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premature rupture membranes

Ali Ovayolu, Gamze Ovayolu, Erbil Karaman, Tuncay Yuce, Abdulkadir Turgut, Nuray Bostancıeri
Objectives To evaluate the maternal serum endocan levels in pregnant women complicated by preterm premature rupture of membranes (PPROM) and to compare the results with healthy pregnancies. Methods This cohort study included 31 pregnant women with PPROM and 34 gestational age-matched healthy subjects in the third trimester of pregnancy. The blood for analysis was obtained on the day of diagnosis and serum endocan levels were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit...
March 15, 2019: Journal of Perinatal Medicine
Thomas Schmitz, Loïc Sentilhes, Elsa Lorthe, Denis Gallot, Hugo Madar, Muriel Doret-Dion, Gaël Beucher, Caroline Charlier, Charles Cazanave, Pierre Delorme, Charles Garabédian, Elie Azria, Véronique Tessier, Marie-Victoire Sénat, Gilles Kayem
In France, the frequency of premature rupture of the membranes (PROM) is 2%-3% before 37 weeks' gestation (level of evidence [LE] 2) and less than 1% before 34 weeks (LE2). Preterm delivery and intrauterine infection are the major complications of preterm PROM (PPROM) (LE2). Prolongation of the latency period is beneficial (LE2). Compared with other causes of preterm delivery, PPROM is associated with a clear excess risk of neonatal morbidity and mortality only in cases of intrauterine infection, which is linked to higher rates of in utero fetal death (LE3), early neonatal infection (LE2), and necrotizing enterocolitis (LE2)...
March 2, 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Hanane Bouchghoul, Gilles Kayem, Thomas Schmitz, Alexandra Benachi, Loïc Sentilhes, Chloé Dussaux, Marie-Victoire Senat
Preterm premature rupture of membranes (PPROM) is associated with an increased risk of serious maternal, fetal, and neonatal morbidities. We compared neonatal outcomes of women with PPROM before 34+0 weeks of gestation according to inpatient or outpatient management policy. 587 women with PPROM >48 hours, 246 (41.9%) in the group with an inpatient care policy (ICP) and 341 (58.1%) in the group with an outpatient care policy (OCP), were identified in France, from 2009 to 2012. Neonatal outcomes were compared between the two groups using logistic regression...
March 12, 2019: Scientific Reports
Anne M Siegel, Robert Phillips Heine, Sarah K Dotters-Katz
Objective  A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN regimens on neonatal outcomes. Study Design  Secondary analysis of randomized controlled trial of antenatal magnesium sulfate. Singleton, nonanomalous pregnancies complicated by PPROM at > 24 weeks of gestation receiving the SAR were compared with women receiving a non- β -lactam regimen and a macrolide (NPCR)...
January 2019: American Journal of Perinatology Reports
Damian D Guerra, K Joseph Hurt
BACKGROUND: Gaso-transmitters are endogenous small gaseous messengers exemplified by nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S or sulfide). Gasotransmitters are implicated in myriad physiologic functions including many aspects of reproduction. OBJECTIVE: Comprehensively review basic mechanisms and functions of gasotransmitters during pregnancy from conception to uterine involution and highlight future research opportunities. . METHODS: We searched PubMed and Web of Science databases using combinations of keywords nitric oxide, carbon monoxide, sulfide, placenta, uterus, labor, and pregnancy...
March 8, 2019: Biology of Reproduction
M Sood, Z Mohd Zain, N A Abu, S C Chee, N S Mohd Nor
INTRODUCTION: Some anecdotal reports suggest that maternal colonisation with Acinetobacter baumannii during pregnancy is associated with adverse maternal and neonatal effects, including preterm premature rupture of membrane (PPROM). The objective of this study was to compare the maternal and neonatal effects of A. baumannii colonisation in cases with PPROM and those with spontaneous onset of labour at term. METHODS: The recruitment of participants' was carried out at Selayang Hospital, Selangor, Malaysia...
