keyword
https://read.qxmd.com/read/38532710/enhancing-stability-and-performance-in-tin-based-perovskite-field-effect-transistors-through-hydrogen-bond-suppression-of-organic-cation-migration
#21
JOURNAL ARTICLE
Wenshu Yang, Kai Zhang, Wei Yuan, Lijun Zhang, Chuanjiang Qin, Haibo Wang
Ion migration poses a substantial challenge in perovskite transistors, exerting detrimental effects on hysteresis and operational stability. This study focuses on elucidating the influence of ion migration on the performance of tin-based perovskite field-effect transistors (FETs). It is revealed that the high background carrier density in FASnI3 FETs arises not only from the oxidation of Sn2+ but also from the migration of FA+ ions. The formation of hydrogen bonding between FA+ and F- ions efficiently inhibits ion migration, leading to a reduction in background carrier density and an improvement in the operational stability of the transistors...
March 27, 2024: Advanced Materials
https://read.qxmd.com/read/38531838/tissue-specific-silencing-of-integrated-transgenes-achieved-through-endogenous-rna-interference-in-caenorhabditis-elegans
#22
JOURNAL ARTICLE
Siyu Chen, Weihong Liu, Lei Xiong, Zhiju Tao, Di Zhao
Transgene silencing is a common phenomenon observed in Caenorhabditis elegans , particularly in the germline, but the precise mechanisms underlying this process remain elusive. Through an analysis of the transcription factors profile of C. elegans , we discovered that the expression of several transgenic reporter lines exhibited tissue-specific silencing, specifically in the intestine of C. elegans . Notably, this silencing could be reversed in mutants defective in endogenous RNA interference (RNAi). Further investigation using knock-in strains revealed that these intestine-silent genes were indeed expressed in vivo , indicating that the organism itself regulates the intestine-specific silencing...
January 2024: RNA Biology
https://read.qxmd.com/read/38531434/an-enhanced-cardio-protective-effect-of-nanoparticles-loaded-with-active-components-from-polygonum-orientale-l-against-isoproterenol-induced-myocardial-ischemia-in-rats
#23
JOURNAL ARTICLE
Jincheng Jing, Shumei Fang, Yueting Li, Wenting Liu, Cong Wang, Yanyu Lan, Yonglin Wang, Chang Yang
In this study, nanoparticles loaded with active components from Polygonum orientale L. (PO), a traditional Chinese herb known for its anti-myocardial ischemic properties, were investigated for cardio-protective properties. Specifically, OVQ-Nanoparticles (OVQ-NPs) with Orientin (Ori), Vitexin (Vit), and Quercetin (Que) was obtained by double emulsion-solvent evaporation method. The OVQ-NPs exhibited a spherical shape, with a uniform size distribution of 136.77 ± 3.88 nm and a stable ζ-potential of -13...
March 24, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38531221/endothelial-clec-1b-plays-a-protective-role-against-cancer-hematogenous-metastasis
#24
JOURNAL ARTICLE
Ekura Yamazaki, Koji Ikeda, Ryota Urata, Daisuke Ueno, Akiko Katayama, Fumiaki Ito, Hiroshi Ikegaya, Satoaki Matoba
Metastasis, which is the spread of cancer cells into distant organs, is a critical determinant of prognosis in patients with cancer, and blood vessels are the major route for cancer cells to spread systemically. Extravasation is a critical process for the hematogenous metastasis; however, its underlying molecular mechanisms remain poorly understood. Here, we identified that senescent ECs highly express C-type lectin domain family 1 member B (CLEC-1b), and that endothelial CLEC-1b inhibits the hematogenous metastasis of a certain type of cancer...
