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Salmonella AND cancer

SeungBeum Suh, Ami Jo, Mahama A Traore, Ying Zhan, Sheryl L Coutermarsh-Ott, Veronica M Ringel-Scaia, Irving C Allen, Richey M Davis, Bahareh Behkam
Cancer drug delivery remains a formidable challenge due to systemic toxicity and inadequate extravascular transport of nanotherapeutics to cells distal from blood vessels. It is hypothesized that, in absence of an external driving force, the Salmonella enterica serovar Typhimurium could be exploited for autonomous targeted delivery of nanotherapeutics to currently unreachable sites. To test the hypothesis, a nanoscale bacteria-enabled autonomous drug delivery system (NanoBEADS) is developed in which the functional capabilities of the tumor-targeting S ...
February 6, 2019: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Vishnu Raman, Nele Van Dessel, Owen M O'Connor, Neil S Forbes
BACKGROUND: Salmonella have potential as anticancer therapeutic because of their innate tumor specificity. In clinical studies, this specificity has been hampered by heterogeneous responses. Understanding the mechanisms that control tumor colonization would enable the design of more robust therapeutic strains. Two mechanisms that could affect tumor colonization are intracellular accumulation and intratumoral motility. Both of these mechanisms have elements that are controlled by the master motility regulator flhDC...
February 12, 2019: Journal for Immunotherapy of Cancer
Kang Liang, Qing Liu, Pei Li, Hongyan Luo, Haoju Wang, Qingke Kong
Bacteria have been investigated as anti-tumor therapeutic agents for more than a century, since Coley first observed successful curing of a patient with inoperable cancer by injection of streptococcal organisms. Previous studies have demonstrated that some obligate or facultative anaerobes can selectively accumulate and proliferate within tumors and suppress their growth. Developments in molecular biology as well as the complete genome sequencing of many bacterial species have increased the applicability of bacterial organisms for cancer treatment...
February 9, 2019: Cancer Letters
Lucio Capurso
Lactobacillus rhamnosus GG (LGG) was the first strain belonging to the genus Lactobacillus to be patented in 1989 thanks to its ability to survive and to proliferate at gastric acid pH and in medium containing bile, and to adhere to enterocytes. Furthermore LGG is able to produces both a biofilm that can mechanically protect the mucosa, and different soluble factors beneficial to the gut by enhancing intestinal crypt survival, diminishing apoptosis of the intestinal epithelium, and preserving cytoskeletal integrity...
March 2019: Journal of Clinical Gastroenterology
Jaqueline Lopes Damasceno, Yadira Fernández Arnet, Giovanna Capaldi Fortunato, Luiza Girotto, Gabriel Davi Marena, Beatriz Patti Rocha, Flávia Aparecida Resende, Sergio Ricardo Ambrosio, Rodrigo Cássio Sola Veneziani, Jairo Kenupp Bastos, Carlos Henrique Gomes Martins
Trees of the Copaifera genus are native to the tropical regions of Latin America and Western Africa. Copaifera sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in Copaifera and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Bearing in mind the fact that the Ames test is an excellent tool to assess the safety of extracts, oils, and phytochemicals isolated from medicinal plants, from it, we evaluate the mutagenic potential of four species, between oleoresins ( C...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Robert M Hoffman, Shuya Yano, Kentaro Igarashi
Cancer cells are methionine (MET) dependent compared to normal cells as they have an elevated requirement for MET in order to proliferate. MET restriction selectively traps cancer cells in the S/G2 phase of the cell cycle. The cell cycle phase can be visualized by color coding with the fluorescence ubiquitination-based cell cycle indicator (FUCCI). Recombinant methioninase (rMETase) is an enzyme that effectively degrades MET. rMETase induces S/G2 -phase blockage of cancer cells which is identified by the cancer cells' green fluorescence with FUCCI imaging...
2019: Methods in Molecular Biology
Anita Mikołajczyk, Dagmara Złotkowska
Bacterial lipopolysaccharide (LPS) can contribute to the pathogenesis and the clinical symptoms of many diseases such as cancer, mental disorders, neurodegenerative as well as metabolic diseases. The asymptomatic carrier state of Salmonella spp. is a very important public health problem. A subclinical single dose of LPS obtained from S. Enteritidis (5 μg/kg, i.v.) was administered to discern the consequences of changes of various brain peptides such as corticotropin-releasing hormone (CRH), gonadotropin-releasing hormone (GnRH), thyrotropin-releasing hormone (TRH), galanin (GAL), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP), and vasoactive intestinal polypeptide (VIP) in selected clinically important brain sections and endocrine glands of the hypothalamic-pituitary-adrenal (HPA), -thyroid (HPT), -ovarian (HPO) axes...
