keyword
https://read.qxmd.com/read/38469233/a-facs-based-novel-isolation-technique-identifies-heterogeneous-ctcs-in-oral-squamous-cell-carcinoma
#21
JOURNAL ARTICLE
Anshika Chauhan, Arnab Pal, Meenakshi Sachdeva, Geeta S Boora, Monil Parsana, Jaimanti Bakshi, Roshan Kumar Verma, Radhika Srinivasan, Debajyoti Chatterjee, Arindam Maitra, Sushmita Ghoshal
PURPOSE: Isolating circulating tumour cells (CTCs) from the blood is challenging due to their low abundance and heterogeneity. Limitations of conventional CTC detection methods highlight the need for improved strategies to detect and isolate CTCs. Currently, the Food and Drug Administration (FDA)-approved CellSearch™ and other RUO techniques are not available in India. Therefore, we wanted to develop a flexible CTC detection/isolation technique that addresses the limitation(s) of currently available techniques and is suitable for various downstream applications...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38466524/natural-pyrite-stimulative-periodate-activation-efficiency-and-mechanism-study
#22
JOURNAL ARTICLE
Hongwei Ying, Yilin Mao
Natural pyrite (NP) is an alternative catalyst for wastewater purification via advanced oxidation processes (AOPs). However, the activation performance and mechanism of periodate (PI) by NP have not yet been revealed. Herein, this work examines the activation performance of NP towards PI and its application in the degradation of antibiotic wastewater. Interestingly, 95.69% of chlortetracycline (CTC) was degraded by NP within 20 min via PI activation. Besides, NP shows effective degradation of various pollutants such as rhodamine B (65...
March 11, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38465942/ctc-race-single-cell-motility-assay-of-circulating-tumor-cells-from-metastatic-lung-cancer-patients
#23
JOURNAL ARTICLE
Yang Liu, Wujun Zhao, Jamie Hodgson, Mary Egan, Christen N Cooper Pope, Glenda Hicks, Petros G Nikolinakos, Leidong Mao
Distinctive subpopulations of circulating tumor cells (CTCs) with increased motility are considered to possess enhanced tumor-initiating potential and contribute to metastasis. Single-cell analysis of the migratory CTCs may increase our understanding of the metastatic process, yet most studies are limited by technical challenges associated with the isolation and characterization of these cells due to their extreme scarcity and heterogeneity. We report a microfluidic method based on CTCs' chemotactic motility, termed as CTC-Race assay, that can analyze migrating CTCs from metastatic non-small-cell lung cancer (NSCLC) patients with advanced tumor stages and enable concurrent biophysical and biochemical characterization of them with single-cell resolution...
March 11, 2024: ACS Nano
https://read.qxmd.com/read/38465398/technical-note-cryostat-transmission-characterization-for-mr-linac-temporal-stability-clinical-impact-and-change-implementation
#24
JOURNAL ARTICLE
Urszula Jelen, Claire Pagulayan, Zoë Moutrie, Jason Arts, Armia George, Michael G Jameson
BACKGROUND: In the Unity MR linac (Elekta AB, Stockholm, Sweden), the radiation beam traverses the cryostat and the coil support structure. The resulting beam attenuation must be considered for output calibration and its variation with gantry angle must be characterized in the treatment planning system (TPS). PURPOSE: The aim of this work was to investigate the impact of a change of the cryostat transmission characterization (CTC) curve, due to the helium level modification, on clinical treatment plan dosimetry and to report on the experience with the CTC curve update...
March 11, 2024: Medical Physics
https://read.qxmd.com/read/38464883/photoacoustic-microscopy-for-real-time-monitoring-of-near-infrared-optical-absorbers-inside-biological-tissue
#25
JOURNAL ARTICLE
Takeshi Hirasawa, Kazuyoshi Tachi, Tomohiro Ishikawa, Manami Miyashita, Keiichi Ito, Miya Ishihara
SIGNIFICANCE: We developed a high-speed optical-resolution photoacoustic microscopy (OR-PAM) system using a high-repetition-rate supercontinuum (SC) light source and a two-axes Galvano scanner. The OR-PAM system enabled real-time imaging of optical absorbers inside biological tissues with excellent excitation wavelength tunability. AIM: In the near-infrared (NIR) wavelength range, high-speed OR-PAM faces limitations due to the lack of wavelength-tunable light sources...
