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https://read.qxmd.com/read/30878185/harnessing-topographical-biochemical-cues-to-enhance-elastogenesis-by-paediatric-cells-for-cardiovascular-tissue-engineering-applications
#1
Ian Woods, Alexander Black, Stefan Jockenhoevel, Thomas C Flanagan
The development of tissue-engineered vascular grafts (TEVGs) with a biomimetic extracellular matrix (ECM) structure, including a mature elastic network, remains a key challenge for the production of grafts with long-term functionality. The aim of this study was to investigate the influence of aligned nanofiber substrates on ECM protein synthesis by neonatal smooth muscle cells (SMCs), and to examine the combined effects of this topographical cue in conjunction with transforming growth factor beta-1 (TGF-β1) - a biochemical elastogenic promoter...
March 13, 2019: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30875961/acute-effects-of-three-cooked-non-cereal-starchy-foods-on-postprandial-glycemic-responses-and-in-vitro-carbohydrate-digestion-in-comparison-with-whole-grains-a-randomized-trial
#2
Ruixin Zhu, Zhihong Fan, Yue Han, Shuang Li, Guojing Li, Linlin Wang, Ting Ye, Wenqi Zhao
Plant origin, processing, and domestic preparation may affect the postprandial glycemic response (PGR) of starchy foods. The objective of this study was to examine the possibility of integrating domestically cooked non-cereal starchy foods commonly consumed in Northeast Asia into glycemic management diet, and compare their glycemic characteristics with those of waxy and non-waxy whole grains and starchy beans. In a randomized crossover trial, ten healthy subjects consumed dried lily bulb (LB), lotus seed (LS), adlay (AD), waxy black rice (BR), millet (MI), and adzuki bean (AB), pre-soaked and each cooked for two time durations...
March 15, 2019: Nutrients
https://read.qxmd.com/read/30875097/effects-of-nigella-sativa-seeds-black-cumin-on-insulin-secretion-and-lipid-profile-a-pilot-study-in-healthy-volunteers
#3
Sophie Pelegrin, Florence Galtier, Anne Chalançon, Jean-Pierre Gagnol, Anne-Marie Barbanel, Yves Pélissier, Michel Larroque, Samuel Lepape, Marie Faucanié, Isabelle Gabillaud, Pierre Petit, Hugues Chevassus
Nigella sativa seeds (NSS), also known as black cumin, have been claimed to have antidiabetic and lipid-lowering properties. Our pilot study investigated the effects of powdered NSS on insulin secretion and lipid profile in healthy male volunteers. We conducted a double blind randomized placebo-controlled 4-week trial in 30 subjects, receiving NSS powder (1 g/day) or placebo orally (15 subjects/group). Insulin secretion as determined by the hyperglycemic clamp technique, insulin sensitivity as well as cholesterol and triglycerides serum concentrations, were measured before and after treatment...
March 15, 2019: British Journal of Clinical Pharmacology
https://read.qxmd.com/read/30873688/effect-of-nigella-sativa-black-seed-supplementation-on-glycemic-control-a-systematic-review-and-meta-analysis-of-clinical-trials
#4
REVIEW
Gholamreza Askari, Mohammad Hossein Rouhani, Ehsan Ghaedi, Abed Ghavami, Mehran Nouri, Hamed Mohammadi
This study was aimed to quantify the antihyperglycemic effect of Nigella sativa (N. sativa). An in-depth search to identify clinical trials investigating the impact of N. sativa on glycemic indices via MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, and Google scholar databases were performed up to November 2018. We used a random effects model to estimate pooled effect size of fasting plasma glucose (FPG), postprandial blood glucose (PPBG), and hemoglobin A1c (HbA1c). A total of 17 randomized controlled trials investigating the effects of N...
March 14, 2019: Phytotherapy Research: PTR
https://read.qxmd.com/read/30873671/efficacy-of-black-seed-nigella-sativa-l-on-kidney-stone-dissolution-a-randomized-double-blind-placebo-controlled-clinical-trial
#5
Mohammad Reza Ardakani Movaghati, Mahdi Yousefi, Seyed Ahmad Saghebi, Mahmoud Sadeghi Vazin, Aida Iraji, Seyed Hamdollah Mosavat
Preclinical studies have shown beneficial effects of black seed (Nigella sativa L.) in the prevention and treatment of renal stones. Hence, we designed a study to evaluate the renal-stone-dissolving efficacy of black seed. Sixty patients with renal stones were randomly enrolled in two arms of a randomized, triple-blind, placebo-controlled, clinical trial. The patients were treated by black seed capsules (500 mg) or placebo two times per day for 10 weeks. Patients were assessed in terms of size of renal stones by using sonography before and after intervention...
