keyword
https://read.qxmd.com/read/38535343/cyantraniliprole-and-thiamethoxam-exposure-changes-expression-of-transcripts-associated-with-small-non-coding-rna-processing-in-the-colorado-potato-beetle
#1
JOURNAL ARTICLE
Pierre Bastarache, Kenan Timani, Mariem Ben Youssef, Enock Omakele, Jess L Vickruck, Pier Jr Morin
The Colorado potato beetle ( Leptinotarsa decemlineata (Say)) can cause extensive damage to agricultural crops worldwide and is a significant insect pest. This insect is notorious for its ability to evade various strategies deployed to control its spread and is known for its relative ease in developing resistance against different insecticides. Various molecular levers are leveraged by L. decemlineata for this resistance to occur, and a complete picture of the genes involved in this process is lacking. While small non-coding RNAs, including miRNAs, are differentially expressed in insects exposed to insecticides, levels of transcript coding for proteins underlying their synthesis remain to be characterized fully...
February 22, 2024: Insects
https://read.qxmd.com/read/38534792/inheritance-of-stress-responses-via-small-non-coding-rnas-in-invertebrates-and-mammals
#2
REVIEW
Maria C Ow, Sarah E Hall
While reports on the generational inheritance of a parental response to stress have been widely reported in animals, the molecular mechanisms behind this phenomenon have only recently emerged. The booming interest in epigenetic inheritance has been facilitated in part by the discovery that small non-coding RNAs are one of its principal conduits. Discovered 30 years ago in the Caenorhabditis elegans nematode, these small molecules have since cemented their critical roles in regulating virtually all aspects of eukaryotic development...
December 19, 2023: Epigenomes
https://read.qxmd.com/read/38534455/integrative-transcriptome-analysis-of-mrna-and-mirna-in-pepper-s-response-to-phytophthora-capsici-infection
#3
JOURNAL ARTICLE
Yuan Li, Nan Wang, Jianwen Guo, Xianjun Zhou, Xueyi Bai, Muhammad Azeem, Liyun Zhu, Lin Chen, Moli Chu, Hui Wang, Wei Cheng
Phytophthora blight of pepper is a notorious disease caused by the oomycete pathogen Phytophthora capsici , which poses a great threat to global pepper production. MicroRNA (miRNA) is a class of non-coding small RNAs that regulate gene expressions by altering the translation efficiency or stability of targeted mRNAs, which play important roles in the regulation of a plant's response to pathogens. Herein, time-series mRNA-seq libraries and small RNA-seq libraries were constructed using pepper roots from the resistant line CM334 and the susceptible line EC01 inoculated with P...
March 14, 2024: Biology
https://read.qxmd.com/read/38534407/rna-interference-in-insects-from-a-natural-mechanism-of-gene-expression-regulation-to-a-biotechnological-crop-protection-promise
#4
REVIEW
Beltrán Ortolá, José-Antonio Daròs
Insect pests rank among the major limiting factors in agricultural production worldwide. In addition to direct effect on crops, some phytophagous insects are efficient vectors for plant disease transmission. Large amounts of conventional insecticides are required to secure food production worldwide, with a high impact on the economy and environment, particularly when beneficial insects are also affected by chemicals that frequently lack the desired specificity. RNA interference (RNAi) is a natural mechanism gene expression regulation and protection against exogenous and endogenous genetic elements present in most eukaryotes, including insects...
February 21, 2024: Biology
https://read.qxmd.com/read/38534138/the-functional-small-rna-interactome-reveals-targets-for-the-vancomycin-responsive-srna-rsaoi-in-vancomycin-tolerant-staphylococcus-aureus
#5
JOURNAL ARTICLE
Winton Wu, Chi Nam Ignatius Pang, Daniel G Mediati, Jai Justin Tree
UNLABELLED: Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge...
