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JOURNAL ARTICLE
Hannah E Cabre, Alex N Ladan, Sam R Moore, Kelly E Joniak, Malia N M Blue, Brian G Pietrosimone, Anthony C Hackney, Abbie E Smith-Ryan
Cabre, HE, Ladan, AN, Moore, SR, Joniak, KE, Blue, MNM, Pietrosimone, BG, Hackney, AC, and Smith-Ryan, AE. Effects of hormonal contraception and the menstrual cycle on fatigability and recovery from an anaerobic exercise test. J Strength Cond Res XX(X): 000-000, 2024-This study sought to evaluate the effects of oral contraceptive (OC) and hormonal intrauterine device (H-IUD) use, compared with a eumenorrheic (EUM) cycle, on fatigability and recovery between hormone the phases. Peak power (PP), average power (AP), fatigue index (FI), blood lactate, vessel diameter, and blood flow (BF) were measured from a repeated sprint cycle test (10 × 6 seconds) in 60, healthy, active women (mean ± SD; age: 26...
April 9, 2024: Journal of Strength and Conditioning Research
#2
JOURNAL ARTICLE
Bryan Sanchez Jimenez, Trinity Sterling, Austin Brown, Brian Modica, Kaylee Gibson, Hannah Collins, Carolyn Koch, Tyler Schwarz, Kristine N Dye
Wastewater surveillance allows severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection levels to be tracked in a community. Here, we present a protocol to longitudinally quantify SARS-CoV-2 RNA in wastewater using quantitative reverse-transcription PCR (RT-qPCR) and pepper mild mottle virus (PMMoV) normalization. We describe steps for the pasteurization of wastewater samples, solids separation, supernatant filtration, viral precipitation and concentration, and RNA extraction. We then detail procedures for RT-qPCR, viral concentration extrapolation, PMMoV normalization, and longitudinal analysis...
April 9, 2024: STAR protocols
#3
JOURNAL ARTICLE
Garrett Grissim, Ashleigh Walesa, Hannah M Follett, Brian P Higgins, Kaitlin Goetschel, Heather Heitkotter, Joseph Carroll
PURPOSE: Achromatopsia (ACHM) is an autosomal recessive retinal disease associated with reduced or absent cone function. There is debate regarding the extent to which cone structure shows progressive degeneration in patients with ACHM. Here, we used optical coherence tomography (OCT) images to evaluate outer nuclear layer (ONL) thickness and ellipsoid zone (EZ) integrity over time in individuals with ACHM. METHODS: Sixty-three individuals with genetically confirmed ACHM with follow-up ranging from about 6 months to 10 years were imaged using either Bioptigen or Cirrus OCT...
April 1, 2024: Investigative Ophthalmology & Visual Science
#4
JOURNAL ARTICLE
Brian L Sprague, Sarah A Nowak, Thomas P Ahern, Sally D Herschorn, Peter A Kaufman, Catherine Odde, Hannah Perry, Michelle M Sowden, Pamela M Vacek, Donald L Weaver
Purpose To evaluate long-term trends in mammography screening rates and identify sociodemographic and breast cancer risk characteristics associated with return to screening after the COVID-19 pandemic. Materials and Methods In this retrospective study, statewide screening mammography data of 222 384 female individuals aged 40 years or older (mean age, 58.8 years ± 11.7 [SD]) from the Vermont Breast Cancer Surveillance System were evaluated to generate descriptive statistics and Joinpoint models to characterize screening patterns during 2000-2022...
May 2024: Radiology. Imaging cancer
#5
JOURNAL ARTICLE
Hannah I Silverstein, Fursan Sahawneh, Brian D Carpenter
BACKGROUND AND OBJECTIVES: Palliative care (PC) is a specialty medical service that aims to address the bio-psycho-social-spiritual needs of patients with serious illnesses and their care partners. Despite the value of PC, its expansion in Sub-Saharan Africa has been uneven and particularly underdeveloped in Senegal due to variability in access to training resources and funding. This study sought to understand the current landscape of PC services in Senegal and the barriers and opportunities in its growth...
