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https://read.qxmd.com/read/30878464/a-retrospective-analysis-of-data-from-forensic-toxicology-at-the-academy-of-forensic-science-in-2017
#1
Meiru Pan, Xin Wang, Yunli Zhao, Wei Liu, Ping Xiang
Knowing the specific pattern of forensic toxicology cases in a region is vital to help the local government establish an effective prevention and treatment system; currently, there have been no published reports investigating various types of forensic toxicology cases based on a large autopsy series and city size. The data in this study were obtained from records kept at the Academy of Forensic Science (AFS) between February 2017 and December 2017, and the cases were mainly from the Public Security Organs People's Police in Shanghai, China...
February 28, 2019: Forensic Science International
https://read.qxmd.com/read/30878247/feline-herpesvirus-vectored-rabies-vaccine-in-cats-a-dual-protection
#2
Teng Chen, Xintao Zhou, Yu Qi, Lijuan Mi, Xuefei Sun, Shoufeng Zhang, Ye Liu, Victoria Olson, Wei Qiu, Xianfu Wu, Rongliang Hu
In China, cats cause about 5% of human rabies cases. Rabies control in cats plays a role in achieving the ultimate goal of elimination of dog rabies-mediated human deaths. However, there is no cat-specific rabies vaccine in China yet. In this study, we constructed a recombinant rabies vaccine by using a felid herpesvirus 1 (FHV-1) isolate, and deleted the gI/E in the FHV-1 and replaced the region with a glycoprotein (G) of rabies virus (RABV) strain BD06 through homologous recombination. The recombinant virus FHV-RVG was recovered and purified, and the expression of RABV glycoprotein was verified by indirect immunofluorescent assay...
March 13, 2019: Vaccine
https://read.qxmd.com/read/30876707/trends-in-cause-specific-mortality-among-children-aged-5-14-years-from-2005-to-2016-in-india-china-brazil-and-mexico-an-analysis-of-nationally-representative-mortality-studies
#3
Shaza A Fadel, Cynthia Boschi-Pinto, Shicheng Yu, Luz Myriam Reynales-Shigematsu, Geetha R Menon, Leslie Newcombe, Kathleen L Strong, Qiqi Wang, Prabhat Jha
BACKGROUND: With global survival increasing for children younger than 5 years of age, attention is required to reduce the approximately 1 million deaths of children aged 5-14 years occurring every year. Causes of death at these ages remain poorly documented. We aimed to explore trends in mortality by causes of death in India, China, Brazil, and Mexico, which are home to about 40% of the world's children aged 5-14 years and experience more than 200 000 deaths annually at these ages. METHODS: We examined data on 244 401 deaths in children aged 5-14 years from four nationally representative data sources that obtained direct distributions of causes of death: the Indian Million Death Study, the Chinese Disease Surveillance Points, mortality data from the Mexican Instituto Nacional de Estadística y Geografía, and mortality data from the Brazilian Institute of Geography and Statistics...
March 8, 2019: Lancet
https://read.qxmd.com/read/30870407/risk-factors-for-congenital-syphilis-transmitted-from-mother-to-infant-suzhou-china-2011-2014
#4
Yajie Wang, Minzhi Wu, Xiangdong Gong, Liang Zhao, Jing Zhao, Chuanwu Zhu, Chancong Gong
Mother-to-child transmission of syphilis remains a major global public health issue, and elimination of congenital syphilis is one of the millennium development goals of the World Health Organization (1). In 2012, an estimated 930,000 maternal syphilis infections caused 350,000 adverse pregnancy outcomes, including 143,000 early fetal deaths and stillbirths, 62,000 neonatal deaths, 44,000 preterm or low-weight births, and 102,000 infected infants worldwide (2). In China, the number of congenital syphilis cases reported annually increased from 468 in 2000 to 10,032 in 2013; the corresponding national congenital syphilis incidence rate increased nearly 26-fold, from 2...
March 15, 2019: MMWR. Morbidity and Mortality Weekly Report
https://read.qxmd.com/read/30865505/injury-prevention-in-china-government-supported-initiatives-on-the-leading-causes-of-injury-related-deaths
#5
Liping Li, Jingzhen Yang
No abstract text is available yet for this article.
