keyword
https://read.qxmd.com/read/37482814/toxicological-profile-of-the-hymenaea-courbaril-stem-bark-hydroalcoholic-extract-using-in-vitro-bioassays-and-an-alternative-in-vivo-caenorhabditis-elegans-model
#21
JOURNAL ARTICLE
Larissa Aline Carneiro Lobo, Peterson Alves Santos, Jayne Torres de Sousa, Jaqueline Nascimento Picada, Sara Elis Bianchi, Valquiria Linck Bassani, Francisco Carlos da Silva, Eduardo Miranda Ethur, Márcia Inês Goettert, Patrícia Pereira
Hymenaea genus has been used in folk medicine in Brazil, but few studies investigated its toxicity profile. Thus, the aim of this study was to determine toxicological parameters of Hymenaea courbaril stem bark hydroalcoholic extract by utilizing three cell lines including murine macrophages (RAW 264.7), mouse fibroblast cells (L929) and human lung fibroblast (MRC-5), as well as Salmonella/ microsome assay, and in vivo Caenorhabditis elegans model. The predominant detected phytoconstituents in the extract were coumarins, flavonoids, phenolics, tannins and saponins and by HPLC analysis, astilbin (AST) was found to be the main component...
July 24, 2023: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/37480360/short-communication-evaluation-of-an-endotoxin-challenge-and-intraruminal-bacterial-inoculation-model-to-induce-liver-abscesses-in-holstein-steers
#22
JOURNAL ARTICLE
Zach S McDaniel, Kristin E Hales, T G Nagaraja, Ty E Lawrence, Raghavendra G Amachawadi, Jeff A Carroll, Nicole C Burdick Sanchez, Michael L Galyean, Taylor M Smock, Michael A Ballou, Vinicius S Machado, Paul R Broadway
Holstein steers (n = 40; initial body weight; BW = 96.0 ± 10.5 kg) were individually housed in a climate-controlled barn to evaluate potential models for the genesis of liver abscesses (LA). In this 2 x 2 factorial, steers were balanced by BW and randomly assigned to 1 of 2 treatments: 1) intravenous saline injection followed by intraruminal bacterial inoculation with Fusobacterium necrophorum subsp. necrophorum (1 × 109colony forming unit [CFU]/mL) and Salmonella enterica serovar Lubbock (1 × 106CFU/mL; CON; n = 20 steers); or 2) intravenous injection with 0...
July 22, 2023: Journal of Animal Science
https://read.qxmd.com/read/37329122/systemic-salmonellosis-in-4-cats
#23
JOURNAL ARTICLE
Jesse Riker, Doris M Miller, Uriel Blas-Machado, Danielle E Lieske, Justin M Stilwell, Kathryn McCullough, Susan Sanchez, Daniel R Rissi
Clinical signs in 4 cases of salmonellosis in cats included vomiting, diarrhea (2 cases each), fever, dystocia, icterus, and seizures (1 case each). Three cats died, and one was euthanized. Grossly, all cats were in poor body condition and had yellow-to-dark-red perianal feces (3 cases), oral and ocular pallor (2 cases) or icterus (1 case), fluid or pasty yellow intestinal contents (4 cases), white or dark-red-to-black depressed areas on the hepatic surface (2 cases), yellow abdominal fluid with swollen abdominal lymph nodes (1 case), and fibrin strands on the placental chorionic surface (1 case)...
June 16, 2023: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/37231163/divergent-metabolic-programmes-control-two-populations-of-mait-cells-that-protect-the-lung
#24
JOURNAL ARTICLE
Thomas Riffelmacher, Mallory Paynich Murray, Chantal Wientjens, Shilpi Chandra, Viankail Cedillo-Castelán, Ting-Fang Chou, Sara McArdle, Christopher Dillingham, Jordan Devereaux, Aaron Nilsen, Simon Brunel, David M Lewinsohn, Jeff Hasty, Gregory Seumois, Christopher A Benedict, Pandurangan Vijayanand, Mitchell Kronenberg
Although mucosal-associated invariant T (MAIT) cells provide rapid, innate-like responses, they are not pre-set, and memory-like responses have been described for MAIT cells following infections. The importance of metabolism for controlling these responses, however, is unknown. Here, following pulmonary immunization with a Salmonella vaccine strain, mouse MAIT cells expanded as separate CD127- Klrg1+ and CD127+ Klrg1- antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue...