March 14, 2019: Phytotherapy Research: PTR
https://read.qxmd.com/read/30868814/-study-on-quality-characteristics-of-ligustri-lucidi-fructus-in-national-resource-survey-and-consideration-on-standards-of-ligustri-lucidi-fructus-in-chinese-pharmacopoeia
#6
Huan Liu, Hui Xiong, Xue Xue, Meng-Nan Liu, Hai-Li Wang, Wei Liu, Feng Wei, Xiang-Ri Li
The content of tyrosol,salidroside,echinacoside,rutin,acteoside,ligustroflavone,specnuezhenide,and quercetin were determined by HPLC,and the color of Ligustri Lucidi Fructus was determined by comparison with color card.Hundred-seed weight was analyzed by using gravimetric method.The correlation analysis and One-way ANOVA were used to analyze the relationship between the characters,the chemical composition,the harvest time and the geographical location of Ligustri Lucidi Fructus,for giving a comprehensive evaluation of the quality of Ligustri Lucidi Fructus The results showed that 92% of Ligustri Lucidi Fructus were all up to quality standard of Chinese Pharmacopoeia,and the contents of 7 components in Ligustri Lucidi Fructus(except quercetin) were higher than those in samples with black colors...
January 2019: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/30850726/development-of-an-snp-based-high-density-linkage-map-and-qtl-analysis-for-bruchid-callosobruchus-maculatus-f-resistance-in-black-gram-vigna-mungo-l-hepper
#7
Prakit Somta, Jingbin Chen, Chutintorn Yundaeng, Xingxing Yuan, Tarika Yimram, Norihiko Tomooka, Xin Chen
Black gram (Vigna mungo var. mungo) is an important pulse crop in Asia. The cowpea weevil (Callosobruchus maculatus) is a stored-seed insect pest (seed weevil/bruchid) that causes serious postharvest losses in pulse crops, including black gram. In this study, we constructed a high-density linkage map for black gram and identified quantitative trait loci (QTLs) for C. maculatus resistance. A recombinant inbred line (RIL) population of 150 lines from a cross between BC48 [cultivated black gram (var. mungo); bruchid-susceptible] and TC2210 [wild black gram (var...
March 8, 2019: Scientific Reports
https://read.qxmd.com/read/30847671/first-insights-into-the-feeding-habits-of-the-critically-endangered-black-snub-nosed-monkey-rhinopithecus-strykeri-colobinae-primates
#8
Yin Yang, Colin Groves, Paul Garber, Xinwen Wang, Hen Li, Yongchen Long, Guangsong Li, Yingping Tian, Shaohua Dong, Shiyi Yang, Alison Behie, Wen Xiao
Since its initial discovery in 2010 in the Gaoligong Mountains on the Sino-Myanmar border, there remains no direct information on the feeding habits of the black snub-nosed monkey (Rhinopithecus strykeri). This species is on the verge of extinction, with an estimated remaining population of < 400 individuals. Due to difficulties in following these monkeys across steep mountainous terrain, during 203 observation days (September 2015-January 2017) we recorded 80 h of behavioral records of a wild population (Luoma group)...
March 7, 2019: Primates; Journal of Primatology
https://read.qxmd.com/read/30843322/holocene-paleodepositional-changes-reflected-in-the-sedimentary-microbiome-of-the-black-sea
#9
Kuldeep D More, Liviu Giosan, Kliti Grice, Marco J L Coolen
Subsurface microbial communities are generally thought to be structured through in situ environmental conditions such as the availability of electron acceptors and donors and porosity, but recent studies suggest that the vertical distribution of a subset of subseafloor microbial taxa, which were present at the time of deposition, were selected by the paleodepositional environment. However, additional highly resolved temporal records of subsurface microbiomes and paired paleoenvironmental reconstructions are needed to justify this claim...
March 6, 2019: Geobiology
https://read.qxmd.com/read/30842710/thymoquinone-a-constituent-of-prophetic-medicine-black-seed-is-a-miracle-therapeutic-molecule-against-multiple-diseases
#10
EDITORIAL
Masood Alam Khan
No abstract text is available yet for this article.