March 27, 2024: MSystems
https://read.qxmd.com/read/38532845/acute-response-in-circulating-micrornas-following-a-single-bout-of-short-sprint-and-heavy-strength-training-in-well-trained-cyclists
#6
JOURNAL ARTICLE
Anita Ryningen, Kari Rostad, Elisabeth Ersvær, Gry Sjøholt, Gøran Paulsen, Hilde Gundersen, Morten Kristoffersen, Lise Bjørkhaug
Background: Heavy strength (HS) and short-sprint (SS) are commonly used training methods for competitive road cyclists, with the aim to improve the anaerobic power and short time cycling performance. Knowledge of how such training methods affects biochemical as well as molecular factors, are particularly important for determining individual recovery and long-term adaptations. The primary aim of the current study was to investigate the expression levels of small non-coding RNAs in response to HS and SS training in elite cyclists as potential biomarkers for individual optimal restitution time...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38532500/divergent-composition-and-transposon-silencing-activity-of-small-rnas-in-mammalian-oocytes
#7
JOURNAL ARTICLE
Li Hou, Wei Liu, Hongdao Zhang, Ronghong Li, Miao Liu, Huijuan Shi, Ligang Wu
BACKGROUND: Small RNAs are essential for germ cell development and fertilization. However, fundamental questions remain, such as the level of conservation in small RNA composition between species and whether small RNAs control transposable elements in mammalian oocytes. RESULTS: Here, we use high-throughput sequencing to profile small RNAs and poly(A)-bearing long RNAs in oocytes of 12 representative vertebrate species (including 11 mammals). The results show that miRNAs are generally expressed in the oocytes of each representative species (although at low levels), whereas endo-siRNAs are specific to mice...
March 26, 2024: Genome Biology
https://read.qxmd.com/read/38531653/2-o-methylation-nm-in-rna-progress-challenges-and-future-directions
#8
JOURNAL ARTICLE
Katherine I Zhou, Chad V Pecot, Christopher L Holley
RNA 2'-O-methylation (Nm) is highly abundant in noncoding RNAs including ribosomal RNA (rRNA), transfer RNA (tRNA), and small nuclear RNA (snRNA), and occurs in the 5' cap of virtually all messenger RNAs (mRNAs) in higher eukaryotes. More recently, Nm has also been reported to occur at internal sites in mRNA. High-throughput methods have been developed for the transcriptome-wide detection of Nm. However, these methods have mostly been applied to abundant RNAs such as rRNA, and the validity of the internal mRNA Nm sites detected with these approaches remains controversial...
March 26, 2024: RNA
https://read.qxmd.com/read/38528582/lncrna-wfdc21p-interacts-with-sec63-to-promote-gastric-cancer-malignant-behaviors-by-regulating-calcium-homeostasis-signaling-pathway
#9
JOURNAL ARTICLE
Jinyao Dong, Yongqiang Lv, Debin Meng, Ruyi Shi, Feng Li, Rui Guo, Yi Wang, Jiansheng Guo, Yanyan Zhang
BACKGROUND: Gastric cancer is currently estimated to be the fifth leading common cancer in the world, and responsible for about one million new cases and an estimated 769,000 cancer-related deaths each year. WFDC21P is long non-coding RNA and has been reported to play critical roles in serval types of cancer. Our research aims to investigate the biological effects and molecular mechanism of WFDC21P in gastric cancer. METHODS: Datasets (GSE53137, GSE58828, and GSE109476) in GEO database were used to screen differential expressed lncRNAs in gastric cancer by online GEO2R analysis tool...
March 25, 2024: Cancer Cell International
https://read.qxmd.com/read/38528147/an-expanded-transcriptome-atlas-for-bacteroides-thetaiotaomicron-reveals-a-small-rna-that-modulates-tetracycline-sensitivity
#10
JOURNAL ARTICLE
Daniel Ryan, Elise Bornet, Gianluca Prezza, Shuba Varshini Alampalli, Taís Franco de Carvalho, Hannah Felchle, Titus Ebbecke, Regan J Hayward, Adam M Deutschbauer, Lars Barquist, Alexander J Westermann
Plasticity in gene expression allows bacteria to adapt to diverse environments. This is particularly relevant in the dynamic niche of the human intestinal tract; however, transcriptional networks remain largely unknown for gut-resident bacteria. Here we apply differential RNA sequencing (RNA-seq) and conventional RNA-seq to the model gut bacterium Bacteroides thetaiotaomicron to map transcriptional units and profile their expression levels across 15 in vivo-relevant growth conditions. We infer stress- and carbon source-specific transcriptional regulons and expand the annotation of small RNAs (sRNAs)...
