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Ragab A Mahfouz, Mohammad Gouda, Mohamed S Ghareb, Islam Galal
OBJECTIVE: We aimed to investigate the relation between the presence of fragmented QRS (FQRS) and exercise intolerance as assessed by 6 minute walking test (6MWT) and its association with coronary flow reserve (CFR). METHODS: One hundred and twenty patients with hypertension (age: 47.3 + 6.9) who were never treated and without left ventricular hypertrophy underwent 6MWT. Echocardiographic examination was obtained for all patients. CFR was calculated as the hyperemic to baseline mean velocity ratio (hyperemia was induced by intravenous adenosine 0...
January 22, 2019: Blood Pressure
Lütfü Bekar, Macit Kalçık, Muzaffer Katar, Mucahit Yetim, Oğuzhan Çelik, Tolga Doğan, Yusuf Karavelioğlu, Zehra Gölbaşı
OBJECTIVE: Fragmented QRS (fQRS) detected on a 12-lead electrocardiogram (ECG) has been demonstrated to be a marker of myocardial fibrosis. Intercellular adhesion molecule-1 (ICAM-1) is a protein which plays an important role in fibro-inflammatory processes. In this study, we aimed to investigate the relationship between ICAM-1 levels and the presence of fQRS in hypertensive patients. METHODS: Ninety consecutive patients who were diagnosed with hypertension were included in the study...
January 16, 2019: Acta Cardiologica
Lütfü Bekar, Macit Kalçık, Oğuzhan Çelik, Çağlar Alp, Mucahit Yetim, Tolga Doğan, İsmail Ekinözü, Osman Karaarslan, Volkan Çamkıran, Yusuf Karavelioğlu, Zehra Gölbaşı
BACKGROUND: Epicardial adipose tissue (EAT) is a cardiometabolic risk factor, and its possible relationship with hypertension has been reported previously. Fragmented QRS (fQRS) detected on electrocardiography (ECG) has been demonstrated to be a marker of myocardial fibrosis. In this study, we aimed to investigate the relationship between the thickness of EAT, and presence of fQRS in hypertensive patients. METHODS: Consecutive patients who were diagnosed with hypertension were included in the study...
January 4, 2019: Journal of Clinical Ultrasound: JCU
Aneesh C Ratheendran, Muthiah Subramanian, Devi K Bhanu, Mukund A Prabhu, Rajesh Kannan, K U Natarajan, S Saritha Sekhar, Rajesh Thachathodiyil, M S Harikrishnan, Praveen G Pai
BACKGROUND: Fragmented QRS (fQRS) and Q waves are ECG findings in patients with myocardial scar. fQRS is more sensitive than pathological Q waves in detecting myocardial fibrosis in patients with coronary artery disease (CAD). Cardiac magnetic resonance (CMR) imaging is used for the diagnosis and for quantifying scar tissue in patients with HCM. Our aim was to correlate ECG parameters like fQRS and Q waves with the presence of late gadolinium enhancement (LGE) assessed by contrast CMR imaging to elucidate ECG markers which might predict scar tissue in HCM...
January 3, 2019: Acta Cardiologica
Hyun Jun Cho, Jae Yong Yoon, Namkyun Kim, Se Yong Jang, Myung Hwan Bae, Jang Hoon Lee, Dong Heon Yang, Hun Sik Park, Yongkeun Cho, Shung Chull Chae
BACKGROUND: A fragmented QRS complex (fQRS) is caused by conduction abnormalities of the ventricle secondary to myocardial ischemia and/or scar in patients with myocardial infarction. However, the implications of the fQRS in the development of coronary artery disease with myocardial ischemia in those without a scar remain unknown. METHODS: We studied electrocardiograms (ECGs) obtained from 150 patients (60.5±8.5 years, 102 men) with myocardial ischemia, which was confirmed by performing both, a nuclear exercise stress test and coronary angiography...
December 31, 2018: Clinical Cardiology
Sepideh Hekmat, Leili Pourafkari, Mojan Ahmadi, Mohammad Reza Chavoshi, Bijan Zamani, Nader D Nader
BACKGROUND: Fragmented QRS (FQRS) on surface electrocardiogram (ECG) is associated with the presence of myocardial scar tissue and may have prognostic value after certain ischemic events. We aimed to examine the anatomical correlation of FQRS with the presence of perfusion abnormalities in patients with suspected coronary artery disease (CAD). METHODS: Patients without a known history of CAD, who were referred for myocardial perfusion imaging (MPI) between January 2016 and May 2016, were enrolled...
