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https://read.qxmd.com/read/30779459/building-blocks-for-thoracic-mri-challenges-sequences-and-protocol-design
#1
REVIEW
Constantine A Raptis, Daniel R Ludwig, Mark M Hammer, Antonio Luna, Jordi Broncano, Travis S Henry, Sanjeev Bhalla, Jeanne B Ackman
Thoracic MRI presents important and unique challenges. Decreased proton density in the lung in combination with respiratory and cardiac motion can degrade image quality and render poorly executed sequences uninterpretable. Despite these challenges, thoracic MRI has an important clinical role, both as a problem-solving tool and in an increasing array of clinical indications. Advances in scanner and sequence design have also helped to drive this development, presenting the radiologist with improved techniques for thoracic MRI...
February 19, 2019: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/30772224/prognostic-role-of-cardiac-mri-and-conventional-risk-factors-in-myocardial-infarction-with-nonobstructed-coronary-arteries
#2
Amardeep Ghosh Dastidar, Anna Baritussio, Estefania De Garate, Zsofia Drobni, Giovanni Biglino, Priyanka Singhal, Elena G Milano, Gianni D Angelini, Stephen Dorman, Julian Strange, Thomas Johnson, Chiara Bucciarelli-Ducci
OBJECTIVES: This study sought to assess the prognostic impact of cardiovascular magnetic resonance (CMR) and conventional risk factors in patients with myocardial infarction with nonobstructed coronaries (MINOCA). BACKGROUND: Myocardial infarction with nonobstructed coronary arteries (MINOCA) represents a diagnostic dilemma, and the prognostic markers have not been clarified. METHODS: A total of 388 consecutive patients with MINOCA undergoing cardiac magnetic resonance (CMR) assessment were identified retrospectively from a registry database and prospectively followed for a primary clinical endpoint of all-cause mortality...
February 11, 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/30764853/persistent-exercise-limitation-after-successful-pulmonary-endoarterectomy-frequency-and-determinants
#3
Angelo G Corsico, Andrea M D'Armini, Valentina Conio, Antonio Sciortino, Maurizio Pin, Valentina Grazioli, Giulia Di Vincenzo, Rita Di Domenica, Anna Celentano, Benedetta Vanini, Amelia Grosso, Erica Gini, Federica Albicini, Vera N Merli, Vanessa Ronzoni, Stefano Ghio, Catherine Klersy, Isa Cerveri
BACKGROUND: After successful pulmonary endoarterectomy (PEA), patients may still suffer from exercise limitation, despite normal pulmonary vascular resistance. We sought to assess the proportion of these patients after the extension of PEA to frail patients, and the determinants of exercise limitation. METHODS: Out of 553 patients treated with PEA from 2008 to 2016 at our institution, a cohort of 261 patients was followed up at 12 months. They underwent clinical, haemodynamic, echocardiographic, respiratory function tests and treadmill exercise testing...
February 14, 2019: Respiratory Research
https://read.qxmd.com/read/30747764/adherence-to-nstemi-guidelines-in-the-emergency-department-regression-to-reality
#4
Harel Gilutz, Sevatlana Shindel, Ilana Shoham-Vardi
BACKGROUND: Adherence to guidelines for the initial treatment of ST-Segment Elevation Myocardial Infarction has been thoroughly studied, whereas the study of emergency department (ED) adherence to guidelines for Non-ST-Segment Elevation Myocardial Infarction-Acute Coronary Syndrome (NSTEMI-ACS) has been much scarcer. The recommended guidelines for the initial prompt workup and treatment of NSTEMI-ACS remains a challenge. AIM: We studied adherence to guidelines for NSTEMI in the ED...
March 2019: Critical Pathways in Cardiology
https://read.qxmd.com/read/30745592/comparison-of-electroglottographic-variability-index-in-euphonic-and-pathological-voice
#5
A Nacci, S O Romeo, M D Cavaliere, A Macerata, L Bastiani, G Paludetti, J Galli, M R Marchese, M R Barillari, U Barillari, S Berrettini, C Laschi, M Cianchetti, M Manti, F Ursino, B Fattori
In a recent study we introduced a new approach for analysis of the electroglottographic (ECG) signal. This method is based on the evaluation of variation of the EGG signal and its first derivative, through new software developed by the Pisan phoniatric school. This software is designed to extract quantitative indices related to the contacting and decontacting phases of the vocal folds during phonation. The software allows us to study the combined variability of vibration amplitude and velocity (i.e. the first derivative of the EGG signal)...
