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TBI rat

Isabel H Bleimeister, Mia Wolff, Tracey R Lam, Derrick M Brooks, Reece Patel, Jeffrey P Cheng, Corina O Bondi, Anthony E Kline
Environmental enrichment (EE) and amantadine (AMT) enhance motor and cognitive outcome after experimental traumatic brain injury (TBI). However, there are no data on the effects of combining these two therapies. Hence, the aim of the current study was to combine EE and AMT after TBI to determine if their net effect further enhances motor and cognitive performance. Anesthetized adult male rats received either a cortical impact of moderate severity or sham injury and then were randomly assigned to EE or standard (STD) housing and once daily administration of AMT (20 mg/kg; i...
March 12, 2019: Brain Research
Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe, Jianjing Yang
BACKGROUND: Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injured brain. It is well known that calpain activation plays a critical role in traumatic brain injury (TBI)-mediated inflammation and cell death; previous studies showed that inhibiting calpain activation is neuroprotective after TBI...
March 15, 2019: Stem Cell Research & Therapy
Jea-Young Lee, Sandra Acosta, Julian P Tuazon, Kaya Xu, Hung Nguyen, Trenton Lippert, Michael G Liska, Andrey Semechkin, Ibon Garitaonandia, Rodolfo Gonzalez, Russell Kern, Cesario V Borlongan
International Stem Cell Corporation human parthenogenetic neural stem cells (ISC-hpNSC) have potential therapeutic value for patients suffering from traumatic brain injury (TBI). Here, we demonstrate the behavioral and histological effects of transplanting ISC-hpNSC intracerebrally in an animal model of TBI. Methods : Sprague-Dawley rats underwent a moderate controlled cortical impact TBI surgery. Transplantation occurred at 72 h post-TBI with functional readouts of behavioral and histological deficits conducted during the subsequent 3-month period after TBI...
2019: Theranostics
Olga Kononenko, Hiroyuki Watanabe, Lada Stålhandske, Ann Zarelius, Fredrik Clausen, Tatiana Yakovleva, Georgy Bakalkin, Niklas Marklund
BACKGROUND/OBJECTIVES: Motor impairment induced by traumatic brain injury (TBI) may be mediated through changes in spinal molecular systems regulating neuronal plasticity. We assessed whether a focal controlled cortical impact (CCI) TBI in the rat alters expression of the Tgfb1, c-Fos, Bdnf, and Gap43 neuroplasticity genes in lumbar spinal cord.Approach/Methods:Adult male Sprague-Dawley rats (n = 8) were subjected to a right-side CCI over the anterior sensorimotor hindlimb representation area or sham-injury (n = 8)...
March 7, 2019: Restorative Neurology and Neuroscience
Peng Gao, Mengliang Zhou, Yiming Ouyang, Handong Wang
Oxidative stress is a critical mechanism underlying secondary injury during diffuse axonal injury (DAI), and nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) is an important element in the antioxidative stress pathway. This study investigated changes in Nrf2-ARE expression in rats with DAI to provide a basis for studying the DAI mechanism and a guide for clinical practice. The rat traumatic brain injury (TBI) model was established by a speeding rotation device and confirmed by neural scoring and silver staining...
March 7, 2019: Neuroreport
Satoko Kawauchi, Wataru Okuda, Hiroshi Nawashiro, Shunichi Sato, Izumi Nishidate
Blast-induced traumatic brain injury has been a recent major concern in neurotraumatology. However, its pathophysiology and mechanism are not understood partly due to insufficient information on the brain pathophysiology during/immediately after shock wave exposure. We transcranially applied a laser-induced shock wave (LISW, ∼19  Pa  ·  s) to the left frontal region in a rat and performed multispectral imaging of the ipsilateral cortex through a cranial window (n  =  4). For the spectral data obtained, we conducted multiple regression analysis aided by Monte Carlo simulation to evaluate vascular diameters, regional hemoglobin concentration (rCHb), tissue oxygen saturation (StO2), oxygen extraction fraction, and light-scattering signals as a signature of cortical spreading depolarization (CSD)...
March 2019: Journal of Biomedical Optics
Alina Arulsamy, Frances Corrigan, Lyndsey E Collins-Praino
Traumatic brain injury (TBI) is a common risk factor for later neurodegeneration, which can manifest as dementia. Despite this, little is known about the time-course of development of functional deficits, particularly cognitive and neuropsychiatric impairments, and whether these differ depending on the nature of the initiating insult. Therefore, this study investigated long term functional impairment at 12 months post-injury following diffuse TBI of different severities. Male Sprague-Dawley rats (420-480 g; 10-12 weeks) were either given a sham surgery (n = 14) or subjected to Marmarou's impact acceleration model of diffuse TBI for a single mild TBI (n = 12), repetitive mild TBI (3 mild diffuse injuries at 5 day intervals) (n = 14) or moderate to severe TBI (n = 14)...
