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Diagnostic histopathology

Simon Heeke, Hervé Delingette, Youta Fanjat, Elodie Long-Mira, Sandra Lassalle, Véronique Hofman, Jonathan Benzaquen, Charles-Hugo Marquette, Paul Hofman, Marius Ilié
Histopathology is the fundamental tool of pathology used for more than a century to establish the final diagnosis of lung cancer. In addition, the phenotypic data contained in the histological images reflects the overall effect of molecular alterations on the behavior of cancer cells and provides a practical visual reading of the aggressiveness of the disease. However, the human evaluation of the histological images is sometimes subjective and may lack reproducibility. Therefore, computational analysis of histological imaging using so-called "artificial intelligence" (AI) approaches has recently received considerable attention to improve this diagnostic accuracy...
February 13, 2019: Annales de Pathologie
Chiara Eberspacher, D Mascagni, L Fralleone, A Maturo, F M Di Matteo, F De Cristofaro, D Merletti, A Santoro, P Mascagni, S Pontone, D Pironi
BACKGROUND: Inflammatory bowel diseases may be associated with many extraintestinal complications, that in some cases can represent the first onset of these disorders. In particular during the course of the disease, Ulcerative Colitis develops extraintestinal manifestations very frequently. One of the rarest is pyoderma gangrenosum, a noninfectious neuthrophilic dermatosis, that can involve most commonly legs but also other parts of the skin or mucosas. It can be idiopathic or associated with gammopathies, vasculitis, chronic arthritis or, like in our case, with inflammatory bowel disease and malignancies...
January 2019: Il Giornale di Chirurgia
Krzysztof Stachura, Ewelina Grzywna, Roger M Krzyżewski, Borys M Kwinta, Dariusz Adamek, Marek M Moskała
Introduction: Selection of the optimal treatment method of intra- and paraventricular tumors often requires histopathological verification that can be obtained by endoscopic biopsy. Aim: To discuss the usefulness of the method in their own experience. Material and methods: The results of 32 biopsies carried out during a 15-year period were reviewed retrospectively. All tumors were located supratentorially, 25 of them were intraventricular and 7 paraventricular...
January 2019: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
Jakub Malinowski, Miłosz Wilczyński, Adam Depta, Andrzej Malinowski
Vulvovaginal atrophy accompanied by lower urinary tract dysfunction related to low levels of estrogen and androgens is labeled as genitourinary syndrome of menopause (GSM). Although this condition affects most postmenopausal women worldwide, it seems to be underdiagnosed and undertreated. Women should be properly advised to choose an adequate treatment modality to improve their quality of life, sexual relationships and social activity. The aim of this article is to increase knowledge of GSM. The current treatment options, both hormonal and non-hormonal, are reviewed...
December 2018: Przeglad Menopauzalny, Menopause Review
Christine Fenton, Karen Reidy, Marina Demyanenko, Ricardo Palma-Dias, Stephen Cole, Mark P Umstad
BACKGROUND: Detection of a single yolk sac on early first trimester ultrasound was previously thought to be a reliable diagnostic feature of monochorionic monoamniotic (MCMA) twin pregnancies. OBJECTIVES: To determine the frequency of two yolk sacs in MCMA twin pregnancies and the association of yolk sac number with pregnancy outcomes. METHODS: A retrospective cohort analysis of MCMA twins managed at a tertiary obstetric centre from January 2003 until February 2017...
February 14, 2019: Fetal Diagnosis and Therapy
Yosuke Namba, Akihiko Oshita, Takashi Nishisaka, Maiko Namba, Tamito Sasaki, Yasuhiro Matsugu, Toshiyuki Itamoto
INTRODUCTION: A lymphoepithelial cyst (LEC) of the pancreas is a benign and rare lesion that is difficult to diagnose preoperatively based on imaging studies. PRESENTATION OF CASE: We report a case of a 49-year-old man who presented with weight loss and diarrhea. The serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were slightly elevated to 6.7 ng/mL (reference value <5.0 ng/mL) and 45 U/mL (reference value <37 U/mL), respectively...
