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Metabolic syndrom in children

Saravanakumar Jeevanandam, K M Prathibha
Introduction: A bidirectional relationship between testosterone and obesity is explained by the hypogonadal obesity cycle and evidence from reports stating that weight loss leads to increased testosterone levels. There is an alarming rise in the prevalence of obesity among children and adolescents. The objectives of the present study were to measure the 2D:4D ratio of adolescent students and study its association with neck circumference (NC). Materials and Methods: After obtaining ethical clearance, the study was conducted on 168 adolescents pursuing their undergraduate education in a South Indian university...
November 2018: Indian Journal of Endocrinology and Metabolism
Deniz Özalp Kızılay, Semra Şen, Betül Ersoy
Objective: In this study we aimed to assess the association between serum uric acid (SUA) concentration and metabolic syndrome (MetS) parameters and insulin resistance (IR). Our second aim was evaluate whether hyperuricemia is related with renal injury and cardiovascular risk in obese (OB) and overweight(OW) children. Methods: This study was conducted on 128 OB/OW children and adolescents (ages: 8-18 years), of whom 52 (40%) with SUA elevation (SUA persantile>75), 76 with (60%) normal SUA level (SUAL)...
February 14, 2019: Journal of Clinical Research in Pediatric Endocrinology
Gurinder Kumar, Rajendran Nair, Bassem Soliman Hendawy, Omar Ahmed AlShkeili, Ahmed Abdulla Alabdouli, Adnan Mohamed Al Ali, Amal Mohamed Jasem AlTenaiji
Metabolic disorders, although rare, can involve multiple organ systems and have a varied presentation. Renal involvement has been reported in several metabolic disorders in the pediatric age group. We report a rare metabolic disorder, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, in a child who developed steroid-resistant nephrotic syndrome at the age of 5 years. Renal biopsy showed features of collapsing glomerulopathy. The child had progressive chronic kidney disease. Alternative immunosuppressants including tacrolimus failed to show any clinical improvement...
February 12, 2019: CEN Case Reports
Daniel Vasile Balaban, Alina Dima, Ciprian Jurcut, Alina Popp, Mariana Jinga
BACKGROUND: Celiac crisis (CC), a potentially life-threatening condition, is one of the rare clinical presentations of celiac disease (CD). Several cases have been documented in the literature, mostly in children. AIM: To perform a review of CC cases reported in adult CD patients. METHODS: A systematic search of the literature was conducted in two databases, PubMed/MEDLINE and EMBASE, using the term "celiac crisis" and its variant "coeliac crisis", from January 1970 onwards...
February 6, 2019: World Journal of Clinical Cases
Kayoung Lee
BACKGROUND: Few studies have compared the local and international body mass index (BMI) reference sets for their relationship with metabolic syndrome (MetS) in children. This study aimed to compare the BMI percentiles using Korean, United States Centers for Disease Control and Prevention (US-CDC), and World Health Organization (WHO) charts for their ability to detect MetS in Korean children and examine their associations with the severity of MetS. METHODS: Among 3094 children (1653 boys, age: 10-16 years) from the Korean National Health and Examination Survey 2011-2016, age and sex-specific BMI percentiles using the three charts (Korean, US-CDC, and WHO charts) were determined...
February 11, 2019: Metabolic Syndrome and related Disorders
Sarvenaz Vandyousefi, Michael I Goran, Erica P Gunderson, Erfan Khazaee, Matthew J Landry, Reem Ghaddar, Fiona M Asigbee, Jaimie N Davis
BACKGROUND: The effects of breastfeeding (BF) on metabolic syndrome (MetS) and diabetes mellitus in children exposed to gestational diabetes mellitus (GDM) in utero have rarely been evaluated. OBJECTIVE: This study assessed BF and GDM in relation to the prevalence of prediabetes and MetS in Hispanic children and adolescents (8-19 y). METHODS: This is a longitudinal study with 229 Hispanic children (8-13 y) with overweight/obesity, family history of diabetes, and an average of four annual visits (AV)...
February 8, 2019: Pediatric Obesity
Jorge Sapunar, Nicolás Aguilar-Farías, Juan Navarro, Gustavo Araneda, Damian Chandia-Poblete, Víctor Manríquez, Roberto Brito, Alvaro Cerda
BACKGROUND: Childhood and adolescent obesity is a major public health problem in Chile. AIM: To characterize cardiometabolic risk factors in a population of schoolchildren from Carahue, Chile. MATERIAL AND METHODS: Cross-sectional assessment of 208 children aged 10.4 ± 1.0 years (106 women). A clinical evaluation was carried out including pubertal development according to Tanner and anthropometric parameters. A fasting blood sample was obtained to measure glucose, insulin and lipid profile...
