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Cisplatin ototoxicity

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https://read.qxmd.com/read/30753979/the-protective-role-of-ferulic-acid-against-cisplatin-induced-ototoxicity
#1
Eu-Ri Jo, Cha Kyung Youn, Yonghyun Jun, Sung Il Cho
OBJECTIVES: While cisplatin is an effective chemotherapeutic agent, it can cause irreversible hearing loss. Ototoxicity leads to dose reduction during the cisplatin chemotherapy and results in inadequate treatment of malignant tumors. This study aimed to investigate the protective effects of ferulic acid on cisplatin-induced ototoxicity. METHODS: House Ear Institute-Organ of Corti 1 (HEI-OC1) cells were exposed to 30 μM of cisplatin for 24 h with or without pretreatment with ferulic acid...
February 4, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30743189/genetic-susceptibility-to-aminoglycoside-ototoxicity
#2
Tien Nguyen, Anita Jeyakumar
INTRODUCTION: Aminoglycosides are a well-known clinically relevant antibiotic family used to treat bacterial infections in humans and animals and can produce toxic side effects. Aminoglycoside-induced hearing loss (HL) has been shown to have a genetic susceptibility. Mitochondrial DNA mutations have been implicated in inherited and acquired hearing impairment. OBJECTIVE: Literature review of genetic mutations associated with aminoglycoside-induced ototoxicity. METHODS: PubMed was accessed from 1993 to 2017 using the search terms "aminoglycoside, genetic, ototoxicity, hearing loss"...
February 4, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30738797/ampk-a-promising-molecular-target-for-combating-cisplatin-toxicities
#3
REVIEW
Nadereh Rashtchizadeh, Hassan Argani, Amir Ghorbani Haghjo, Davoud Sanajou, Vahid Hosseini, Siavoush Dastmalchi, Saeed Nazari Soltan Ahmad
Cisplatin is a broadly prescribed anti-tumor agent for the treatment of diverse cancers. Therapy with cisplatin, however, is associated with various adverse effects including nephrotoxicity and ototoxicity. AMPkinase (AMPK), an evolutionarily conserved enzyme, functions as the fundamental regulator of energy homeostasis. While AMPK activation protects normal tissues against cisplatin-induced toxicities, its impact in cancer is context-dependent and there is no single, uniform role for AMPK. On one hand, some report that AMPK activation augments cisplatin-induced apoptosis in cancer, while on the other hand, few reports indicate that AMPK activation rescues cancer cells from the cytotoxicity induced by cisplatin...
February 7, 2019: Biochemical Pharmacology
https://read.qxmd.com/read/30733218/necroptosis-and-apoptosis-contribute-to-cisplatin-and-aminoglycoside-ototoxicity
#4
Douglas Ruhl, Ting-Ting Du, Elizabeth L Wagner, Jeong Hwan Choi, Sihan Li, Robert Reed, Kitae Kim, Michael Freeman, George Hashisaki, John R Lukens, Jung-Bum Shin
Ototoxic side effects of cisplatin and aminoglycosides have been extensively studied, but no therapy is available to date. Sensory hair cells, upon exposure to cisplatin or aminoglycosides, undergo apoptotic and necrotic cell death. Blocking these cell death pathways has therapeutic potential in theory, but incomplete protection and lack of therapeutic targets in the case of necrosis, has hampered the development of clinically applicable drugs. Over the past decade, a novel form of necrosis, termed necroptosis, was established as an alternative cell death pathway...
February 7, 2019: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://read.qxmd.com/read/30732962/predictors-of-cisplatin-induced-ototoxicity-and-survival-in-chemoradiation-treated-head-and-neck-cancer-patients
#5
Wendy A Teft, Eric Winquist, Anthony C Nichols, Sara Kuruvilla, Suzanne Richter, Christina Parker, Peggy Francis, Maureen Trinnear, Jelena Lukovic, Nedal Bukhari, Yun-Hee Choi, Stephen Welch, David A Palma, John Yoo, Richard B Kim
OBJECTIVES: Cisplatin-induced ototoxicity is a common permanent consequence of curative chemoradiation for locally advanced head and neck squamous cell carcinoma (HNSCC). Predictors of ototoxicity in HNSCC were examined. MATERIALS AND METHODS: In this prospective, observational cohort study, 206 adult HNSCC patients underwent audiometric testing at baseline, during and after treatment with cisplatin-based chemoradiation. Ototoxicity was defined as ≥grade 2 audiometric change from baseline (CTCAE v4...
