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MULTICENTER STUDY
Michael C Fiore, Stevens S Smith, Robert T Adsit, Daniel M Bolt, Karen L Conner, Steven L Bernstein, Oliver D Eng, David Lazuk, Alec Gonzalez, Douglas E Jorenby, Heather D'Angelo, Julie A Kirsch, Brian Williams, Margaret B Nolan, Todd Hayes-Birchler, Sean Kent, Hanna Kim, Thomas M Piasecki, Wendy S Slutske, Stan Lubanski, Menggang Yu, Youmi Suk, Yuxin Cai, Nitu Kashyap, Jomol P Mathew, Gabriel McMahan, Betsy Rolland, Hilary A Tindle, Graham W Warren, Lawrence C An, Andrew D Boyd, Darlene H Brunzell, Victor Carrillo, Li-Shiun Chen, James M Davis, Deepika Dilip, Edward F Ellerbeck, Eduardo Iturrate, Thulasee Jose, Niharika Khanna, Andrea King, Elizabeth Klass, Michael Newman, Kimberly A Shoenbill, Elisa Tong, Janice Y Tsoh, Karen M Wilson, Wendy E Theobald, Timothy B Baker
MAIN OBJECTIVE: There is limited information on how patient outcomes have changed during the COVID-19 pandemic. This study characterizes changes in mortality, intubation, and ICU admission rates during the first 20 months of the pandemic. STUDY DESIGN AND METHODS: University of Wisconsin researchers collected and harmonized electronic health record data from 1.1 million COVID-19 patients across 21 United States health systems from February 2020 through September 2021...
2022: PloS One
#22
JOURNAL ARTICLE
Thomas M Piasecki, Stevens S Smith, Timothy B Baker, Wendy S Slutske, Robert T Adsit, Daniel M Bolt, Karen L Conner, Steven L Bernstein, Oliver D Eng, David Lazuk, Alec Gonzalez, Douglas E Jorenby, Heather D'Angelo, Julie A Kirsch, Brian S Williams, Margaret B Nolan, Todd Hayes-Birchler, Sean Kent, Hanna Kim, Stan Lubanski, Menggang Yu, Youmi Suk, Yuxin Cai, Nitu Kashyap, Jomol P Mathew, Gabriel McMahan, Betsy Rolland, Hilary A Tindle, Graham W Warren, Lawrence C An, Andrew D Boyd, Darlene H Brunzell, Victor Carrillo, Li-Shiun Chen, James M Davis, Vikrant G Deshmukh, Deepika Dilip, Edward F Ellerbeck, Adam O Goldstein, Eduardo Iturrate, Thulasee Jose, Niharika Khanna, Andrea King, Elizabeth Klass, Robin J Mermelstein, Elisa Tong, Janice Y Tsoh, Karen M Wilson, Wendy E Theobald, Michael C Fiore
INTRODUCTION: Available evidence is mixed concerning associations between smoking status and COVID-19 clinical outcomes. Effects of nicotine replacement therapy (NRT) and vaccination status on COVID-19 outcomes in smokers are unknown. METHODS: Electronic health record data from 104 590 COVID-19 patients hospitalized February 1, 2020 to September 30, 2021 in 21 U.S. health systems were analyzed to assess associations of smoking status, in-hospital NRT prescription, and vaccination status with in-hospital death and ICU admission...
September 7, 2022: Nicotine & Tobacco Research
#23
JOURNAL ARTICLE
Iliyan Ivanov, Premika S W Boedhoe, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Paul D Arnold, Srinivas Balachander, Justin T Baker, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan Buitelaar, Rosa Calvo, Yuqi Cheng, Kang Ik K Cho, Sara Dallaspezia, Damiaan Denys, Juliana B Diniz, Benjamin A Ely, Jamie D Feusner, Sónia Ferreira, Kate D Fitzgerald, Patricia Gruner, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Hoexter, Chaim Huyser, Keisuke Ikari, Anthony James, Fern Jaspers-Fayer, Hongyan Jiang, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Jun Soo Kwon, Luisa Lázaro, Yanni Liu, Christine Lochner, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Astrid Morer, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Sanghoon Oh, Chris Perriello, John C Piacentini, Maria Picó-Pérez, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Daniela Rodriguez Manrique, Oana Yuki Sakai, Eiji Shimizu, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R Stern, Michael C Stevens, S Evelyn Stewart, Philip R Szeszko, David F Tolin, Daan van Rooij, Dick J Veltman, Ysbrand D van der Werf, Guido A van Wingen, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij H Wolters, Xiufeng Xu, Je-Yeon Yun, Mojtaba Zarei, Fengrui Zhang, Qing Zhao, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Joseph O'Neill
BACKGROUND: Widely used psychotropic medications obsessive-compulsive disorder (OCD) may change the volumes of subcortical brain structures, and differently in children vs. adults. We measured subcortical volumes cross-sectionally in patients finely stratified for age taking various common classes of OCD drugs. METHODS: The ENIGMA-OCD consortium sample (1081 medicated/1159 unmedicated OCD patients and 2057 healthy controls aged 6-65) was divided into six successive 6-10-year age-groups...