2024: Innovation in Aging
#6
JOURNAL ARTICLE
Taylor D Steuber, Hannah Gipson, Brian Boyett, Madeline Belk, Blain Thayer, Jonathan Edwards
BACKGROUND: Oritavancin and dalbavancin are long-acting lipoglycopeptide antibiotics approved for the treatment of skin and skin structure infections. Recently, they have been used for outpatient antimicrobial therapy for complicated infections. No head-to-head studies exist for this purpose. OBJECTIVE: To compare outcomes of patients treated with multiple doses of oritavancin or dalbavancin for complicated infections. PATIENTS AND METHODS: This was a single-center, retrospective cohort study evaluating adult patients who received 2 or more doses of lipoglycopeptides for complicated infections from February 2019 through December 2022...
April 1, 2024: International Journal of Antimicrobial Agents
#7
JOURNAL ARTICLE
Lindsay S Miles, Hannah Waterman, Nadia A Ayoub, Jessica E Garb, Robert A Haney, Michael S Rosenberg, Trevor J Krabbenhoft, Brian C Verrelli
Although spiders are one of the most diverse groups of arthropods, the genetic architecture of their evolutionary adaptations is largely unknown. Specifically, ancient genome-wide duplication occurring during arachnid evolution ~450 mya resulted in a vast assembly of gene families, yet the extent to which selection has shaped this variation is understudied. To aid in comparative genome sequence analyses, we provide a chromosome-level genome of the Western black widow spider (Latrodectus hesperus)-a focus due to its silk properties, venom applications, and as a model for urban adaptation...
March 20, 2024: Journal of Heredity
#8
JOURNAL ARTICLE
Emily A G Faherty, Taylor Holly, Yasmin P Ogale, Hillary Spencer, Ashley M Becht, Gordon Crisler, Michael Wasz, Patrick Stonehouse, Hannah J Barbian, Christy Zelinski, Alyse Kittner, Dorothy Foulkes, Kendall W Anderson, Tiffany Evans, Lavinia Nicolae, Amber Staton, Carla Hardnett, Michael B Townsend, William C Carson, S Satheshkumar Panayampalli, Christina L Hutson, Crystal M Gigante, Laura A S Quilter, Susan Gorman, Brian Borah, Stephanie R Black, Massimo Pacilli, David Kern, Janna Kerins, Andrea M McCollum, Agam K Rao, Irina Tabidze
BACKGROUND: After months of few mpox cases, an increased number of cases were reported in Chicago during May 2023; predominantly among fully vaccinated patients. We investigated the outbreak scope, differences between vaccinated and unvaccinated patients, and hypotheses for monkeypox virus (MPXV) infection after vaccination. METHODS: We interviewed patients and reviewed medical records to assess demographic, behavioral, and clinical characteristics, mpox vaccine status, and vaccine administration routes...
April 3, 2024: Clinical Infectious Diseases
#9
JOURNAL ARTICLE
Hannah A Levy, Zachariah W Pinter, Andrew Pumford, Sarah Padilla, Harold I Salmons, Sarah Townsley, Konstantinos Katsos, Michelle Clarke, Mohamad Bydon, Jeremy L Fogelson, Benjamin D Elder, Bradford Currier, Brett A Freedman, Ahmad N Nassr, Brian A Karamian, Arjun S Sebastian
PURPOSE: To determine if C2 pedicle versus pars screw type predicts change in fusion status, C2 screw loosening, cervical alignment, and patient-reported outcomes measures (PROMs) after C2-T2 posterior cervical decompression and fusion (PDCF). METHODS: All adult patients who underwent C2-T2 PCDF for myelopathy or myeloradiculopathy between 2013-2020 were retrospectively identified. Patients were dichotomized by C2 screw type into bilateral C2 pedicle and bilateral C2 pars screw groups...
April 2, 2024: European Spine Journal
#10
Natalie E Jasiewicz, Kuo-Ching Mei, Hannah M Oh, Emily E Bonacquisti, Ameya Chaudhari, Camryn Byrum, Brian C Jensen, Juliane Nguyen
UNLABELLED: Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are a promising treatment for myocardial infarction, but their therapeutic efficacy is limited by inefficient accumulation at the target site. A non-invasive MSC EV therapy that enhances EV accumulation at the disease site and extends EV retention could significantly improve post-infarct cardiac regeneration. Here we show that EVs decorated with the next-generation of high-affinity heterodimerizing leucine zippers, termed high-affinity (HiA) Zippersomes, amplify targetable surface areas through in situ crosslinking and exhibited ∼7-fold enhanced accumulation within the infarcted myocardium in mice after three days and continued to be retained up to day 21, surpassing the performance of unmodified EVs...