April 2019: American Journal of Public Health
https://read.qxmd.com/read/30865215/burden-of-cardiovascular-diseases-in-china-1990-2016-findings-from-the-2016-global-burden-of-disease-study
#6
Shiwei Liu, Yichong Li, Xinying Zeng, Haidong Wang, Peng Yin, Lijun Wang, Yunning Liu, Jiangmei Liu, Jinlei Qi, Sha Ran, Shiya Yang, Maigeng Zhou
Importance: Cardiovascular disease (CVD) remains the top cause of death in China. To our knowledge, no consistent and comparable assessments of CVD burden have been produced at subnational levels, and little is understood about the spatial patterns and temporal trends of CVD in China. Objective: To determine the national and province-level burden of CVD from 1990 to 2016 in China. Design, Setting, and Participants: Following the methodology framework and analytical strategies used in the 2016 Global Burden of Disease study, the mortality, prevalence, and disability-adjusted life-years (DALYs) of CVD in the Chinese population were examined by age, sex, and year and according to 10 subcategories...
March 13, 2019: JAMA Cardiology
https://read.qxmd.com/read/30863118/development-of-treatment-options-for-chinese-patients-with-advanced-squamous-cell-lung-cancer-focus-on-afatinib
#7
REVIEW
Shun Lu
Lung cancer is the leading cause of cancer death in China, and approximately one third of these cancers are squamous cell carcinoma (SqCC) of the lung. Ethnic diversity and country-specific environmental factors can account for interindividual variations in response to and tolerability of anticancer therapies. Although several targeted therapies have recently been approved for patients with relapsed/refractory SqCC of the lung, only afatinib, an irreversible ErbB family blocker, has data of Chinese patients...
2019: OncoTargets and Therapy
https://read.qxmd.com/read/30861472/forensic-entomology-application-in-china-four-case-reports
#8
Man Wang, Jun Chu, Yu Wang, Fagui Li, Mingqing Liao, He Shi, Yingna Zhang, Guoliang Hu, Jiangfeng Wang
We present four cases that use entomological data to estimate postmortem interval (PMI). In the first case, the body was found in an outdoor environment at 26 °C and was at the fresh stage. However, the PMImin estimated using maggots collected from the corpse was more than 68 h. This was certainly an incorrect estimation because the degree of the body decomposition was light, and it may have been caused by flies invading the corpse before death occurred. In the second case, a corpse of an adult male was found in a semi-closed room, and the body was highly decomposed and mummified...
March 5, 2019: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/30858617/causal-associations-of-blood-lipids-with-risk-of-ischemic-stroke-and-intracerebral-hemorrhage-in-chinese-adults
#9
Luanluan Sun, Robert Clarke, Derrick Bennett, Yu Guo, Robin G Walters, Michael Hill, Sarah Parish, Iona Y Millwood, Zheng Bian, Yiping Chen, Canqing Yu, Jun Lv, Rory Collins, Junshi Chen, Richard Peto, Liming Li, Zhengming Chen
Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China1,2 . Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS1,2 . Stroke incidence and ICH proportion are higher in China than in Western populations3-5 , despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Observational studies reported weaker positive associations of LDL-C with IS than with coronary heart disease (CHD)6,7 , but LDL-C-lowering trials demonstrated similar risk reductions for IS and CHD8-10 ...
March 11, 2019: Nature Medicine
https://read.qxmd.com/read/30855460/the-burden-of-air-pollution-and-weather-condition-on-daily-respiratory-deaths-among-older-adults-in-china-jinan-from-2011-to-2017
#10
Wan-Mei Song, Yi Liu, Jin-Yue Liu, Ning-Ning Tao, Yi-Fan Li, Yao Liu, Liu-Xin Wang, Huai-Chen Li
The health effects of short-term exposure to air pollutants on respiratory deaths and its modifiers such as meteorological indexes have been widely investigated. However, most of the previous studies are limited to single pollutants or total respiratory deaths, and their findings are inconsistent.To comprehensively examine the short-term effects of air pollutants on daily respiratory mortality.Our analysis included 16,931 nonaccidental respiratory deaths (except lung cancer and tuberculosis) among older adults (>65 years) from 2011 to 2017 in Jinan, China...
