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Compensation and injury

Austin D Hocker, Sarah A Beyeler, Alyssa N Gardner, Stephen M Johnson, Jyoti J Watters, Adrianne G Huxtable
Neonatal inflammation is common and has lasting consequences for adult health. We investigated the lasting effects of a single bout of neonatal inflammation on adult respiratory control in the form of respiratory motor plasticity induced by acute intermittent hypoxia, which likely compensates and stabilizes breathing during injury or disease and has significant therapeutic potential. Lipopolysaccharide-induced inflammation at postnatal day four induced lasting impairments in two distinct pathways to adult respiratory plasticity in male and female rats...
March 22, 2019: ELife
Lea Siegenthaler, Michael Strehl, Alessio Vaghi, Philippe Zysset, Beat P Kneubuehl, Martin Frenz
The formation of skull fractures is an important topic in legal medicine. In particular, the influence of boundary conditions is controversially discussed in the literature. A study focusing solely on this aspect was missing. This study aimed to investigate the influence of boundary conditions on the energy threshold for head fractures. Because of the great variability of biological tissue of real skulls, we opted for a head model made from a polyurethane sphere filled with gelatin. Furthermore, we decided to investigate two opposite situations: A fixed configuration where a model was placed on a rigid surface and a (quasi) free boundary configuration where the head model was held at a force of 5 N compensating for gravity...
March 19, 2019: International Journal of Legal Medicine
Dan L Hunt, Ryan D Artuso, Nimisha Kalia, Nina Leung, Edward J Bernacki, Xuguang Grant Tao
BACKGROUND: Antidepressants, benzodiazapines and opioid medications are used to manage the pain, anxiety or depression associated with workplace injuries. OBJECTIVE: To evaluate the impact of these medications on workers' compensation costs and time lost from work. METHODS: A cohort of 22,383 indemnity claims from 2008-2013 were evaluated for the association of prescribed medications on claim cost and delayed claim closure controlling for confounders...
March 13, 2019: Journal of Occupational and Environmental Medicine
Tayana Silva de Carvalho, Eduardo H Sanchez-Mendoza, Luiza M Nascentes Melo, Adriana R Schultz Moreira, Maryam Sardari, Egor Dzyubenko, Christoph Kleinschnitz, Dirk M Hermann
Malnutrition predisposes to poor stroke outcome. In animal models, undernutrition protected against ischemic injury in some, but not in other studies. In view of diverse stroke models and food restriction paradigms, the consequences of undernutrition are poorly understood. Herein, we exposed mice to energy-reduced and protein-energy-reduced diets for 7-30 days and subsequently induced intraluminal middle cerebral artery occlusion. Undernutrition phase dependently influenced ischemic injury. Short-lasting 7 days of protein-energy undernutrition, but not energy undernutrition, decreased post-ischemic brain leukocyte infiltration and microglial activation and reduced brain Il-1β mRNA, but did not protect against ischemic injury...
March 18, 2019: Translational Stroke Research
Hadi Akbarzadeh Khorshidi, Miriam Marembo, Uwe Aickelin
Purpose This study evaluates the Occupational Rehabilitation (OR) initiatives regarding return to work (RTW) and sustaining at work following work-related injuries. This study also identifies the predictors and predicts the likelihoods of RTW and sustainability for OR users. Methods The study is conducted on the compensation claim data for people who are injured at work in the state of Victoria, Australia. The claims which commenced OR services between the first of July 2012 and the end of June 2015 are included...
March 14, 2019: Journal of Occupational Rehabilitation
Benjamin W Lindsey, Georgia E Aitken, Jean K Tang, Mitra Khabooshan, Alon M Douek, Celia Vandestadt, Jan Kaslin
How diverse adult stem and progenitor populations regenerate tissue following damage to the brain is poorly understood. In highly regenerative vertebrates, such as zebrafish, radial-glia (RG) and neuro-epithelial-like (NE) stem/progenitor cells contribute to neuronal repair after injury. However, not all RG act as neural stem/progenitor cells during homeostasis in the zebrafish brain, questioning the role of quiescent RG (qRG) post-injury. To understand the function of qRG during regeneration, we performed a stab lesion in the adult midbrain tectum to target a population of homeostatic qRG, and investigated their proliferative behaviour, differentiation potential, and Wnt/β-catenin signalling...
March 14, 2019: Scientific Reports
Nathalie Rion, Perrine Castets, Shuo Lin, Leonie Enderle, Judith R Reinhard, Christopher Eickhorst, Markus A Rüegg
The formation of multi-nucleated muscle fibers from progenitors requires the fine-tuned and coordinated regulation of proliferation, differentiation and fusion, both during development and after injury in the adult. While some of the key factors involved in the different steps are well known, how intracellular signals are coordinated and integrated is largely unknown. Here, we investigated the role of the cell-growth regulator mTOR by eliminating essential components of the mTOR complexes 1 (mTORC1) and 2 (mTORC2) in muscle progenitors...