February 28, 2019: Behavioural Brain Research
Cole Vonder Haar, Kris M Martens, Asma Bashir, Kurt A McInnes, Wai Hang Cheng, Honor Cheung, Sophie Stukas, Carlos Barron, Tessa Ladner, Kassandra A Welch, Peter A Cripton, Catharine A Winstanley, Cheryl L Wellington
Traumatic brain injury (TBI) affects at least 3 M people annually. In humans, repetitive mild TBI (rmTBI) can lead to increased impulsivity and may be associated with chronic traumatic encephalopathy. To better understand the relationship between repetitive TBI (rTBI), impulsivity and neuropathology, we used CHIMERA (Closed-Head Injury Model of Engineered Rotational Acceleration) to deliver five TBIs to rats, which were continuously assessed for trait impulsivity using the delay discounting task and for neuropathology at endpoint...
February 26, 2019: Experimental Neurology
Nolan B Skop, Sweta Singh, Henri Antikainen, Chaitali Saqcena, Frances Calderon, Deborah E Rothbard, Cheul H Cho, Chirag D Gandhi, Steven W Levison, Radek Dobrowolski
There is intense interest and effort toward regenerating the brain after severe injury. Stem cell transplantation after insult to the central nervous system has been regarded as the most promising approach for repair; however, engrafting cells alone might not be sufficient for effective regeneration. In this study, we have compared neural progenitors (NPs) from the fetal ventricular zone (VZ), the postnatal subventricular zone, and an immortalized radial glia (RG) cell line engineered to conditionally secrete the trophic factor insulin-like growth factor 1 (IGF-1)...
January 2019: ASN Neuro
Shoji Yokobori, Kazuma Sasaki, Takahiro Kanaya, Yutaka Igarashi, Ryuta Nakae, Hidetaka Onda, Tomohiko Masuno, Satoshi Suda, Kota Sowa, Masataka Nakajima, Markus S Spurlock, Lee Onn Chieng, Tom G Hazel, Karl Johe, Shyam Gajavelli, Akira Fuse, M Ross Bullock, Hiroyuki Yokota
Human neural stem cells (hNSCs) transplantation in several brain injury models has established their therapeutic potential. However, the feasibility of hNSCs transplantation is still not clear for acute subdural hematoma (ASDH) brain injury that needs external decompression. Thus, the aim of this pilot study was to test feasibility using a rat ASDH decompression model with two clinically relevant transplantation methods. Two different methods, in situ stereotactic injection and hNSC-embedded matrix seating on the brain surface, were attempted...
2019: Frontiers in Neurology
Xian-Liang Lai, Zhi-Feng Deng, Xin-Gen Zhu, Zhi-Hua Chen
BACKGROUND: Intracranial aneurysm (IA) is a critical acquired cerebrovascular disease that may cause subarachnoid hemorrhage and nuclear factor-kappaB (NF-κB)-mediated inflammation is involved in the pathogenesis of IA. Adenomatous polyposis coli (Apc) gene is a tumor suppressor gene associated with both familial and sporadic cancer. Herein, the purpose of our study is to validate effect of Apc gene on IA formation and rupture by regulating the NF-κB signaling pathway mediated inflammatory response...
February 26, 2019: Bioscience Reports
Jingjing Liu, Xin Xiong, Yutong Sui
OBJECTIVES: Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is a bioactive component extracted from licorice roots, which possesses anti-inflammatory and anti-apoptotic properties. This study aims to investigate the potential effects of isoliquiritigenin on neuroinflammation in a rat model of TBI. METHODS: The SH-SY5Y cells were subjected to cell injury induced by shear stress and the effect of isoliquiritigenin on cell apoptosis was measured...
February 15, 2019: Neuroimmunomodulation
Chengxu Ma, Zhaoyuan Fu, Huan Guo, Huiping Wei, Xinke Zhao, Yingdong Li
Radix Angelica Sinensis and Radix Hedysari are traditional Chinese medicines that are used for preventing and treating various diseases. This study aimed to investigate the effect and possible underlying mechanisms of Radix Angelica Sinensis and Radix Hedysari ultrafiltration extract (RAS-RH) on X-irradiation-induced cardiac fibrosis in rats. Our data demonstrated that (a) a single dose of total body irradiation (TBI) at 8 Gy resulted in cardiac fibrosis, whereas the control hearts exhibited less collagen and fibrosis...
