Lumlertdacha, F X Meslin, T Müler, L H Nel, C Schneider, N Tordo, A I Wandeler
Rabies, an acute progressive encephalitis, is an ancient zoonosis. Its distribution encompasses all continents, except Antarctica. Agents consist of at least 11 species orgenotypes of rhabdoviruses, in the Genus Lyssavirus. Susceptible natural hosts include all mammals. Primary reservoirs reside in the Orders Carnivora and Chiroptera. A plethora of variants, maintained by a diversity of abundant hosts, presents a challenge to a strict concept of true eradication. Globally, the domestic dog remains the most significant species for viral transmission, responsible for millions of suspect human exposures and tens of thousands of fatalities...
2008: Developments in Biologicals
keyword
keyword
162312
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.