March 14, 2019: Development
Thomas Leclerc, Arnaud Baus, Patrick Duhamel, Clément Hoffmann
Acute inpatient treatment of severe burns. Acute in-hospital care of severely burned patients intricately combines surgery and intensive care. Systemic and supportive care is centered on hemodynamic management of the initial plasmorrhagic shock, airway control, enteral nutrition in order to compensate for hypercatabolism, analgesia and adjuncts. Infection is a major risk, to be prevented and managed topically. Sytemic administration of antibiotics is limited to documented sepsis. Smoke inhalation injury is diagnosed by fiberoptic bronchoscopy and managed with protective ventilation, iterative bronchoscopic cleansing, and nebulized heparin, mucolytics and bronchodilators...
December 2018: La Revue du Praticien
Miriam M Calkins, David Bonauto, Anjum Hajat, Max Lieblich, Noah Seixas, Lianne Sheppard, June T Spector
Objectives The primary objective of this study was to assess the relationship between heat exposure and occupational traumatic injuries among construction workers. Methods We assessed the relationship between humidex, a measure of apparent temperature, and Washington State Fund workers' compensation injuries among outdoor construction workers using a case-crossover design with time-stratified referent selection. Warm month (March-October) adult outdoor construction traumatic injury claims from 2000-2012 were spatiotemporally joined with high-resolution meteorological data...
March 14, 2019: Scandinavian Journal of Work, Environment & Health
Lauren N Miterko, Joshua J White, Tao Lin, Amanda M Brown, Kevin J O'Donovan, Roy V Sillitoe
BACKGROUND: Purkinje cells play a central role in establishing the cerebellar circuit. Accordingly, disrupting Purkinje cell development impairs cerebellar morphogenesis and motor function. In the Car8wdl mouse model of hereditary ataxia, severe motor deficits arise despite the cerebellum overcoming initial defects in size and morphology. METHODS: To resolve how this compensation occurs, we asked how the loss of carbonic anhydrase 8 (CAR8), a regulator of IP3R1 Ca2+ signaling in Purkinje cells, alters cerebellar development in Car8wdl mice...
March 12, 2019: Neural Development
Merethe Ravlo, Marit Lieng, Ida Rashida Khan Bukholm, Mette Haase Moen, Eszter Vanky
INTRODUCTION: The Norwegian System of Patient Injury Compensation (NPE) evaluates all patient reported claims in Norway. Our aim was to study the cases from gynecological patients approved by NPE, in order to identify the main reasons for the injuries, the consequences of the treatment failure for the women, and the time course when the treatment failure occurred. MATERIAL AND METHODS: A retrospective, descriptive study of approved gynecological compensation claims during a 14-year period, based on patient files from NPE...
March 12, 2019: Acta Obstetricia et Gynecologica Scandinavica
Zoe Durand, Sarah Nechuta, Shanthi Krishnaswami, Eric L Hurwitz, Melissa McPheeters
PURPOSE: This is the first study in Tennessee to measure opioid use in injured workers and among the first nationally to use a prescription drug monitoring program to do so. We conducted a retrospective cohort study to evaluate the prevalence of opioid use after injury and associated characteristics among workers reporting one injury to Tennessee Workers' Compensation. METHODS: Injured workers identified in Workers' Compensation records 2013-2015 were linked to their prescription history in Tennessee's prescription drug monitoring database...
February 14, 2019: Annals of Epidemiology
T Kučera, M Grinac, O Valtr, P Šponer
PURPOSE OF THE STUDY The aim of this study was to evaluate the mid-term outcomes of the surgical reconstruction of Charcot Foot Neuroarthropathy in diabetic patients with failed conservative treatment and indicated for a below-knee amputation. MATERIAL AND METHODS In the period from 2010 to 2015 the surgical reconstruction of inactive, chronic Charcot Foot Neuroarthropathy classified as type II and III by Sanders and Frykbeg was performed in 16 patients with failed conservative treatment. All these patients were by the diabetes centres initially indicated for a below-knee amputation...
2019: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
Elizabeth M Leimer, Matthew G Gayoso, Liufang Jing, Simon Y Tang, Munish C Gupta, Lori A Setton
Low back pain is associated with degeneration of the intervertebral disc, but specific mechanisms of pain generation in this pathology remain unknown. Sensory afferent nerve fiber growth into the intervertebral disc after injury-induced inflammation may contribute to discogenic pain. We describe a clinically relevant behavioral phenotype in a rodent model of chronic intervertebral disc degeneration which provides a means to map sensory neuron changes to a single affected lumbar intervertebral disc. Unilateral disc puncture of one lumbar intervertebral disc revealed a bilateral behavioral phenotype characterized by gait changes and decreased activity...