August 27, 2022: Journal of Affective Disorders
#24
JOURNAL ARTICLE
Margaret B Nolan, Thomas M Piasecki, Stevens S Smith, Timothy B Baker, Michael C Fiore, Robert T Adsit, Daniel M Bolt, Karen L Conner, Steven L Bernstein, Oliver D Eng, David Lazuk, Alec Gonzalez, Todd Hayes-Birchler, Douglas E Jorenby, Heather D'Angelo, Julie A Kirsch, Brian S Williams, Sean Kent, Hanna Kim, Stanley A Lubanski, Menggang Yu, Youmi Suk, Yuxin Cai, Nitu Kashyap, Jomol Mathew, Gabriel McMahan, Betsy Rolland, Hilary A Tindle, Graham W Warren, Noor Abu-El-Rub, Lawrence C An, Andrew D Boyd, Darlene H Brunzell, Victor A Carrillo, Li-Shiun Chen, James M Davis, Vikrant G Deshmukh, Deepika Dilip, Adam Goldstein, Patrick K Ha, Eduardo Iturrate, Thulasee Jose, Niharika Khanna, Andrea King, Elizabeth Klass, Michelle Lui, Robin J Mermelstein, Chester Poon, Elisa Tong, Karen M Wilson, Wendy E Theobald, Wendy S Slutske
BACKGROUND: There is mixed evidence about the relations of current versus past cancer with severe COVID-19 outcomes and how they vary by patient and cancer characteristics. METHODS: Electronic health record data of 104,590 adult hospitalized patients with COVID-19 were obtained from 21 United States health systems from February 2020 through September 2021. In-hospital mortality and ICU admission were predicted from current and past cancer diagnoses. Moderation by patient characteristics, vaccination status, cancer type, and year of the pandemic was examined...
August 15, 2022: Cancer Epidemiology, Biomarkers & Prevention
#25
Tracey D Graves, Robert C Griggs, Brian N Bundy, Joanna C Jen, Robert W Baloh, Michael G Hanna
No abstract text is available yet for this article.
July 29, 2022: Cerebellum
#26
JOURNAL ARTICLE
Tracey D Graves, Robert C Griggs, Brian N Bundy, Joanna C Jen, Robert W Baloh, Michael G Hanna
Episodic ataxia type 1 (EA1) is a rare autosomal potassium channelopathy, due to mutations in KCNA1. Patients have childhood onset of intermittent attacks of ataxia, dizziness or imbalance. In order to quantify the natural history of EA1, its effect on quality of life and in preparation for future clinical trials, we set up an international multi-centre study of EA1. We recruited thirty-three participants with EA1: twenty-three completed 1-year follow-up and eighteen completed 2-year follow-up. There was very little accumulation of disability or impairment over the course of the 2 years of the study...
June 3, 2022: Cerebellum
#27
JOURNAL ARTICLE
Giorgio A Medranda, Cesar E Soria Jimenez, Rebecca Torguson, Brian C Case, Brian J Forrestal, Syed W Ali, Corey Shea, Cheng Zhang, John C Wang, Paul Gordon, Afshin Ehsan, Sean R Wilson, Robert Levitt, Puja Parikh, Thomas Bilfinger, Nicholas Hanna, Maurice Buchbinder, Federico M Asch, Gaby Weissman, Christian C Shults, Hector M Garcia-Garcia, Itsik Ben-Dor, Lowell F Satler, Ron Waksman, Toby Rogers
BACKGROUND: Given enough time, transcatheter heart valves (THVs) will degenerate and may require reintervention. Redo transcatheter aortic valve implantation (TAVI) is an attractive strategy but carries a risk of coronary obstruction. AIMS: We sought to predict how many TAVIs patients could undergo in their lifetime using computed tomography (CT) simulation. METHODS: We analysed paired CT scans (baseline and 30 days post-TAVI) from patients in the LRT trials and EPROMPT registry...
March 25, 2022: EuroIntervention
#28
RANDOMIZED CONTROLLED TRIAL
Bhavna Oza, Eleni Frangou, Ben Smith, Hanna Bryant, Rick Kaplan, Babak Choodari-Oskooei, Tom Powles, Grant D Stewart, Laurence Albiges, Axel Bex, Toni K Choueiri, Ian D Davis, Tim Eisen, Alison Fielding, David Harrison, Anita McWhirter, Salena Mulhere, Paul Nathan, Brian Rini, Alastair Ritchie, Sarah Scovell, Clare Shakeshaft, Martin R Stockler, Nat Thorogood, Mahesh K B Parmar, James Larkin, Angela Meade
BACKGROUND: 20-60% of patients with initially locally advanced Renal Cell Carcinoma (RCC) develop metastatic disease despite optimal surgical excision. Adjuvant strategies have been tested in RCC including cytokines, radiotherapy, hormones and oral tyrosine-kinase inhibitors (TKIs), with limited success. The predominant global standard-of-care after nephrectomy remains active monitoring. Immune checkpoint inhibitors (ICIs) are effective in the treatment of metastatic RCC; RAMPART will investigate these agents in the adjuvant setting...
