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Liposomes nanosomes

O A Kulikov, N A Pyataev, A V Zaborovskii, I V Maev, V P Ageev, E E Marochkina, I S Dolgacheva, I S Avdyushkina, A V Kokorev, K G Gurevich, L A Tatarina, D V Yunina
Liposomes containing aprotinin were produced by the phase inversion technique and purified by gel filtration. Aprotinin inclusion was assessed fluorescence labeling of the protein. The size of obtained liposomes was 212±35 nm and aprotinin concentration in the liposomal suspension was 3000 KIU/ml. The efficiency of aprotinin inclusion into liposomes was 31.9%.
October 2017: Bulletin of Experimental Biology and Medicine
Islane Espirito Santo, Roberta Campardelli, Elaine Cabral Albuquerque, Silvio A B Vieira De Melo, Ernesto Reverchon, Giovanna Della Porta
Supercritical fluid extraction using a high-pressure packed tower is proposed not only to remove the ethanol residue from liposome suspensions but also to affect their size and distribution leading the production of nanosomes. Different operating pressures, temperatures, and gas to liquid ratios were explored and ethanol was successfully extracted up to a value of 400 ppm; liposome size and distribution were also reduced by the supercritical processing preserving their integrity, as confirmed by Z-potential data and Trasmission Electron Microscopy observations...
November 2015: Journal of Pharmaceutical Sciences
Lauren R Eichaker, Hongsik Cho, Craig L Duvall, Thomas A Werfel, Karen A Hasty
Current treatments for osteoarthritis (OA) are largely palliative until the joints become totally dysfunctional and prosthetic replacement becomes necessary. Effective methods are needed for diagnosing OA and monitoring its progression during its early stages, when the effects of therapeutic drugs or biological agents are most likely to be effective. Theranostic nanosomes and nanoparticles have the potential to noninvasively detect, track and treat the early stages of OA. As articular cartilage does not regenerate once it is degraded, cell-based treatments aided by superparamagnetic iron oxide nanoparticle tracking are attractive future treatment modalities for the later stages of OA progression, when significant cartilage replacement is needed...
July 2014: Nanomedicine
Ateeq Ahmad, Saifuddin Sheikh, Rakesh Taran, Shanti P Srivastav, Krishna Prasad, Senthil J Rajappa, Vijay Kumar, Mamillapalli Gopichand, Mahesh Paithankar, Manish Sharma, Rajendra C Rane, Imran Ahmad
BACKGROUND: Nanosomal docetaxel lipid suspension formulation was developed to eliminate ethanol and polysorbate 80 from the currently used docetaxel (Taxotere) drug for treatment of cancer patients. NDLS clinical safety and efficacy was evaluated and compared with Taxotere at 75 mg/m(2) in metastatic breast cancer patients. PATIENTS AND METHODS: A total of 72 patients were randomized in a ratio of 2:1 (NDLS:Taxotere). Patients treated with NDLS were not premedicated with corticosteroids as required with solvent-based Taxotere...
June 2014: Clinical Breast Cancer
G Fond, S Miot
INTRODUCTION: Nanomedicine is defined as the area using nanotechnology's concepts for the benefit of human beings, their health and well being. The field of nanotechnology opened new unsuspected fields of research a few years ago. AIM OF THE STUDY: To provide an overview of nanotechnology application areas that could affect care for psychiatric illnesses. METHODS: We conducted a systematic review using the PRISMA criteria (preferred reporting items for systematic reviews and meta-analysis)...
September 2013: L'Encéphale
G Fond, A Macgregor, S Miot
Nanomedicine is defined as the area using nanotechnology's concepts for the benefit of human beings' health and well being. In this article, we aimed to provide an overview of areas where nanotechnology is applied and how they could be extended to care for psychiatric illnesses. The main applications of nanotechnology in psychiatry are (i) pharmacology. There are two main difficulties in neuropharmacology: drugs have to pass the blood-brain barrier and then to be internalized by targeted cells. Nanoparticles could increase drugs bioavailability and pharmacokinetics, especially improving safety and efficacy of psychotropic drugs...
September 2013: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Silpa Raj, Shoma Jose, U S Sumod, M Sabitha
Nanotechnology is the science of manipulating atoms and molecules in the nanoscale - 80,000 times smaller than the width of a human hair. The world market for products that contain nanomaterials is expected to reach $2.6 trillion by 2015. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has now found applications in the field of cosmetics by taking the name of nanocosmetics. This widespread influence of nanotechnology in the cosmetic industries is due to the enhanced properties attained by the particles at the nano level including color, transparency, solubility etc...