February 2019: Oral Oncology
https://read.qxmd.com/read/30651130/a-randomized-controlled-trial-to-test-the-efficacy-of-trans-tympanic-injections-of-a-sodium-thiosulfate-gel-to-prevent-cisplatin-induced-ototoxicity-in-patients-with-head-and-neck-cancer
#6
Viannique Rolland, François Meyer, Matthieu J Guitton, Richard Bussières, Daniel Philippon, Isabelle Bairati, Mathieu Leclerc, Mathieu Côté
BACKGROUND: Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. METHODS: Eligible participants were newly diagnosed patients with stage III or IV squamous cell carcinoma of the mouth, oropharynx, hypopharynx, or larynx and scheduled to be treated by concurrent chemoradiation (CCR)...
January 16, 2019: Journal of Otolaryngology—Head & Neck Surgery
https://read.qxmd.com/read/30587464/isotretinoin-s-action-against-cisplatin-induced-ototoxicity-in-rats
#7
Mehmet Akif Alan, Mehmet Akif Eryılmaz, Figen Kaymaz, Aysegul Suzer, Mitat Arıcıgil
Current data do not support the routine use of any agent to prevent cisplatin ototoxicity. Although there are various diseases in which derivatives of vitamin A are used due to their antioxidant effects, there is no study for prevention from ototoxicity. In this study, the protective effect of isotretinoin was investigated on cisplatin ototoxicity in rats. 21 Wistar Albino rats were divided randomly into 3 groups. Group I: cisplatin, Group II: cisplatin + isotretinoin and Group III was the control group. Hearing assessment of all rats was done with ABR and DPOAE tests before and after the procedure...
November 2018: Pakistan Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/30559765/pharmacokinetics-of-sodium-thiosulfate-in-guinea-pig-perilymph-following-middle-ear-application
#8
Ronald J Schroeder, Jason Audlin, Juntao Luo, Brian D Nicholas
Hypothesis: To determine the pharmacokinetics of sodium thiosulfate in the inner ear perilymph following middle ear application in Guinea pigs. Background: Cisplatin chemotherapy is often associated with a dose-dependent high frequency sensorineural hearing loss. Sodium thiosulfate has been shown to reduce cisplatin-induced ototoxicity when given intravenously, but this may limit the tumoricidal effects of the chemotherapy. Recent animal studies looking at middle ear application of sodium thiosulfate have shown prevention of outer hair cell and hearing loss, but the perilymph pharmacokinetics have not yet been established...
June 2018: Journal of Otology
https://read.qxmd.com/read/30559254/aminoglycoside-and-cisplatin-induced-ototoxicity-mechanisms-and-otoprotective-strategies
#9
Corné J Kros, Peter S Steyger
Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a variety of environmental or occupational exposures (e.g., metals and solvents). This review provides a narrative derived from relevant papers describing factors contributing to (or increasing the risk of) aminoglycoside and cisplatin-induced ototoxicity. We also review current strategies to protect against ototoxicity induced by these indispensable pharmacotherapeutic treatments for life-threatening infections and solid tumors...
December 17, 2018: Cold Spring Harbor Perspectives in Medicine
https://read.qxmd.com/read/30536479/ototoxicity-in-locally-advanced-head-and-neck-cancer-patients-treated-with-induction-chemotherapy-followed-by-intermediate-or-high-dose-cisplatin-based-chemoradiotherapy
#10
Chantal M L Driessen, Joop Leijendeckers, Ad Snik, Winette T A van der Graaf, Jan Paiul de Boer, Hans Gelderblom, Johannes H A M Kaanders, Robert Takes, Carla M L van Herpen
BACKGROUND: This study evaluated ototoxicity in locally advanced head and neck cancer patients treated in the CONDOR study with docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with concomitant cisplatin 100 mg/m2 on days 1, 22, and 43 (cis100+RT) versus accelerated radiotherapy with concomitant cisplatin weekly 40 mg/m2 (cis40+ART). METHODS: Sixty-two patients were treated in this study. Audiometry was performed at baseline, during TPF, before start of chemoradiotherapy, and 1, 4, 8, and 12 months after treatment...