January 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38458203/aging-induced-trna-glu-derived-fragment-impairs-glutamate-biosynthesis-by-targeting-mitochondrial-translation-dependent-cristae-organization
#26
JOURNAL ARTICLE
Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu
Mitochondrial cristae, infoldings of the mitochondrial inner membrane, undergo aberrant changes in their architecture with age. However, the underlying molecular mechanisms and their contribution to brain aging are largely elusive. Here, we observe an age-dependent accumulation of Glu-5'tsRNA-CTC, a transfer-RNA-derived small RNA (tsRNA), derived from nuclear-encoded tRNAGlu in the mitochondria of glutaminergic neurons. Mitochondrial Glu-5'tsRNA-CTC disrupts the binding of mt-tRNALeu and leucyl-tRNA synthetase2 (LaRs2), impairing mt-tRNALeu aminoacylation and mitochondria-encoded protein translation...
March 1, 2024: Cell Metabolism
https://read.qxmd.com/read/38457882/efficacy-and-comparison-of-corticosteroids-only-and-corticosteroids-with-plasmapheresis-or-intravenous-immunoglobulin-for-the-treatment-of-optic-neuritis-in-demyelinating-disease-a-systematic-review-and-network-meta-analysis
#27
REVIEW
Arnaud Gaulier, Jean-Benoit Hardouin, Sandrine Wiertlewski, Pierre Lebranchu
PURPOSE: To compare the efficacy of treatment of optic neuritis (ON) with corticosteroids (CTC) alone, CTC+plasmapheresis (PLP), and CTC+intravenous immunoglobulin (IVIG). DESIGN: After an episode of ON, although visual recovery is usually good, some patients may have significant visual sequelae. While the efficacy of first-line CTC is now indisputable, there is no consensus on the nature of second-line treatment. To date, no systematic review has compared the efficacy of treatment of ON with CTC alone, CTC+plasmapheresis (PLP), and CTC+intravenous immunoglobulin (IVIG)...
February 27, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38455127/circulating-tumor-cells-as-prognostic-marker-in-pancreatic-cancer
#28
EDITORIAL
Melek Yakar, Durmuş Etiz
In this editorial we comment on the article by Zhang et al published in the recent issue of the World Journal of Clinical Oncology . Pancreatic cancer is the fourth most common cause of cancer-related mortality and has the lowest survival rate among all solid cancers. It causes 227000 deaths annually worldwide, and the 5-year survival rate is very low due to early metastasis, which is 4.6%. Cancer survival increases with better knowledge of risk factors and early and accurate diagnosis. Circulating tumor cells (CTCs) are tumor cells that intravasate from the primary tumor or metastasis foci into the peripheral blood circulation system spontaneously or during surgical operations...
February 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38445526/analyzing-circulating-tumor-cells-and-epithelial-mesenchymal-transition-status-of-papillary-thyroid-carcinoma-patients-following-thyroidectomy-a-prospective-cohort-study
#29
JOURNAL ARTICLE
Hyeong Won Yu, Eunju Park, Ja Kyung Lee, Woochul Kim, Ju Hyun Kong, Joseph Sunoo, Soon-Cheol Hong, June Young Choi
BACKGROUND: This study investigated the prevalence and subtype distribution of circulating tumor cells (CTCs) in patients with papillary thyroid cancer (PTC) before and after thyroidectomy to determine the potential of CTC count as a non-invasive marker of the efficacy of surgical treatment in PTC. MATERIALS AND METHODS: Between January 2021 and January 2022, 62 PTC patients who underwent thyroidectomy at OOOOOOO Hospital were prospectively evaluated. Peripheral blood samples (7...
March 4, 2024: International Journal of Surgery
https://read.qxmd.com/read/38445253/meibomian-gland-probing-stimulates-a-proliferative-epithelial-response-resulting-in-duct-regeneration
#30
JOURNAL ARTICLE
Steven L Maskin, Claire Toland
PURPOSE: To demonstrate that the meibomian gland ductal basement membrane and basal epithelial cell layer are in continuity with and may derive from lid margin orifice-associated rete ridge epithelial/basement membrane structures (OARREBS) and to characterize changes in the distal duct microanatomy after meibomian gland probing (MGP) using in vivo confocal microscopy (IVCM). PATIENTS AND METHODS: Pre/post-MGP IVCM examinations were performed on upper lids. Thirty-six identical glands from 20 lids of 16 patients (49...