February 16, 2019: Biomedicine & Pharmacotherapy
Shu-Jun Lin, Yu-Juan Zhang, Ji-Huan Lin, Yi-Min Zhang, Ming-Min Zhu, Yu-Qing Zhang, Liu Pu, Shu-Lian Chen, Wei-Hao Chen, Shao-Bing Cheng
OBJECTIVE: To observe the effect of acupuncture on activities of microglia in traumatic brain injury (TBI) rats. METHODS: Fifty-four male SD rats were randomly and equally divided into normal control, model and acupuncture groups according to the random number table ( n =18 rats in each group). The TBI model was established by using a free fall brain injury striking device after exposing the local cranial bone (to induce the left parietal cerebral contusion). Acupoints "Baihui" (GV20), "Shuigou" (GV26), "Fengfu" (GV16), "Yamen" (GV15) and bilateral "Hegu" (LII4) were stimulated intensively by twirling the filiform needles with force at a range of >360° and a frequency of 160-180 cycles/min for 10 sec in every acupoint, once every 5 min during the 15 minutes' needle retaining...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
Aidan C Smith, Ryan C Holden, Sherry M Rasmussen, Michael R Hoane, Michael J Hylin
Age is a consistent predictor of outcome following traumatic brain injury (TBI). Although children and adolescents have the highest rate of hospitalizations and long-term disabilities, few preclinical studies have attempted to model and treat TBI in this population. Studies using nicotinamide (NAM), a soluble B-group vitamin, in older animals (3-6 months) have shown improved functional recovery in experimental models of TBI. The purpose of this study was two-fold: to examine the preclinical efficacy of NAM at different doses on behavioral outcomes in juvenile rats and examine the microglial response over time...
February 13, 2019: Behavioural Brain Research
Jigang Chen, Wen Chen, Kaiwei Han, Enbo Qi, Rongbin Chen, Minkun Yu, Lijun Hou, Liquan Lv
Sympathetic hyperactivity occurs in a subgroup of patients after traumatic brain injury (TBI). The rostral ventrolateral medulla (RVLM) is a key region for the activity of sympathetic nervous system. Oxidative stress in the RVLM is proved to be responsible for the increased level of sympathetic activity in animal models of hypertension and heart failure. In this study, we investigated whether oxidative stress in the RVLM contributed to the development of sympathetic hyperactivity after TBI in rats. Model of diffuse axonal injury was induced using Sprague-Dawley rats, and level of mean arterial pressure (MAP) and plasma Norepinephrine (NE) was measured to evaluate the sympathetic activity...
February 14, 2019: European Journal of Neuroscience
Yukitoshi Kaizawa, Austin Franklin, Jacinta Leyden, Anthony W Behn, U Serdar Tulu, Daniel Leon, Zhen Wang, Geoffrey D Abrams, James Chang, Paige M Fox
Rotator cuff (RTC) repair outcomes are unsatisfactory due to the poor healing capacity of the tendon bone interface (TBI). In our preceding study, tendon hydrogel (tHG), which is a type I collagen rich gel derived from human tendons, improved biomechanical properties of the TBI in a rat chronic RTC injury model. Here we investigated whether adipose-derived stem cell (ASC)-seeded tHG injection at the repair site would further improve RTC healing. Rats underwent bilateral supraspinatus tendon detachment. Eight weeks later injured supraspinatus tendons were repaired with one of four treatments...
February 12, 2019: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Benjamin M Aertker, Akshita Kumar, Karthik S Prabhakara, Philippa Smith, Naama E Toledano Furman, Xue Hasen, Charles S Cox, Supinder S Bedi
Traumatic brain injury (TBI) effects both the brain and the immune system. Circulating monocytes/macrophages (Mo /Ma ) after a TBI may play an important role in preserving the blood-brain barrier (BBB), reducing brain edema, and interacting with resident microglia. To elucidate the role of circulating Mo /Ma , we utilized a monocyte/macrophage depletion model in response to TBI in male rats. Clodronate liposomes (CL) were used to deplete circulating Mo /Ma . A controlled cortical impact (CCI) injury model was used to create a TBI...
February 12, 2019: Journal of Neuroscience Research
Rogerio R Gerbatin, Luiz Fernando Almeida Silva, Maurício S Hoffmann, Iuri D Della-Pace, Patricia Severo do Nascimento, Aline Kegler, Viviane Nogueira de Zorzi, Jane Marçal Cunha, Priscilla Botelho, João Bento Torres Neto, Ana Flavia Furian, Mauro Schneider Oliveira, Michele R Fighera, Luiz Fernando Freire Royes
Traumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although reasonable progress in understanding its pathophysiology has been made, treatment of PTE is still limited. Several studies have shown the neuroprotective effect of creatine in different models of brain pathology, but its effects on PTE is not elucidated. Thus, we decided to investigate the impact of delayed and chronic creatine supplementation on susceptibility to epileptic seizures evoked by pentylenetetrazol (PTZ) after TBI...
February 8, 2019: Progress in Neuro-psychopharmacology & Biological Psychiatry
Stephanie W Lee, Juan Pablo de Rivero Vaccari, Jessie S Truettner, W Dalton Dietrich, Robert W Keane
BACKGROUND: Traumatic brain injury remains a significant cause of death and disability in the USA. Currently, there are no effective therapies to mitigate disability except for surgical interventions necessitating a need for continued research into uncovering novel therapeutic targets. In a recent study, we used a rodent model of penetrating traumatic brain injury known as penetrating ballistic-like brain injury (PBBI) to examine the role of innate immunity in post-traumatic secondary injury mechanisms...
February 8, 2019: Journal of Neuroinflammation
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