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https://read.qxmd.com/read/30744208/acute-effect-of-kettlebell-swings-on-sprint-performance
#1
Kishen Kartages, Guy C Wilson, Che Fornusek, Mark Halaki, Daniel A Hackett
Previous research has shown that kettlebell swings (KBS), utilizing the hip-hinge technique, exhibit similar lower-limb muscle activation patterns to sprint running. This study investigated whether the inclusion of KBS in the warm-up enhances sprint performance. Moderately trained males ( n = 12) and females ( n = 8) performed KBS and a control (CON) condition (passive rest) in random order before performing three 20-m sprint trials separated by 4 minutes. No condition (KBS versus CON) effects, time effects or condition by time interactions were found for sprint times at 5-m and 10-m...
February 10, 2019: Sports
https://read.qxmd.com/read/30714865/a-retrospective-cohort-study-of-racing-performance-in-quarter-horses-undergoing-prosthetic-laryngoplasty-for-treatment-of-recurrent-laryngeal-neuropathy
#2
Clarisa R Krueger, Robert D Lewis, C Wayne McIlwraith, Michael D Major, Jeffrey E Brakenhoff, D Reese Hand, Aileen L Rowland, Ann M Hess, Samuel W Johnson, Eileen S Hackett
OBJECTIVE To determine effects of prosthetic laryngoplasty on return to racing, performance index, and career longevity in racing Quarter Horses with recurrent laryngeal neuropathy (RLN) and to evaluate performance variables for horses with RLN undergoing prosthetic laryngoplasty, compared with a control horse population. DESIGN Multicenter, retrospective cohort study. ANIMALS 162 racing Quarter Horses with RLN treated with prosthetic laryngoplasty (case horses) and 324 racing Quarter Horse without RLN (control horses)...
February 15, 2019: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/30706554/the-causes-of-nail-apparatus-pigmentation-presenting-to-a-melanoma-screening-clinic-a-prospective-study
#3
A Alani, C Blasdale, T Oliphant, C Hackett, J A A Langtry
BACKGROUND: Advanced stage primary cutaneous malignant melanoma (PCMM) has a high mortality. PCMM may affect any area of the skin, including the nail apparatus (malignant melanoma or subungual melanoma). Although nail apparatus malignant melanoma (NAMM) is rare, delayed diagnosis carries a poor prognosis. AIM: The primary aim was to study the range of nail presentations and identify key patterns to aid in differential diagnosis. A secondary aim was to quantify the number of patients requiring surgery, indications for biopsy, and the incidence and characteristics of NAMM...
January 31, 2019: Clinical and Experimental Dermatology
https://read.qxmd.com/read/30705983/muscadine-grape-skin-extract-inhibits-prostate-cancer-cells-by-inducing-cell-cycle-arrest-and-decreasing-migration-through-heat-shock-protein-40
#4
Diane N Ignacio, Kimberly D Mason, Ezra C Hackett-Morton, Christopher Albanese, Lymor Ringer, William D Wagner, Paul C Wang, Michael A Carducci, Sushant K Kachhap, Channing J Paller, Janet Mendonca, Leo Li-Ying Chan, Bo Lin, Diane K Hartle, Jeffrey E Green, Collis A Brown, Tamaro S Hudson
Previously we demonstrated that muscadine grape skin extract (MSKE), a natural product, significantly inhibited androgen-responsive prostate cancer cell growth by inducing apoptosis through the targeting of survival pathways. However, the therapeutic effect of MSKE on more aggressive androgen-independent prostate cancer remains unknown. This study examined the effects of MSKE treatment in metastatic prostate cancer using complementary PC-3 cells and xenograft model. MSKE significantly inhibited PC-3 human prostate cancer cell tumor growth in vitro and in vivo ...