September 2021: Contemporary Clinical Trials
#29
JOURNAL ARTICLE
Angela Meade, Bhavna Oza, Eleni Frangou, Ben Smith, Hanna Bryant, Rick Kaplan, Babak Choodari-Oskooei, Tom Powles, Grant D Stewart, Laurence Albiges, Axel Bex, Toni K Choueiri, Ian D Davis, Tim Eisen, Alison Fielding, David J Harrison, Anita McWhirter, Salena Mulhere, Paul Nathan, Brian Rini, Alastair Ritchie, Sarah Scovell, Clare Shakeshaft, Martin R Stockler, Nat Thorogood, James Larkin, Mahesh K B Parmar
The development of therapeutics in oncology is a highly active research area for the pharmaceutical and biotechnology industries, but also has a strong academic base. Many new agents have been developed in recent years, most with specific biological targets. This has mandated the need to look at different ways to streamline the evaluation of new agents. One solution has been the development of adaptive trial designs that allow the evaluation of multiple agents, concentrating on the most promising agents while screening out those which are unlikely to benefit patients...
September 2021: Contemporary Clinical Trials
#30
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James R Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 2021: World Journal of Otorhinolaryngology—Head and Neck Surgery
#31
JOURNAL ARTICLE
Brian A Karamian, Gregory D Schroeder, Hanna A Levy, Jose A Canseco, Lorin M Benneker, Frank Kandziora, Shanmuganathan Rajasekaran, F Cumhur Öner, Klaus J Schnake, Christopher K Kepler, Alexander R Vaccaro
STUDY DESIGN: Cross-sectional survey. OBJECTIVE: To determine the influence of surgeons' level of experience and subspeciality training on the reliability, reproducibility, and accuracy of sacral fracture classification using the Arbeitsgemeinschaft für Osteosynthesefragen Spine Sacral Classification System. SUMMARY OF BACKGROUND DATA: A surgeons' level of experience or subspecialty may have a significant effect on the reliability and accuracy of sacral classification given various levels of comfort with imaging assessment required for accurate diagnosis and classification...
December 15, 2021: Spine
#32
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 2021: Journal of Voice
#33
JOURNAL ARTICLE
Odayme Quesada, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley E Moncrieft, Karin Garcia, Marina Del Rios Rivera, David B Hanna, Martha L Daviglus, Gregory A Talavera, C Noel Bairey Merz, Scott D Solomon, Susan Cheng, Natalie A Bello
[Figure: see text].
September 2021: Hypertension
#34
JOURNAL ARTICLE
Y X Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James R Tysome, Peter C Weber, D Bradley Welling, Xinhao Zhang, Zheng Liu
No abstract text is available yet for this article.
July 7, 2021: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
#35
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 2021: Ear, Nose, & Throat Journal
#36
JOURNAL ARTICLE
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 2021: Journal of Laryngology and Otology
#37
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
August 2021: International Journal of Pediatric Otorhinolaryngology
#38
JOURNAL ARTICLE
Giovanni Lujan, Jennifer C Quigley, Douglas Hartman, Anil Parwani, Brian Roehmholdt, Bryan Van Meter, Orly Ardon, Matthew G Hanna, Dan Kelly, Chelsea Sowards, Michael Montalto, Marilyn Bui, Mark D Zarella, Victoria LaRosa, Gerard Slootweg, Juan Antonio Retamero, Mark C Lloyd, James Madory, Doug Bowman
We believe the switch to a digital pathology (DP) workflow is imminent and it is essential to understand the economic implications of conversion. Many aspects of the adoption of DP will be disruptive and have a direct financial impact, both in short term costs, such as investment in equipment and personnel, and long term revenue potential, such as improved productivity and novel tests. The focus of this whitepaper is to educate pathologists, laboratorians and other stakeholders about the business and monetary considerations of converting to a digital pathology workflow...
2021: Journal of Pathology Informatics
#39
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 1, 2021: Journal of Otolaryngology—Head & Neck Surgery
#40
EDITORIAL
Robert T Sataloff, Matthew L Bush, Rakesh Chandra, Douglas Chepeha, Brian Rotenberg, Edward W Fisher, David Goldenberg, Ehab Y Hanna, Joseph E Kerschner, Dennis H Kraus, John H Krouse, Daqing Li, Michael Link, Lawrence R Lustig, Samuel H Selesnick, Raj Sindwani, Richard J Smith, James Tysome, Peter C Weber, D Bradley Welling
No abstract text is available yet for this article.
July 2021: American Journal of Rhinology & Allergy
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