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https://read.qxmd.com/read/30901344/methicillin-resistant-staphylococcus-aureus-eradication-in-cystic-fibrosis-patients-a-randomized-multicenter-study
#1
Daniela Dolce, Stella Neri, Laura Grisotto, Silvia Campana, Novella Ravenni, Francesca Miselli, Erica Camera, Lucia Zavataro, Cesare Braggion, Ersilia V Fiscarelli, Vincenzina Lucidi, Lisa Cariani, Daniela Girelli, Nadia Faelli, Carla Colombo, Cristina Lucanto, Mariangela Lombardo, Giuseppe Magazzù, Antonella Tosco, Valeria Raia, Serena Manara, Edoardo Pasolli, Federica Armanini, Nicola Segata, Annibale Biggeri, Giovanni Taccetti
BACKGROUND: Few studies, based on a limited number of patients using non-uniform therapeutic protocols, have analyzed Methicillin-resistant Staphylococcus aureus (MRSA) eradication. METHODS: In a randomized multicenter trial conducted on patients with new-onset MRSA infection we evaluated the efficacy of an early eradication treatment (arm A) compared with an observational group (B). Arm A received oral rifampicin and trimethoprim/sulfamethoxazole (21 days). Patients' microbiological status, FEV1, BMI, pulmonary exacerbations and use of antibiotics were assessed...
2019: PloS One
https://read.qxmd.com/read/30899753/influence-of-physical-rehabilitation-on-heart-rate-dynamics-in-patients-with-idiopathic-pulmonary-fibrosis
#2
Sameera Senanayake, Nicholas Harrison, Michael Lewis
This study sought to determine whether a 6-week physical rehabilitation programme has a measurable influence on heart rate responsiveness to changing metabolic demand in patients with pulmonary fibrosis. Fifteen individuals (13 with idiopathic pulmonary fibrosis and two with pulmonary fibrosis associated with rheumatoid disease) underwent assessments of physical function (6-min walk test), ventilatory function (spirometry), and cardio-respiratory function (respiratory gas analysis and electrocardiogram [ECG] recording during a protocol consisting of periods of rest, incremental bicycle exercise to maximal effort, and post-exercise recovery)...
February 2019: Journal of Exercise Rehabilitation
https://read.qxmd.com/read/30899735/the-relationship-between-peripheral-muscle-strength-and-respiratory-function-and-respiratory-muscle-strength-in-athletes
#3
Bihter Akınoğlu, Tuğba Kocahan, Taşkın Özkan
The aim of this study is to determine the relationship between peripheral muscle strength, respiratory function and respiratory muscle strength in athletes. The study included a total of 150 elite athletes (judo, rowing, gymnastics) (age, 16.94±2.37 years; length, 167.70±12.23 cm; body weight, 62.87±17.33 kg; body mass index, 21.95±2.92 kg/m2 ). Isomed 2000 isokinetic dynamometer was used to assess peripheral muscle strength. The strength of the dominant side knee flexor and extensor muscles was evaluated at 60°/sec and 180°/sec...
February 2019: Journal of Exercise Rehabilitation
https://read.qxmd.com/read/30899279/availability-and-affordability-of-medicines-and-diagnostic-tests-recommended-for-management-of-asthma-and-chronic-obstructive-pulmonary-disease-in-sub-saharan-africa-a-systematic-review
#4
Davis Kibirige, Richard E Sanya, Rebecca Nantanda, William Worodria, Bruce Kirenga
Background: Early accurate diagnosis and sustainable availability of affordable medicines and diagnostic tests is fundamental in optimal management of asthma and chronic obstructive pulmonary disease (COPD). We systematically reviewed original research articles about availability and affordability of medicines and diagnostic tests recommended for management of asthma and COPD in sub-Saharan Africa (SSA). Methods: We searched PubMed, Scopus and African Journal Online for original research articles conducted in SSA between 2000 and March 2018 containing information about availability and affordability of any recommended medicine and diagnostic test for asthma and COPD...
2019: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/30899189/assessing-airflow-limitation-among-smokers-in-a-primary-care-setting
#5
Chean Kooi Yau, Fairuz Fadzilah Rahim, Chin Jiunn Sheng, Choi Xin Ling, Liew Kah Weng, Tan Chia Chia, Tan Kean Chye, Ooi Siew Ting, Tan Hong Jin, Irfhan Ali Hyder Ali
Background: Many smokers have undiagnosed chronic obstructive pulmonary disease (COPD), and yet screening for COPD is not recommended. Smokers who know that they have airflow limitation are more likely to quit smoking. This study aims to identify the prevalence and predictors of airflow limitation among smokers in primary care. Methods: Current smokers ≥ 40 years old who were asymptomatic clinic attendees in a primary care setting were recruited consecutively for two months...