March 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38531078/stable-n-type-perylene-derivative-ladder-polymer-with-antiambipolarity-for-electrically-reconfigurable-organic-logic-gates
#25
JOURNAL ARTICLE
Xihu Wu, Qiang He, Zhongliang Zhou, Teck Lip Dexter Tam, Cindy Tang, Ming Lin, Maximilian Moser, Sophie Griggs, Adam Marks, Shuai Chen, Jianwei Xu, Iain McCulloch, Wei Lin Leong
Organic electrochemical transistors (OECTs) are one of the promising building blocks to realize next-generation bioelectronics. To date, however, the performance and signal processing capabilities of these devices remain limited by their stability and speed. Herein, we demonstrate a stable and fast n-type organic electrochemical transistors based on a side-chain-free ladder polymer, poly(benzimidazoanthradiisoquinolinedione). The device demonstrated fast normalized transient speed of 0.56 ± 0.17 ms/um2 and excellent long-term stability in aqueous electrolytes, with no significant drop in its doping current after 50,000 successive doping/dedoping cycles and 2 months storage at ambient conditions...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38530881/chromatographic-separation-a-versatile-strategy-to-prepare-discrete-and-well-defined-polymer-libraries
#26
JOURNAL ARTICLE
Elizabeth A Murphy, Cheng Zhang, Christopher M Bates, Craig J Hawker
ConspectusThe preparation of discrete and well-defined polymers is an emerging strategy for emulating the remarkable precision achieved by macromolecular synthesis in nature. Although modern controlled polymerization techniques have unlocked access to a cornucopia of materials spanning a broad range of monomers, molecular weights, and architectures, the word "controlled" is not to be confused with "perfect". Indeed, even the highest-fidelity polymerization techniques─yielding molar mass dispersities in the vicinity of Đ = 1...
March 26, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38530812/microplate-based-cryopreservation-of-adherent-cultured-human-cell-lines-using-amino-acids-and-proteins
#27
JOURNAL ARTICLE
Kenta Morita, Tomoko Yashiro, Takashi Aoi, Ryutaro Imamura, Tomoyuki Ohtake, Norihiro Yoshizaki, Tatsuo Maruyama
With the progression of regenerative medicine and cell therapy, the importance of cryopreservation techniques for cultured cells continues to rise. Traditional cryoprotectants, such as dimethyl sulfoxide and glycerol, are effective in cryopreserving suspended cells, but they do not demonstrate sufficient efficacy for two-dimensional (2D)-cultured cells. In the past decade, small molecules and polymers have been studied as cryoprotectants. Some L-amino acids have been reported to be natural and biocompatible cryoprotectants...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38530775/prevalence-and-concentration-of-pesticides-in-european-waters-a-protocol-for-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Manuel Serrano Valera, Nuria Vela, Grasiela Piuvezam, Francisco Mateo-Ramírez, Isac Davidson Santiago Fernandes Pimenta, Isabel Martínez-Alcalá
There is currently a growing interest in the so-called emerging pollutants, such as pesticides, pharmaceuticals, personal hygiene care products, drugs, etc., whose presence in natural ecosystems is not necessarily recent, but the development in latest years of new and more sensitive methods of analysis has allowed their detection. They can be present in the natural environment, food, and many products of everyday origin, which suggests that human exposure to them is massive and universal. Therefore, the study of this type of substances is becoming one of the priority lines of research of the main agencies dedicated to the protection of public and environmental health, such as the World Health Organization (WHO), United States Environmental Protection Agency (USEPA) or European Union (EU)...
2024: PloS One
https://read.qxmd.com/read/38530638/a-wave-of-specific-transcript-and-protein-accumulation-accompanies-pollen-dehydration
#29
JOURNAL ARTICLE
Heven Sze, Božena Klodová, John M Ward, Jeffrey F Harper, Ravishankar Palanivelu, Mark A Johnson, David Honys
In flowering plants, male gametes are immotile and carried by dry pollen grains to the female organ. Dehydrated pollen is thought to withstand abiotic stress when grains are dispersed from the anther to the pistil, after which sperm cells are delivered via pollen tube growth for fertilization and seed set. Yet, the underlying molecular changes accompanying dehydration and the impact on pollen development are poorly understood. To gain a systems perspective, we analyzed published transcriptomes and proteomes of developing Arabidopsis thaliana pollen...
