Xiangzhi Li, Kyo-Ichi Isono, Daisuke Yamada, Takaho A Endo, Mitsuhiro Endoh, Jun Shinga, Yoko Mizutani-Koseki, Arie P Otte, Miguel Casanova, Hiroshi Kitamura, Takehiko Kamijo, Jafar Sharif, Osamu Ohara, Tetsuro Toyada, Bradley E Bernstein, Neil Brockdorff, Haruhiko Koseki
The Polycomb group of proteins forms at least two distinct complexes designated the Polycomb repressive complex-1 (PRC1) and PRC2. These complexes cooperate to mediate transcriptional repression of their target genes, including the Hox gene cluster and the Cdkn2a genes. Mammalian Polycomb-like gene Pcl2/Mtf2 is expressed as four different isoforms, and the longest one contains a Tudor domain and two plant homeodomain (PHD) fingers. Pcl2 forms a complex with PRC2 and binds to Hox genes in a PRC2-dependent manner...
January 2011: Molecular and Cellular Biology