January 2019: Heliyon
https://read.qxmd.com/read/30693534/loneliness-and-biological-responses-to-acute-stress-in-people-with-type-2-diabetes
#5
Ruth A Hackett, Lydia Poole, Elizabeth Hunt, Laura Panagi, Andrew Steptoe
Loneliness is linked with all-cause mortality and coronary heart disease. Altered neuroendocrine and inflammatory responses to stress constitute potential pathways linking loneliness and ill-health. Stress responsivity is modified in people with Type 2 diabetes, but it is unclear whether loneliness influences biological stress responses in this population. We assessed interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1RA), monocyte chemoattractant protein-1 (MCP-1), and cortisol responses to acute stress in 135 people with Type 2 diabetes...
January 28, 2019: Psychophysiology
https://read.qxmd.com/read/30690085/cardiac-structure-doses-in-women-irradiated-for-breast-cancer-in-the-past-and-their-use-in-epidemiological-studies
#6
Frances K Duane, Paul McGale, Dorthe Brønnum, David J Cutter, Sarah C Darby, Marianne Ewertz, Sara Hackett, Per Hall, Ebbe L Lorenzen, Kazem Rahimi, Zhe Wang, Samantha Warren, Carolyn W Taylor
BACKGROUND: and Purpose: Incidental cardiac exposure during radiotherapy may cause heart disease. Dose-response relationships for cardiac structures (segments) may show which are most sensitive to radiation. As radiation-related cardiac injury can take years to develop, such studies inevitably need involve women treated using 2-dimensional planning, with segment doses estimated using a "typical CT-scan". We assessed whether such segment doses are accurate enough for use in dose-response relationships using the radiotherapy charts of women with known segment injury...
January 25, 2019: Practical Radiation Oncology
https://read.qxmd.com/read/30679208/acute-and-evolving-mri-of-high-altitude-cerebral-edema-microbleeds-edema-and-pathophysiology
#7
P H Hackett, P R Yarnell, D A Weiland, K B Reynard
MR imaging of high-altitude cerebral edema shows reversible WM edema, especially in the corpus callosum and subcortical WM. Recent studies have revealed hemosiderin deposition in WM long after high-altitude cerebral edema has resolved, providing a high-altitude cerebral edema "footprint." We wished to determine whether these microbleeds are present acutely and also describe the evolution of all MR imaging findings. In 8 patients with severe high-altitude cerebral edema, we obtained 26 studies: 18 with 3T and 8 with 1...
January 24, 2019: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/30674979/in-vivo-assessment-of-increased-oxidation-of-branched-chain-amino-acids-in-glioblastoma
#8
Eul Hyun Suh, Edward P Hackett, R Max Wynn, David T Chuang, Bo Zhang, Weibo Luo, A Dean Sherry, Jae Mo Park
Altered branched-chain amino acids (BCAAs) metabolism is a distinctive feature of various cancers and plays an important role in sustaining tumor proliferation and aggressiveness. Despite the therapeutic and diagnostic potentials, the role of BCAA metabolism in cancer and the activities of associated enzymes remain unclear. Due to its pivotal role in BCAA metabolism and rapid cellular transport, hyperpolarized 13 C-labeled α-ketoisocaproate (KIC), the α-keto acid corresponding to leucine, can assess both BCAA aminotransferase (BCAT) and branched-chain α-keto acid dehydrogenase complex (BCKDC) activities via production of [1-13 C]leucine or 13 CO2 (and thus H13 CO3 - ), respectively...
January 23, 2019: Scientific Reports
https://read.qxmd.com/read/30670683/transcriptome-profiling-of-caspase-2-deficient-e%C3%AE-myc-and-th-mycn-mouse-tumors-identifies-distinct-putative-roles-for-caspase-2-in-neuronal-differentiation-and-immune-signaling
#9
Loretta Dorstyn, Emily Hackett-Jones, Andrej Nikolic, Murray D Norris, Yoon Lim, John Toubia, Michelle Haber, Sharad Kumar
Caspase-2 is a highly conserved cysteine protease with roles in apoptosis and tumor suppression. Our recent findings have also demonstrated that the tumor suppression function of caspase-2 is context specific. In particular, while caspase-2 deficiency augments lymphoma development in the EμMyc mouse model, it leads to delayed neuroblastoma development in Th-MYCN mice. However, it is unclear how caspase-2 mediates these differential outcomes. Here we utilized RNA sequencing to define the transcriptomic changes caused by caspase-2 (Casp2-/- ) deficiency in tumors from EμMyc and Th-MYCN mice...