May 25, 2023: Nature Cell Biology
https://read.qxmd.com/read/37222166/aptamer-functionalized-quantum-dots-as-theranostic-nanotools-against-cancer-and-bacterial-infections-a-comprehensive-overview-of-recent-trends
#25
REVIEW
Fatemeh Davodabadi, Shekoufeh Mirinejad, Sonia Fathi-Karkan, Mahdi Majidpour, Narges Ajalli, Roghayeh Sheervalilou, Saman Sargazi, Dominika Rozmus, Abbas Rahdar, Ana M Diez-Pascual
Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various molecules, including amino acids, proteins, and pharmaceuticals. Through a series of adsorption, recovery, and amplification steps, Apts are extracted from combinatorial libraries of synthesized nucleic acids. Using aptasensors in bioanalysis and biomedicine can be improved by combining them with nanomaterials. Moreover, Apt-associated nanomaterials, including liposomes, polymeric, dendrimers, carbon nanomaterials, silica, nanorods, magnetic NPs, and quantum dots (QDs), have been widely used as promising nanotools in biomedicine...
May 24, 2023: Biotechnology Progress
https://read.qxmd.com/read/37189117/bacterial-extracellular-vesicles-repress-the-vascular-protective-factor-rnase1-in-human-lung-endothelial-cells
#26
JOURNAL ARTICLE
Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preußer, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck, Anna Lena Jung
BACKGROUND: Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) acts as a protective factor of vascular homeostasis and is known to be repressed by massive and persistent inflammation, associated to the development of vascular pathologies. Bacterial extracellular vesicles (bEVs) are released upon infection and may interact with ECs to mediate EC barrier dysfunction...
May 15, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37168394/bioactive-metabolites-of-streptomyces-misakiensis-display-broad-spectrum-antimicrobial-activity-against-multidrug-resistant-bacteria-and-fungi
#27
JOURNAL ARTICLE
Rewan Abdelaziz, Yasmine H Tartor, Ahmed B Barakat, Gamal El-Didamony, Marwa M Gado, Adina Berbecea, Habil Dr Isidora Radulov
BACKGROUND: Antimicrobial resistance is a serious threat to public health globally. It is a slower-moving pandemic than COVID-19, so we are fast running out of treatment options. PURPOSE: Thus, this study was designed to search for an alternative biomaterial with broad-spectrum activity for the treatment of multidrug-resistant (MDR) bacterial and fungal pathogen-related infections. METHODS: We isolated Streptomyces species from soil samples and identified the most active strains with antimicrobial activity...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37168190/a-rare-case-of-salmonella-gastroenteritis-presenting-as-aspiration-pneumonia-with-pleural-empyema-in-an-immunocompetent-patient
#28
Asif Mehmood, Muhammad Fahad Amin
Non-typhoidal salmonella (NTS) can cause infections ranging from self-limited chronic carriers to gastroenteritis, bacteremia, and extraintestinal infections. Pulmonary involvement, particularly empyema, is quite rare and generally found in immunosuppressed individuals. We present a case of salmonellosis in an immunocompetent patient with rare pulmonary complications of empyema. The patient, with no underlying immunocompromised illness, presented with a one-day history of worsening generalized weakness, fever, shortness of breath, and productive cough after having gastroenteritis symptoms of five days duration, which stopped two days prior to admission...
April 2023: Curēus
https://read.qxmd.com/read/37154735/homologous-sequential-immunization-using-salmonella-oral-administration-followed-by-an-intranasal-boost-with-ferritin-based-nanoparticles-enhanced-the-humoral-immune-response-against-h1n1-influenza-virus
#29
JOURNAL ARTICLE
Zhannan Wang, Tongyu Zhang, Futing Jia, Chongbo Ge, Yingkai He, Yawen Tian, Wenfeng Wang, Guilian Yang, Haibin Huang, Jianzhong Wang, Chunwei Shi, Wentao Yang, Xin Cao, Yan Zeng, Nan Wang, Aidong Qian, Chunfeng Wang, Yanlong Jiang
The influenza virus continues to pose a great threat to public health due to the frequent variations in RNA viruses. Vaccines targeting conserved epitopes, such as the extracellular domain of the transmembrane protein M2 (M2e), a nucleoprotein, and the stem region of hemagglutinin proteins, have been developed, but more efficient strategies, such as nanoparticle-based vaccines, are still urgently needed. However, the labor-intensive in vitro purification of nanoparticles is still necessary, which could hinder the application of nanoparticles in the veterinary field in the future...
May 8, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37140113/oral-inoculation-of-point-of-lay-hens-with-the-new-south-wales-outbreak-strain-of-salmonella-enteritidis-phage-type-12-causes-infection-but-minimal-histopathology
#30
JOURNAL ARTICLE
Alison Collins, Anne Jordan, Yuanshuo Gao, Peter Groves
An outbreak of food poisoning in New South Wales (NSW) Australia in 2018, caused by Salmonella enterica serovar Enteritidis phage type 12 (PT12), was traced to eggs consumed from a NSW layer flock. This was the first report of Salmonella Enteritidis infection in NSW layer flocks, despite ongoing environmental monitoring. Clinical signs and mortalities were minimal in most flocks, although seroconversion and infection were demonstrated in some flocks. An oral dose-response challenge study with Salmonella Enteritidis PT12 was undertaken in commercial point-of-lay hens...