March 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30855427/the-distributional-characteristic-and-growing-trend-of-pancreatic-cancer-in-china
#11
Chengfei Zhao, Feng Gao, Quwen Li, Qicai Liu, Xinhua Lin
Pancreatic cancer is a malignant tumor with difficulty in diagnosis and treatment and was the sixth leading cause of cancer death among both men and women in China. The 5-year relative survivals of pancreatic cancer were only 7.2% in China and the lowest level in all cancers. The proportion of estimated new cases of pancreatic cancer in China was comparatively high in East China, Northeast, North China, and Northwest and relatively low in Central China, Southwest, and South China, showing obvious regional characteristics...
March 2019: Pancreas
https://read.qxmd.com/read/30854128/transarterial-chemoembolization-tace-combined-with-sorafenib-versus-tace-alone-for-unresectable-hepatocellular-carcinoma-a-propensity-score-matching-study
#12
Baosheng Ren, Wansheng Wang, Jian Shen, Wanci Li, Caifang Ni, Xiaoli Zhu
Objective : To compare the outcomes of transarterial chemoembolization (TACE) combined with sorafenib versus TACE alone for treating patients with unresectable hepatocellular carcinoma (HCC). Methods : This retrospective analysis included all patients receiving either TACE plus sorafenib therapy or TACE alone for unresectable HCC between February 2008 and August 2015 at the First Affiliated Hospital of Soochow University, China. Propensity score matching (PSM) was carried out to reduce bias due to confounding variables...
2019: Journal of Cancer
https://read.qxmd.com/read/30850023/optimal-strategy-of-primary-percutaneous-coronary-intervention-for-acute-myocardial-infarction-due-to-unprotected-left-main-coronary-artery-occlusion-optimal-study-protocol-for-a-randomised-controlled-trial
#13
Yang Gao, Feng Zhang, Chenguang Li, Yuxiang Dai, Ji'e Yang, Ya'nan Qu, Juying Qian, Junbo Ge
BACKGROUND: Primary percutaneous coronary intervention (PCI) for patients presenting with acute myocardial infarction (AMI) caused by left main coronary artery occlusion is associated with significantly higher mortality and risks of major adverse cardiovascular events. Deferred stent implantation may improve prognosis of primary PCI by reducing distal embolization and no-reflow phenomenon. There is no randomized clinical trial focusing on the effect and outcome of deferred stent implantation on primary PCI for left main coronary artery occlusion in contrast with conventional strategy...
March 8, 2019: Trials
https://read.qxmd.com/read/30841410/effects-of-heat-on-first-ever-strokes-and-the-effect-modification-of-atmospheric-pressure-a-time-series-study-in-shenzhen-china
#14
Junzhe Bao, Yanfang Guo, Qiong Wang, Yiling He, Rui Ma, Junjie Hua, Chengsheng Jiang, Marco Morabito, Lin Lei, Ji Peng, Cunrui Huang
BACKGROUND: Stroke is a leading cause of death globally. Extreme temperatures may induce stroke, but evidence on the effects of heat on first-ever strokes is not clear. Low air pressure can lead to depression and an increase in blood pressure, and it may exacerbate the health impact of heat. In this study, we aimed to evaluate the effects of heat on first-ever strokes, the possible sensitive populations, and the effect of modification of atmospheric pressure. METHODS: We collected data on 142,569 first-ever strokes during 2005-2016 in Shenzhen, a coastal city in southern China, with subtropical oceanic monsoon climate...
March 1, 2019: Science of the Total Environment
https://read.qxmd.com/read/30825772/a-retrospective-study-of-poisoning-deaths-from-forensic-autopsy-cases-in-northeast-china-liaoning
#15
Lin-Lin Wang, Miao Zhang, Wei Zhang, Bing-Xuan Li, Ru-Bo Li, Bao-Li Zhu, Xu Wu, Da-Wei Guan, Guo-Hua Zhang, Rui Zhao
Acute poisoning is a public health threat that leads to morbidity and mortality worldwide. In this retrospective study, we evaluated autopsies from deaths caused by acute poisoning from 2008 to 2017 at the School of Forensic Medicine, China Medical University (SFMCMU) in the Liaoning Province, northeast China. A total of 140 poisoning deaths were investigated and the demographic characteristics, causes and manner of death, toxics category were analyzed. The number of poisoning deaths gradually increased during the study period...