March 16, 2024: bioRxiv
#11
JOURNAL ARTICLE
Brian R Leon, Robert M Lubitz, Sarah A Landsberger, Hannah D Buckingham, Rachael A Hiday, K Nicole Bradner, Catherine H Adaniya
AIMS: This research assessed the safety of aqueous ozone (AO) on human skin after multiple exposures for up to 40 hours. METHODS AND RESULTS: Full thickness recombinant human skin (EpiDerm FT, EFT-400) was exposed to AO for 7 seconds per minute for the first 6 minutes of each hour, repeated hourly over four time periods (4, 10, 20 and 40 hours). An MTT assay assessed viability of skin cells after exposure, compared to incubator control, negative control and vehicle control (distilled water)...
April 2024: Skin Research and Technology
#12
JOURNAL ARTICLE
Ilja Dubinski, Susanne Bechtold-Dalla Pozza, Martin Bidlingmaier, James Hawley, Brian Keevil, Sonja Kunz, Hannah Franziska Nowotny, Nicole Reisch, Katharina Schiergens, Lea Tschaidse, Heinrich Schmidt
OBJECTIVES: The most suitable biochemical markers for therapy adjustment in patients with congenital adrenal hyperplasia are controversial. 11-Oxygenated androgens are a promising new approach. The objective of this study was to investigate the diurnal rhythm of 11-ketotestosterone in children and adolescents in saliva and to correlate it with salivary 17-hydroxyprogesterone. METHODS: Fifty-one samples of steroid day-profiles from 17 patients were additionally analysed for 11-ketotestosterone, retrospectively...
April 2, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
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JOURNAL ARTICLE
Zachary J Kastenberg, Scott S Short, Kimberly J Riehle, Alan Utria, Timothy B Lautz, Katherine C Ott, Andrew J Murphy, Sara Mansfield, Dave R Lal, Brian Hallis, Joseph T Murphy, Jonathan P Roach, Stephanie F Polites, Catherine Beckhorn, Elisabeth T Tracy, Elizabeth A Fialkowski, Natashia M Seemann, Andreana M Bütter, Barrie S Rich, Richard D Glick, Alex J Bondoc, Blessing S Ofori-Atta, Angela P Presson, Stephanie Y Chen, Abigail K Zamora, Eugene S Kim, Sanjeev Vasudevan, Hannah N Rinehardt, Marcus M Malek, Eveline Lapidus-Krol, Juan Putra, Riccardo A Superina, Max R Langham, Rebecka L Meyers, Greg Tiao, Roshni Dasgupta, Reto Baertschiger
BACKGROUND: Undifferentiated embryonal sarcoma of the liver (UESL) is a rare tumor for which there are few evidence-based guidelines. The aim of this study was to define current management strategies and outcomes for these patients using a multi-institutional dataset curated by the Pediatric Surgical Oncology Research Collaborative. METHODS: Data were collected retrospectively for patients with UESL treated across 17 children's hospitals in North America from 1989 to 2019...
March 31, 2024: Pediatric Blood & Cancer
#14
JOURNAL ARTICLE
Nicholas D Nolan, Xuan Cui, Brian M Robbings, Aykut Demirkol, Kriti Pandey, Wen-Hsuan Wu, Hannah F Hu, Laura A Jenny, Chyuan-Sheng Lin, Daniel T Hass, Jianhai Du, James B Hurley, Stephen H Tsang
Retinitis pigmentosa (RP) is one of the most common forms of hereditary neurodegeneration. It is caused by one or more of at least 3,100 mutations in over 80 genes that are primarily expressed in rod photoreceptors. In RP, the primary rod-death phase is followed by cone death, regardless of the underlying gene mutation that drove the initial rod degeneration. Dampening the oxidation of glycolytic end products in rod mitochondria enhances cone survival in divergent etiological disease models independent of the underlying rod-specific gene mutations...