May 2018: Malaysian Journal of Medical Sciences: MJMS
https://read.qxmd.com/read/30898804/trends-in-the-prevalence-of-airflow-limitation-in-a-general-japanese-population-two-serial-cross-sectional-surveys-from-the-hisayama-study
#6
Hiroaki Ogata, Yoichiro Hirakawa, Koichiro Matsumoto, Jun Hata, Daigo Yoshida, Satoru Fukuyama, Hiromasa Inoue, Takanari Kitazono, Toshiharu Ninomiya, Yoichi Nakanishi
OBJECTIVES: Chronic obstructive airway disease, which is characterised by airflow limitation, is a major burden on public health. Reductions in environmental pollution in the atmosphere and workplace and a decline in the prevalence of smoking over recent decades may have affected the prevalence of airflow limitation in Japan. The present epidemiological study aimed to evaluate trends in the prevalence of airflow limitation and in the influence of risk factors on airflow limitation in a Japanese community...
March 20, 2019: BMJ Open
https://read.qxmd.com/read/30895186/combined-pulmonary-fibrosis-and-emphysema-characteristics-in-a-greek-cohort
#7
Foteini Malli, Despoina Papakosta, Katerina Antoniou, Maria Dimadi, Vlassis Polychronopoulos, Katerina Malagari, Anastasia Oikonomou, Demosthenes E Bouros, Zoe Daniil
Background: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This nationwide study aimed to describe a large cohort of Greek CPFE patients and to examine potential prognostic factors for survival. Methods: This retrospective study included 97 patients with CPFE. Demographic and clinical data, pulmonary function tests, echocardiography results and bronchoalveolar lavage analysis were recorded...
February 2019: ERJ Open Research
https://read.qxmd.com/read/30894506/relation-of-warrick-score-and-polysomnographic-parameters-in-patients-with-interstitial-lung-disease
#8
Sema Sarac, Murat Kavas, Murat Sahin, Gülfidan Aras, Gulgun Cetintas Afsar, Yelda B Tezel
BACKGROUND Obstructive sleep apnea (OSA) is often reported in connection with interstitial lung disease. As yet, there is insufficient data on the association of OSA severity parameters with lung involvement. We purposed to assess the frequency of OSA in our study group and to investigate the relationship between radiological involvement and OSA severity parameters. MATERIAL AND METHODS The study included 79 patients with interstitial lung disease who underwent spirometry, a carbon monoxide diffusion test (DLCO), high-resolution computed tomography, and polysomnography...
March 21, 2019: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/30892731/circulating-mast-cell-progenitors-correlate-with-reduced-lung-function-in-allergic-asthma
#9
M Salomonsson, A Malinovschi, P Kalm-Stephens, J S Dahlin, C Janson, K Alving, J Hallgren
BACKGROUND: Studies using mouse models have revealed that mast cell progenitors are recruited from the blood circulation to the lung during acute allergic airway inflammation. The discovery of a corresponding human mast cell progenitor population in the blood has enabled to study the relation of circulating mast cell progenitors in clinical settings. OBJECTIVES: To explore the possible association between the frequency of mast cell progenitors in the blood circulation and allergic asthma, we assessed the relation of this recently identified cell population with asthma outcomes and inflammatory mediators in allergic asthmatics and controls...
March 20, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30892662/effects-of-replacing-sitting-time-with-physical-activity-on-lung-function-an-analysis-of-the-canadian-longitudinal-study-on-aging
#10
Shilpa Dogra, Joshua Good, Paul A Gardiner, Jennifer L Copeland, Michael K Strickland, David Rudoler, Matthew P Buman
BACKGROUND: Sitting time and physical activity may be modifiable determinants of lung function. The purpose of this study was to assess the effect that replacing various movement behaviours has on lung function among individuals with and without obstructive lung disease. DATA AND METHODS: For analysis, data were used from participants of the Canadian Longitudinal Study on Aging, recruited between 2012 and 2015. Lung function was assessed using spirometry. A modified version of the Physical Activity Scale for the Elderly was used to assess sitting time and physical activity levels...