March 26, 2024: Plant Physiology
https://read.qxmd.com/read/38530369/igg-hexamers-initiate-complement-dependent-acute-lung-injury
#30
JOURNAL ARTICLE
Simon J Cleary, Yurim Seo, Jennifer J Tian, Nicholas Kwaan, David P Bulkley, Arthur E H Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James C Zimring, Mark R Looney
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, transfusion reactions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving assembly of IgG hexamer structures that activate C1 complexes. The importance of IgG hexamers in initiating injury responses was unclear, so we tested their relevance in a mouse model of alloantibody and complement-mediated acute lung injury...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38530223/history-and-investigation-of-the-chemical-odors-and-explosion-in-the-university-avenue-sanitary-sewer
#31
JOURNAL ARTICLE
Adam Krajicek, Neil G Carlson, Caylin Crawford
During the summer of 2022, a fire and explosion occurred in a sanitary sewer tunnel adjacent to the University of Minnesota Twin Cities campus, propelling utility maintenance covers several meters into the air and jeopardizing the safety of the public and emergency responders. The investigation into the explosion highlighted the complex variables involved in the response to sanitary sewer events. This case study outlines current approaches and proposes recommendations for agencies to be better prepared to prevent, detect, and respond to sewer-related incidents in the future...
March 26, 2024: Journal of Occupational and Environmental Hygiene
https://read.qxmd.com/read/38530212/prevalence-of-intestinal-trichomonads-in-captive-non-human-primates-in-china
#32
JOURNAL ARTICLE
Ping-Ping Ma, Yang Zou, Wen-Jie Mu, Yue-Yue Zhang, Ya-Qi Li, Zhong-Li Liu, Long Zhang, Li-Xian Chen, Guo-Hua Liu, Shuai Wang
Trichomonads are protozoan symbionts with the capacity to infect vertebrates including humans and non-human primates (NHPs), sometimes with pathogenic effects. However, their diversity and prevalence in NHPs in China are poorly understood. A total of 533 fecal samples were collected from captive NHPs in Yunnan Province, China, of which 461 samples from Macaca fascicularis and 72 from Macaca mulatta. Trichomonadidae species were identified using PCR amplification of the ITS-1/5.8S/ITS-2 sequences. The overall prevalence of trichomonads in NHPs was determined to be 11...
2024: Parasite: Journal de la Société Française de Parasitologie
https://read.qxmd.com/read/38530073/mitochondrial-targeted-copper-delivery-for-cuproptosis-based-synergistic-cancer-therapy
#33
JOURNAL ARTICLE
Jinpeng Deng, Huilan Zhuang, Sijie Shao, Xuemei Zeng, Panpan Xue, Tingjie Bai, Xiaoman Wang, Shijie Shangguan, Yuanchun Chen, Shuangqian Yan, Wei Huang
Cuproptosis is dependent on mitochondrial respiration modulation by targeting lipoylated tricarboxylic acid cycle (TCA) cycle proteins, showing great potential in cancer treatment. However, the specific release of copper ions at mitochondrial is highly needed and still a major challenge to trigger cellular cuproptosis. Herein, we designed a metal-organic framework-based nanoplatform (ZCProP) for mitochondrial-targeted and ATP/pH-responsive Cu2+ and prodigiosin release. The released Cu2+ promotes aggregation of lipoylated protein and loss of Fe-S cluster protein, resulting in cell cuproptosis...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38529841/stabilizing-ni-2-in-hollow-nano-mof-polymetallic-phosphides-composites-for-enhanced-electrochemical-performance-in-3d-printed-micro-supercapacitors
#34
JOURNAL ARTICLE
Huijie Zhou, Shunyu Gu, Yibo Lu, Guangxun Zhang, Bing Li, Fei Dou, Shuai Cao, Qian Li, Yangyang Sun, Mohsen Shakouri, Huan Pang
Polymetallic phosphides exhibit favorable conductivities. A reasonable design of nano-Metal-organic frame (MOF) composite morphologies and in-situ introduction of polymetallic phosphides into the framework can effectively improve electrolyte penetration and rapid electron transfer. To address existing challenges, Ni, with a strong coordination ability with N, is introduced to partially replace Co in the nano-Co-MOF composite. The hollow nanostructure is stabilized through CoNi bimetallic coordination and a low-temperature controllable polymetallic phosphide generation rate...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38529835/biofabrication-strategies-for-oral-soft-tissue-regeneration
#35
REVIEW
Maedeh Rahimnejad, Hardik Makkar, Renan Dal-Fabbro, Jos Malda, Gopu Sriram, Marco C Bottino
Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the exposure of tooth root surfaces due to the displacement of the gingival margin. This review explores conventional treatments, highlighting their limitations and the quest for innovative alternatives. Importantly, it emphasizes the critical considerations in gingival tissue engineering leveraging on cells, biomaterials, and signaling factors. Successful tissue-engineered gingival constructs hinge on strategic choices such as cell sources, scaffold design, mechanical properties, and growth factor delivery...