March 15, 2024: Cell reports medicine
#15
JOURNAL ARTICLE
Yuanfei Zhao, Leigh Nicholson, Hannah Wang, Yi Wen Qian, Wayne J Hawthorne, Elvira Jimenez-Vera, Brian S Gloss, Joey Lai, Adwin Thomas, Yi Vee Chew, Heather Burns, Geoff Y Zhang, Yuan Min Wang, Natasha M Rogers, Guoping Zheng, Shounan Yi, Stephen I Alexander, Philip J O'Connell, Min Hu
CD4+Foxp3+ regulatory T cells (Tregs) play an essential role in suppressing transplant rejection, but their role within the graft and heterogeneity in tolerance are poorly understood. Here, we compared phenotypic and transcriptomic characteristics of Treg populations within lymphoid organs and grafts in an islet xenotransplant model of tolerance. We showed Tregs were essential for tolerance induction and maintenance. Tregs demonstrated heterogeneity within the graft and lymphoid organs of tolerant mice. A subpopulation of CD127hi Tregs with memory features were found in lymphoid organs, presented in high proportions within long-surviving islet grafts, and had a transcriptomic and phenotypic profile similar to tissue Tregs...
February 13, 2024: JCI Insight
#16
JOURNAL ARTICLE
Christopher G Kemp, Brian W Pence, Jennifer Velloza, Tessa Concepcion, Modhurima Moitra, Michael Iroezindu, Emmanuel Bahemana, Hannah Kibuuka, Michael Semwogerere, John Owuoth, Jonah Maswai, Rither Langat, Allahna L Esber, Nicole F Dear, Ajay Parikh, Trevor A Crowell, Julie A Ake, Christina S Polyak, Pamela Y Collins
OBJECTIVE: :We estimated the effects of cumulative exposure to depressive symptoms on risk of all-cause mortality among people living with HIV in four African countries. DESIGN: :Analysis of prospective cohort data. METHODS: :The African Cohort Study (AFRICOS) is a prospective cohort of people receiving care at twelve clinics in Kenya, Nigeria, Tanzania, and Uganda. Every six months from January 2013 to May 2020, participants underwent laboratory monitoring, structured surveys, and assessment of depressive symptom severity using the Center for Epidemiologic Studies Depression Scale (CES-D)...
March 20, 2024: AIDS
#17
JOURNAL ARTICLE
Jessica N Perelman, Kisei R Tanaka, Joy N Smith, Hannah C Barkley, Brian S Powell
As ocean temperatures continue to rise, coral bleaching events around the globe are becoming stronger and more frequent. High-resolution temperature data is therefore critical for monitoring reef conditions to identify indicators of heat stress. Satellite and in situ measurements have historically been relied upon to study the thermal tolerances of coral reefs, but these data are quite limited in their spatial and temporal coverage. Ocean circulation models could provide an alternative or complement to these limited data, but a thorough evaluation against in situ measurements has yet to be conducted in any Pacific Islands region...
March 19, 2024: Scientific Reports
#18
Pavithra Nagarajan, Thomas W Winkler, Amy R Bentley, Clint L Miller, Aldi T Kraja, Karen Schwander, Songmi Lee, Wenyi Wang, Michael R Brown, John L Morrison, Ayush Giri, Jeffrey R O'Connell, Traci M Bartz, Lisa de Las Fuentes, Valborg Gudmundsdottir, Xiuqing Guo, Sarah E Harris, Zhijie Huang, Mart Kals, Minjung Kho, Christophe Lefevre, Jian'an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Yuri Milaneschi, Nicholette D Palmer, Varun Rao, Rainer Rauramaa, Botong Shen, Stefan Stadler, Quan Sun, Jingxian Tang, Sébastien Thériault, Adriaan van der Graaf, Peter J van der Most, Yujie Wang, Stefan Weiss, Kenneth E Westerman, Qian Yang, Tabara Yasuharu, Wei Zhao, Wanying Zhu, Drew Altschul, Md Abu Yusuf Ansari, Pramod Anugu, Anna D Argoty-Pantoja, Michael Arzt, Hugues Aschard, John R Attia, Lydia Bazzanno, Max A Breyer, Jennifer A Brody, Brian E Cade, Hung-Hsin Chen, Yii-Der Ida Chen, Zekai Chen, Paul S de Vries, Latchezar M Dimitrov, Anh Do, Jiawen Du, Charles T Dupont, Todd L Edwards, Michele K Evans, Tariq Faquih, Stephan B Felix, Susan P