March 2023: Avian Diseases
https://read.qxmd.com/read/37110539/effect-of-microencapsulated-basil-extract-on-cream-cheese-quality-and-stability
#31
JOURNAL ARTICLE
Liliana Popescu, Daniela Cojocari, Ildiko Lung, Irina Kacso, Alexandra Ciorîţă, Aliona Ghendov-Mosanu, Greta Balan, Adela Pintea, Rodica Sturza
The antimicrobial and antioxidant effects of plant extracts are well known, but their use is limited because they affect the physicochemical and sensory characteristics of products. Encapsulation presents an option to limit or prevent these changes. The paper presents the composition of individual polyphenols (HPLC-DAD-ESI-MS) from basil ( Ocimum basilicum L.) extracts (BE), and their antioxidant activity and inhibitory effects against strains of Staphylococcus aureus , Geobacillus stearothermophilus , Bacillus cereus , Candida albicans , Enterococcus faecalis , Escherichia coli , and Salmonella Abony ...
April 7, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37107268/the-effect-of-aromatic-plant-extracts-encapsulated-in-alginate-on-the-bioactivity-textural-characteristics-and-shelf-life-of-yogurt
#32
JOURNAL ARTICLE
Liliana Popescu, Daniela Cojocari, Aliona Ghendov-Mosanu, Ildiko Lung, Maria-Loredana Soran, Ocsana Opriş, Irina Kacso, Alexandra Ciorîţă, Greta Balan, Adela Pintea, Rodica Sturza
The article investigated the antioxidant and antimicrobial activity of extracts from two aromatic plants- Satureja hortensis L. (SE) and Rosmarinus officinalis L. (RE), encapsulated in alginate, on-yogurt properties. The encapsulation efficiency was controlled by FTIR and SEM analysis. In both extracts, the individual polyphenol content was determined by HPLC-DAD-ESI-MS. The total polyphenol content and the antioxidant activity were spectrophotometrically quantified. The antimicrobial properties of SE and RE against gram-positive bacteria ( Bacillus cereus , Enterococcus faecalis , Staphylococcus aureus , Geobacillus stearothermophilus ), gram-negative bacteria ( Escherichia coli , Acinetobacter baumannii , Salmonella abony ) and yeasts ( Candida albicans ) were analyzed in vitro...
April 6, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37044178/novel-pro-and-eukaryotic-expression-plasmid-expressing-omicron-antigens-delivered-via-salmonella-elicited-mhc-class-i-and-ii-based-protective-immunity
#33
JOURNAL ARTICLE
Chandran Sivasankar, Chamith Hewawaduge, John Hwa Lee
The latest omicron variants are emerging with mutations in the receptor binding domain (RBD) that confer immune evasion and resistance against current vaccines. Such variants have raised the peril of future vaccine effectiveness, as leading vaccines target the spike protein. Type-IV hypersensitivity, and other ailments due to the dominant Th1 response by leading vaccines, is also to be resolved. Therefore, vaccine that target diverse SARS-CoV-2 proteins and provide broad-spectrum protection and a balanced Th1 and Th2 response is an indispensable armament against the pandemic...
April 10, 2023: Journal of Controlled Release
https://read.qxmd.com/read/36978183/bacterial-vesicles-block-viral-replication-in-macrophages-via-tlr4-trif-axis
#34
JOURNAL ARTICLE
Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N Schulte, Stefan Bauer, Elke Pogge von Strandmann, Eva Böttcher-Friebertshäuser, Bernd Schmeck, Anna Lena Jung
Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important resident immune cells, alveolar macrophages are located at the air-tissue interface where they comprise the first line of defence against inhaled microorganisms and particles. To date, little is known about the interplay between alveolar macrophages and OMVs from pathogenic bacteria...
March 28, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/36922786/bioprospecting-of-desert-actinobacteria-with-special-emphases-on-griseoviridin-mitomycin-c-and-a-new-bacterial-metabolite-producing-streptomyces-sp-pu-kb10-4
#35
JOURNAL ARTICLE
Maira Saleem, Ashba Hassan, Feina Li, Qinpei Lu, Larissa V Ponomareva, Sean Parkin, Chenghang Sun, Jon S Thorson, Khaled A Shaaban, Imran Sajid
BACKGROUND: Bioprospecting of actinobacteria isolated from Kubuqi desert, China for antibacterial, antifungal and cytotoxic metabolites production and their structure elucidation. RESULTS: A total of 100 actinobacteria strains were selectively isolated from Kubuqi desert, Inner Mongolia, China. The taxonomic characterization revealed Streptomyces as the predominant genus comprising 37 different species, along with the rare actinobacterial genus Lentzea. The methanolic extracts of 60...