January 30, 2019: International Journal of Surgery Case Reports
Nuri Murat Arar, Pushpak Pati, Aditya Kashyap, Anna Fomitcheva Khartchenko, Orcun Goksel, Govind V Kaigala, Maria Gabrani
Accurate profiling of tumors using immunohistochemistry (IHC) is essential in cancer diagnosis. The inferences drawn from IHC-stained images depend to a great extent on the quality of immunostaining, which is in turn affected strongly by assay parameters. To optimize assay parameters, the available tissue sample is often limited. Moreover, with current practices in pathology, exploring the entire assay parameter space is not feasible. Thus, the evaluation of IHC stained slides is conventionally a subjective task, in which diagnoses are commonly drawn on images that are suboptimal...
February 13, 2019: IEEE Transactions on Bio-medical Engineering
Charu Agarwal, Varsha Chauhan, Mukta Pujani, Kanika Singh, Sujata Raychaudhari, Mitasha Singh
OBJECTIVE: As fine needle aspiration cytology (FNAC) is the primary tool for evaluation of breast lesions, it is essential to segregate lesions with low and high risk of malignancy. To address this, Masood proposed a cytological scoring system for categorization, Masood's Scoring Index (MSI), which was modified later (Modified Masood's Scoring Index [MMSI]). This study analyses the effectiveness of MMSI over MSI and assesses the concordance between cytological scoring and histopathology...
February 13, 2019: Acta Cytologica
Christian Salib, Morris Edelman, Joshua Lilly, John E Fantasia, Aaron E Yancoskie
Cranial fasciitis (CF) is an uncommon benign myofibroblastic proliferation involving the soft and hard tissues of the cranium. It typically occurs in the pediatric population with a male predilection (male-to-female ratio 1.5:1). The clinical presentation is usually a rapidly expanding, painless nodule. Bone erosion may be appreciated radiographically. Histopathologic sections of CF show plump, fibroblast-like cells with pale, oval shaped nuclei and prominent nucleoli in a fibrous or myxoid background. Growth is self-limited and surgical excision is considered curative...
February 13, 2019: Head and Neck Pathology
M Grade, H Flebbe, B M Ghadimi
Over the past four decades, the treatment algorithms for rectal cancer have fundamentally changed, which resulted in a considerable improvement of oncological outcomes. In this context, the surgical concept of total mesorectal excision and the implementation of multimodal treatment strategies represent key milestones. These improvements were complemented by a standardized histopathological work-up of the surgical specimen and the introduction of high-resolution magnetic resonance imaging (MRI) diagnostics...
February 13, 2019: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Aleksandra Djuric-Stefanovic, Aleksandra Jankovic, Dusan Saponjski, Marjan Micev, Suzana Stojanovic-Rundic, Milena Cosic-Micev, Predrag Pesko
PURPOSE: To evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT. METHODS: Contrast-enhanced (CE)-MDCT examinations in portal venous phase of one hundred patients with locally advanced ESCC who received nCRT and underwent esophageal resection and histopathology assessment of tumor regression grade (TRG) were retrospectively analyzed by measuring the maximal thickness and mean density of the esophageal wall in the segment involved by tumor and visually searching for hyperdense foci within it...
February 13, 2019: Abdominal Radiology
T R Khan, N Afroze, M R Islam, M M Rahman, A M Sadeque, E R Khan
This cross sectional study was carried out in the Department of Radiology & Imaging, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh from July 2010 to June 2011 with a view to evaluate the diagnostic accuracy of refractory shadowing on transabdominal pelvic sonography for leiomyomas and in differentiating them from other pelvic masses. Histopathological examination of the surgically resected masses was taken as the standard diagnostic tool...
January 2019: Mymensingh Medical Journal: MMJ
J Shang, L-T Ruan, Y-Y Wang, X-J Zhang, Y Dang, B Liu, W-L Wang, Y Song, S-J Chang
AIM: To investigate the role of utilizing size-based thresholds of stiffness gradient in diagnosing solid breast lesions and optimizing original Breast Imaging-Reporting And Data System (BI-RADS) classifications. MATERIALS AND METHODS: Two-hundred and twenty-seven consecutive women underwent shear-wave elastography (SWE) before ultrasound-guided biopsy, and 234 solid breast lesions categorized as BI-RADS 3-5 were analysed. Receiver operating characteristic curve analysis was performed based on histopathology...
February 9, 2019: Clinical Radiology
Bonnie B Boudreaux, Susan M LaRue, Nathalie Rademacher, Daniel Neck, Britton Grasperge, Charles Wood, David G Baker
A 10-year-old male captive tiger (Panthera tigris) developed right-sided facial asymmetry and enlargement. Computed tomography revealed a destructive mass of the right maxillary bone with right nasal cavity involvement. Histopathology indicated a spindle cell sarcoma. A single fraction of 22 Gy using stereotactic radiotherapy was prescribed. After treatment, the facial conformation returned to normal and the tiger resumed normal behavior. Diagnostics 4 months later indicated severe metastatic disease. Humane euthanasia and necropsy were performed...