January 31, 2019: Acta Otorhinolaryngologica Italica
https://read.qxmd.com/read/30741702/a-study-into-the-feasibility-of-using-hrv-variables-to-guide-treatment-in-patients-with-paroxystic-sympathetic-hyperactivity-in-a-neurointensive-step-down-unit
#6
H Honoré, K Eggertsen, S Sondergaard
BACKGROUND: Patients suffering brain injury may experience paroxystic sympathetic hyperactivity, presenting diagnostic and therapeutic challenges in neurointensive rehabilitation. The syndrome has been modelled as peripheral and central excitatory:inhibitory ratios of autonomous nervous activity. Another model represents the symptoms as oscillations of the two components of the autonomous nervous system. In therapeutic framework, the syndrome is perceived as the patient misconstruing sensory input relating body positioning...
February 4, 2019: NeuroRehabilitation
https://read.qxmd.com/read/30740229/statistical-ranking-of-electromechanical-dyssynchrony-parameters-for-crt
#7
Serge Cazeau, Matthieu Toulemont, Philippe Ritter, Julien Reygner
Objective: Mechanical evaluation of dyssynchrony by echocardiography has not replaced ECG in routine cardiac resynchronisation therapy (CRT) evaluation because of its complexity and lack of reproducibility. The objective of this study was to evaluate the potential correlations between electromechanical parameters (atrioventricular, interventricular and intraventricular from the dyssynchrony model presented in 2000), their ability to describe dyssynchrony and their potential use in resynchrony...
2019: Open Heart
https://read.qxmd.com/read/30734091/irbesartan-suppresses-cardiac-toxicity-induced-by-doxorubicin-via-regulating-the-p38-mapk-nf-%C3%AE%C2%BAb-and-tgf-%C3%AE-1-pathways
#8
Nermin T El-Said, Eman A Mohamed, Ragia A Taha
Doxorubicin (DOX) so far continues to be one of the most potent and effective anticancer drugs. Therefore, it is still needed to search for a safe and effective therapy that can opposite DOX-induced cardiotoxicity. Irbesartan (IRB), an angiotensin II receptor blocker, has a wide-ranging variety of biological activities. The present study was designed to explore the possible protective effects of IRB against DOX-induced cardiotoxicity and the underlying mechanisms. Rats were divided into four groups: control, IRB (40 mg/kg, orally/daily) for 3 weeks, DOX (2...
February 7, 2019: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/30723724/heart-rate-and-heart-rate-variability-of-rhesus-macaques-macaca-mulatta-affected-by-left-ventricular-hypertrophy
#9
Yu Ueda, Taylor L Slabaugh, Ashley L Walker, Eric S Ontiveros, Paul-Michael Sosa, Rachel Reader, Jeffrey A Roberts, Joshua A Stern
Hypertrophic cardiomyopathy (HCM) is frequently associated with sudden cardiac death, presumably due to the development of malignant arrhythmias. The risk of sudden cardiac death due to HCM has been reported to be predicted by assessing electrocardiographic (ECG) changes including frequencies and complexities of arrhythmias as well as heart rate variability (HRV) as an assessment of autonomic balance. Sudden cardiac death in association with naturally-occurring left ventricular hypertrophy (LVH) has been reported in a colony of rhesus macaques and is under investigation as a potential non-human primate model of human HCM...
2019: Frontiers in Veterinary Science
https://read.qxmd.com/read/30689812/machine-learning-algorithms-estimating-prognosis-and-guiding-therapy-in-adult-congenital-heart-disease-data-from-a-single-tertiary-centre-including-10-019-patients
#10
Gerhard-Paul Diller, Aleksander Kempny, Sonya V Babu-Narayan, Marthe Henrichs, Margarita Brida, Anselm Uebing, Astrid E Lammers, Helmut Baumgartner, Wei Li, Stephen J Wort, Konstantinos Dimopoulos, Michael A Gatzoulis
Aims: To assess the utility of machine learning algorithms on estimating prognosis and guiding therapy in a large cohort of patients with adult congenital heart disease (ACHD) or pulmonary hypertension at a single, tertiary centre. Methods and results: We included 10 019 adult patients (age 36.3 ± 17.3 years) under follow-up at our institution between 2000 and 2018. Clinical and demographic data, ECG parameters, cardiopulmonary exercise testing, and selected laboratory markers where collected and included in deep learning (DL) algorithms...