February 2, 2019: Toxins
Kentaro Miyake, Tasuku Kiyuna, Shukuan Li, Qinghong Han, Yuying Tan, Ming Zhao, Hiromichi Oshiro, Kei Kawaguchi, Takashi Higuchi, Zhiying Zhang, Sahar Razmjooei, Maryam Barangi, Sintawat Wangsiricharoen, Takashi Murakami, Arun S Singh, Yunfeng Li, Scott D Nelson, Fritz C Eilber, Michael Bouvet, Yukihiko Hiroshima, Takashi Chishima, Ryusei Matsuyama, Shree Ram Singh, Itaru Endo, Robert M Hoffman
BACKGROUND: Ewing's sarcoma (ES) is a recalcitrant disease in need of transformative therapeutics. OBJECTIVES: The aim of this study was to investigate the efficacy of tumor-selective Salmonella typhimurium A1-R combined with tumor metabolism targeting with oral administration of recombinant methioninase (o-rMETase), on an ES patient-derived orthotopic xenograft (PDOX) model. METHODS: The ES PDOX models were previously established in the right chest wall...
January 23, 2019: Chemotherapy
Chin Piaw Gwee, Chai Hoon Khoo, Swee Keong Yeap, Geok Chin Tan, Yoke Kqueen Cheah
The fight against cancer has been a never-ending battle. Limitations of conventional therapies include lack of selectivity, poor penetration and highly toxic to the host. Using genetically modified bacteria as a tumour therapy agent has gained the interest of scientist from the past few decades. Low virulence and highly tolerability of Salmonella spp. in animals and humans make it as the most studied pathogen with regards to anti-tumour therapy. The present study aims to construct a genetically modified S. Agona auxotroph as an anti-tumour agent...
2019: PeerJ
David Quintero, Jamie Carrafa, Lena Vincent, Hee Jong Lee, James Wohlschlegel, David Bermudes
Sunflower trypsin inhibitor (SFTI) is a 14-amino-acid bicyclic peptide that contains a single internal disulfide bond. We initially constructed chimeras of SFTI with N-terminal secretion signals from the Escherichia coli OmpA and Pseudomonas aeruginosa ToxA, but only detected small amounts of protease inhibition resulting from these constructs. A substantially higher degree of protease inhibition was detected from a C-terminal SFTI fusion with E. coli YebF, which radiated more than a centimeter from an individual colony of E...
December 28, 2018: Journal of Microbiology and Biotechnology
Shamik Majumdar, Vasista Adiga, Abinaya Raghavan, Supriya Rajendra Rananaware, Dipankar Nandi
The development of immunocompetent T cells entails a complex pathway of differentiation in the thymus. Thymic atrophy occurs with ageing and during conditions such as malnutrition, infections, cancer chemotherapy etc. The comparative changes in thymic subsets under different modes of thymic atrophy and the mechanisms involved are not well characterized. These aspects were investigated, using mice infected with Salmonella Typhimurium, injection with lipopolysaccharide (LPS), an inflammatory but non-infectious stimulus, Etoposide (Eto), a drug used to treat some cancers, and Dexamethasone (Dex), a steroid which is used to lower some inflammatory diseases...
January 19, 2019: Immunology
Aslı Türe, Deniz Cansen Kahraman, Rengul Cetin-Atalay, Sinem Helvacıoğlu, Mohammad Charehsaz, İlkay Küçükgüzel
Thirty-two novel urea/thiourea compounds as potential kinase inhibitor were designed, synthesized and evaluated for their cytotoxic activity on breast (MCF7), colon (HCT116) and liver (Huh7) cancer cell lines. Compounds 10, 19 and 30 possessing anticancer activity with IC50 values of 0.9, 0.8 and 1.6μM respectively on Huh7 cells were selected for further studies. These hit compounds were tested against liver carcinoma panel. Real time cell electronic sensing assay was used to evaluate the effects of the compounds 10, 19 and 30 on the growth pattern of liver cancer cells...
December 12, 2018: Computational Biology and Chemistry
Sumit Tahlan, Kalavathy Ramasamy, Siong Meng Lim, Syed Adnan Ali Shah, Vasudevan Mani, Balasubramanian Narasimhan
BACKGROUND: The emergence of bacterial resistance is a major public health problem. It is essential to develop and synthesize new therapeutic agents with better activity. The mode of actions of certain newly developed antimicrobial agents, however, exhibited very limited effect in treating life threatening systemic infections. Therefore, the advancement of multi-potent and efficient antimicrobial agents is crucial to overcome the increased multi-drug resistance of bacteria and fungi. Cancer, which remains as one of the primary causes of deaths and is commonly treated by chemotherapeutic agents, is also in need of novel and efficacious agents to treat resistant cases...
December 19, 2018: Chemistry Central Journal
Qiao-Yan Yi, Wen-Yao Zhang, Miao He, Fan Du, Xiu-Zhen Wang, Yang-Jie Wang, Yi-Ying Gu, Lan Bai, Yun-Jun Liu
Three iridium(III) polypyridyl complexes [Ir(ppy)2 (PYTA)](PF6 ) (1) (ppy = 2-phenylpyridine), [Ir(bzq)2 (PYTA)](PF6 ) (2) (bzq = benzo[h]quinolone) and [Ir(piq)2 (PYTA)](PF6 ) (3) (piq = 1-phenylisoquinoline, PYTA = 2,4-diamino-6-(2'-pyridyl)-1,3,5-triazine) were synthesized and characterized by elemental analysis, IR, 1 H NMR and 13 C NMR. The cytotoxic activity of the complexes toward cancer SGC-7901, Eca-109, A549, HeLa, HepG2, BEL-7402 and normal LO2 cell lines was investigated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method...