January 2019: International Journal of Health Sciences
https://read.qxmd.com/read/30842658/hepatocytes-direct-the-formation-of-a-pro-metastatic-niche-in-the-liver
#11
Jae W Lee, Meredith L Stone, Paige M Porrett, Stacy K Thomas, Chad A Komar, Joey H Li, Devora Delman, Kathleen Graham, Whitney L Gladney, Xia Hua, Taylor A Black, Austin L Chien, Krishna S Majmundar, Jeffrey C Thompson, Stephanie S Yee, Mark H O'Hara, Charu Aggarwal, Dong Xin, Abraham Shaked, Mingming Gao, Dexi Liu, Mitesh J Borad, Ramesh K Ramanathan, Erica L Carpenter, Ailing Ji, Maria C de Beer, Frederick C de Beer, Nancy R Webb, Gregory L Beatty
The liver is the most common site of metastatic disease1 . Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a 'pro-metastatic' niche that supports the spread of tumour cells to the liver2,3 . The mechanisms that direct the formation of this niche are poorly understood. Here we show that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth...
March 6, 2019: Nature
https://read.qxmd.com/read/30823525/antioxidant-and-anti-inflammatory-properties-of-nigella-sativa-oil-in-human-pre-adipocytes
#12
Laura Bordoni, Donatella Fedeli, Cinzia Nasuti, Filippo Maggi, Fabrizio Papa, Martin Wabitsch, Raffaele De Caterina, Rosita Gabbianelli
The oil obtained from the seeds of Nigella sativa L. ( N. sativa ), also known as black cumin, is frequently used in the Mediterranean area for its anti-inflammatory, anti-oxidant, and anti-cancer activities. The aim of the present study was to evaluate the antioxidant and anti-inflammatory properties of the oil extracted from seeds of a N. sativa cultivar produced in the Marche region of Italy, and to determine if the thymoquinone content, antioxidant properties, and biological activity would decay during storage...
February 25, 2019: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/30823448/differences-in-the-quantity-and-types-of-foods-and-beverages-consumed-by-canadians-between-2004-and-2015
#13
Claire N Tugault-Lafleur, Jennifer L Black
This study examined differences in food and beverage intake estimated from nationally representative surveys of Canadians in 2004 and 2015 collected through the Canadian Community Health Surveys. Differences in mean daily energy intake and amounts of food consumed were compared between 2004 and 2015 and across age groups for all energy reporters (aged 2 years+) and among only plausible energy reporters. From 2004 to 2015, mean energy intake decreased by 228 kcal/day (all energy reporters) and 74 kcal/day (plausible energy reporters)...
February 28, 2019: Nutrients
https://read.qxmd.com/read/30821568/effects-of-gamma-radiation-%C3%AE-on-biochemical-and-antioxidant-properties-in-black-gram-vigna-mungo-l-hepper
#14
Yasmin K, D Arulbalachandran, Soundarya V, S Vanmathi
PURPOSE: The present study focused on the role of primary metabolites, antioxidant activities in black gram (Vigna mungo L. Hepper) variety Vamban-4 under the impact of gamma irradiation. MATERIALS AND METHODS: The black gram seeds were irradiated at a different dose of gamma rays viz., 200, 400, 600, 800, 1000 and 1200 Gray (Gy), and analysed the changes of biochemical and antioxidants contents. RESULTS: Biochemical contents increased with increasing doses up to 800 Gy and reduced at higher dose viz...
March 1, 2019: International Journal of Radiation Biology
https://read.qxmd.com/read/30817908/crystallographic-structure-of-a-complex-between-trypsin-and-a-nonapeptide-derived-from-a-bowman-birk-inhibitor-found-in-vigna-unguiculata-seeds
#15
João Paulo Campos Fernandes, Azadeh Mehdad, Napoleão Fonseca Valadares, Caroline Barbosa Farias Mourão, Manuel Mateus Ventura, João Alexandre Ribeiro Gonçalves Barbosa, Sonia Maria de Freitas
Natural inhibitors of proteases have been classified into different families, among them is the Bowman-Birk Inhibitor (BBI) family. Members of BBI have two structurally reactive loops that simultaneously inhibit trypsin and chymotrypsin. Here, we have investigated the binding of bovine trypsin by a cyclic nonapeptide, named PTRY9 (CTKSIPPQC), derived of the black-eyed pea trypsin/chymotrypsin inhibitor (BTCI) from Vigna unguiculata seeds. This peptide was synthetically produced with the disulfide bond restraining its conformation to mimic the reactive loop that inhibits trypsin...