December 7, 2018: Head & Neck
https://read.qxmd.com/read/30532536/a666-conjugated-nanoparticles-target-prestin-of-outer-hair-cells-preventing-cisplatin-induced-hearing-loss
#11
Xueling Wang, Yuming Chen, Yong Tao, Yunge Gao, Dehong Yu, Hao Wu
Background: The delivery of treatment agents to inner ear with drug delivery system (DDS) has been under investigation to overcome the limitations of the conventional therapeutic agents in curing or alleviating the cisplatin ototoxicity. Methods: In the present study, a novel targeted dexamethasone (DEX)-loaded DDS, A666-DEX-NP, was constructed for prevention from cisplatin-induced hearing loss. A666-(CLEPRWGFGWWLH) peptides specifically bind to prestin, which is limited to the outer hair cells (OHCs)...
2018: International Journal of Nanomedicine
https://read.qxmd.com/read/30529910/noise-induced-trauma-produces-a-temporal-pattern-of-change-in-blood-levels-of-the-outer-hair-cell-biomarker-prestin
#12
Kourosh Parham, Maheep Sohal, Mathieu Petremann, Charlotte Romanet, Audrey Broussy, Christophe Tran Van Ba, Jonas Dyhrfjeld-Johnsen
Biomarkers in easy-to-access body fluid compartments, such as blood, are commonly used to assess health of various organ systems in clinical medicine. At present, no such biomarkers are available to inform on the health of the inner ear. Previously, we proposed the outer-hair-cell-specific protein prestin, as a possible biomarker and provided proof of concept in noise- and cisplatin-induced hearing loss. Our ototoxicity data suggest that circulatory prestin changes after inner ear injury are not static and that there is a temporal pattern of change that needs to be further characterized before practical information can be extracted...
January 2019: Hearing Research
https://read.qxmd.com/read/30452777/analyses-of-adverse-drug-reactions-nationwide-active-surveillance-network-canadian-pharmacogenomics-network-for-drug-safety-database
#13
Reo Tanoshima, Amna Khan, Agnieszka K Biala, Jessica N Trueman, Britt I Drögemöller, Galen E B Wright, Jafar S Hasbullah, Gabriella S S Groeneweg, Colin J D Ross, Bruce C Carleton
Adverse drug reactions (ADRs) are a major problem in modern medicine, representing up to the fourth-highest cause of mortality. Pharmacogenomic tests are 1 of the most promising methods to tackle the challenge of ADRs. The objective of this study was to analyze the clinical and demographic information of the pan-Canadian active surveillance network, Canadian Pharmacogenomics Network for Drug Safety (CPNDS). Information entered into the database by trained active surveillors between May 15, 2005 and May 9, 2017 was collected and analyzed...
November 19, 2018: Journal of Clinical Pharmacology
https://read.qxmd.com/read/30361796/contribution-of-the-gstp1-c-313a-g-variant-to-hearing-loss-risk-in-patients-exposed-to-platin-chemotherapy-during-childhood
#14
P H P Liberman, M V S Goffi-Gomez, C Schultz, P L Jacob, C A A de Paula, E L Sartorato, G T Torrezan, E N Ferreira, D M Carraro
BACKGROUND AND AIM: Ototoxicity is a potential adverse effect of chemotherapy with platin drugs, such as cisplatin and carboplatin, in children. Hearing loss (HL) affecting frequencies below 4 kHz can compromise speech perception. The aim of this study was to investigate whether genetic variants previously implicated in ototoxicity are associated with HL overall and HL below 4 kHz in pediatric oncology patients treated with cisplatin or carboplatin. MATERIALS AND METHODS: Patients given cisplatin or carboplatin for a pediatric cancer at least 5 years prior to the start of the study were enrolled...
October 25, 2018: Clinical & Translational Oncology
https://read.qxmd.com/read/30334605/asymmetric-sensorineural-hearing-loss-is-a-risk-factor-for-late-onset-hearing-loss-in-pediatric-cancer-survivors-following-cisplatin-treatment
#15
Margaret S Robertson, Susan S Hayashi, Miranda L Camet, Kathryn Trinkaus, Jennifer Henry, Robert J Hayashi
BACKGROUND: Ototoxicity is a significant complication of cisplatin treatment. Hearing loss can be symmetric or asymmetric, and may decline after therapy. This study examined the risks of asymmetric and late-onset hearing loss (LOHL) in cisplatin-treated pediatric patients with cancer. METHODS: A retrospective review of 993 patients' medical and audiological charts from August 1990 to March 2015 was conducted using stringent criteria to characterize patients with asymmetric hearing loss (AHL) or LOHL...