December 2018: Indian Heart Journal
Sridharan Umapathy, Rakesh Yadav, Kewal C Goswami, Ganesan Karthikeyan, Neeraj Parakh, Vinay K Bahl
BACKGROUND & OBJECTIVES: This longitudinal study was carried out to evaluate the prognostic significance of fragmented QRS (fQRS) in patients with acute ST elevation myocardial infarction (STEMI) undergoing revascularization. METHODS: This study included 103 STEMI patients belonging to Killip class I and II who underwent primary revascularization. All patients underwent twelve lead ECG at admission before PCI. Serial ECG were done after PCI at 3 hours, 6 hours, 24 hours, 48 hours and at discharge for detection of fQRS and echocardiography on day 3 post revascularization...
December 2018: Indian Heart Journal
Mehmet Eyuboglu, Bahri Akdeniz
BACKGROUND: Fragmented QRS (fQRS) is a sign of adverse cardiovascular events in various cardiovascular diseases. It is also associated with increased blood pressure and non-dipping in hypertensive patients. However, no study has investigated the importance of fQRS in prehypertensive patients. OBJECTIVES: The aim of our study is to investigate the relationship between fQRS and non-dipper status in prehypertensive patients. METHODS: Two hundred and sixteen eligible, newly diagnosed prehypertensive patients who underwent 24-hour ambulatory blood pressure monitoring (ABPM) for further evaluation of blood pressure between June 2015 and July 2016 were included into the study...
December 17, 2018: Arquivos Brasileiros de Cardiologia
Kevin M W Leong, Fu Siong Ng, Sian Jones, Ji-Jian Chow, Norman Qureshi, Michael Koa-Wing, Nicholas W F Linton, Zachary I Whinnett, David C Lefroy, David Wyn Davies, Phang Boon Lim, Nicholas S Peters, Prapa Kanagaratnam, Amanda M Varnava
INTRODUCTION: A spontaneous type I electrocardiogram (ECG) pattern and/or unheralded syncope are conventionally used as risk markers for primary prevention of sudden cardiac arrest/death (SCA/SCD) in Brugada syndrome (BrS). In this study, we determine the prevalence of conventional and newer markers of risk in those with and without previous aborted SCA events. METHODS: All patients with BrS were identified at our institute. History of symptoms was obtained from medical tests or from interviews...
February 2019: Pacing and Clinical Electrophysiology: PACE
Adil Bayramoğlu, Hakan Taşolar, Osman Bektaş, Ahmet Kaya, Zeki Yüksel Günaydın
OBJECTIVE: Smoking is a known risk factor for cardiovascular diseases and may cause myocardial damage independently of coronary artery disease. Fragmented QRS (fQRS) is an important marker of myocardial fibrosis, while speckle-tracking echocardiography is a method used to show subclinical left ventricle dysfunction. METHODS: Our study included 230 healthy individuals aged 18-40 years. The patients included were separated into two groups: those smokers (n = 130) and non-smokers (n = 100)...
December 18, 2018: Echocardiography
Nuray Kahraman Ay, Asim Enhos, Yasin Ay, Nijad Bakhshaliyev, Aydin Nadir, Erdem Karacop, Ilke Celikkale, Mahmut Uluganyan, Razaman Ozdemir, Omer Goktekin
BACKGROUND: Although transcatheter aortic valve implantation (TAVI) can successfully correct aortic narrowing, pre-existing pathophysiological alterations in the left ventricle are still a concern in terms of long-term mortality. This study aimed to examine the predictive role of fQRS morphology on long-term prognosis in patients undergoing TAVI due to severe aortic stenosis. METHODS: A total of 117 patients undergoing TAVI due to severe aortic stenosis were included in this retrospective cohort study...
November 2018: Journal of Electrocardiology
Kenichi Hashimoto, Bonpei Takase, Masaaki Nagashima, Yuji Kasamaki, Hiroaki Shimabukuro, Masayoshi Soma, Tomohiro Nakayama
BACKGROUND: A novel signal-averaged electrocardiogram (SAECG) device and a novel ambulatory SAECG device are clinically available, but reference values have not been established. This study aimed to validate the novel SAECG and the novel ambulatory-based SAECG devices by comparison with the conventional SAECG device. METHODS AND RESULTS: High-resolution SAECGs were recorded consecutively in 83 healthy volunteers using the 3 devices. A novel ambulatory SAECG device was used as real-time recording within 15 min for validation study (15 min ambulatory-based SAECG)...
November 2018: Journal of Electrocardiology
Osman Bektaş, Ahmet Karagöz, Adil Bayramoğlu, Erdal Benli, Zeki Yüksel Günaydın, Mehmet Yaman, Ahmet Kaya
Purpose: The aim of this study was to investigate the association between fragmented QRS and left ventricular (LV) systolic function in patients with erectile dysfunction (ED). Methods: A total of 106 patients with ED and without a history of coronary artery disease (CAD) were compared with 54 age- and gender-matched healthy controls. LV systolic function was evaluated using speckle tracking echocardiography via global longitudinal strain (GLS) and global circumferential strain (GCS)...