March 20, 2019: Health Reports
https://read.qxmd.com/read/30892545/exercise-capacity-in-children-and-adolescents-with-post-infectious-bronchiolitis-obliterans-a-systematic-review
#11
Camila Menna Barros Rodrigues, Daniele Schiwe, Natália Evangelista de Campos, Fabiana Niederauer, João Paulo Heinzmann-Filho
OBJECTIVE: To evaluate exercise capacity in children and adolescents with post-infectious bronchiolitis obliterans. DATA SOURCE: This is a systematic review based on data from PubMed, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), and Physiotherapy Evidence Database (PEDro). We used the following search strategy: "Exercise capacity OR Exercise Test OR Physical fitness OR Functional capacity OR Six-minute walk test OR Shuttle walk test OR Cardiopulmonary exercise test AND Bronchiolitis obliterans...
March 18, 2019: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://read.qxmd.com/read/30891435/use-of-symptoms-scores-spirometry-and-other-pulmonary-function-testing-for-asthma-monitoring
#12
REVIEW
Marcella Gallucci, Paolo Carbonara, Angela Maria Grazia Pacilli, Emanuela di Palmo, Giampaolo Ricci, Stefano Nava
Asthma is a global problem affecting millions of people all over the world. Monitoring of asthma both in children and in adulthood is an indispensable tool for the optimal disease management and for the maintenance of clinical stability. To date, several resources are available to assess the asthma control, first is the monitoring of symptoms, both through periodic follow-up visits and through specific quality of life measures addressed to the patient in first person or to parents. Clinical monitoring is not always sufficient to predict the risk of future exacerbations, which is why further instrumental examinations are available including lung function tests, the assessment of bronchial hyper-reactivity and bronchial inflammation...
2019: Frontiers in Pediatrics
https://read.qxmd.com/read/30890630/comparison-of-the-forced-and-slow-vital-capacity-maneuvers-in-defining-airway-obstruction
#13
Nikhil A Huprikar, Andrew J Skabelund, Valerie G Bedsole, Tyson J Sjulin, Asmita V Karandikar, James K Aden, Michael J Morris
BACKGROUND: Obstructive lung disease is diagnosed by a decreased ratio of FEV1 to the vital capacity (VC). Although the most commonly used VC is FVC, American Thoracic Society guidelines suggest alternative VCs, for example, slow VC (SVC), may offer a more-accurate evaluation of breathing capacity. There is recent evidence that using only FEV1 /FVC underrecognizes obstruction in subjects at high risk and who are symptomatic. Previous studies have indicated that healthy individuals show a minimum difference between FVC and SVC; however, testing of individuals with asthma and who are symptomatic indicates that SVC can be markedly larger than FVC...
March 19, 2019: Respiratory Care
https://read.qxmd.com/read/30890287/quality-of-pulmonary-function-tests-in-participants-with-down-syndrome
#14
Rosario Fernández-Plata, Rogelio Pérez-Padilla, Rodrigo Del Río-Hidalgo, Cecilia García-Sancho, Laura Gochicoa-Rangel, Christian Rodríguez-Hernández, Luis Torre-Bouscoulet, David Martínez-Briseño
INTRODUCTION: People with Down syndrome (DS) have high respiratory morbidity, evaluating their respiratory health with standardized, objective tests is desirable. Thus, the objective of this study was to evaluate the technical quality of Pulmonary Function Tests (PFTs) to determine which ones are most suitable for this population. METHODS: Participants included children, teenagers and adults with DS, 5 years of age or older (n=302). The technical quality of the impulse oscillometry system (IOS), forced spirometry, lung-diffusing capacity for carbon monoxide (DLCO ), and 6-min walk test (6MWT) were analyzed by age group...
March 16, 2019: Archivos de Bronconeumología
https://read.qxmd.com/read/30889905/choline-supplementation-in-cystic-fibrosis-the-metabolic-and-clinical-impact
#15
Wolfgang Bernhard, Robert Lange, Ute Graepler-Mainka, Corinna Engel, Jürgen Machann, Verena Hund, Anna Shunova, Andreas Hector, Joachim Riethmüller
BACKGROUND: Choline is essential for the synthesis of liver phosphatidylcholine (PC), parenchymal maintenance, bile formation, and lipoprotein assembly to secrete triglycerides. In choline deficiency, the liver accretes choline/PC at the expense of lung tissue, thereby impairing pulmonary PC homoeostasis. In cystic fibrosis (CF), exocrine pancreas insufficiency results in impaired cleavage of bile PC and subsequent fecal choline loss. In these patients, the plasma choline concentration is low and correlates with lung function...
