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JOURNAL ARTICLE
Claire McCallum, Miglena Campbell, John Vines, Tim Rapley, Jason Ellis, Vincent Deary, Katie Hackett
BACKGROUND: Sjögren's syndrome (SS) is the second most common autoimmune rheumatic disease, and the range of symptoms includes fatigue, dryness, sleep disturbances, and pain. Smartphone apps may help deliver a variety of cognitive and behavioral techniques to support self-management in SS. However, app-based interventions must be carefully designed to promote engagement and motivate behavior change. OBJECTIVE: We aimed to explore self-management approaches and challenges experienced by people living with SS and produce a corresponding set of design recommendations that inform the design of an engaging, motivating, and evidence-based self-management app for those living with SS...
April 17, 2024: JMIR Human Factors
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JOURNAL ARTICLE
Elizabeth J Price, Stuart Benjamin, Michele Bombardieri, Simon Bowman, Sara Carty, Coziana Ciurtin, Bridget Crampton, Annabel Dawson, Benjamin A Fisher, Ian Giles, Peter Glennon, Monica Gupta, Katie L Hackett, Genevieve Larkin, Wan-Fai Ng, Athimalaipet V Ramanan, Saad Rassam, Saaeha Rauz, Guy Smith, Nurhan Sutcliffe, Anwar Tappuni, Stephen B Walsh
Sjögren disease (SD) is a chronic, autoimmune disease of unknown aetiology with significant impact on quality of life. Although dryness (sicca) of the eyes and mouth are the classically described features, dryness of other mucosal surfaces and systemic manifestations are common. The key management aim should be to empower the individual to manage their condition-conserving, replacing and stimulating secretions; and preventing damage and suppressing systemic disease activity. This guideline builds on and widens the recommendations developed for the first guideline published in 2017...
April 16, 2024: Rheumatology
#3
JOURNAL ARTICLE
Affan Mahmood Shahzad, Wenying Lu, Surajit Dey, Prem Bhattarai, Archana Vijay Gaikwad, Jade Jaffar, Glen Westall, Darren Sutherland, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Mathew Suji Eapen, Sukhwinder Singh Sohal
Background : Idiopathic pulmonary fibrosis (IPF) is an irreversible lung fibrotic disorder of unknown cause. It has been reported that bacterial and viral co-infections exacerbate disease pathogenesis. These pathogens use adhesion molecules such as platelet activating factor receptor (PAFR) and intercellular adhesion molecule-1 (ICAM-1) to gain cellular entry, causing infections. Methods : Immunohistochemical staining was carried out for lung resections from IPF patients (n = 11) and normal controls (n = 12)...
April 6, 2024: Journal of Clinical Medicine
#4
JOURNAL ARTICLE
Theresa N Wang, Vennila Padmanaban, Elizabeth J Bashian, Harold W Davis, Michael J Kirsch, John E Phay, Barbra S Miller, Caitlin E Hackett, Priya H Dedhia
BACKGROUND: Although uncommon, adrenal hemorrhage has multiple etiologies. Because clinical characteristics, management, and outcomes of patients with adrenal hemorrhage are inadequately described, we examined the underlying etiology, need for intervention, evolution of imaging characteristics, and adequacy of subsequent evaluation. METHODS: We performed a retrospective review of patients diagnosed with adrenal hemorrhage (radiologist-confirmed density consistent with hemorrhage on computed tomography) from 2005 to 2021 at a university-based institution...
April 8, 2024: Surgery
#5
JOURNAL ARTICLE
Sabine M Allida, Maree L Hackett, Richard Lindley, Kelvin Hill, Caleb Ferguson
Living evidence involves continuous evidence surveillance to incorporate new relevant evidence into systematic reviews and clinical practice guideline recommendations as soon as it becomes available. Thus, living evidence may improve the timeliness of recommendation updates and reduce the knowledge-to-practice gap. When considering a living evidence model, several processes and practical aspects need to be explored. Some of these include identifying the need for a living evidence model, funding, governance structure, time, team skills and capabilities, frequency of updates, approval and endorsement and publication and dissemination...
April 8, 2024: European Journal of Cardiovascular Nursing
#6
JOURNAL ARTICLE
Scott E McIntosh, Luanne Freer, Colin K Grissom, George W Rodway, Gordon G Giesbrecht, Marion McDevitt, Christopher H Imray, Eric L Johnson, Prativa Pandey, Jennifer Dow, Peter H Hackett
The Wilderness Medical Society convened an expert panel to develop a set of evidence-based guidelines for the prevention and treatment of frostbite. We present a review of pertinent pathophysiology. We then discuss primary and secondary prevention measures and therapeutic management. Recommendations are made regarding each treatment and its role in management. These recommendations are graded on the basis of the quality of supporting evidence and balance between the benefits and risks or burdens for each modality according to methodology stipulated by the American College of Chest Physicians...