February 21, 2019: Journal of Forensic and Legal Medicine
https://read.qxmd.com/read/30824328/factors-influencing-mortality-in-hospital-acquired-pneumonia-caused-by-gram-negative-bacteria-in-china
#16
Ding-Yun Feng, Yu-Qi Zhou, Xiao-Ling Zou, Mi Zhou, Wen-Bin Wu, Xiao-Xia Chen, Yan-Hong Wang, Tian-Tuo Zhang
BACKGROUND: Hospital-acquired pneumonia (HAP) remains an important cause of morbidity and mortality despite advances in antimicrobial therapy. The emergence of Gram-negative bacteria (GNB) is of major concern. The objective of this study was to describe the epidemiology, microbiology, and predictors of infection-related 30-day mortality in HAP with GNB. METHODS: We performed a retrospective, single-center analysis of HAP patients with GNB occurring from January 2014 and December 2017...
February 26, 2019: Journal of Infection and Public Health
https://read.qxmd.com/read/30822665/hemolymph-and-transcriptome-analysis-to-understand-innate-immune-responses-to-hypoxia-in-pacific-abalone
#17
Yawei Shen, Zekun Huang, Guangmou Liu, Caihuan Ke, Weiwei You
Hypoxia was thought to inhibit immune responses, causing severe mortality to marine organisms. The Pacific abalone, Haliotis discus hannai, is the most widely cultured abalone species in China, but suffering from "summer mortality" in which hypoxia has been one of the main reasons. The effect of hypoxia exposure on immune responses in H. discus hannai was investigated, including cellular immune response using flow cytometry and transcriptome profiles. The influence of hypoxia treatment on the total hemocyte count (THC) of H...
February 6, 2019: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://read.qxmd.com/read/30822387/evidence-for-urban-rural-disparity-in-temperature-mortality-relationships-in-zhejiang-province-china
#18
Kejia Hu, Yuming Guo, Stefan Hochrainer-Stigler, Wei Liu, Linda See, Xuchao Yang, Jieming Zhong, Fangrong Fei, Feng Chen, Yunquan Zhang, Qi Zhao, Gongbo Chen, Qian Chen, Yizhe Zhang, Tingting Ye, Lu Ma, Shanshan Li, Jiaguo Qi
BACKGROUND: Temperature-related mortality risks have mostly been studied in urban areas, with limited evidence for urban-rural differences in the temperature impacts on health outcomes. OBJECTIVES: We investigated whether temperature-mortality relationships vary between urban and rural counties in China. METHODS: We collected daily data on 1 km gridded temperature and mortality in 89 counties of Zhejiang Province, China, for 2009 and 2015...
March 2019: Environmental Health Perspectives
https://read.qxmd.com/read/30819828/retrospect-and-prospect-for-lung-cancer-in-china-clinical-advances-of-immune-checkpoint-inhibitors
#19
Shun Lu, Yongfeng Yu, Yi Yang
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer-related deaths in China. The recent emergence of immunotherapy treatment options, such as the use of programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) checkpoint inhibitors, has also led to a paradigm shift in the treatment of non-small cell lung cancer, and has provided promising directions for the treatment of small cell lung cancer. This review provides a summary of the developmental process of immunotherapy, especially immune checkpoint inhibitors in lung cancer, ongoing international and domestic clinical trials in this field, and the challenges and considerations related to the use of immunotherapy in Chinese patients with lung cancer, with the aim of providing detailed information for future immunotherapy-related clinical trials in China...
February 2019: Oncologist
https://read.qxmd.com/read/30816516/protective-effect-of-troxerutin-and-cerebroprotein-hydrolysate-injection-on-cerebral-ischemia-through-inhibition-of-oxidative-stress-and-promotion-of-angiogenesis-in-rats
#20
Wenbing Ma, Shixiang Wang, Xuanlin Liu, Fengru Tang, Peipei Zhao, Kai Cheng, Qiaowei Zheng, Yingchen Zhuo, Xue Zhao, Xueqian Li, Weiyi Feng
Brain ischemia, including cerebral ischemia and cerebrovascular ischemia, leads to poor oxygen supply or cerebral hypoxia, and causes brain tissue death or cerebral infarction/ischemic stroke. The troxerutin and cerebroprotein hydrolysate injection (TCHI), is widely applied in China to improve blood supply in ischemic brain tissues and to enhance neuroprotective effects in clinical practice. However, the benefits and detailed underlying mechanism elaborating the effectiveness of TCHI in cerebrovascular diseases require further investigation...
February 15, 2019: Molecular Medicine Reports
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