March 18, 2019: Nutrients
https://read.qxmd.com/read/30889207/acute-effects-of-three-pulmonary-reexpansion-modalities-on-thoracoabdominal-motion-of-healthy-subjects-randomized-crossover-study
#16
Rêncio Bento Florêncio, Andrea Aliverti, Marina Lyra Lima Cabral Fagundes, Ilsa Priscila Dos Santos Batista, Antônio José Sarmento da Nóbrega, Vanessa Regiane Resqueti, Guilherme Augusto de Freitas Fregonezi
BACKGROUND: Chest physiotherapy can be an alternative to increase lung volumes through pulmonary expansion therapies, but there is still inconsistency in the literature in order to determine which device can promote a greater volume increase at the expense of a better ventilatory pattern. Therefore, the aim of this study was to evaluate and compare the chest wall kinematics of healthy subjects submitted to the use of three different devices for pulmonary reexpansion. METHODS: Chest wall compartmental and operational volumes, breathing pattern and thoracoabdominal asynchrony were evaluated in 12 healthy individuals through optoelectronic plethysmography during quiet breathing, pulmonary reexpansion and recovery...
2019: PloS One
https://read.qxmd.com/read/30885002/the-value-of-spirometry-in-subglottic-stenosis
#17
Alhelali Abdullah, A Alrabiah, Sayed S Habib, Y Aljathlany, A Aljasser, M Bukhari, A Y Al-Ammar
The diagnosis of subglottic stenosis (SGS) is usually made by clinical assessment and definitively by a direct endoscopic examination. This study aimed to evaluate different spirometric values in relation to anatomical grading and severity of subglottic stenosis cases of upper airway obstruction. Cases of SGS that underwent dilatational procedures endoscopically at the otolaryngology department of the King Saud University Medical City, Riyadh, Saudi Arabia, from June 2015 to October 2017 were collected. Pulmonary function test (PFT) pre- and postoperative parameters and the grades of subglottic stenosis were extracted...
February 2019: Ear, Nose, & Throat Journal
https://read.qxmd.com/read/30879046/preoperative-pulmonary-function-in-all-comers-for-cardiac-surgery-predicts-mortality%C3%A2
#18
Emilie C Risom, Katrine B Buggeskov, Ulla B Mogensen, Martin Sundskard, Jann Mortensen, Hanne B Ravn
OBJECTIVES: Although reduced lung function and chronic obstructive pulmonary disease (COPD) is associated with higher risk of death following cardiac surgery, preoperative spirometry is not performed routinely. The aim of this study was to investigate the relationship between preoperative lung function and postoperative complications in all comers for cardiac surgery irrespective of smoking or COPD history. METHODS: Preoperative spirometry was performed in elective adult cardiac surgery patients...
March 15, 2019: Interactive Cardiovascular and Thoracic Surgery
https://read.qxmd.com/read/30876830/exploring-the-relevance-and-extent-of-small-airways-dysfunction-in-asthma-atlantis-baseline-data-from-a-prospective-cohort-study
#19
Dirkje S Postma, Chris Brightling, Simonetta Baldi, Maarten Van den Berge, Leonardo M Fabbri, Alessandra Gagnatelli, Alberto Papi, Thys Van der Molen, Klaus F Rabe, Salman Siddiqui, Dave Singh, Gabriele Nicolini, Monica Kraft
BACKGROUND: Small airways dysfunction (SAD) is well recognised in asthma, yet its role in the severity and control of asthma is unclear. This study aimed to assess which combination of biomarkers, physiological tests, and imaging markers best measure the presence and extent of SAD in patients with asthma. METHODS: In this baseline assessment of a multinational prospective cohort study (the Assessment of Small Airways Involvement in Asthma [ATLANTIS] study), we recruited participants with and without asthma (defined as Global Initiative for Asthma severity stages 1-5) from general practices, the databases of chest physicians, and advertisements at 29 centres across nine countries (Brazil, China, Germany, Italy, Spain, the Netherlands, the UK, the USA, and Canada)...
March 12, 2019: Lancet Respiratory Medicine
https://read.qxmd.com/read/30876466/sf-6d-utility-scores-of-smokers-and-ex-smokers-with-or-without-respiratory-symptoms-attending-primary-care-clinics
#20
Sau-Nga Fu, Man-Chi Dao, Carlos King-Ho Wong, Wai-Cho Yu
INTRODUCTION: The aim of this paper is to find out generic preference-based Short-Form 6 Dimensions (SF-6D) utility scores of smokers and ex-smokers with varying cigarette exposure, with and without respiratory symptoms. METHODS: Seven hundred thirty one people aged ≥30 with a history of smoking who attended 5 public primary care clinics completed a cross-sectional survey using SF-6D utility score, Breathlessness, Cough, and Sputum Scale (BCSS©) and office spirometry...
March 15, 2019: Health and Quality of Life Outcomes
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