February 2019: Medical Journal of Malaysia
Jussara Leiko Sato Tebet, Gianna Mastroianni Kirsztajn, Thais Alquezar Facca, Sonia K Nishida, Amelia Rodrigues Pereira, Silvia Regina Moreira, José Osmar Pestana Medina, Nelson Sass
OBJECTIVES: We aimed to evaluate laboratory markers in women who got pregnant after renal transplantation. STUDY DESIGN: Cross-sectional prospective study. MAIN OUTCOME MEASURES: Renal function parameters and maternal and fetal data were assessed in renal transplant recipients. RESULTS: Forty-three women who got pregnant after renal transplantation (mean age, 28.5 years; mean gestational age, 35.6 weeks) were included...
January 2019: Pregnancy Hypertension
Lumbani Tshotetsi, Loveness Dzikiti, Precious Hajison, Shingairai Feresu
BACKGROUND: Low birth weight continues to be a main cause of child morbidity and mortality. Low birth weight can cause complications in adult life, and is therefore a public health concern. In this study, we determined the maternal factors that contribute to low birth weight (LBW) deliveries in Tshwane District, South Africa. METHODS: We conducted a case control study of 1073 randomly selected mothers who delivered babies in four hospitals in the district. We reviewed antenatal and maternity registers to obtain information about the mothers and their offspring...
2019: PloS One
Vikas Yadav, J B Sharma, Garima Kachhawa, Vidushi Kulshrestha, Reeta Mahey, Rajesh Kumari, Alka Kriplani
Tuberculosis (TB) is a major health problem and a leading cause of illness and death from infectious disease. Tuberculosis in pregnancy has been associated with increased risks of prematurity and small for gestational age (SGA)infants.The present study is aimed to examine obstetrical and perinatal outcomes among women who had extra-pulmonary tuberculosis. MATERIAL AND METHODS: It was retrospective study involving patient who presented with extra pulmonary tuberculosis over a period of ten years (2008-2017)was reviewed...
January 2019: Indian Journal of Tuberculosis
Chenchen Zhang, Yixia Yang, Ruiying Chen, Youheng Wei, Youji Feng, Wenxin Zheng, Hong Liao, Zhenbo Zhang
Gestational diabetemellitus (GDM) is a condition whereby a mother's glucose tolerance is impaired with onset or first recognition during pregnancy which is not either type 1 or type 2 diabetes mellitus. Oxidative stress plays an essential role in diabetes, however, whether it also includes in GDM has not been fully clarified. Therefore, we investigated the changes of oxidative stress biomarkers and their relationship with pregnancy outcomes in patients with GDM. The serum and placenta were collected for absorbance-based assay and immunohistochemistry assay (IHC)...
2019: American Journal of Translational Research
Uwe Schmidt, Claudia Capek, Cahit Birdir, Christine Erfurt, Katharina Nitzsche
INTRODUCTION: It can be observed that there is an increase in the methamphetamine (MA) consumption in Saxony (Federal Republic of Germany). There is so far no data available in German speaking countries about the risk of MA consumption in pregnancy or delivery. METHODS: The data from all pregnant women who were examined or delivered at the Clinic for Obstetrics and Gynaecology between 2010-2015 were retrospectively searched for MA consumption. 119 pregnancies with 113 deliveries of 115 women consuming MA could be evaluated...
February 20, 2019: Zeitschrift Für Geburtshilfe und Neonatologie
Lindsay L Richter, Joseph Ting, Giulia M Muraca, Anne Synnes, Kenneth I Lim, Sarka Lisonkova
OBJECTIVE: After a decade of increase, the preterm birth (PTB) rate has declined in the USA since 2006, with the largest decline at late preterm (34-36 weeks). We described concomitant changes in gestational age-specific rates of neonatal mortality and morbidity following spontaneous and clinician-initiated PTB among singleton infants. DESIGN, SETTING AND PARTICIPANTS: This retrospective population-based study included 754 763 singleton births in Washington State, USA, 2004-2013, using data from birth certificates and hospitalisation records...
February 1, 2019: BMJ Open
Lina Salman, Amir Aviram, Roie Holzman, Hadar Hay-Azogui, Eran Ashwal, Eran Hadar, Rinat Gabbay-Benziv
OBJECTIVE: To determine predictors for cesarean delivery (CD) in pregnancies complicated by preterm premature rupture of membranes (PPROM) with an intention for vaginal delivery. MATERIALS AND METHODS: A retrospective cohort analysis of all singleton, preterm deliveries (24 + 0 to 36 + 6 weeks) following PPROM (2007-2014). Exclusion criteria included: cases intended for CD prior to delivery; short interval from PPROM to delivery (< 24 hours); cervical dilatation upon admission ≥ 4 cm; and major fetal anatomical/chromosomal abnormalities...