March 15, 2023: BMC Microbiology
https://read.qxmd.com/read/36911881/identification-of-phytochemical-compounds-of-fagopyrum-dibotrys-and-their-targets-by-metabolomics-network-pharmacology-and-molecular-docking-studies
#36
JOURNAL ARTICLE
Min Zhang, Xinke Zhang, Jin Pei, Baolin Guo, Guoshuai Zhang, Minhui Li, Linfang Huang
Acute lung injury (ALI) is a clinically severe lung illness with high incidence rate and mortality. Especially, coronavirus disease 2019 (COVID-19) poses a serious threat to world wide governmental fitness. It has distributed to almost from corner to corner of the universe, and the situation in the prevention and control of COVID-19 remains grave. Traditional Chinese medicine plays a vital role in the precaution and therapy of sicknesses. At present, there is a lack of drugs for treating these diseases, so it is necessary to develop drugs for treating COVID-19 related ALI...
March 2023: Heliyon
https://read.qxmd.com/read/36872243/-anti-infectious-pneumonia-target-discovery-and-molecular-mechanism-study-of-jingfang-granules
#37
JOURNAL ARTICLE
Mei-Mei Zhao, Lu Yao, Jing-Chun Yao, Cheng-Hong Sun, Gui-Min Zhang, Ke-Wu Zeng
This study aimed to identify the direct pharmacological targets of Jingfang Granules in treating infectious pneumonia via "target fishing" strategy. Moreover, the molecular mechanism of Jingfang Granules in treating infectious pneumonia was also investigated based on target-related pharmacological signaling pathways. First, the Jingfang Granules extract-bound magnetic nanoparticles were prepared, which were incubated with lipopolysaccharide(LPS)-induced mouse pneumonia tissue lysates. The captured proteins were analyzed by high-resolution mass spectrometry(HRMS), and the target groups with specific binding to the Jingfang Granules extract were screened out...
February 2023: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/36849453/salmonella-typhimurium-expressing-chromosomally-integrated-schistosoma-mansoni-cathepsin-b-protects-against-schistosomiasis-in-mice
#38
JOURNAL ARTICLE
Adam S Hassan, Sébastien Houle, Lydia Labrie, Dilhan J Perera, Charles M Dozois, Brian J Ward, Momar Ndao
Schistosomiasis threatens hundreds of millions of people worldwide. The larval stage of Schistosoma mansoni migrates through the lung and adult worms reside adjacent to the colonic mucosa. Several candidate vaccines are in preclinical development, but none is designed to elicit both systemic and mucosal responses. We have repurposed an attenuated Salmonella enterica Typhimurium strain (YS1646) to express Cathepsin B (CatB), a digestive enzyme important for the juvenile and adult stages of the S. mansoni life cycle...
February 27, 2023: NPJ Vaccines
https://read.qxmd.com/read/36834525/bacterial-infections-and-cancer-exploring-this-association-and-its-implications-for-cancer-patients
#39
REVIEW
Kafayat Yusuf, Venkatesh Sampath, Shahid Umar
Bacterial infections are common in the etiology of human diseases owing to the ubiquity of bacteria. Such infections promote the development of periodontal disease, bacterial pneumonia, typhoid, acute gastroenteritis, and diarrhea in susceptible hosts. These diseases may be resolved using antibiotics/antimicrobial therapy in some hosts. However, other hosts may be unable to eliminate the bacteria, allowing them to persist for long durations and significantly increasing the carrier's risk of developing cancer over time...
February 4, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36813061/gene-expression-of-trpmls-and-its-regulation-by-pathogen-stimulation
#40
JOURNAL ARTICLE
Zhiqiang Xia, Lixia Xie, Dongyuan Li, Xinyi Hong, Chenhu Qin
The transient receptor potential mucolipin (TRPML) subfamily in mammalian has three members, namely TRPML1, TRPML2, and TRPML3, who play key roles in regulating intracellular Ca2+ homeostasis, endosomal pH, membrane trafficking and autophagy. Previous studies had shown that three TRPMLs are closely related to the occurrence of pathogen invasion and immune regulation in some immune tissues or cells, but the relationship between TRPMLs expression and pathogen invasion in lung tissue or cell remains elusive. Here, we investigated the expression distribution of three TRPML channels in mouse different tissues by qRT-PCR, and then found that all three TRPMLs were highly expressed in the mouse lung tissue, as well as mouse spleen and kidney tissues...
February 20, 2023: Gene
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