January 22, 2019: Cell Death & Disease
https://read.qxmd.com/read/30666678/monte-carlo-simulations-of-out-of-field-skin-dose-due-to-spiralling-contaminant-electrons-in-a-perpendicular-magnetic-field
#10
Victor N Malkov, Sara L Hackett, Bram van Asselen, Bas W Raaymakers, Jochem W H Wolthaus
PURPOSE: To evaluate the potential skin dose toxicity contribution of spiralling contaminant electrons (SCE) generated in the air in an MR-linac with a 0.35 T or 1.5 T magnetic field using the EGSnrc Monte Carlo (MC) code. Comparisons to experimental results at 1.5 T are also performed. METHODS: An Elekta generated phase-space file for the Unity MR-linac is used in conjunction with the EGSnrc enhanced electric and magnetic field transport macros to simulate surface dose profiles and depth dose curves in panels located 5 cm away from the beam edge and positioned either parallel or perpendicular to the magnetic field...
January 21, 2019: Medical Physics
https://read.qxmd.com/read/30666661/sex-differences-in-interleukin-6-stress-responses-in-people-with-type-2-diabetes
#11
Laura Panagi, Lydia Poole, Ruth A Hackett, Andrew Steptoe
People with Type 2 diabetes (T2D) show dysregulated inflammatory responses to acute stress, but the effect of sex on inflammatory responses in T2D remains unclear. The purpose of this study was to investigate differences in interleukin (IL)-6 stress responses between older men and women with T2D. One hundred and twenty-one people (76 men; mean age = 64.09, SD = 7.35, 45 women; mean age = 63.20, SD = 6.70) with doctor-verified T2D took part in this laboratory-based stress testing study. Participants carried out acute mental stress tasks, and blood was sampled at baseline, immediately poststress, 45 min poststress, and 75 min poststress to detect plasma IL-6 concentrations...
January 22, 2019: Psychophysiology
https://read.qxmd.com/read/30656770/insect-pest-control-approximate-dynamic-programming-and-the-management-of-the-evolution-of-resistance
#12
Sean C Hackett, Michael B Bonsall
Ecological decision problems, such as those encountered in agriculture often require managing conflicts between short-term costs and long-term benefits. Dynamic programming is an ideal method for optimally solving such problems but agricultural problems are often subject to additional complexities which produce state spaces intractable to exact solutions. In contrast, lookahead policies, a class of approximate dynamic programming (ADP) algorithm, may attempt to solve problems of arbitrary magnitude. However, these algorithms focus on a temporally truncated caricature of the full decision problem over a defined planning horizon and as such are not guaranteed to suggest optimal actions...
January 17, 2019: Ecological Applications: a Publication of the Ecological Society of America
https://read.qxmd.com/read/30654379/returning-to-unpaid-work-after-stroke-the-psychosocial-outcomes-in-stroke-cohort-study
#13
Cheryl Carcel, Sara Farnbach, Beverley M Essue, Qiang Li, Nick Glozier, Stephen Jan, Richard Lindley, Maree L Hackett
BACKGROUND: While returning to paid work is a crucial marker of stroke recovery, little is known about the differences in unpaid work by sex following stroke. We aimed to determine the sex differences in participation in unpaid work 12 months after stroke. METHODS: Psychosocial outcomes in stroke were a prospective, multicentre observational study that recruited individuals, 18-64 years, within 28 days of stroke from New South Wales, Australia. Unpaid work was defined as ≥5 h per week of one or more of: unpaid domestic work for the household; unpaid care of others; looking after own children without pay or looking after someone else's children without pay...