February 19, 2019: Journal of Maternal-fetal & Neonatal Medicine
Hikaru Kiyokawa, Haruta Mogami, Yusuke Ueda, Yosuke Kawamura, Mai Sato, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh
Glucocorticoid use during pregnancy is known to increase the risk of preterm birth and preterm premature rupture of membranes (pPROM). Here, we investigated the mechanism of how glucocorticoids weaken the fetal membranes. The amnion mesenchymal layer was significantly thinner in pregnant women treated with prednisolone and corticosterone-injected mice compared to control groups. Matrix metalloproteinse-9 (MMP9) mRNA and its activity, COX2 mRNA levels, and PGE2 synthesis were increased whereas type 1 collagen (COL1A1) mRNA levels were decreased in the fetal membranes of corticosterone-injected mice...
February 18, 2019: Endocrinology
Amanda L Phillips, Frank Cetta, Sarah E Kerr, E Heidi Cheek, Carl H Rose, Crystal R Bonnichsen, Sabrina D Phillips
BACKGROUND: Placental insufficiency may be the cause of the high preterm birth rate in women after Fontan operation. In this study we reviewed the clinical course and pregnancy outcome of women with Fontan physiology with a focus on placental pathology. METHODS: We reviewed clinical charts and placental pathology from 7 women with Fontan physiology who had pregnancies at Mayo Clinic, Rochester, Minnesota. The review was limited to cases where placental pathologic specimens were rigorously examined...
February 5, 2019: International Journal of Cardiology
Rebecca J Baer, Christina D Chambers, Kelli K Ryckman, Scott P Oltman, Larry Rand, Laura L Jelliffe-Pawlowski
BACKGROUND: Few studies have examined the relationship between sexually transmitted infections (STIs) and preterm birth (<37 weeks gestation) by subtype (<32 weeks, 32 - 36 weeks, spontaneous, provider-initiated). Here, we evaluate the odds of preterm (by subtype) and early term (37 and 38 weeks gestation) birth in women with an STI compared to a propensity score matched reference population. METHODS: The sample was selected from California births in 2007-2012...
February 11, 2019: Sexually Transmitted Diseases
Judith Rittenschober-Böhm, Thomas Waldhoer, Stefan M Schulz, Birgit Pimpel, Katharina Goeral, David C Kasper, Armin Witt, Angelika Berger
BACKGROUND: Ureaplasma species (spp.) are the bacteria most often isolated from the amniotic cavity of women with preterm labor or preterm premature rupture of membranes, thus, the link between intrauterine Ureaplasma spp. infection and adverse pregnancy outcome is clearly established. However, as vaginal Ureaplasma spp. colonization is very common in pregnant women, it is not clear why these microorganisms cause ascending infections in some cases but remain asymptomatic in most pregnancies...
February 5, 2019: American Journal of Obstetrics and Gynecology
Gabriele Saccone, Luigi Della Corte, Giuseppe M Maruotti, Johanna Quist-Nelson, Antonio Raffone, Valentino De Vivo, Gennaro Esposito, Fulvio Zullo, Vincenzo Berghella
INTRODUCTION: The lowest incidence of perinatal morbidity and mortality occurs around 39-40 weeks. Therefore, some have advocated induction of uncomplicated singleton gestations once they reach full-term. The aim of the study was to evaluate the risk of cesarean delivery, and any maternal and perinatal effects of a policy of induction of labor in women with full-term uncomplicated singleton gestations. MATERIAL AND METHODS: We performed an electronic search from inception of each database to August 2018...
February 5, 2019: Acta Obstetricia et Gynecologica Scandinavica
Ashlee K Rigby, Janet N Richards, Jennene Greenhill
INTRODUCTION: The provision of critical management of obstetric emergencies is a vital service for rural women and their families. Emergency obstetric transfers are indispensable to reduce maternal and neonatal mortality and morbidity because local rural hospitals often do not have the resources or expertise to manage both maternal and neonatal outcomes. However, the transfer of a rural pregnant woman to a higher level, tertiary perinatal centre (TPC) is often stressful for the patient and costly for health services...
February 2019: Rural and Remote Health
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March 2019: International Journal of Gynaecology and Obstetrics
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