Yalei Liu, Shasha Tang, Yu Feng, Binghua Xue, Chaofei Cheng, Yong Su, Wei Wei, Lijun Zhang, Zhoufeng Huang, Xiaoyang Shi, Yuanyuan Fang, Junpeng Yang, Yun Zhang, Xinru Deng, Limin Wang, Hongyan Ren, Chongjian Wang, Huijuan Yuan
BACKGROUND: Graves' disease (GD), characterized by immune aberration, is associated with gut dysbiosis. Despite the growing interest, substantial evidence detailing the precise impact of gut microbiota on GD's autoimmune processes remains exceedingly rare. OBJECTIVE: This study was designed to investigate the influence of gut microbiota on immune dysregulation in GD. METHODS: It encompassed 52 GD patients and 45 healthy controls (HCs), employing flow cytometry and enzyme-linked immunosorbent assay to examine lymphocyte and cytokine profiles, alongside lipopolysaccharide (LPS) levels...
2024: Frontiers in Cellular and Infection Microbiology