February 12, 2019: Veterinary Radiology & Ultrasound
Roupen Djinbachian, Anne-Julie Dubé, Daniel von Renteln
PURPOSE OF REVIEW: Optical diagnosis of diminutive colorectal polyps has been recently proposed as an alternative to histopathologic diagnosis. Recent developments in imaging techniques, new classification systems, and the use of artificial intelligence have allowed for increased viability of optical diagnosis. This review provides an up-to-date overview of optical diagnosis recommendations, classifications, outcomes, and recent developments. RECENT FINDINGS: There are currently seven major classification systems and three major society recommendations for quality benchmarks for optical diagnosis of diminutive polyps...
February 12, 2019: Current Treatment Options in Gastroenterology
A M Al Khatib, A E Stepan, C Mărgăritescu, B C Andreiana, M M Florescu, C E Simionescu, R N Ciurea
The majority of colorectal carcinomas are adenocarcinomas derived from the colic mucosae cell, more frequently moderately differentiated. The purpose of this study was to determine de incidence of CRC and the relationship between histopathological risk factors in patients with colic adenocarcinomas. The study included 144 cases of CRC diagnosed within the Pathology Laboratory of the Clinical County Hospital of Craiova in the year 2017.The biological material consisted in samples from colectomies and hemicolectomies provided from patients admitted within the surgical clinics of the same hospital, then fixed with 10% buffered formalin and afterwards processed using the classic histopathological technique of paraffin inclusion and staining with hematoxylin and eosin...
April 2018: Current Health Sciences Journal
Paricha Upadhyaya, Sushil Dhakal, Purbesh Adhikari, Bindu Adhikari, Dibika Khadka, Surya R Niraula
Context: Fine needle aspiration (FNA) plays a crucial role in the evaluation of patients with thyroid lesions. The Bethesda system for reporting thyroid cytopathology (TBSRTC) was designed with a mission to standardize the process of diagnosis and management of thyroid lesions by FNA cytology (FNAC). Aim: We aim to see the benefits of adopting TBSRTC, seek the cytological pitfalls in the diagnosis of thyroid FNAC, and identify the spectrum of thyroid lesions in our setup...
January 2019: Journal of Cytology
Subhash Bhardwaj, Gousia Rather
Cysticercosis is a systemic parasitic disease caused by larval stage of Taenia solium. It is the most common parasitic disease worldwide. It is potentially a dangerous systemic disease with variable clinical manifestations. It can be diagnosed by radiological imaging and serology but demonstration of parasitic larva by cytology or histopathology is still the gold standard. Fine needle aspiration cytology (FNAC) plays an important role in prompt diagnosis of this disease. Aim: To study the role of FNAC in the diagnosis of cysticercosis...
January 2019: Journal of Cytology
Ziqiang Wen, Yan Chen, Xinyue Yang, Baolan Lu, Yiyan Liu, Bingqi Shen, Shenping Yu
BACKGROUND: To evaluate the diagnostic performance of diffusion kurtosis imaging (DKI) for distinguishing different histopathological subtypes and grades of rectal carcinoma and to compare DKI with conventional diffusion-weighted imaging (DWI). METHODS: This prospective study involved 132 patients with rectal carcinoma, comprising 116 with adenocarcinoma not otherwise specified (AC) and 16 with mucinous carcinoma (MC). High spatial resolution magnetic resonance (MR) and DKI sequences (b values of 0, 600, 1000, 1500 and 2000 s/mm2 ) were performed for pretreatment evaluation...
February 11, 2019: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Emin Köse, Mustafa Hasbahçeci, Mehmet Can Aydın, Canberk Toy, Tuba Saydam, Ayhan Özsoy, Servet Rüştü Karahan
BACKGROUND: Clinical scoring systems have been used to reduce negative appendectomy rate for several decades. However, the use of these systems has been questioned due to differences in their diagnostic accuracies. The aim of this prospective study was to develop a new clinical scoring system using a combination of all previously described variables for the diagnosis of acute appendicitis (AA). METHODS: Consecutive patients who underwent emergency appendectomy for AA between December 2016 and April 2017 were prospectively included in the study...
January 2019: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
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