Fisher-Hoch, James S Floyd, Mariaelisa Graff, Charles Gu, Dongfeng Gu, Kristen G Hairston, Anthony J Hanley, Iris M Heid, Sami Heikkinen, Heather M Highland, Michelle M Hood, Mika Kähönen, Carrie A Karvonen-Gutierrez, Takahisa Kawaguchi, Setoh Kazuya, Tanika N Kelly, Pirjo Komulainen, Daniel Levy, Henry J Lin, Peter Y Liu, Pedro Marques-Vidal, Joseph B McCormick, Hao Mei, James B Meigs, Cristina Menni, Kisung Nam, Ilja M Nolte, Natasha L Pacheco, Lauren E Petty, Hannah G Polikowsky, Michael A Province, Bruce M Psaty, Laura M Raffield, Olli T Raitakari, Stephen S Rich, Renata L Riha, Lorenz Risch, Martin Risch, Edward A Ruiz-Narvaez, Rodney J Scott, Colleen M Sitlani, Jennifer A Smith, Tamar Sofer, Maris Teder-Laving, Uwe Völker, Peter Vollenweider, Guanchao Wang, Ko Willems van Dijk, Otis D Wilson, Rui Xia, Jie Yao, Kristin L Young, Ruiyuan Zhang, Xiaofeng Zhu, Jennifer E Below, Carsten A Böger, David Conen, Simon R Cox, Marcus Dörr, Mary F Feitosa, Ervin R Fox, Nora Franceschini, Sina A Gharib, Vilmundur Gudnason, Sioban D Harlow, Jiang He, Elizabeth G Holliday, Zoltan Kutalik, Timo A Lakka, Deborah A Lawlor, Seunggeun Lee, Terho Lehtimäki, Changwei Li, Ching-Ti Liu, Reedik Mägi, Fumihiko Matsuda, Alanna C Morrison, Brenda Wjh Penninx, Patricia A Peyser, Jerome I Rotter, Harold Snieder, Tim D Spector, Lynne E Wagenknecht, Nicholas J Wareham, Alan B Zonderman, Kari E North, Myriam Fornage, Adriana M Hung, Alisa K Manning, James Gauderman, Han Chen, Patricia B Munroe, Dabeeru C Rao, Diana van Heemst, Susan Redline, Raymond Noordam, Heming Wang
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discover 22 novel gene-sleep duration interaction loci for blood pressure, mapped to genes involved in neurological, thyroidal, bone metabolism, and hematopoietic pathways...
March 8, 2024: medRxiv
#19
JOURNAL ARTICLE
Corey C Baker, Jessica L Sessenwein, Hannah M Wood, Yang Yu, Quentin Tsang, Taylor A Alward, Nestor N Jimenez Vargas, Amal Abu Omar, Abby McDonnel, Julia Segal, Calvin P Sjaarda, Nigel W Bunnett, Brian L Schmidt, Alberto Caminero, Nadejda Boev, Courtney Bannerman, Nader Ghasemlou, Prameet M Sheth, Stephen J Vanner, David E Reed, Alan E Lomax
Abdominal pain is a major symptom of diseases that are associated with microbial dysbiosis, including irritable bowel syndrome and inflammatory bowel disease. Germ-free mice are more prone to abdominal pain than conventionally-housed mice, and reconstitution of the microbiota in germ-free mice reduces abdominal pain sensitivity. However, the mechanisms underlying microbial modulation of pain remain elusive. We hypothesized that disruption of the intestinal microbiota modulates the excitability of peripheral nociceptive neurons...
March 15, 2024: Cellular and Molecular Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Timothy F Huddy, Yang Hsia, Ryan D Kibler, Jinwei Xu, Neville Bethel, Deepesh Nagarajan, Rachel Redler, Philip J Y Leung, Connor Weidle, Alexis Courbet, Erin C Yang, Asim K Bera, Nicolas Coudray, S John Calise, Fatima A Davila-Hernandez, Hannah L Han, Kenneth D Carr, Zhe Li, Ryan McHugh, Gabriella Reggiano, Alex Kang, Banumathi Sankaran, Miles S Dickinson, Brian Coventry, T J Brunette, Yulai Liu, Justas Dauparas, Andrew J Borst, Damian Ekiert, Justin M Kollman, Gira Bhabha, David Baker
A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in comparison, has been much more complex, largely owing to the irregular shapes of protein structures1 . Here we describe extendable linear, curved and angled protein building blocks, as well as inter-block interactions, that conform to specified geometric standards; assemblies designed using these blocks inherit their extendability and regular interaction surfaces, enabling them to be expanded or contracted by varying the number of modules, and reinforced with secondary struts...
March 13, 2024: Nature
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