2024: Clinical Ophthalmology
https://read.qxmd.com/read/38442207/microfluidic-system-consisting-of-a-magnetic-3d-printed-microchannel-filter-for-isolation-and-enrichment-of-circulating-tumor-cells-targeted-by-anti-her2-mof-ferrite-core-shell-nanostructures-a-theranostic-ctc-dialysis-system
#31
JOURNAL ARTICLE
Amirhosein Kefayat, Omid Sartipzadeh, Fatemeh Molaabasi, Maryam Amiri, Reza Gholami, Motahareh Mirzadeh, Farhad Shokati, Mansoureh Khandaei, Fatemeh Ghahremani, Seyed Ali Poursamar, Ramin Sarrami-Forooshani
Low number of circulating tumor cells (CTCs) in the blood samples and time-consuming properties of the current CTC isolation methods for processing a small volume of blood are the biggest obstacles to CTC usage in practice. Therefore, we aimed to design a CTC dialysis system with the ability to process cancer patients' whole blood within a reasonable time. Two strategies were employed for developing this dialysis setup, including (i) synthesizing novel in situ core-shell Cu ferrites consisting of the Cu-CuFe2 O4 core and the MIL-88A shell, which are targeted by the anti-HER2 antibody for the efficient targeting and trapping of CTCs; and (ii) fabricating a microfluidic system containing a three-dimensional (3D)-printed microchannel filter composed of a polycaprolactone/Fe3 O4 nanoparticle composite with pore diameter less than 200 μm on which a high-voltage magnetic field is focused to enrich and isolate the magnetic nanoparticle-targeted CTCs from a large volume of blood...
March 5, 2024: Analytical Chemistry
https://read.qxmd.com/read/38441840/prognostic-value-of-cerebrospinal-fluid-tumor-cell-count-in-leptomeningeal-disease-from-solid-tumors
#32
JOURNAL ARTICLE
Andrew B Barbour, Barbara Blouw, Lynne P Taylor, Jerome J Graber, Tresa McGranahan, Molly Blau, Lia M Halasz, Simon S Lo, Yolanda D Tseng, Vyshak Venur, Jonathan T Yang
PURPOSE: Treatment decisions for leptomeningeal disease (LMD) rely on patient risk stratification, since clinicians lack objective prognostic tools. The introduction of rare cell capture technology for identification of cerebrospinal fluid tumor cells (CSF-TCs), such as CNSide assay, improved the sensitivity of LMD diagnosis, but prognostic value is unknown. This study assesses the prognostic value of CSF-TC density in patients with LMD from solid tumors. METHODS: We conducted a retrospective cohort study of patients with newly diagnosed or previously treated LMD from a single institution who had CNSide assay testing for CSF-TCs from 2020 to 2023...
March 5, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38441194/molecular-and-nutritional-markers-in-head-and-neck-cancer
#33
JOURNAL ARTICLE
Gerard Milano, Jocelyn Gal, René-Jean Bensadoun
PURPOSE OF REVIEW: There is still a need of biomarkers in the induction and neoadjuvant settings for squamous cell carcinoma of the head and neck (SCCHN). The objective of this concise review article is to give an overview on both predictive and prognostic biomarkers potentially useful for the management of SCCHN. RECENT FINDINGS: Human papilloma virus (HPV) positivity translated by the presence of the protein indicator p16 is synonymous of favorable prognosis SCCHN...
March 1, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38438242/nanozyme-induced-deep-learning-assisted-smartphone-integrated-colorimetric-and-fluorometric-dual-mode-for-detection-of-tetracycline-analogs
#34
JOURNAL ARTICLE
Yi Zhang, Mingyang Wang, Chunfeng Shao, Tao Liu, Mengmeng Sun, Chun Wu, Gehong Su, Yanying Wang, Jianshan Ye, Haipeng Hu, Yanbin Li, Hanbing Rao, Zhiwei Lu
In this work, a colorimetric and fluorescent dual-mode probe controlled by NH2 -MIL-88 B (Fe, Ni) nanozymes was developed to visually detect tetracycline antibiotics (TCs) residues quantitatively, as well as accurately distinguish the four most widely used tetracycline analogs (tetracycline (TC), chrycline (CTC), oxytetracycline (OTC), and doxycycline (DC)). Colorless substrate 3,3',5,5'-tetramethylbenzidine (TMB) may be oxidized to blue oxidized TMB by the Fe Fenton reaction, which was catalyzed by the NH2 -MIL-88 B (Fe, Ni) nanozyme with POD-like activity...
April 8, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38438224/a-multilocus-dendritic-boronic-acid-functionalized-magnetic-nanoparticle-for-capturing-circulating-tumor-cells-in-the-peripheral-blood-of-mice-with-metastatic-breast-cancer
#35
JOURNAL ARTICLE
Yue Chen, Zhengkun Tang, Jiajia Liu, Chuanyang Ren, Yiwen Zhang, Huarong Xu, Qing Li, Qian Zhang
BACKGROUND: Dynamic fluctuation of circulating tumor cells (CTCs) can serve as an indicator of tumor progression. However, the sensitive isolation of CTCs remains extremely challenging due to their rarity and heterogeneity. Against this dilemma, dendritic boronic acid-modified magnetic nanoparticles (MNPs) were prepared in this study, and polyethyleneimine (PEI) was utilized as a scaffold to significantly increase the number of boronic acid moieties. Then the novel developed material was applied to monitor the number of CTCs in mice with metastatic breast cancer to evaluate the therapeutic effects of matrine (Mat), doxorubicin (Dox), and Mat in combination with Dox...