January 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/30317595/isolation-cultivation-and-characterization-of-primary-bovine-cochlear-pericytes-a-new-in-vitro-model-of-stria-vascularis
#16
Giovanni Giurdanella, Giuseppe Montalbano, Florinda Gennuso, Serena Brancati, Debora Lo Furno, Antonio Augello, Claudio Bucolo, Filippo Drago, Salvatore Salomone
The study of strial pericytes has gained great interest as they are pivotal for the physiology of stria vascularis. To provide an easily accessible in vitro model, here we described a growth medium-based approach to obtain and cultivate primary bovine cochlear pericytes (BCP) from the stria vascularis of explanted bovine cochleae. We obtained high-quality pericytes in 8-10 days with a > 90% purity after the second passage. Immunocytochemical analysis showed a homogeneous population of cells expressing typical pericyte markers, such as neural/glial antigen 2 (NG2), platelet-derived growth factor receptorβ (PDGFRβ), α-smooth muscle actin (α-SMA), and negative for the endothelial marker von Willebrand factor...
March 2019: Journal of Cellular Physiology
https://read.qxmd.com/read/30310154/quinoxaline-protects-zebrafish-lateral-line-hair-cells-from-cisplatin-and-aminoglycosides-damage
#17
Sonia M Rocha Sanchez, Olivia Fuson, Shikha Tarang, Linda Goodman, Umesh Pyakurel, Huizhan Liu, David Z He, Marisa Zallocchi
Hair cell (HC) death is the leading cause of hearing and balance disorders in humans. It can be triggered by multiple insults, including noise, aging, and treatment with certain therapeutic drugs. As society becomes more technologically advanced, the source of noise pollution and the use of drugs with ototoxic side effects are rapidly increasing, posing a threat to our hearing health. Although the underlying mechanism by which ototoxins affect auditory function varies, they share common intracellular byproducts, particularly generation of reactive oxygen species...
October 11, 2018: Scientific Reports
https://read.qxmd.com/read/30305294/genetic-and-modifiable-risk-factors-contributing-to-cisplatin-induced-toxicities
#18
Matthew R Trendowski, Omar El Charif, Paul C Dinh, Lois B Travis, M Eileen Dolan
Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent that has potent antineoplastic activity due to its affinity for DNA and other intracellular nucleophiles. Despite its efficacy against many adult-onset and pediatric malignancies, cisplatin elicits multiple off-target toxicities that can not only severely impact a patient's quality of life, but also lead to dose reductions or the selection of alternative therapies that can ultimately affect outcomes...
October 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://read.qxmd.com/read/30281285/reduction-of-cisplatin-induced-ototoxicity-without-compromising-its-antitumor-activity
#19
Bapurao Surnar, Nagesh Kolishetti, Uttara Basu, Anis Ahmad, Erik Goka, Brian Marples, David Kolb, Marc E Lippman, Shanta Dhar
Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority of patients who receive cisplatin therapy often suffer from nephrotoxicity, neurotoxicity, nausea, and ototoxicity...
November 7, 2018: Biochemistry
https://read.qxmd.com/read/30268784/protective-effect-of-n-acetylcysteine-against-cisplatin-ototoxicity-in-rats-a-study-with-hearing-tests-and-scanning-electron-microscopy
#20
Mehmet Akif Somdaş, İnayet Güntürk, Esra Balcıoğlu, Deniz Avcı, Cevat Yazıcı, Saim Özdamar
INTRODUCTION: Ototoxicity is a health problem appearing after powerful treatments in serious health conditions. It is sometimes inevitable when treatment of the serious disease is required. Cisplatin is an antineoplastic agent which was investigated previously to reveal increased nitrogen and reactive oxygen radicals that damages hair cells, resulting in ototoxicity. N-acetylcysteine, previously shown to decrease ototoxicity caused by different agents, is known to be a powerful in vitro antioxidant...
September 14, 2018: Brazilian Journal of Otorhinolaryngology
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