July 2012: Journal of Pharmacy & Bioallied Sciences
Partha K Chandra, Anup K Kundu, Sidhartha Hazari, Sruti Chandra, Lili Bao, Tara Ooms, Gilbert F Morris, Tong Wu, Tarun K Mandal, Srikanta Dash
Sustained antiviral responses of chronic hepatitis C virus (HCV) infection have improved recently by the use of direct-acting antiviral agents along with interferon (IFN)-α and ribavirin. However, the emergence of drug-resistant variants is expected to be a major problem. We describe here a novel combinatorial small interfering RNA (siRNA) nanosome-based antiviral approach to clear HCV infection. Multiple siRNAs targeted to the highly conserved 5'-untranslated region (UTR) of the HCV genome were synthesized and encapsulated into lipid nanoparticles called nanosomes...
September 2012: Molecular Therapy
Rehab Mohamed Sobhi, Ahmed Mohamed Sobhi
BACKGROUND:   Melasma is a common pigmentary disorder. Despite the availability of a wide range of skin-lightening treatments, melasma of skin remains a therapeutic challenge. OBJECTIVE:   The aim of this study was to evaluate the efficacy and safety of nanosome vitamin C iontophoresis and to compare the therapeutic effects of nanosome vitamin C iontophoresis vs. glycolic acid peel 70% in the treatment of melasma in Egyptian women. METHODS:   This study included 14 patients of melasma with skin type IV-V taken for a right-left comparison study of six sessions...
March 2012: Journal of Cosmetic Dermatology
Anup K Kundu, Partha K Chandra, Sidhartha Hazari, Grace Ledet, Yashoda V Pramar, Srikanta Dash, Tarun K Mandal
The goal of this study is to evaluate the stability of lyophilized siRNA formulations. The gene silencing efficiency of a stored lyophilized siRNA formulation (i.e. siRNA nanosomes) was evaluated in interferon-α (IFN-α) resistant hepatitis C virus (HCV) at different time points up to three months in an in vitro cell culture model and compared with freshly prepared siRNA formulations. Novel siRNA sequences were encapsulated within nanosize liposomes following condensation with protamine sulfate. The siRNA encapsulated nanosomes were lyophilized and stored at 4 °C for 3 months, along with liquid liposomes (L) and lyophilized liposome powder (P) which were subsequently used to prepare siRNA nanosomes (L) and siRNA nanosomes (P), respectively at different time points...
February 28, 2012: International Journal of Pharmaceutics
Anup K Kundu, Partha K Chandra, Sidhartha Hazari, Yashoda V Pramar, Srikanta Dash, Tarun K Mandal
The objective of this study is to develop an effective siRNA delivery system for successful delivery to the liver for the treatment of HCV. Nanosize liposomes (nanosomes) have been prepared using a mixture of cholesterol and DOTAP. A functional siRNA was encapsulated into nanosomes following condensation with protamine sulfate. The delivery of siRNA was optimized in an in vitro cell culture system. The efficacy of the formulations was evaluated by measuring functional gene silencing and cytotoxicity. Encapsulation of siRNA ≥ 7...
February 2012: European Journal of Pharmaceutics and Biopharmaceutics
V A Shkurupy, S A Arkhipov, A V Troitsky, N G Luzgina, M V Zaikovskaja, E G Ufimceva, D A Iljine, E S Akhramenko, E P Gulyaeva, T N Bistrova
We studied phagocytic activity of macrophages towards hybrid molecular nanosomal compositions consisting of 150-800-nm nanoliposomes containing oxidized dextrans with a molecular weight of 35 and 60 kDa obtained by chemical ("permanganate") and radiochemical oxidation of dextran conjugated with isonicotinic acid hydrazide (dextrazides, intracellular prolonged antituberculous drugs). Phagocytic activity of macrophages towards hybrid molecular nanosomal compositions containing dextrazides obtained by chemical oxidation of dextrans is higher than activity towards hybrid molecular nanosomal compositions containing dextrazides prepared by radiochemical oxidation and depends on the size of hybrid molecular nanosomal compositions and molecular weight of oxidized dextrans...
December 2009: Bulletin of Experimental Biology and Medicine
Anup K Kundu, Sidhartha Hazari, Dakshinamurthy Devanga Chinta, Yashoda V Pramar, Srikanta Dash, Tarun K Mandal
OBJECTIVES: The aim of this project was to develop a novel lipid-based formulation suitable for gene therapy. METHODS: Novel nanosize liposome (nanosome) formulations containing pDNA (plasmid DNA) were developed using high-pressure homogenization (HPH). The effect of lipid concentration was studied at two levels: 3 mm and 20 mm. The preformed nanosomes were incubated for 18-20 h with pDNA or pDNA/protamine sulfate (PS) complex. The physical properties of the pDNA nanosomes were compared by particle size distribution and zeta-potential measurements...