January 17, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/30651008/important-lessons-about-testosterone-therapy-weight-loss-vs-testosterone-therapy-for-symptom-resolution-classical-vs-functional-hypogonadism-and-shortterm-vs-lifelong-testosterone-therapy
#14
Monica Caliber, Geoff Hackett
In this commentary, we highlight important findings from a notable RCT by Ng Tang Fui et al. 2016 which investigated the effects of testosterone treatment in dieting obese men. First, a myopic focus on weight loss can detract from important improvements in body composition. Second, while weight loss in obese men may increase testosterone levels, this increase is commonly not enough to result in an improvement in symptoms associated with testosterone deficiency. Third, the RCT by Ng Tang Fui et al. adds evidence to the growing number of clinical trials showing that testosterone therapy should not be restricted to men with classical hypogonadism...
January 16, 2019: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://read.qxmd.com/read/30609142/parent-experiences-with-paediatric-allergy-pathways-in-the-west-midlands-a-qualitative-study
#15
Lavanya Diwakar, Carole Cummins, Scott Hackett, Martyn Rees, Lynette Charles, Caroline Kerrigan, Helen Creed, Tracy Roberts
BACKGROUND: The prevalence, severity and complexity of allergic diseases has been increasing steadily in the UK over the last few decades. Primary care physicians are often not adequately trained in allergy management whilst specialist services for allergy are scarce and heterogeneous. Services, therefore, have been unable to meet the rising demand. This is particularly true for paediatric allergy services in the UK. OBJECTIVE: To understand parent experiences with paediatric allergy pathways in the West Midlands (WM) region of the UK...
January 4, 2019: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://read.qxmd.com/read/30608854/first-search-for-short-baseline-neutrino-oscillations-at-hfir-with-prospect
#16
J Ashenfelter, A B Balantekin, C Baldenegro, H R Band, C D Bass, D E Bergeron, D Berish, L J Bignell, N S Bowden, J Bricco, J P Brodsky, C D Bryan, A Bykadorova Telles, J J Cherwinka, T Classen, K Commeford, A J Conant, A A Cox, D Davee, D Dean, G Deichert, M V Diwan, M J Dolinski, A Erickson, M Febbraro, B T Foust, J K Gaison, A Galindo-Uribarri, C E Gilbert, K E Gilje, A Glenn, B W Goddard, B T Hackett, K Han, S Hans, A B Hansell, K M Heeger, B Heffron, J Insler, D E Jaffe, X Ji, D C Jones, K Koehler, O Kyzylova, C E Lane, T J Langford, J LaRosa, B R Littlejohn, F Lopez, X Lu, D A Martinez Caicedo, J T Matta, R D McKeown, M P Mendenhall, H J Miller, J M Minock, P E Mueller, H P Mumm, J Napolitano, R Neilson, J A Nikkel, D Norcini, S Nour, D A Pushin, X Qian, E Romero-Romero, R Rosero, D Sarenac, B S Seilhan, R Sharma, P T Surukuchi, C Trinh, M A Tyra, R L Varner, B Viren, J M Wagner, W Wang, B White, C White, J Wilhelmi, T Wise, H Yao, M Yeh, Y-R Yen, A Zhang, C Zhang, X Zhang, M Zhao
This Letter reports the first scientific results from the observation of antineutrinos emitted by fission products of ^{235}U at the High Flux Isotope Reactor. PROSPECT, the Precision Reactor Oscillation and Spectrum Experiment, consists of a segmented 4 ton ^{6}Li-doped liquid scintillator detector covering a baseline range of 7-9 m from the reactor and operating under less than 1 m water equivalent overburden. Data collected during 33 live days of reactor operation at a nominal power of 85 MW yield a detection of 25 461±283 (stat) inverse beta decays...