April 5, 2024: Wilderness & Environmental Medicine
#7
JOURNAL ARTICLE
Tiffany N Harris-Jones, Jia Mun Chan, Kathleen T Hackett, Nathan J Weyand, Ryan E Schaub, Joseph P Dillard
Neisseria gonorrhoeae , a human restricted pathogen, releases inflammatory peptidoglycan (PG) fragments that contribute to the pathophysiology of pelvic inflammatory disease. The genus Neisseria is also home to multiple species of human- or animal-associated Neisseria that form part of the normal microbiota. Here we characterized PG release from the human-associated nonpathogenic species Neisseria lactamica and Neisseria mucosa and animal-associated Neisseria from macaques and wild mice. An N. mucosa strain and an N...
April 2, 2024: Infection and Immunity
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JOURNAL ARTICLE
Suzanne Máté, Nicholas Corr, Daniel Hackett, Michael Barnett, Maria Fiatarone Singh, Ché Fornusek
BACKGROUND: Lower limb muscle weakness and reduced balance due to disease progression in multiple sclerosis (MS) may make robust aerobic exercise difficult. Functional electrical stimulation (FES) cycling combined with voluntary cycling may allow people with severe MS to enhance the intensity of aerobic exercise. The aim of this study was to investigate the cardiorespiratory, power, and participant-reported perceptions during acute bouts of FES cycling, voluntary cycling, and FES cycling combined with voluntary cycling (FES assist cycling)...
March 20, 2024: Multiple Sclerosis and related Disorders
#9
Suzanne O Nolan, Patrick R Melugin, Kirsty R Erickson, Wilson R Adams, Zahra Z Farahbakhsh, Colleen E Mcgonigle, Michelle H Kwon, Vincent D Costa, Christopher C Lapish, Troy A Hackett, Verginia C Cuzon Carlson, Christos Constantinidis, Kathleen A Grant, Cody A Siciliano
Human and non-human primate data clearly implicate the dorsolateral prefrontal cortex (dlPFC) as critical for advanced cognitive functions 1,2 . It is thought that intracortical synaptic architectures within dlPFC are the integral neurobiological substrate that gives rise to these processes, including working memory, inferential reasoning, and decision-making 3-7 . In the prevailing model, each cortical column makes up one fundamental processing unit composed of dense intrinsic connectivity, conceptualized as the 'canonical' cortical microcircuit 3,8 ...
September 24, 2023: bioRxiv
#10
JOURNAL ARTICLE
Ruth A Hackett, Myra S Hunter, Sarah E Jackson
BACKGROUND: Emerging evidence suggests that perceived gender discrimination negatively impacts mental wellbeing in young women. PURPOSE: This study explored whether a similar relationship exists in middle-aged and older women. METHODS: A total of 3081 women (aged ≥52 years) from the English Longitudinal Study of Ageing provided data on perceived gender discrimination in 2010/11. Depressive symptoms, loneliness, quality of life and life satisfaction were assessed in 2010/11 and in 2016/17...
2024: PloS One
#11
JOURNAL ARTICLE
Mathew Suji Eapen, Wenying Lu, Surajit Dey, Collin Chia, Ashutosh Hardikar, Md Imtaiyaz Hassan, Prem Bhattarai, Archana Vijay Gaikwad, Shatarupa Das, Philip M Hansbro, Gurpreet Kaur Singhera, Tillie-Louise Hackett, Sukhwinder Singh Sohal
BACKGROUND: COPD patients suffer from dysregulated and suppressed immune functionality, determined by their loss of degranulating capacity. Here we provide crucial information on the presence of degranulated mast cells (MCs) in COPD airways and demonstrate their relationship to lung physiology and airway remodelling. METHODS: Small airway lung resections from non-smoking controls (NC), normal lung function smokers (NLFS), small airway disease (SAD), and mild-to-moderate COPD current smokers (COPD-CS) and ex-smokers (COPD-ES) were dual immuno-stained with MC tryptase and degranulation marker lysosome-associated membrane protein (LAMP)-1...
March 2024: ERJ Open Research
#12
JOURNAL ARTICLE
Gillian Elizabeth Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BACKGROUND: Three large randomised controlled trials of fluoxetine for stroke recovery have been performed. We perfomed an individual patient data meta-analysis (IPDM) on the combined data. METHODS: Fixed effects meta-analyses was performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity analysis, summary statistics from each trial were created and combined...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
#13
REVIEW
Mary Ann Anderson, Renata Walewska, Fidelma Hackett, Arnon P Kater, Josie Montegaard, Susan O'Brien, John F Seymour, Matthew Smith, Stephan Stilgenbauer, Ashley Whitechurch, Jennifer R Brown
Venetoclax, a highly selective, oral B-cell lymphoma 2 inhibitor, provides a robust targeted-therapy option for the treatment of chronic lymphocytic leukemia (CLL), including patients with high-risk del(17p)/mutated- TP53 and immunoglobulin heavy variable region unmutated CLL and those refractory to chemoimmunotherapy across all age groups. Due to the potent pro-apoptotic effect of venetoclax, treatment initiation carries a risk of tumor lysis syndrome (TLS). Prompt and appropriate management is needed to limit clinical TLS, which may entail serious adverse events and death...
