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https://read.qxmd.com/read/30786191/pituitary-hyperplasia-from-primary-hypothyroidism
#1
K S Shivaprasad, Kollareddy Siddardha
New England Journal of Medicine, Volume 380, Issue 8, February 2019.
February 21, 2019: New England Journal of Medicine
https://read.qxmd.com/read/30785998/adrenal-steroids-in-female-hypothyroid-neonates-unraveling-an-association-between-thyroid-hormones-adrenal-remodeling
#2
Sofia Galanou, Giorgos Chouliaras, Panagiotis Girginoudis, Chryssanthi Mengreli, Amalia Sertedaki, Maria Dracopoulou, Ioanna Farakla, Dimitris Platis, Alexandra Iliadi, George P Chrousos, Catherine Dacou-Voutetakis, Emanuil Zoumakis, Alexandra-Maria Magiakou, Christina Kanaka-Gantenbein, Antonis Voutetakis
CONTEXT: The adrenal gland undergoes significant remodeling during the neonatal period, an essential developmental process that still remains incompletely understood. With respect to control over the remodeling process and, specifically, the role of thyroid hormones (TH), no human studies have been published. The effect of both hypo- and hyper-thyroidism has only been evaluated in adults, focusing on the mature adrenal. Recently, Huang et al identified expression of the TH receptor β1 in the mouse adrenal X-zone and demonstrated that TH administration could alter the postnatal adrenal remodeling process...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785995/stimulated-thyroglobulin-and-thyroglobulin-reduction-index-predict-excellent-response-in-differentiated-thyroid-cancers
#3
Bertrand Barres, Antony Kelly, Fabrice Kwiatkowski, Marie Batisse-Lignier, Geneviève Fouilhoux, Bernadette Aubert, Frédéric Dutheil, Igor Tauveron, Florent Cachin, Salwan Maqdasy
INTRODUCTION: Despite its good prognosis, differentiated thyroid cancer (DTC) is characterized by a high risk of disease persistence and/or recurrence. Estimation of long-term remission (excellent response) thanks to specific parameters could help to personalize the schedule of active surveillance. OBJECTIVE: Evaluation of the value of stimulated thyroglobulin and thyroglobulin reduction index (TRI) to predict long-term remission in patients with DTC managed by thyroidectomy and radioactive iodine (RAI) remnant ablation...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785993/improving-risk-stratification-strategies-for-thyroid-disease-during-pregnancy
#4
Tim I M Korevaar, Robin P Peeters
No abstract text is available yet for this article.
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785992/female-pattern-hair-loss-and-androgen-excess-a-report-from-the-multidisciplinary-androgen-excess-and-pcos-committee
#5
E Carmina, R Azziz, W Bergfeld, H F Escobar Morreale, W Futterweit, H Huddleston, R A Lobo, E Olsen
OBJECTIVE: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved. PARTICIPANTS: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/30785841/transoral-robotic-thyroidectomy-versus-conventional-open-thyroidectomy-comparative-analysis-of-surgical-outcomes-in-thyroid-malignancies
#6
Ji Young You, Hoon Yub Kim, Young Jun Chai, Hong Kyu Kim, Angkoon Anuwong, Ralph P Tufano, Gianlorenzo Dionigi
BACKGROUND: Various approaches for thyroid surgery became possible with the use of robotic systems. Transoral robotic thyroidectomy (TORT) is one of the newest approaches and draws attention because of its cosmetic excellence. In this study, we compared the surgical outcomes of TORT and conventional open thyroidectomy (OT). METHODS: We retrospectively reviewed and compared the medical records of consecutive patients who underwent TORT or OT for thyroid carcinoma from April 2016 to March 2017...
February 20, 2019: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/30785603/clinical-features-and-comorbidities-of-patients-with-necrobiosis-lipoidica-with-or-without-diabetes
#7
David A Hashemi, Zoe O Brown-Joel, Elizabeth Tkachenko, Caroline A Nelson, Megan H Noe, Sotonye Imadojemu, Ruth Ann Vleugels, Arash Mostaghimi, Karolyn A Wanat, Misha Rosenbach
Importance: Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes. Objective: To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes...
February 20, 2019: JAMA Dermatology
https://read.qxmd.com/read/30785482/thyroid-disorders-in-brazil-the-contribution-of-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#8
I M Bensenor
Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests...