March 26, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38529723/chemical-synthesis-of-modified-rna
#36
JOURNAL ARTICLE
Laurin Flemmich, Raphael Bereiter, Ronald Micura
Ribonucleic acids play a vital role in living organisms. Many of their cellular functions depend critically on chemical modification. Methods to modify RNA in a controlled manner - both in vitro and in vivo - are thus essential to evaluate and understand RNA biology at the molecular and mechanistic levels. The diversity of modifications, combined with the size and uniformity of RNA (made up of only 4 nucleotides) makes its site-specific modification a challenging task that needs to be addressed by complementary approaches...
March 26, 2024: Angewandte Chemie
https://read.qxmd.com/read/38529666/suppressing-ion-migration-by-synergistic-engineering-of-anion-and-cation-towards-high-performance-inverted-perovskite-solar-cells-and-modules
#37
JOURNAL ARTICLE
Zuolin Zhang, Mengjia Li, Ru Li, Xinmeng Zhuang, Chenglin Wang, Xueni Shang, Dongmei He, Jiangzhao Chen, Cong Chen
Ion migration-induced intrinsic instability and large-area fabrication pose a tough challenge for the commercial deployment of perovskite photovoltaics. Herein, we develop an interface heterojunction and metal electrode stabilization strategy by suppressing ion migration via managing lead-based imperfections. After screening a series of cations and nonhalide anions, the ideal organic salt molecule dimethylammonium trifluoroacetate (DMATFA) consisting of dimethylammonium (DMA+ ) cation and trifluoroacetate (TFA- ) anion is selected to manipulate the surface of perovskite films...
March 26, 2024: Advanced Materials
https://read.qxmd.com/read/38529489/ehmt2-inactivation-in-pancreatic-epithelial-cells-shapes-the-transcriptional-landscape-and-inflammation-response-of-the-whole-pancreas
#38
Gareth Pollin, Angela J Mathison, Thiago M de Assuncao, Anju Thomas, Lida Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J Pandol, Michael T Zimmermann, Juan Iovanna, Victor X Jin, Raul Urrutia, Gwen Lomberk
The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown that EHMT2 inactivation alters growth and immune gene expression networks, antagonizing KRAS-mediated pancreatic cancer initiation and promotion. Here, we elucidate the essential role of EHMT2 in maintaining a transcriptional landscape that protects organs from inflammation...
March 16, 2024: bioRxiv
https://read.qxmd.com/read/38529096/the-ripple-effect-of-strain-in-times-of-change-how-manager-emotional-exhaustion-affects-team-psychological-safety-and-readiness-to-change
#39
JOURNAL ARTICLE
Patrick Groulx, Francis Maisonneuve, Jean-François Harvey, Kevin J Johnson
INTRODUCTION: Managers assume a pivotal role during periods of organizational change, yet there exists a notable gap in our understanding of how their emotional exhaustion may impact their capacity to generate readiness to change within their teams. Grounded in the conservation of resources theory (COR), this study explores the crossover effect of managers' emotional exhaustion on team readiness to change. We expect this to occur through higher levels of laissez-faire leadership, which impacts the teams' psychological safety...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38528718/the-cytoplasmic-sensor-the-aim2-inflammasome-a-precise-therapeutic-target-in-vascular-and-metabolic-diseases
#40
REVIEW
Jiuguo Lin, Jiaojiao Wang, Jian Fang, Meihang Li, Suowen Xu, Peter J Little, Dongmei Zhang, Zhiping Liu
Cardio-cerebrovascular diseases encompass pathological changes in the heart, brain and vascular system, which pose a great threat to health and well-being worldwide. Moreover, metabolic diseases contribute to and exacerbate the impact of vascular diseases. Inflammation is a complex process that protects against noxious stimuli but is also dysregulated in numerous so-called inflammatory diseases, one of which is atherosclerosis. Inflammation involves multiple organ systems and a complex cascade of molecular and cellular events...
March 25, 2024: British Journal of Pharmacology
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