January 26, 2019: European Heart Journal
https://read.qxmd.com/read/30684863/evaluation-of-ventricular-repolarization-parameters-during-migraine-attacks
#11
Mustafa Öztürk, Oğuzhan Ekrem Turan, Kayıhan Karaman, Nuray Bilge, Gökhan Ceyhun, Ugur Aksu, Emrah Aksakal, Oktay Gulcu, Kamuran Kalkan, Selami Demirelli
AIMS: Migraine is a chronic neurovascular disorder characterized by intermittent episodes of severe headache. Abnormalities in the autonomic nervous system (sympathetic and parasympathetic nervous systems) have been detected during migraine-free periods in patients with migraine. In these patients, disrupted autonomic innervations of the heart and coronary arteries may lead to electrocardiographic changes during a migraine attack. T-wave peak-to-end interval (Tp-e interval) and Tp-e/QT ratio are relatively new markers of ventricular arrhythmogenesis and repolarization heterogeneity...
December 21, 2018: Journal of Electrocardiology
https://read.qxmd.com/read/30680521/effect-of-niraparib-on-cardiac-repolarization-in-patients-with-platinum-sensitive-recurrent-epithelial-ovarian-fallopian-tube-and-primary-peritoneal-cancer
#12
Kathleen Moore, John K Chan, Angeles Alvarez Secord, Manish R Patel, Timothy Callahan, Wei Guo, Zhi-Yi Zhang
PURPOSE: Anticancer drugs may cause cardiovascular toxicities, including QT interval prolongation. Niraparib, a potent and selective once-daily oral poly (ADP-ribose) polymerase inhibitor, is approved as a maintenance therapy in platinum-sensitive recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer (EOC). Here, we present the effects of niraparib on cardiac repolarization, and the correlation between changes in baseline QT interval corrected by Fridericia's formula (ΔQTcF) and niraparib plasma concentrations...
January 24, 2019: Cancer Chemotherapy and Pharmacology
https://read.qxmd.com/read/30669438/a-physiological-sensor-based-android-application-synchronized-with-a-driving-simulator-for-driver-monitoring
#13
David González-Ortega, Francisco Javier Díaz-Pernas, Mario Martínez-Zarzuela, Míriam Antón-Rodríguez
In this paper, we present an Android application to control and monitor the physiological sensors from the Shimmer platform and its synchronized working with a driving simulator. The Android app can monitor drivers and their parameters can be used to analyze the relation between their physiological states and driving performance. The app can configure, select, receive, process, represent graphically, and store the signals from electrocardiogram (ECG), electromyogram (EMG) and galvanic skin response (GSR) modules and accelerometers, a magnetometer and a gyroscope...
January 19, 2019: Sensors
https://read.qxmd.com/read/30668432/attenuation-of-isoproterenol-induced-cardiotoxicity-in-rats-by-narirutin-rich-fraction-from-grape-fruit
#14
Shagufta Shaikh, Lokesh Kumar Bhatt, Kalyani Barve
BACKGROUND: Oxidative stress is one of the major mechanism involved in pathogenesis of myocardial infarction. Use of natural products as therapeutic approach for ischemic myocardial injury is gaining attention worldwide. PURPOSE: This study was designed to investigate efficacy of Narirutin rich fraction (NRF), obtained from grape fruit peel, in the treatment of isoproterenol induced myocardial infarction in rats. METHODS: After 3-days pretreatment with NRF (100  mg/kg and 200  mg/kg, p...
August 11, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://read.qxmd.com/read/30659785/safety-assessment-during-initiation-and-maintenance-of-propranolol-therapy-for-infantile-hemangiomas
#15
Lidia Babiak-Choroszczak, Kaja Giżewska-Kacprzak, Grażyna Dawid, Elżbieta Gawrych, Maciej Bagłaj
BACKGROUND: Propranolol is an effective method of treatment for infantile hemangiomas (IH). A recent concern is a shift of the therapy into outpatient settings. OBJECTIVES: The aim of the study was to evaluate the safety of initiating and maintaining propranolol therapy for IH. MATERIAL AND METHODS: The study involved 55 consecutive children with IH being treated with propranolol. The patients were assessed in the hospital at the initiation of the therapy and later in outpatient settings during and after the therapy...