September 2010: Journal of Pharmacy and Pharmacology
Saifuddin Sheikh, Shoukath M Ali, Moghis U Ahmad, Ateeq Ahmad, Mohammad Mushtaq, Mahesh Paithankar, Jayanta Mandal, Dipak Saptarishi, Ashish Sehgal, Kirti Maheshwari, Imran Ahmad
Amphotericin B was formulated in lipids (Nanosomal Amphotericin B) without using any detergent or toxic organic solvents during the preparation. Electron microscopy and particle size determination of Nanosomal Amphotericin B showed a homogeneous population of nanosized particles below 100 nm. Hemolysis assay indicated that Nanosomal Amphotericin B causes significantly less lysis of red blood cells than Amphotericin B deoxycholate and was comparable to Ambisome. A maximum daily dose of Nanosomal Amphotericin B at 5 mg/kg in rabbits and 10 mg/kg in mice for 28 days showed no symptoms of toxicity, mortality or significant body weight reduction...
September 15, 2010: International Journal of Pharmaceutics
Ahmet Erten, Wolf Wrasidlo, Miriam Scadeng, Sadik Esener, Robert M Hoffman, Michael Bouvet, Milan Makale
We report here the in vivo combined-modality imaging of multifunctional drug delivery nanoparticles. These dextran core-based stealth liposomal nanoparticles (nanosomes) contained doxorubicin, iron oxide for magnetic resonance imaging (MRI) contrast, and BODIPY for fluorescence. The particles were long-lived in vivo because of surface decoration with polyethylene glycol and the incorporation of acetylated lipids that were ultraviolet cross-linked for physical stability. We developed a rodent dorsal skinfold window chamber that facilitated both MRI and non-invasive optical imaging of nanoparticle accumulation in the same tumors...
December 2010: Nanomedicine: Nanotechnology, Biology, and Medicine
Moghis U Ahmad, Shoukath M Ali, Ateeq Ahmad, Saifuddin Sheikh, Imran Ahmad
Two guggullipid derivatives, Z-guggulsulfate [4,17(20)-pregnadiene-3-one-16beta-sulfate] sodium salt and Z-guggullaurate [4,17(20)-pregnadiene-3-one-16beta-laurate], have been synthesized and evaluated for liposomal drug delivery system. Its precursor, Z-guggulsterol [4,17(20)-pregnadiene-3-one-16beta-ol], is also synthesized in gram scale starting from guggulsterone using the novel combination of known reactions in fewer steps and with higher yield than previously reported synthesis. These new synthetic guggullipid derivatives were also used in the preparation of liposomes...
May 2010: Chemistry and Physics of Lipids
A Surendiran, S Sandhiya, S C Pradhan, C Adithan
Current modalities of diagnosis and treatment of various diseases, especially cancer have major limitations such as poor sensitivity or specificity and drug toxicities respectively. Newer and improved methods of cancer detection based on nanoparticles are being developed. They are used as contrast agents, fluorescent materials, molecular research tools and drugs with targeting antibodies. Paramagnetic nanoparticles, quantum dots, nanoshells and nanosomes are few of the nanoparticles used for diagnostic purposes...
December 2009: Indian Journal of Medical Research
V A Shkurupy, S A Arkhipov, V O Tkachev, A V Troitsky, N G Luzgina, M V Zaikovskaja, E P Gulyaeva, T N Bistrova, E G Ufimtceva
The effects of molecular nanosomal hybrid compositions consisting of nanoliposomes with oxidized dextrans (mol. weights 35 and 60 kDa) conjugated with isonicotinic acid hydrazine (dextrazides) on peritoneal macrophages were studied in vitro. Incubation of peritoneal cells with molecular nanosomal hybrid compositions modified the immunological phenotype of macrophage populations, which reflected an increase in their functional activity. Molecular nanosomal hybrid compositions containing dextrazide with 60-kDa dextran more effectively activated macrophages...
November 2008: Bulletin of Experimental Biology and Medicine
V A Shkurupiy, S A Arkhipov, A V Troitsky, N G Luzgina, M V Zaikovskaja, E P Gulyaeva, T N Bistrova, E G Ufimceva, D A Iljin, E S Akhramenko
We studied the in vitro effect of hybrid molecular-nanosomal biocompatible compositions on cultured peritoneal cells. The compositions consisted of oxidized dextrans with a mean molecular weight of 35 and 60 kDa, which were obtained by chemical and radiochemical oxidation of dextran. Hybrid nanoliposomal compositions of chemically oxidized dextran (permanganate method) had greater biocompatibility and tropic activity to macrophages compared to nanoliposomes of radiochemically oxidized dextran.
December 2008: Bulletin of Experimental Biology and Medicine
William C Zamboni
Major advances in the use of carrier vehicles delivering pharmacologic agents and enzymes to sites of disease have occurred over the past 10 years. This review focuses on the concepts and clinical evaluation of carrier-mediated anticancer agents that are administered i.v. or orally. The primary types of carrier-mediated anticancer agents are nanoparticles, nanosomes, which are nanoparticle-sized liposomes, and conjugated agents. Nanosomes are further subdivided into stabilized and nonstabilized or conventional nanosomes...
March 2008: Oncologist
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