February 25, 2019: Archives of Biochemistry and Biophysics
https://read.qxmd.com/read/30811596/combating-breast-cancer-using-combination-therapy-with-3-phytochemicals-piperine-sulforaphane-and-thymoquinone
#16
REVIEW
M Zakariyyah Aumeeruddy, M Fawzi Mahomoodally
Despite the significant advances in screening methods for early diagnosis, breast cancer remains a global threat and continues to be the leading cancer diagnosed in women, requiring effective therapy. Currently, combination therapy has become the hallmark of breast cancer treatment due to the high incidence of tumor recurrence and disease progression after monotherapeutic treatments, including surgery, radiotherapy, endocrine therapy, and chemotherapy. Over the past decades, there has been considerable interest in studying the anticancer effect of bioactive phytochemicals from medicinal plants combined with these conventional therapies...
February 27, 2019: Cancer
https://read.qxmd.com/read/30795574/the-effect-of-microfluidic-geometry-on-myoblast-migration
#17
Rahul Atmaramani, Bryan J Black, Kevin H Lam, Vinit M Sheth, Joseph J Pancrazio, David W Schmidtke, Nesreen Zoghoul Alsmadi
In vitro systems comprised of wells interconnected by microchannels have emerged as a platform for the study of cell migration or multicellular models. In the present study, we systematically evaluated the effect of microchannel width on spontaneous myoblast migration across these microchannels-from the proximal to the distal chamber. Myoblast migration was examined in microfluidic devices with varying microchannel widths of 1.5⁻20 µm, and in chips with uniform microchannel widths over time spans that are relevant for myoblast-to-myofiber differentiation in vitro...
February 21, 2019: Micromachines
https://read.qxmd.com/read/30790614/beyond-tribulus-tribulus-terrestris-l-the-effects-of-phytotherapics-on-testosterone-sperm-and-prostate-parameters
#18
REVIEW
Heitor O Santos, Scott Howell, Filipe J Teixeira
ETHNO-PHARMACOLOGICAL RELEVANCE: Phytotherapeutic approaches have been widely proposed to improve male health. Despite the well-touted effects of tribulus (Tribulus terrestris L) on men's health, an optimal phytotherapy remains an elusive challenge. AIM OF THE REVIEW: We sought to critically analyze the evidence in the phytotherapic literature beyond the effects of tribulus on testosterone (T) concentration and sperm analysis to also include indications for prostate health...
February 18, 2019: Journal of Ethnopharmacology
https://read.qxmd.com/read/30744324/use-of-natural-ingredients-in-the-japanese-quail-diet-and-their-effect-on-carcass-and-meat-quality-review
#19
Rey David Vargas Sanchez, Félix Joel Ibarra-Arias, Brisa Del Mar Torres-Martínez, Armida Sánchez-Escalante, Gastón Ramón Torrescano-Urrutia
The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the Japanese quail diet improved carcass quality characteristics compared to the control diets (basal diets)...
February 9, 2019: Asian-Australasian Journal of Animal Sciences
https://read.qxmd.com/read/30743169/application-and-enantioselective-residue-determination-of-chiral-pesticide-penconazole-in-grape-tea-aquatic-vegetables-and-soil-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#20
Xinzhong Zhang, Xinru Wang, Fengjian Luo, Huishan Sheng, Li Zhou, Qing Zhong, Zhengyun Lou, Hezhi Sun, Mei Yang, Xuan Cui, Zongmao Chen
Penconazole is a typical triazole fungicide with wide use on fruits, vegetables, and tea plants to control powdery mildew. In the present study, an efficient graphite carbon black solid phase extraction (GCB-SPE) purification combined with chiral ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method was developed for determination of penconazole enantiomers in different complex matrices, including grape, tea, soil, lotus root, lotus leaf, lotus seed and hulls. The method was then applied to investigate the enantioselective dissipation of penconazole enantiomers in a real field experiment of grape and soil...
February 8, 2019: Ecotoxicology and Environmental Safety
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