January 15, 2019: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/30622395/evaluation-of-heart-rate-variability-in-drug-free-panic-disorder-patients
#16
Gözde Şirin Durdu, Meral Kayikcioğlu, Şebnem Pirildar, Timur Köse
Introduction: It is well-known that autonomic function is impaired in panic disorder (PD). Heart rate variability (HRV) is a reliable and noninvasive method to evaluate autonomic functions. The aim of this study is to evaluate 24-hour heart rate variability (HRV) parameters in drug-free panic disorder patients. These results are compared with those obtained from healthy controls. Methods: Thirty-two (mean age 33.12±11.94 years, 20 female, 12 male) drug-free patients for at least 2 weeks, (for fluoksetin 3 weeks) diagnosed with panic disorder (PD) on the basis of DSM-IV criteria were included in the study...
December 2018: Noro Psikiyatri Arsivi
https://read.qxmd.com/read/30615243/computational-multivariate-modeling-of-electrical-activity-of-the-porcine-uterus-during-spontaneous-and-hormone-induced-estrus
#17
Malgorzata Domino, Krzysztof Domino, Bartosz Pawlinski, Maria Sady, Magdalena Gajewska, Zdzislaw Gajewski
NEW FINDINGS: What is the central question of this study? Does estrous cycle synchronization influence myoelectrical activity of porcine myometrium? What is the main finding and its importance? Exogenous hormones used to synchronize estrus in pigs altered myoelectrical activity which was effectively modeled. As a result of higher order multivariate statistic modeling, we observed evidence of similar strange in both types of estrus but a larger order of EMG signals during induced estrus...
January 7, 2019: Experimental Physiology
https://read.qxmd.com/read/30602338/fragmented-qrs-on-electrocardiography-as-a-predictor-of-myocardial-scar-in-patients-with-hypertrophic-cardiomyopathy
#18
Aneesh C Ratheendran, Muthiah Subramanian, Devi K Bhanu, Mukund A Prabhu, Rajesh Kannan, K U Natarajan, S Saritha Sekhar, Rajesh Thachathodiyil, M S Harikrishnan, Praveen G Pai
BACKGROUND: Fragmented QRS (fQRS) and Q waves are ECG findings in patients with myocardial scar. fQRS is more sensitive than pathological Q waves in detecting myocardial fibrosis in patients with coronary artery disease (CAD). Cardiac magnetic resonance (CMR) imaging is used for the diagnosis and for quantifying scar tissue in patients with HCM. Our aim was to correlate ECG parameters like fQRS and Q waves with the presence of late gadolinium enhancement (LGE) assessed by contrast CMR imaging to elucidate ECG markers which might predict scar tissue in HCM...
January 3, 2019: Acta Cardiologica
https://read.qxmd.com/read/30598626/red-blood-cell-distribution-width-improves-reclassification-of-patients-admitted-to-the-emergency-department-with-acute-decompensated-heart-failure
#19
Gianni Turcato, Gianfranco Cervellin, Antonio Bonora, Danieli Prati, Elisabetta Zorzi, Giorgio Ricci, Gian Luca Salvagno, Antonio Maccagnani, Giuseppe Lippi
Background: The usual history of chronic heart failure (HF) is characterized by frequent episodes of acute decompensation (ADHF), needing urgent management in the emergency department (ED). Since the diagnostic accuracy of routine laboratory tests remains quite limited for predicting short-term mortality in ADHF, this retrospective study investigated the potential significance of combining red blood cell distribution width (RDW) with other conventional tests for prognosticating ADHF upon ED admission...
July 2018: Journal of Medical Biochemistry
https://read.qxmd.com/read/30563577/myocarditis-in-a-patient-treated-with-nivolumab-and-prostvac-a-case-report
#20
Cecilia Monge, Hoyoung Maeng, Alessandra Brofferio, Andrea B Apolo, Bharath Sathya, Andrew E Arai, James L Gulley, Marijo Bilusic
BACKGROUND: Immune checkpoint inhibitors have revolutionized treatment and improved survival in many cancers. However, since immune-related adverse events (irAEs) are potentially fatal, early recognition and prompt treatment are warranted. One of the rarest but most dramatic irAE is myocarditis, which has significant morbidity and mortality if not recognized and treated early. OBJECTIVE: To report the first case of myocarditis in a patient with metastatic castration-resistant prostate cancer (mCRPC) treated with a combination of nivolumab, an anti-programmed cell death protein 1 antibody, and PROSTVAC, a vector-based therapeutic prostate cancer vaccine...
December 18, 2018: Journal for Immunotherapy of Cancer
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