December 21, 2018: Physical Review Letters
https://read.qxmd.com/read/30605389/laparoscopic-ovariohysterectomy-in-goats
#17
Alexander J Daniel, Jeremiah T Easley, Timothy N Holt, Gregg M Griffenhagen, Eileen S Hackett
OBJECTIVE To describe a minimally invasive 3-portal laparoscopic approach for elective ovariohysterectomy and the outcome of that procedure in a population of goats. DESIGN Descriptive clinical study. ANIMALS 16 healthy client-owned goats. PROCEDURES Food but not water was withheld from all goats for 24 hours before the procedure. Goats were anesthetized and positioned in dorsal recumbency. Three laparoscopic portals were created in the caudoventral portion of the abdomen, and the abdomen was insufflated to a maximum pressure of 10 mm Hg...
January 15, 2019: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/30605321/structural-and-antiviral-studies-of-the-human-norovirus-gii-4-protease
#18
Kendall M Muzzarelli, Benjamin D Kuiper, Nicholas Spellmon, Joseph S Brunzelle, Justin Hackett, Franck Amblard, Shaoman Zhou, Peng Liu, Iulia A Kovari, Zhe Yang, Raymond Felix Schinazi, Ladislau C Kovari
Norovirus is the leading cause of acute gastroenteritis worldwide with a yearly reported 700 million cases driving a $60 billion global socioeconomic burden. With no FDA approved therapeutics and the chance for severe chronic infection and life-threatening complications, researchers have identified the protease as a potential target. However, drug development has focused on the norovirus GI.1 strain despite its accounting for less than 5% of all outbreaks. Our lab aims to change focus for norovirus drug design from GI...
January 3, 2019: Biochemistry
https://read.qxmd.com/read/30547383/imaging-of-bronchial-pathology-in-antibody-deficiency-data-from-the-european-chest-ct-group
#19
Katharina Schütz, Diana Alecsandru, Bodo Grimbacher, Jamanda Haddock, Annemarie Bruining, Gertjan Driessen, Esther de Vries, Peter M van Hagen, Ieneke Hartmann, Francesco Fraioli, Cinzia Milito, Milica Mitrevski, Isabella Quinti, Goffredo Serra, Peter Kelleher, Michael Loebinger, Jiri Litzman, Vera Postranecka, Vojtech Thon, Judith Babar, Alison M Condliffe, Andrew Exley, Dinakantha Kumararatne, Nick Screaton, Alison Jones, Maria P Bondioni, Vassilios Lougaris, Alessandro Plebani, Annarosa Soresina, Cesare Sirignano, Giuseppe Spadaro, Nermeen Galal, Luis I Gonzalez-Granado, Sabine Dettmer, Robert Stirling, Helen Chapel, Mary Lucas, Smita Patel, Claire-Michele Farber, Isabelle Meyts, Arpan K Banerjee, Scott Hackett, John R Hurst, Klaus Warnatz, Benjamin Gathmann, Ulrich Baumann
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency...
December 13, 2018: Journal of Clinical Immunology
https://read.qxmd.com/read/30538240/publisher-correction-tracing-the-transitions-from-pluripotency-to-germ-cell-fate-with-crispr-screening
#20
Jamie A Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A Gretarsson, Toshihiro Kobayashi, M Azim Surani
Ufuk Günesdogan was incorrectly associated with Center for Genetic Analysis of Behaviour, National Institute for Physiological Sciences, 5-1 Higashiyama Myodaiji, Okazaki, Aichi 444-8787, Japan and Toshihiro Kobayashi was incorrectly associated with Department of Developmental Biology, University of Göttingen, Göttingen Center for Molecular Biosciences, Justus-von-Liebig Weg 11, 37077 Göttingen, Germany. This has now been corrected in both the PDF and HTML versions of the Article.
December 11, 2018: Nature Communications
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