September 2018: Revista Médica de Chile
Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Mercedes Gil-Campos, Angel Gil
Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts; however, dead bacteria and their components can also exhibit probiotic properties. Bifidobacterium and strains of lactic acid bacteria are the most widely used bacteria that exhibit probiotic properties and are included in many functional foods and dietary supplements. Probiotics have been shown to prevent and ameliorate the course of digestive disorders such as acute, nosocomial, and antibiotic-associated diarrhea; allergic disorders such as atopic dermatitis (eczema) and allergic rhinitis in infants; and Clostridium difficile-associated diarrhea and some inflammatory bowel disorders in adults...
January 1, 2019: Advances in Nutrition
Alessia Di Costanzo, Lucia Pacifico, Claudio Chiesa, Francesco Massimo Perla, Fabrizio Ceci, Antonio Angeloni, Laura D'Erasmo, Michele Di Martino, Marcello Arca
OBJECTIVES: To comprehensively explore metabolic and genetic contributors to liver fat accumulation in overweight/obese children. METHODS: Two hundred thirty Italian children with obesity were investigated for metabolic parameters and genotyped for PNPLA3, TM6SF2, GCKR, and MBOAT7 gene variants. Percentage hepatic fat content (HFF%) was measured by nuclear magnetic resonance. RESULTS: HFF% was positively related with BMI, HOMAIR , metabolic syndrome, ALT, AST, γGT, and albumin...
January 23, 2019: Pediatric Research
Feyza Darendeliler
The children with intrauterine growth restriction (IUGR) especially if they make a catch-up growth in early life have a higher risk for long term problems including short stature and also developing metabolic syndrome, Type 2 diabetes, insulin resistance and cardiovascular diseases. The studies also support that these children may have abnormalities in pubertal timing, adrenarche and reproductive function. The aim of this review was to summarize the published reports mainly on puberty and reproductive functions in children born IUGR at older ages in association with metabolic problems that they encounter...
January 22, 2019: Best Practice & Research. Clinical Endocrinology & Metabolism
Po-Chang Wu, Wen-Ho Chuo, Shih-Chao Lin, Caitlin W Lehman, Christopher Z Lien, Chieh-Shan Wu, Chi-Chien Lin
CONTEXT: Atopic dermatitis is a common chronic inflammatory skin disease affecting up to 20% of children and 1% of adults worldwide. Treatment of atopic dermatitis include corticosteroids and immunosuppressants, such as calcineurin inhibitors and methotrexate. However, these treatments often bring about adverse effects including skin atrophy, osteoporosis, skin cancer, and metabolic syndrome. OBJECTIVE: In this study, we evaluated the therapeutic effects and mechanisms of sclareol, a natural diterpene, on atopic dermatitis (AD)-like skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) in mice...
February 1, 2019: Immunopharmacology and Immunotoxicology
Sarah J Mi, Nichole R Kelly, Robert J Brychta, Anne Claire Grammer, Manuela Jaramillo, Kong Y Chen, Laura A Fletcher, Shanna B Bernstein, Amber B Courville, Lisa M Shank, Jeremy J Pomeroy, Sheila M Brady, Miranda M Broadney, Marian Tanofsky-Kraff, Jack A Yanovski
BACKGROUND: Self-reported short sleep duration is associated with greater risk for metabolic syndrome (MetS), obesity, and higher energy intake (EI). However, studies of these associations in children using objective methods are sparse. OBJECTIVES: The study aims to determine the associations for sleep patterns with MetS indices, body composition, and EI using objective measures in children. METHODS: Free-living sleep and physical activity were measured in 125 children (aged 8-17 years, BMI z = 0...
January 31, 2019: Pediatric Obesity
N Tskhvedadze, E Giorgadze, Sh Janjgava
The aim of our investigation was to determine the impact of the degree of obesity on metabolic characteristics in children and adolescents with metabolic syndrome. We studied 117 children and adolescents 8-15 years of age with BMI exceeded the 85th percentile for their age and sex and the complaints associated with obesity. Investigated patients were divided according BMI percentiles for age and sex established by the U.S. Centers for Disease Control and Prevention (CDC) as follows: Group 1. Overweight (OW; 85-94...