March 25, 2024: Nature Microbiology
https://read.qxmd.com/read/38527246/evaluation-of-5-trf-his-gtg-as-a-molecular-biomarker-in-breast-cancer-diagnoses-and-prognosis
#11
JOURNAL ARTICLE
Xun Tang, Jun Wu, Yan Chen, Daojuan Wang, Tingyu Wang, Yajing Weng, Zhengquan Zhu, Rui Peng, Yong Wang, Feng Yan
Background: Breast cancer (BC) is the most prevalent cancer among women worldwide. Although advances have been made in the identification of predictive biomarkers, current options for early diagnosis and prognostic analysis are still suboptimal. Recently, transfer-RNA-derived RNA fragments (tRFs) have emerged as a class of small noncoding RNAs that play a role in the cancer progression. The authors aimed to identify a specific class of tRFs as a molecular marker for BC diagnosis and prognosis in clinical management...
March 25, 2024: Cancer Biotherapy & Radiopharmaceuticals
https://read.qxmd.com/read/38525907/group-i-introns-structure-splicing-and-their-applications-in-medical-mycology
#12
JOURNAL ARTICLE
Ronald Muryellison Oliveira da Silva Gomes, Kássia Jéssica Galdino da Silva, Raquel Cordeiro Theodoro
Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with their host genomes. In this work, we review its basic structure, self-splicing and its mechanisms of gene mobility. As they are widely found in unicellular eukaryotes, especially fungi, we gathered information regarding their possible impact on the physiology of fungal cells and the possible application of these introns in medical mycology...
2024: Genetics and Molecular Biology
https://read.qxmd.com/read/38523014/snornas-in-cardiovascular-development-function-and-disease
#13
REVIEW
Alzbeta Chabronova, Terri L Holmes, Duc M Hoang, Chris Denning, Victoria James, James G W Smith, Mandy J Peffers
Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hypertrophic and dilated cardiomyopathies, coronary heart disease (CHD), myocardial infarction (MI), cardiac fibrosis, and heart failure. Furthermore, reports of changes in vesicular snoRNA expression and altered levels of circulating snoRNAs in response to cardiac stress suggest that snoRNAs also function in cardiac signaling and intercellular communication...
March 23, 2024: Trends in Molecular Medicine
https://read.qxmd.com/read/38522697/harnessing-the-potential-of-nanoengineered-sirnas-carriers-for-target-responsive-glioma-therapy-recent-progress-and-future-opportunities
#14
REVIEW
Kailash Ahirwar, Ankit Kumar, Nidhi Srivastava, Shubhini A Saraf, Rahul Shukla
Past scientific testimonials in the field of glioma research, the deadliest tumor among all brain cancer types with the life span of 10-15 months after diagnosis is considered as glioblastoma multiforme (GBM). Even though the availability of treatment options such as chemotherapy, radiotherapy, and surgery, are unable to completely cure GBM due to tumor microenvironment complexity, intrinsic cellular signalling, and genetic mutations which are involved in chemoresistance. The blood-brain barrier is accountable for restricting drugs entry at the tumor location and related biological challenges like endocytic degradation, short systemic circulation, and insufficient cellular penetration lead to tumor aggression and progression...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521196/elucidating-mir-146a-3p-as-a-key-player-in-autophagy-and-lipid-metabolism-in-leishmania-major-infection
#15
JOURNAL ARTICLE
Prajakta Ingale, Shailza Singh
Autophagy is a key step involved in many unicellular eukaryotic diseases, including leishmaniasis, for cellular remodelling and differentiation during parasite's lifecycle. Lipids play a significant role in the infection process that begins with Leishmania major invading host cells. MicroRNAs (miRNAs), a family of small, 22-24 nucleotide noncoding regulatory RNAs, target mRNAs to modify gene expression and, subsequently, proteome output may have a regulatory role in altering the host cell processes. We observed miR-146a-3p expression increases in a time-dependent manner post Leishmania major infection...