February 14, 2019: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://read.qxmd.com/read/30785065/circrapgef5-contributes-to-papillary-thyroid-proliferation-and-metastatis-by-regulation-mir-198-fgfr1
#9
Weiwei Liu, Ji Zhao, Mingming Jin, Ming Zhou
The circular RNA RAPGEF5 (circRAPGEF5) is generated from five exons of the RAPGEF5 gene and abnormal expression in papillary thyroid cancer (PTC). However, whether circRAPGEF5 plays a role in PTC tumorigenesis remains unclear. The aim of the present study was to investigate the role of circRAPGEF5 in PTC. The results showed that circRAPGEF5 was upregulated in PTC tissues and cell lines. circRAPGEF5 knockdown inhibited cell proliferation, migration, and invasion in vitro; and circRAPGEF5 silencing downregulated fibroblast growth factor receptor 1 (FGFR1) expression by "sponging" miR-198, suppressing the aggressive biological behaviors of PTC...
January 15, 2019: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/30785015/defining-and-listing-very-rare-cancers-of-paediatric-age-consensus-of-the-joint-action-on-rare-cancers-in-cooperation-with-the-european-cooperative-study-group-for-pediatric-rare-tumors
#10
Andrea Ferrari, Ines B Brecht, Gemma Gatta, Dominik T Schneider, Daniel Orbach, Giovanni Cecchetto, Jan Godzinski, Yves Reguerre, Ewa Bien, Teresa Stachowicz-Stencel, Michael Ost, Chiara Magni, Pamela Kearns, Gilles Vassal, Maura Massimino, Andrea Biondi, Gianni Bisogno, Annalisa Trama
Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries...
February 19, 2019: European Journal of Cancer
https://read.qxmd.com/read/30785006/malignant-peripheral-nerve-sheath-tumor-of-the-pancreas-a-case-report
#11
Pradeep Balineni, Rekha Arcot, Kannan Devygounder, Khalilur Rahaman, Bharath Narayansamy, Manoj Prabhu, Shantini Vaitheeswaran
INTRODUCTION: Nerve sheath tumors are tumors arising from nerve sheaths or which show nerve sheath differentiation. They are divided as benign and malignant. They are associated with Von Recklinghausen syndrome. Characterised by café-au-lait spots, lisch nodules, acoustic neuromas, pheochromocytomas. PRESENTATION OF CASE: A 62 year old gentleman came with complaints of Abdominal discomfort for 1month. He also had Left sided abdominal pain, Anorexia, Vomiting, No history of dyspepsia, fever, bowel disturbance...
February 13, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30784791/thyroid-hormone-profiles-and-tsh-evaluation-during-early-pregnancy-and-the-transition-period-in-dairy-cows
#12
L Steinhoff, K Jung, M M Meyerholz, J Heidekorn-Dettmer, M Hoedemaker, M Schmicke
The thyroid hormone axis is one important endocrine system within a complex system of various factors and hormones necessary to establish and maintain pregnancy in cattle and in metabolic adaptations towards lactation. Pregnancy and lactation occur contemporaneously in dairy cows, and have major impacts on thyroid hormones as well as status of the hypothalamus-pituitary thyroid axis influences pregnancy and lactation. As especially the thyroid hormone axis with special focus to TSH is not well studies in the past, the aim of the study was to examine the thyroid hormone axis, especially in heifers during adaptation to the first lactation, to verify the association between lactation and thyroid hormones...
January 29, 2019: Theriogenology
https://read.qxmd.com/read/30784774/a-case-of-treatable-dementia-with-lewy-bodies-remarkably-improved-by-immunotherapy
#13
Kie Abe, Yuhei Chiba
We report a case of probable dementia with Lewy bodies (DLB) with several findings indicating autoimmune encephalitis (e.g. anti-thyroid antibodies in serum and oligoclonal band and anti-N-methyl-d-aspartic acid receptor antibodies in cerebrospinal fluid). The symptoms and the findings of ancillary tests such as Iodine-123-metaiodobenzylguanidine myocardial scintigraphy and 99m Technetium-ethyl-cysteinate-dimer single photon emission computed tomography were improved after the pulse and oral steroid treatment...
February 16, 2019: Journal of Neuroimmunology
https://read.qxmd.com/read/30784617/hormonal-therapy-in-organ-donors
#14
REVIEW
Helen Ingrid Opdam
Optimal supportive treatment of brain dead potential organ donors maximizes donation and transplant outcomes. Brain death is associated with activation of inflammatory pathways and loss of autoregulatory brain functions that may include hypothalamic-pituitary dysfunction. As well as general supportive care, specific treatment to counter the common sequelae of brain death such as hypotension, hypothermia, and diabetes insipidus is required. In addition, the provision of specific hormonal therapy (thyroid hormone, vasopressin, and steroids) has been proposed but is controversial due to lack of high level evidence to support its efficacy...