February 28, 2024: Cancers
#14
Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff
Chimeric antigen receptor (CAR)-engineered T and NK cells can cause durable remission of B-cell malignancies; however, limited persistence restrains the full potential of these therapies in many patients. The FAS ligand (FAS-L)/FAS pathway governs naturally-occurring lymphocyte homeostasis, yet knowledge of which cells express FAS-L in patients and whether these sources compromise CAR persistence remains incomplete. Here, we constructed a single-cell atlas of diverse cancer types to identify cellular subsets expressing FASLG , the gene encoding FAS-L...
March 1, 2024: bioRxiv
#15
JOURNAL ARTICLE
Jikui Shen, Raquel Lima E Silva, Mingliang Zhang, Kathryn M Luly, Sean F Hackett, Stephany Y Tzeng, Shirley M Lowmaster, Sydney R Shannon, David R Wilson, Jordan J Green, Peter A Campochiaro
Suprachoroidal nonviral gene therapy with biodegradable poly(β-amino ester) nanoparticles (NPs) provides widespread expression in photoreceptors and retinal pigmented epithelial (RPE) cells and therapeutic benefits in rodents. Here, we show in a human-sized minipig eye that suprachoroidal injection of 50 μl of NPs containing 19.2 μg of GFP expression plasmid caused GFP expression in photoreceptors and RPE throughout the entire eye with no toxicity. Two weeks after injection of 50, 100, or 200 μl, there was considerable within-eye and between-eye variability in expression that was reduced 3 months after injection of 200 μl and markedly reduced after three suprachoroidal injections at different locations around the eye...
March 8, 2024: Science Advances
#16
JOURNAL ARTICLE
Victoria Kammin, Lorna Fraser, Kate Flemming, Julia Hackett
BACKGROUND: Children and young people with life-limiting conditions and their families need physical and emotional support to manage the challenges of their lives. There is a lack of synthesised qualitative research about how music therapy is experienced by children, young people and their families supported by paediatric palliative care services. AIM: To systematically identify and synthesise qualitative research on experiences of music therapy in paediatric palliative care from stakeholder perspectives...
March 7, 2024: Palliative Medicine
#17
JOURNAL ARTICLE
Geoffrey Hackett, Amar Mann, Ahmad Haider, Karim S Haider, Pieter Desnerck, Carola S König, Richard C Strange, Sudarshan Ramachandran
PURPOSE: While testosterone therapy can improve the various pathologies associated with adult-onset testosterone deficiency (TD), Summary of Product Characteristics (SPC) of five testosterone preparations caution that treatment may be associated with hypertension. This paper evaluates the impact of testosterone undecanoate (TU) on blood pressure (BP) in men with adult-onset TD. MATERIALS AND METHODS: Of 737 men with adult-onset TD in an on-going, observational, prospective, cumulative registry, we studied changes in BP using non-parametric sign-rank tests at final assessment and fixed time points...
February 14, 2024: World Journal of Men's Health
#18
JOURNAL ARTICLE
Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Leonard E Munstermann, Sinnathamby N Surendran, Chun-Hong Chen, Kevin Maringer, Isra Wahid, Shomen Mukherjee, Jiannon Xu, Michael C Fontaine, Elizabet L Estallo, Marina Stein, Todd Livdahl, Patricia Y Scaraffia, Brendan H Carter, Motoyoshi Mogi, Nobuko Tuno, James W Mains, Kim A Medley, David E Bowles, Richard J Gill, Roger Eritja, Ranulfo González-Obando, Huynh T T Trang, Sébastien Boyer, Ann-Marie Abunyewa, Kayleigh Hackett, Tina Wu, Justin Nguyễn, Jiangnan Shen, Hongyu Zhao, Jacob E Crawford, Peter Armbruster, Adalgisa Caccone
BACKGROUND: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases...
March 4, 2024: Parasites & Vectors
#19
JOURNAL ARTICLE
Yuliya Tishova, Svetlana Kalinchenko, George Mskhalaya, Geoffrey Hackett, Mark Livingston, Carola König, Richard Strange, Michael Zitzmann, Amar Mann, Amro Maarouf, Sudarshan Ramachandran
AIMS: To describe changes in homeostasis model assessment of insulin resistance index (HOMA-IR) following testosterone therapy in men with hypogonadism and metabolic syndrome (MetS). MATERIALS AND METHODS: A randomized, placebo-controlled, double-blind randomized controlled trial (RCT) comprising 184 men with MetS and hypogonadism (testosterone undecanoate [TU]: 113 men, placebo: 71 men) was conducted. This was followed by an open-label phase in which all men were given TU...
March 3, 2024: Diabetes, Obesity & Metabolism
#20
JOURNAL ARTICLE
Maryam Zare, Afrouz Mardi, Paria Yeghanenia, Daniel Hackett
The objective of this study is to determine the healthy behaviors of mothers with gestational diabetes mellitus (GDM) in Ardabil in 2020. An analytic cross-sectional study was conducted on 360 mothers with GDM in Ardabil in 2020. Self-reported data was collected using a sociodemographic and a lifestyle questionnaire (LSQ) with assistance from health staff. Univariate and multivariate linear regression tests were used to assess risk variables associated with health behaviors and GDM. The total score of the LSQ was 123...
March 1, 2024: Medicine (Baltimore)
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