April 8, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38435366/effect-of-tea-polyphenols-on-intestinal-barrier-and-immune-function-in-weaned-lambs
#36
JOURNAL ARTICLE
Yuewen Xu, Fuquan Yin, Jialin Wang, Pengxin Wu, Xiaoyuan Qiu, Xiaolin He, Yimei Xiao, Shangquan Gan
INTRODUCTION: The purpose of this study was to explore the effects of tea polyphenols on growth performance, cytokine content, intestinal antioxidant status and intestinal barrier function of lambs, in order to provide reference for intestinal health of ruminants. METHODS: Thirty weaned lambs (average initial weight 9.32 ± 1.72 kg) were randomly divided into five groups with six lambs in each group. The control group did not add anything but the basic diet mainly composed of Pennisetum and Corn, and the other four groups added 2, 4, 6 g/kg tea polyphenols and 50 mg/kg chlortetracycline to the basic diet, respectively...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38430265/differential-patterns-of-functional-connectivity-in-tremor-dominant-parkinson-s-disease-and-essential-tremor-plus
#37
JOURNAL ARTICLE
Shweta Prasad, Jitender Saini, Rose Dawn Bharath, Pramod Kumar Pal
Tremor dominant Parkinson's disease (TDPD) and essential tremor plus (ETP) syndrome are commonly encountered tremor dominant neurological disorders. Although the basal ganglia thalamocortical (BGTC) and cerebello thalamocortical (CTC) networks are implicated in tremorogenesis, the extent of functional connectivity alterations across disorders is uncertain. This study aims to evaluate functional connectivity of the BGTC and CTC in TDPD and ETP. Resting state functional MRI was acquired for 25 patients with TDPD, ETP and 22 healthy controls (HC)...
March 2, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38430012/the-role-of-mir96-in-predicting-ctc-status-and-prognostic-evaluation-in-gastric-cancer-patients
#38
JOURNAL ARTICLE
Qi Zheng, Haiyan Ge
In this study, 20 patients clinically diagnosed with advanced gastric cancer were selected as subjects. Circulating tumor cells (CTCs) in the peripheral blood of gastric cancer patients were detected and counted by collecting peripheral blood samples at Ningbo No. 2 Hospital and using the Cell Rich TM system combined with a negative enrichment strategy. In addition, routine pathological examination and immunohistochemical staining were performed on surgical specimens, including HER2, EBER, E-cadherin, and vimentin indicators...
February 29, 2024: Cellular and Molecular Biology
https://read.qxmd.com/read/38427120/research-progress-on-the-multi-omics-and-survival-status-of-circulating-tumor-cells
#39
REVIEW
Qingming Xie, Shilei Liu, Sai Zhang, Liqiu Liao, Zhi Xiao, Shouman Wang, Pengfei Zhang
In the dynamic process of metastasis, circulating tumor cells (CTCs) emanate from the primary solid tumor and subsequently acquire the capacity to disengage from the basement membrane, facilitating their infiltration into the vascular system via the interstitial tissue. Given the pivotal role of CTCs in the intricate hematogenous metastasis, they have emerged as an essential resource for a deeper comprehension of cancer metastasis while also serving as a cornerstone for the development of new indicators for early cancer screening and new therapeutic targets...
March 1, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38425405/prognostic-value-of-circulating-tumor-cells-combined-with-neutrophil-lymphocyte-ratio-in-patients-with-hepatocellular-carcinoma
#40
JOURNAL ARTICLE
Jia-Li Chen, Lu Guo, Zhen-Ying Wu, Kun He, Han Li, Chi Yang, Yun-Wei Han
BACKGROUND: Circulating tumor cell (CTC) count and neutrophil-to-lymphocyte ratio (NLR) are both closely associated with the prognosis of hepatocellular carcinoma (HCC). AIM: To investigate the prognostic value of combining these two indicators in HCC. METHODS: Clinical data were collected from patients with advanced HCC who received immune therapy combined with targeted therapy at the Department of Oncology, the Affiliated Hospital of Southwest Medical University, Sichuan, China, from 2021 to 2023...
February 15, 2024: World Journal of Gastrointestinal Oncology
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