April 2019: Critical Care Clinics
https://read.qxmd.com/read/30784616/thyroid-hormones-in-critical-illness
#15
REVIEW
Matthew J Maiden, David J Torpy
Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement.
April 2019: Critical Care Clinics
https://read.qxmd.com/read/30784360/the-jak-stat3-and-nf-%C3%AE%C2%BAb-signaling-pathways-regulate-cancer-stem-cell-properties-in-anaplastic-thyroid-cancer-cells
#16
Ken Shiraiwa, Michiko Matsuse, Yuka Nakazawa, Tomoo Ogi, Keiji Suzuki, Vladimir A Saenko, Shuhang Xu, Kazuo Umezawa, Shunichi Yamashita, Kazuhiro Tsukamoto, Norisato Mitsutake
<b>Background:</b> Anaplastic thyroid carcinoma (ATC) is still one of the most aggressive cancers, and a therapy with a new concept needs to be developed. Recently, the research of cancer stem cells (CSCs) has been progressed, and CSCs have been suggested to be responsible for metastasis, recurrence, and therapy resistance. In ATC-CSCs, aldehyde dehydrogenase (ALDH) activity is the most reliable marker to enrich the CSCs; however, it itself is just a marker and is not involved in CSC properties...
February 20, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30784243/mouse-models-as-a-tool-for-understanding-progression-in-braf-v600e-driven-thyroid-cancers
#17
REVIEW
Iñigo Landa, Jeffrey A Knauf
The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of mutually-exclusive oncogenic alterations affecting BRAF and RAS proto-oncogenes in all stages of thyroid cancer. Initially identified by traditional sequencing approaches, the NGS studies also confirmed the acquisition of alterations that inactivate tumor protein p53 ( TP53 ) and activate phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA ) in advanced thyroid cancers...
February 15, 2019: Endocrinology and Metabolism
https://read.qxmd.com/read/30784242/-99m-tc-pertechnetate-scintigraphy-predicts-successful-postoperative-ablation-in-differentiated-thyroid-carcinoma-patients-treated-with-low-radioiodine-activities
#18
Luca Giovanella, Gaetano Paone, Teresa Ruberto, Luca Ceriani, Pierpaolo Trimboli
BACKGROUND: Postoperative routine radioiodine (RAI) treatment is currently debated for patients with low-risk differentiated thyroid carcinoma (DTC) patients. If performed, a low ¹³¹I activity (i.e., 1 to 2 GBq) is recommended with the aim to ablate thyroid remnant and facilitate subsequent follow-up by thyroglobulin measurement. The purpose of this study was to evaluate the relationship between postsurgical technetium-99m (99m Tc)-pertechnetate scintigraphy and the rate of successful remnant ablation after low activity radioiodine ablation in patients with DTC...
February 15, 2019: Endocrinology and Metabolism
https://read.qxmd.com/read/30784141/cost-for-treatment-and-follow-up-of-thyroid-cancer-increases-according-to-the-severity-of-disease
#19
Soo Young Kim, Seok-Mo Kim, Hojin Chang, Bup-Woo Kim, Yong Sang Lee, Soon-Sun Kwon, Hyunjung Shin, Hang-Seok Chang, Cheong Soo Park
BACKGROUND: The aim of this study was to provide an analysis of thyroid cancer-related health care costs over a 5-year period, according to the extent of thyroid surgery. METHODS: The study included 33 patients from our institutional database who underwent thyroid cancer surgery in 2010. Patients were divided into four groups based on surgical extent: (1) hemithyroidectomy, (2) total thyroidectomy, (3) total thyroidectomy with ipsilateral radical neck dissection, and (4) total thyroidectomy with bilateral radical neck dissection and mediastinal dissection...
February 19, 2019: Head & Neck
https://read.qxmd.com/read/30784009/the-value-of-acoustic-respiratory-rate-monitoring-in-a-patient-with-postoperative-hemorrhage-after-thyroidectomy-a-case-report
#20
Masashi Ishikawa, Dai Namizato, Atsuhiro Sakamoto
Acoustic respiratory rate (RRa) monitoring is a non-invasive method of monitoring respiratory rate in spontaneously breathing individuals. The aim of this report is to highlight the clinical utility of this monitoring system in post-thyroidectomy patients by presenting a case of respiratory compromise due to post-thyroidectomy hematoma, in which the alarm of the respiratory rate monitor alerted the nursing staff about the complication. A 61-year-old woman who uneventfully underwent right thyroid lobectomy for adenomatous goiter under general anesthesia with endotracheal intubation was being monitored postoperatively using the RRa monitoring system...
February 19, 2019: Journal of Clinical Monitoring and Computing
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