December 2018: Georgian Medical News
Meghan E Byrne, Sarah LeMay-Russell, Marian Tanofsky-Kraff
PURPOSE OF REVIEW: This review summarizes findings on pediatric loss-of-control (LOC) eating and obesity published since 2013 in relation to physiological, socioenvironmental, and psychological factors. RECENT FINDINGS: LOC eating and obesity are highly comorbid in youth. Genetic and physiological risk factors are associated with the development of LOC eating. Adverse physiological outcomes of LOC eating include increased risk for overweight and obesity and greater dysfunction in components of metabolic syndrome...
January 30, 2019: Current Obesity Reports
M-P Perriol, I Jullian-Desayes, M Joyeux-Faure, S Bailly, A Andrieux, M Ellaffi, F Jounieaux, J-L Pépin, C Lamblin
PURPOSE: In children, the usual indications for continuous positive airway pressure (CPAP) are residual OSA after adenotonsillectomy and/or persistent OSA due to obesity. Data concerning adherence (hours/night) following ambulatory CPAP initiation are scarce. METHODS: An observational cohort of 78 children was followed over 2 years. All exhibited sleep-disordered breathing (SDB) symptoms, were assessed by polysomnography, and prescribed CPAP. CPAP was initiated at hospital for 10 children...
January 26, 2019: Sleep & Breathing, Schlaf & Atmung
Firdevs Aydın, Nelgin Gerenli, Fatma Dursun, Tülay Öztürk Atasoy, Sevinç Kalın, Heves Kırmızıbekmez
Background Diabetes and hepatosteatosis are dramatically increasing in childhood. Non-alcoholic fatty liver disease (NAFLD) is defined as a common disorder in adulthood, especially with type-2 diabetes and metabolic syndrome, while very few studies are available on liver health in children with type-1 diabetes. Patients and methods One hundred and ten (52 males and 58 females) patients with type-1 diabetes aged between 8 and 18 years were examined. The lipid profile, liver enzymes and hepatobiliary ultrasound findings of patients were investigated in terms of hepatopathies...
January 26, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
Svetlana Gataullina, Thierry Bienvenu, Rima Nabbout, Gilles Huberfeld, Olivier Dulac
The aim of this study was to disentangle mechanisms of epileptogenesis in monogenic epilepsies in children. We reviewed paediatric monogenic epilepsies excluding brain malformation or an inborn error of metabolism, but including the gene function whether there is loss-of-function or gain-of-function, age at gene expression when available, and associated epilepsy syndrome. Genes for which at least five patients with similar epilepsy phenotype had been reported were selected. Three mechanisms are shared by most monogenic epilepsies: (1) excess of N-methyl-d-aspartate (NMDA) transmission activation (NMDA-pathies); (2) abnormal gamma-aminobutyric acid (GABA) transmission with reduced inhibition (phasic GABA-pathies); and (3) tonic activation of extrasynaptic GABAA receptors by extracellular GABA (tonic GABA-pathies)...
January 25, 2019: Developmental Medicine and Child Neurology
Leila Kheirandish-Gozal, David Gozal
Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index...
January 22, 2019: International Journal of Molecular Sciences
Elena Soto-Vega, Luis S Carrillo-Vicente, Juan C Vázquez, María C Pérez de Celis Herrero, María J Muñoz-Pérez
Cancer treatments are associated with short and long-effects. Epidemiological reports have revealed clinical features of metabolic syndrome (MS), obesity or overweight in young cancer survivors. The aim of the study was to examine the prevalence of unhealthy weight status and risk factors associated with MS related to chemotherapy. We study 52 pediatric cancer patients and analyze cholesterol, triglycerides, glycosylated hemoglobin, body mass index, waist circumference (WC), FINDRISC test. All the parameters were analyzed according to the percentile corresponding to sex and age of each child...
January 22, 2019: Journal of Pediatric Hematology/oncology
Kelly Hilk, Melissa Zerofsky, Sue Rhee, Philip Rosenthal, Emily R Perito
INTRODUCTION: PTMS-a clustering of hypertension, dyslipidemia, glucose intolerance/diabetes, and obesity-is increasingly recognized as a contributor to long-term morbidity after transplant. We sought to describe pediatric liver transplant center protocols and provider practices in screening for and managing these conditions. METHODS: Cross-sectional survey of pediatric liver transplant providers from centers that participate in Studies of Liver Transplantation (SPLIT)...
January 21, 2019: Pediatric Transplantation
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