March 6, 2019: Scientific Reports
Jonathan S Calvert, Peter J Grahn, Kristin D Zhao, Kendall H Lee
BACKGROUND: Traumatic spinal cord injury (SCI) disrupts signaling pathways between the brain and spinal networks below the level of injury. In cases of severe SCI, permanent loss of sensorimotor and autonomic function can occur. The standard of care for severe SCI uses compensation strategies to maximize independence during activities of daily living while living with chronic SCI-related dysfunctions. Over the past several years, the research field of spinal neuromodulation has generated promising results that hold potential to enable recovery of functions via epidural electrical stimulation (EES)...
March 6, 2019: Neuromodulation: Journal of the International Neuromodulation Society
Luke R Sheehan, Tyler J Lane, Shannon E Gray, Alex Collie
Purpose The employer/worker relationship can be an important catalyst for-or obstacle to-successful return to work (RTW). An understanding of factors associated with an injured worker's relationship with their employer, and employer involvement in RTW planning, is warranted. Methods Analysis of n = 8808 cross-sectional survey responses from injured workers in nine Australian workers' compensation (WC) jurisdictions. Workers completed a telephone survey between 6 and 24 months post-WC claim acceptance. Factors associated with the worker's perception of employer support were examined using ordinal regression...
February 28, 2019: Journal of Occupational Rehabilitation
Alison Wheatley, Claire Bamford, Caroline Shaw, Elizabeth Flynn, Amy Smith, Fiona Beyer, Chris Fox, Robert Barber, Steve W Parry, Denise Howel, Tara Homer, Louise Robinson, Louise M Allan
BACKGROUND: Falls in people with dementia can result in a number of physical and psychosocial consequences. However, there is limited evidence to inform how best to deliver services to people with dementia following a fall. The aim of the DIFRID study was to determine the feasibility of developing and implementing a new intervention to improve outcomes for people with dementia with fall-related injuries; this encompasses both short-term recovery and reducing the likelihood of future falls...
February 28, 2019: BMC Geriatrics
S S Li, X Han, W Wang, K X Xu, Q Liu, C Wen, T S Chen, P Lin
Objective: To evaluate the frequency characteristics of semicircular canal injury in patients with vestibular neuritis. Method: Fifty-three patients with vestibular neuritis were respectively evaluated by caloric test(CT),head shaking test(HST),video head impulse test (vHIT),which reflects semicircular canal function in the low, middle, high frequency region. The asymmetric value of CT unilateral semicircular canal reaction (UW), head shaking nystagmus induced by HST, gain value of VHIT (VHIT-G) and presence or absence of saccade (VHIT-S) were used as observation indicators...
March 2019: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Iuri Domingues Della-Pace, Thayse Lopes, Ana Claudia Beck Grauncke, Leonardo Magno Rambo, Leandro Rodrigo Ribeiro, Rafael Parcianello Cipolatto, Leandro Severo, Willian Link Papalia, Adair Roberto Soares Santos, Valdir A Facundo, Mauro Schneider Oliveria, Ana Flavia Furian, Michele Rechia Fighera, Luiz Fernando Freire Royes
Traumatic brain injury (TBI) is a public health problem characterized by a combination of immediate mechanical dysfunction of the brain tissue, and secondary damage. Based on the hypothesis that selected targets, such as Na+ K+ -ATPase are involved in the secondary damage after TBI and modulation of this enzyme activity by triterpene 3β, 6β, 16β-trihidroxilup-20 (29)-ene (TTHL) supports the ethnomedical applications of this plant, we decided to investigate whether previous TTHL treatment interrupts the progression of pathophysiology induced by TBI...
February 23, 2019: European Journal of Pharmacology
Rui Ma, Shuang Zhong, Marco Morabito, Shakoor Hajat, Zhiwei Xu, Yiling He, Junzhe Bao, Rongrong Sheng, Changchang Li, Chuandong Fu, Cunrui Huang
BACKGROUND: Climate change has exacerbated the health effects of high ambient temperatures on occupational health and safety; however, to what extent heat stress can induce workplace injuries and economic costs is poorly studied. This study aimed to quantify the attributable fractions of injury claims and subsequent insurance payouts using data from work-related injury insurance system in Guangzhou, China. METHODS: Individual workers' injury claims data were collected for the period of 2011-2012, including demographic characteristics and work-related information...
February 14, 2019: Science of the Total Environment
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