November 2018: Acta Cardiologica Sinica
Chayapat Tangwiwat, Yodying Kaolawanich, Rungroj Krittayaphong
BACKGROUND: Electrocardiography (ECG) may be an efficacious diagnostic and prognostic tool in hypertrophic cardiomyopathy (HCM). This study aimed to investigate association between deep T-wave inversion (TWI) and apical HCM, and between fragmented QRS (fQRS) complex and myocardial fibrosis in patients with HCM. METHODS: Patients with documented HCM by cardiac magnetic resonance imaging (CMR) during 2005-2015 were studied. The 12-lead ECG and CMR were performed on the same day...
November 7, 2018: Annals of Noninvasive Electrocardiology
Griet Goovaerts, Sibasankar Padhy, Bert Vandenberk, Carolina Varon, Rik Willems, Sabine Van Huffel
OBJECTIVE: Fragmented QRS (fQRS) is an accessible biomarker and indication of myocardial scarring that can be detected from the electrocardiogram (ECG). Nowadays, fQRS scoring is done on a visual basis, which is time-consuming and leads to subjective results. This study proposes an automated method to detect and quantify fQRS in a continuous way using features extracted from Variational Mode Decomposition (VMD) and Phase-Rectified Signal Averaging (PRSA). METHODS: In the proposed framework, QRS complexes in the ECG signals were first segmented using VMD...
October 29, 2018: IEEE Journal of Biomedical and Health Informatics
Chanavuth Kanitsoraphan, Pattara Rattanawong, Poemlarp Mekraksakit, Pakawat Chongsathidkiet, Tanawan Riangwiwat, Napatt Kanjanahattakij, Wasawat Vutthikraivit, Saranapoom Klomjit, Subhanudh Thavaraputta
BACKGROUND: Recent studies suggested that fragmented (fQRS) is associated with poor clinical outcomes in heart failure with reduced ejection fraction (HFrEF) patients. However, no systematic review or meta-analysis has been done. We conducted a systematic review and meta-analysis to assess the association between baseline fQRS and all-cause mortality in HFrEF. METHODS: We comprehensively reviewed the databases of MEDLINE and EMBASE from inception to February 2018...
October 17, 2018: Annals of Noninvasive Electrocardiology
Bert Vandenberk, M Juhani Junttila, Tomas Robyns, Christophe Garweg, Joris Ector, Heikki V Huikuri, Rik Willems
BACKGROUND: Sudden cardiac death (SCD) results from a complex interplay of abnormalities in autonomic function, myocardial substrate and vulnerability. We studied whether a combination of noninvasive risk stratification tests reflecting these key players could improve risk stratification. METHODS: Patients implanted with an ICD in whom 24-hr holter recordings were available prior to implant were included. QRS fragmentation (fQRS) was selected as measure of myocardial substrate and a high ventricular premature beat count (VPB >10/hr) for arrhythmic vulnerability...
September 28, 2018: Annals of Noninvasive Electrocardiology
Anna Kucharz, Piotr Kułakowski
BACKGROUND: Incidence of fragmented (fQRS) and predisposing factors in patients with implantable cardioverter-defibrillator (ICD) have not yet been established. Aim To examine incidence of fQRS, associated factors as well as predictive value in identifying site of coronary artery disease (CAD). METHODS: Consecutive patients with ICD. Retrospective analysis of demographic, clinical and ECG data. RESULTS: Of 382 patients, 163 (43%) had fQRS...
September 2018: Journal of Electrocardiology
Mehmet Eyuboglu, Akar Yilmaz, Onur Dalgic, Caner Topaloglu, Yavuz Karabag, Bahri Akdeniz
BACKGROUND: Fragmented QRS (fQRS) as a sign of myocardial fibrosis indicates adverse outcomes in various cardiovascular diseases. However, there are no clear data regarding relationship between obesity and fQRS. We aimed to investigate whether high body mass index (BMI) predicts fQRS on electrocardiography (ECG) independent of underlying cardiovascular status. METHODS: A total of 1530 patients were included into the study. Patients were divided into three groups according to BMI (normal, overweight and obese)...
September 2018: Journal of Electrocardiology
Mahmut Yesin, Metin Çağdaş, Macit Kalçık, İbrahim Rencüzoğulları, Yavuz Karabağ, Mustafa Ozan Gürsoy, Süleyman Karakoyun
BACKGROUND: Even though the relationship between syntax score (SS) and fragmented QRS (fQRS) has been studied, the relation between syntax score II (SS II) and fQRS in patients with ST elevation myocardial infarction (STEMI) is undefined. We aimed to define the relationship between fQRS and SS II for the evaluation of extension and complexity of coronary artery disease. MATERIAL AND METHODS: This study enrolled 167 patients undergoing primary percutaneous coronary intervention (pPCI) for STEMI...
September 2018: Journal of Electrocardiology
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