December 18, 2018: Journal of Biological Inorganic Chemistry: JBIC
Jinkui Ouyang, Ziling Mao, Hui Guo, Yunying Xie, Zehua Cui, Jian Sun, Huixiong Wu, Xiujun Wen, Jun Wang, Tijiang Shan
Four new depsidones, mollicellins O⁻R (compounds 1 ⁻ 4 ), along with three known compounds 5 ⁻ 7 , were isolated from cultures of the fungus Chaetomium sp. Eef-10, an endophyte isolated from Eucalyptus exserta . The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HR-ESI-MS spectra. The known compounds were identified by comparison of their spectral data with published values. Compounds 1 ⁻ 7 were evaluated for antibacterial activities against Staphylococcus aureus (sensitive and resistant strains), Escherichia coli , Agrobacterium tumefaciens , Salmonella typhimurium , Pseudomonas lachrymans , Ralstonia solanacearum , Xanthomonas vesicatoria and cytotoxic activities against two human cancer cell lines (HepG2 and Hela)...
December 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
D Zare, H Fazeli
BACKGROUND: Hospital-associated infections, recently renamed Healthcare-associated infections, are among the most common life-threatening complications of hospitalized patients, especially the immunocompromised patients. Regarding the significant role of Enterobacteriaceae in nosocomial infections and also the increasing trends of carbapenem-resistant strains, the present study aimed to evaluate the antibiotic resistance pattern and the occurrence of metallo-beta-lactamases (MBLs) in Enterobacteriaceae strains from Iranian cancer patients...
January 2019: Annali di Igiene: Medicina Preventiva e di Comunità
Luis Humberto De Loera Rodríguez, Genaro Gabriel Ortiz, Paloma Rivero Moragrega, Irma Ernestina Velázquez Brizuela, Juan Francisco Santoscoy Gutiérrez, Ana Rosa Rincón Sánchez, Claudia Lisette Charles Niño, José Antonio Cruz Serrano, Alfredo De Jesús Celis de la Rosa, Fermín Paul Pacheco Moisés, María Del Refugio Medrano González
BACKGROUND: patients with cervical cancer (CC) receiving chemotherapy and radiotherapy have several gastrointestinal adverse effects. OBJECTIVE: to evaluate the effect of dietary symbiotic supplementation on fecal calprotectin (FCP), bacterial DNA levels, and gastrointestinal adverse effects in patients with CC. METHODS: clinical, controlled, randomized, double-blind trial. Patients consumed symbiotics or placebo three times a day for seven weeks...
December 3, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Hafiz Fakhar Hayat, Nazim Hussain, Sobia Sarwar, Humaira Aslam, Ahmad Nadeem, Junling Shi
The natural antioxidant agent is urgently needed to prevent the negative effects of newly generated free radicals and chronic disorders. Recently, the microbial exopolysaccharide (EPS) is currently used as a potential biopolymer due to its unique biological characteristics. In this study, the biological potential was carried out on the EPSs produced by Lactobacillus reuteri SHA101 (EPS-lr) and Lactobacillus vaginalis SHA110 (EPS-lvg) isolated from gut cecum samples of healthy poultry birds (hen). As results, the EPS-lr and EPS-lvg showed the emulsifying activity of 37...
December 3, 2018: Probiotics and Antimicrobial Proteins
K Karthik, S Dhanuskodi, C Gobinath, S Prabukumar, S Sivaramakrishnan
Magnesium oxide (MgO) nanostructures were prepared using microwave-assisted (M 1) and hydrothermal (M 2) methods and characterized by XRD, SEM and FT-IR. It exhibits cubic structure with an average crystallite size of 20 nm (M 1) and 14 nm (M 2) and the lattice strain (WH plot) is 0.0017 (M 1), 0.0037 (M 2). It's spherical and rods like structures are confirmed through SEM and TEM. The vibrational stretching mode of MgO is 439 (M 1) and 449 cm-1 (M 2). The optical bandgap is estimated as 5.93 eV (M 1) and 5...
November 12, 2018: Journal of Photochemistry and Photobiology. B, Biology
Tingtao Chen, Xiaoxiao Zhao, Yimeng Ren, Yuqing Wang, Xianyao Tang, Puyuan Tian, Huan Wang, Hongbo Xin
The strong human immunity and the associated toxicities of attenuated Salmonella severely limit the clinical use of Salmonella in tumour suppression. In the present study, we constructed an engineered VNP20009-DNase I strain and evaluated the synergistic effects of triptolide (TPL) and VNP20009-DNase I against melanoma in mice. Our results indicated that TPL could significantly inhibit the cell growth and cell migration and significantly enhanced the apoptosis rate of B16F10 cells in vitro. The in vivo results indicated that TPL markedly improved tumour colonisation of VNP20009-DNase I and led to a larger necrotic area in the melanoma...
November 17, 2018: Applied Microbiology and Biotechnology
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