March 21, 2024: Experimental Parasitology
https://read.qxmd.com/read/38520611/parkinson-s-disease-and-micrornas-a-duel-between-inhibition-and-stimulation-of-apoptosis-in-neuronal-cells
#16
REVIEW
Mohamed J Saadh, Ahmed Faisal, Mohaned Adil, Rahman S Zabibah, Abdurakhmon Mamatkulovich Mamadaliev, Mahmood Jasem Jawad, Fahad Alsaikhan, Bagher Farhood
Parkinson's disease (PD) is one of the most prevalent diseases of central nervous system that is caused by degeneration of the substantia nigra's dopamine-producing neurons through apoptosis. Apoptosis is regulated by initiators' and executioners' caspases both in intrinsic and extrinsic pathways, further resulting in neuronal damage. In that context, targeting apoptosis appears as a promising therapeutic approach for treating neurodegenerative diseases. Non-coding RNAs-more especially, microRNAs, or miRNAs-are a promising target for the therapy of neurodegenerative diseases because they are essential for a number of cellular processes, including signaling, apoptosis, cell proliferation, and gene regulation...
March 23, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38520561/biallelic-variants-in-gtf3c5-a-regulator-of-rna-polymerase-iii-mediated-transcription-cause-a-multisystem-developmental-disorder
#17
JOURNAL ARTICLE
Aiko Iwata-Otsubo, Cara M Skraban, Atsunori Yoshimura, Toyonori Sakata, Cesar Augusto P Alves, Sarah K Fiordaliso, Yukiko Kuroda, Jaime Vengoechea, Angela Grochowsky, Paige Ernste, Lauren Lulis, Addie Nesbitt, Ahmad Abou Tayoun, Christopher Gray, Meghan C Towne, Kelly Radtke, Elizabeth A Normand, Lindsay Rhodes, Christoph Seiler, Katsuhiko Shirahige, Kosuke Izumi
General transcription factor IIIC subunit 5 (GTF3C5) encodes transcription factor IIIC63 (TFIIIC63). It binds to DNA to recruit another transcription factor, TFIIIB, and RNA polymerase III (Pol III) to mediate the transcription of small noncoding RNAs, such as tRNAs. Here, we report four individuals from three families presenting with a multisystem developmental disorder phenotype with biallelic variants in GTF3C5. The overlapping features include growth retardation, developmental delay, intellectual disability, dental anomalies, cerebellar malformations, delayed bone age, skeletal anomalies, and facial dysmorphism...
March 23, 2024: Human Genetics
https://read.qxmd.com/read/38518633/ailanthone-inhibits-non-small-cell-lung-cancer-growth-and-metastasis-through-targeting-upf1-gas5-ulk1-signaling-pathway
#18
JOURNAL ARTICLE
Cheng Fang, Wenbin Wu, Zhongya Ni, Yangli Liu, Jiaojiao Luo, Yufu Zhou, Chenyuan Gong, Dan Hu, Chao Yao, Xiao Chen, Lixin Wang, Shiguo Zhu
BACKGROUND: Targeting long non-coding RNAs (LncRNAs) is a novel and promising approach in cancer therapy. In our previous study, we investigated the effects of ailanthone (aila), the main active compound derived from the stem barks of Ailanthus altissima (Mill.) Swingle, on the growth of non-small cell lung cancer (NSCLC) cells. Although we observed significant inhibition of NSCLC cell growth of aila, the underlying mechanisms involving LncRNAs, specifically LncRNA growth arrest specific 5 (GAS5), remain largely unknown...
December 31, 2023: Phytomedicine
https://read.qxmd.com/read/38515760/crosstalk-between-ubiquitin-ligases-and-ncrnas-drives-cardiovascular-disease-progression
#19
REVIEW
Jia-Rui You, Zeng-Jin Wen, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Hui Xin, Pei-Feng Li, Yin-Feng Zhang, Rui Zhang
Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin-proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38514586/in-silico-approach-for-the-identification-of-trna-derived-small-non-coding-rnas-in-sars-cov-infection
#20
JOURNAL ARTICLE
Swati Ajmeriya, Deepak Ramkumar Bharti, Amit Kumar, Shweta Rana, Harpreet Singh, Subhradip Karmakar
tsRNAs (tRNA-derived small non-coding RNAs), including tRNA halves (tiRNAs) and tRNA fragments (tRFs), have been implicated in some viral infections, such as respiratory viral infections. However, their involvement in SARS-CoV infection is completely unknown. A comprehensive analysis was performed to determine tsRNA populations in a mouse model of SARS-CoV-infected samples containing the wild-type and attenuated viruses. Data from the Gene Expression Omnibus (GEO) dataset at NCBI (accession ID GSE90624 ) was used for this study...
March 21, 2024: Journal of Applied Genetics
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